Greg Medlock
@gregmedlock.bsky.social
Interested in drug development, microbial ecology, systems biology, & urbanism. I develop bacterial consortia as drugs: https://www.vedantabio.com
I'll be speaking at Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection @keystonesymposia.bsky.social May 4-7, 2026. Abstract and scholarship submissions are open through Jan 7. Please encourage those in your network working on novel infection prevention/treatment to submit!
November 4, 2025 at 3:36 PM
I'll be speaking at Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection @keystonesymposia.bsky.social May 4-7, 2026. Abstract and scholarship submissions are open through Jan 7. Please encourage those in your network working on novel infection prevention/treatment to submit!
Reposted by Greg Medlock
Incredibly powerful story from endocrinologist Dr. Caroline Fox candidly sharing her experience w an acute mental health crisis & her long, difficult, maddening, deeply inspiring journey towards recovery - & return to work as a senior biopharma R&D leader. www.youtube.com/watch?v=YVWS...
Mental Health Journey to Wellness, Gratitude, and Purpose
YouTube video by Caroline Fox
www.youtube.com
October 12, 2025 at 8:15 PM
Incredibly powerful story from endocrinologist Dr. Caroline Fox candidly sharing her experience w an acute mental health crisis & her long, difficult, maddening, deeply inspiring journey towards recovery - & return to work as a senior biopharma R&D leader. www.youtube.com/watch?v=YVWS...
Largely agree with this—clinical validation of drugs is an extremely small N universe, and it’s not feasible to validate human- vs AI-generated hypothesis prob of success. AI is much better suited to solving the sub-problems in drug dev (which vanilla machine learning was already pretty good at).
October 20, 2025 at 1:52 PM
Largely agree with this—clinical validation of drugs is an extremely small N universe, and it’s not feasible to validate human- vs AI-generated hypothesis prob of success. AI is much better suited to solving the sub-problems in drug dev (which vanilla machine learning was already pretty good at).
Amazing resource—hope it gets used broadly and we see TnSeq datasets become more common for Bacteroidales.
Excited to share our preprint led by Carlos Voogdt et al
We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...
We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...
October 13, 2025 at 8:43 PM
Amazing resource—hope it gets used broadly and we see TnSeq datasets become more common for Bacteroidales.
Things I love about London: BOLLARDS
October 2, 2025 at 7:55 AM
Things I love about London: BOLLARDS
Reposted by Greg Medlock
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine.
1) Fundamental researc...
www.linkedin.com
September 23, 2025 at 10:31 PM
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Reposted by Greg Medlock
Report: You To Be Fired For Reading This Headline About Charlie Kirk
Report: You To Be Fired For Reading This Headline About Charlie Kirk
NEW YORK—Insisting your fate was sealed the moment you clicked the link, a report released Tuesday found that you will be fired for reading this headline about Charlie Kirk. “Shortly after you navigat...
theonion.com
September 16, 2025 at 3:03 PM
Report: You To Be Fired For Reading This Headline About Charlie Kirk
Reposted by Greg Medlock
Such a delight to share our work on the evolution of a cheese rind fungus in @currentbiology.bsky.social.
This is the fantastic PhD work of @nicolasleonlouw.bsky.social and resulted from amazing collaborations, a wedding proposal(!), an undergrad course, & more!
🧵
www.cell.com/current-biol...
This is the fantastic PhD work of @nicolasleonlouw.bsky.social and resulted from amazing collaborations, a wedding proposal(!), an undergrad course, & more!
🧵
www.cell.com/current-biol...
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation
Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated
Penicillium population has adapted in an artisan cheese production facility in Vermont,
USA. Adaptation i...
www.cell.com
September 16, 2025 at 3:56 PM
Such a delight to share our work on the evolution of a cheese rind fungus in @currentbiology.bsky.social.
This is the fantastic PhD work of @nicolasleonlouw.bsky.social and resulted from amazing collaborations, a wedding proposal(!), an undergrad course, & more!
🧵
www.cell.com/current-biol...
This is the fantastic PhD work of @nicolasleonlouw.bsky.social and resulted from amazing collaborations, a wedding proposal(!), an undergrad course, & more!
🧵
www.cell.com/current-biol...
Reposted by Greg Medlock
Preprint out for myloasm, our new nanopore / HiFi metagenome assembler!
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
High-resolution metagenome assembly for modern long reads with myloasm https://www.biorxiv.org/content/10.1101/2025.09.05.674543v1
September 7, 2025 at 11:35 PM
Preprint out for myloasm, our new nanopore / HiFi metagenome assembler!
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
Reposted by Greg Medlock
We published a new lane of research today on human gut fungi. Shout out to 1st author @emilyvansyoc.bsky.social sky.social & @erdavenport.bsky.social For 20 years, bacteria received the lion's share of interest in the human gut. Yet we know little about the gut mycobiome. doi.org/10.1371/jour...
Gut fungi are associated with human genetic variation and disease risk
In contrast to decades of research on gut bacteria, human genetic determinants of the gut fungal community (mycobiome) remain understudied. This investigation presents the first GWAS on the number and...
doi.org
September 2, 2025 at 7:31 PM
We published a new lane of research today on human gut fungi. Shout out to 1st author @emilyvansyoc.bsky.social sky.social & @erdavenport.bsky.social For 20 years, bacteria received the lion's share of interest in the human gut. Yet we know little about the gut mycobiome. doi.org/10.1371/jour...
Reposted by Greg Medlock
Optimizing storage, high-molecular weight DNA extraction and genome reconstructions from human faecal samples. https://www.biorxiv.org/content/10.1101/2025.08.27.672560v1
August 30, 2025 at 12:17 AM
Optimizing storage, high-molecular weight DNA extraction and genome reconstructions from human faecal samples. https://www.biorxiv.org/content/10.1101/2025.08.27.672560v1
Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite
Wonder how frequent this variability in bile acid sensitivity is across bacterial pathogens!
www.cell.com/cell-host-mi...
Wonder how frequent this variability in bile acid sensitivity is across bacterial pathogens!
www.cell.com/cell-host-mi...
Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite
Huang et al. identify a multidrug-resistance-associated ABC transporter, CpMRP1, as
a genetic determinant of pathogenicity in Cryptosporidium parvum. Through genetic
mapping and functional assays, the...
www.cell.com
August 28, 2025 at 7:55 PM
Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite
Wonder how frequent this variability in bile acid sensitivity is across bacterial pathogens!
www.cell.com/cell-host-mi...
Wonder how frequent this variability in bile acid sensitivity is across bacterial pathogens!
www.cell.com/cell-host-mi...
Very neat, looking forward to exploring this hypothesis with gut microbes. Nice work @sulheim.bsky.social
So excited to share this new paper by @sulheim.bsky.social and others! It's rare that you find a pattern, propose a hypothesis and the more you look, the more data you find that fits! Snorre's intuition, hard work and rigour to put it all together have been inspiring! Let us know what you think...
Excited to share the first results from my postdoc at @dmf-unil.bsky.social with @saramitri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 23, 2025 at 3:23 AM
Very neat, looking forward to exploring this hypothesis with gut microbes. Nice work @sulheim.bsky.social
Reposted by Greg Medlock
This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens
Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...
rdcu.be
August 20, 2025 at 1:25 PM
This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Vedanta has an opening for a contract QC analyst. Please share with your network! The ideal candidate will have both micro and molecular biology experience.
job-boards.greenhouse.io/vedantabiosc...
job-boards.greenhouse.io/vedantabiosc...
Contract - Quality Control Specialist
Cambridge, MA
job-boards.greenhouse.io
August 7, 2025 at 5:24 PM
Vedanta has an opening for a contract QC analyst. Please share with your network! The ideal candidate will have both micro and molecular biology experience.
job-boards.greenhouse.io/vedantabiosc...
job-boards.greenhouse.io/vedantabiosc...
Reposted by Greg Medlock
Breaking: The Gates Foundation said it would commit $2.5 billion through 2030 to support women’s health initiatives, its largest funding commitment ever to the issue.
www.statnews.com/2025/08/04/b...
www.statnews.com/2025/08/04/b...
Gates Foundation pledges $2.5 billion to women’s health initiatives
Breaking: The Gates Foundation said it would commit $2.5 billion through 2030 to support women’s health initiatives, its largest funding commitment ever to the issue.
www.statnews.com
August 4, 2025 at 2:09 PM
Breaking: The Gates Foundation said it would commit $2.5 billion through 2030 to support women’s health initiatives, its largest funding commitment ever to the issue.
www.statnews.com/2025/08/04/b...
www.statnews.com/2025/08/04/b...
Reposted by Greg Medlock
Excited to share this collaborative study with @ritatamayo.bsky.social showing that E. faecalis influences C. diff morphology through the phase variable CmrRST system! This work was co-led by the amazing team of @ashleyweiss.bsky.social and Jilarie Santos-Santiago!
Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1
July 26, 2025 at 3:08 AM
Excited to share this collaborative study with @ritatamayo.bsky.social showing that E. faecalis influences C. diff morphology through the phase variable CmrRST system! This work was co-led by the amazing team of @ashleyweiss.bsky.social and Jilarie Santos-Santiago!
Reposted by Greg Medlock
Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1
July 25, 2025 at 4:18 AM
Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1
Reposted by Greg Medlock
New paper is out from our lab showing that some probiotics can accelerate and prolong the return of colonization resistance to C. difficile after antibiotics.
news.ncsu.edu/2025/07/prob...
news.ncsu.edu/2025/07/prob...
Probiotics Can Help or Hinder Gut Recovery After Antibiotic Treatment
news.ncsu.edu
July 21, 2025 at 4:52 PM
New paper is out from our lab showing that some probiotics can accelerate and prolong the return of colonization resistance to C. difficile after antibiotics.
news.ncsu.edu/2025/07/prob...
news.ncsu.edu/2025/07/prob...
8ft tube light, no gas needed
July 18, 2025 at 12:01 AM
8ft tube light, no gas needed
Reposted by Greg Medlock
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
rdcu.be
July 16, 2025 at 9:20 PM
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
After many months of waiting, there is one fewer gas appliance in the world!
This battery-powered range from Copper (copperhome.com) helped us switch without needing a large electrical supply upgrade to our condo building.
This battery-powered range from Copper (copperhome.com) helped us switch without needing a large electrical supply upgrade to our condo building.
July 10, 2025 at 5:37 PM
After many months of waiting, there is one fewer gas appliance in the world!
This battery-powered range from Copper (copperhome.com) helped us switch without needing a large electrical supply upgrade to our condo building.
This battery-powered range from Copper (copperhome.com) helped us switch without needing a large electrical supply upgrade to our condo building.
Reposted by Greg Medlock
Systematic pairwise co-cultures uncover predominant negative interactions among human gut bacteria
-in BMC Microbiome
microbiomejournal.biomedcentral.com/articles/10....
-in BMC Microbiome
microbiomejournal.biomedcentral.com/articles/10....
Systematic pairwise co-cultures uncover predominant negative interactions among human gut bacteria - Microbiome
Background Understanding pairwise bacterial interactions in the human gut is crucial for deciphering the complex networks of bacterial interactions and their contributions to host health. However, the...
microbiomejournal.biomedcentral.com
July 10, 2025 at 2:16 PM
Systematic pairwise co-cultures uncover predominant negative interactions among human gut bacteria
-in BMC Microbiome
microbiomejournal.biomedcentral.com/articles/10....
-in BMC Microbiome
microbiomejournal.biomedcentral.com/articles/10....
The annual PACCARB meeting l, hosted by HHS, is essential for disseminating research on AMR and developing the US national action plan, but was cancelled during the presidential administration transition. Several stakeholders issued this plea to reschedule.
asm.org/articles/pol...
asm.org/articles/pol...
ASM, IDSA, SHEA & PIDS Request PACCARB Meet Immediately | ASM.org
On behalf of 41 organizations, we write to request that the President’s Advisory Council on Combating Antibiotic Resistant Bacteria (PACCARB) meet as soon as possible.
asm.org
June 23, 2025 at 3:44 PM
The annual PACCARB meeting l, hosted by HHS, is essential for disseminating research on AMR and developing the US national action plan, but was cancelled during the presidential administration transition. Several stakeholders issued this plea to reschedule.
asm.org/articles/pol...
asm.org/articles/pol...