Snorre Sulheim
@sulheim.bsky.social
SNSF postdoc fellow in Mitri lab @UNIL
Pinned
Snorre Sulheim
@sulheim.bsky.social
· Dec 3
Do you think transporters in E. coli contribute to metabolite release? No? Explore the effect of 66 different transporter knockout mutations on the exometabolome dynamics of ~300 metabolites yourself: keio.unil.ch
Teaser: Increased proline in ΔputP
#microsky #MEvoSky
Teaser: Increased proline in ΔputP
#microsky #MEvoSky
This project wouldn't been possible without Peter Doubleday and @nzamboni.bsky.social at @imsb-eth.bsky.social. Peter conducted >10,000 mass spec analyses 🤯. So grateful for this opportunity to team up with the best of the best in metabolomics 😍
Read more: www.biorxiv.org/content/10.1...
#microsky
Read more: www.biorxiv.org/content/10.1...
#microsky
Intra-species crossfeeding in K. pneumonia supports growth of co-cultivated partners. I think such commensal interactions are very common
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism and capacity for intra-species co-operation
Why are there so many co-circulating Klebsiella pneumoniae clones? Using genomics and large-scale metabolic modelling of >7000 isolates, this study identifies structured, clone-specific metabolic spec...
journals.plos.org
December 15, 2025 at 7:46 PM
Intra-species crossfeeding in K. pneumonia supports growth of co-cultivated partners. I think such commensal interactions are very common
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Metabolic control of porin permeability
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli - Nature Microbiology
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
www.nature.com
December 13, 2025 at 9:49 AM
Metabolic control of porin permeability
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Snorre Sulheim
New preprint from our lab www.biorxiv.org/content/10.1...! Andrea Dos Santos and Clément Vulin combine experiments and models showing how adding glucose can strengthen negative interactions between microbial species. This can be used in tandem with antibiotic treatment to inhibit pathogens!
December 2, 2025 at 1:12 PM
New preprint from our lab www.biorxiv.org/content/10.1...! Andrea Dos Santos and Clément Vulin combine experiments and models showing how adding glucose can strengthen negative interactions between microbial species. This can be used in tandem with antibiotic treatment to inhibit pathogens!
This project wouldn't been possible without Peter Doubleday and @nzamboni.bsky.social at @imsb-eth.bsky.social. Peter conducted >10,000 mass spec analyses 🤯. So grateful for this opportunity to team up with the best of the best in metabolomics 😍
Read more: www.biorxiv.org/content/10.1...
#microsky
Read more: www.biorxiv.org/content/10.1...
#microsky
Do you think transporters in E. coli contribute to metabolite release? No? Explore the effect of 66 different transporter knockout mutations on the exometabolome dynamics of ~300 metabolites yourself: keio.unil.ch
Teaser: Increased proline in ΔputP
#microsky #MEvoSky
Teaser: Increased proline in ΔputP
#microsky #MEvoSky
December 3, 2025 at 12:50 PM
This project wouldn't been possible without Peter Doubleday and @nzamboni.bsky.social at @imsb-eth.bsky.social. Peter conducted >10,000 mass spec analyses 🤯. So grateful for this opportunity to team up with the best of the best in metabolomics 😍
Read more: www.biorxiv.org/content/10.1...
#microsky
Read more: www.biorxiv.org/content/10.1...
#microsky
Do you think transporters in E. coli contribute to metabolite release? No? Explore the effect of 66 different transporter knockout mutations on the exometabolome dynamics of ~300 metabolites yourself: keio.unil.ch
Teaser: Increased proline in ΔputP
#microsky #MEvoSky
Teaser: Increased proline in ΔputP
#microsky #MEvoSky
December 3, 2025 at 11:11 AM
Do you think transporters in E. coli contribute to metabolite release? No? Explore the effect of 66 different transporter knockout mutations on the exometabolome dynamics of ~300 metabolites yourself: keio.unil.ch
Teaser: Increased proline in ΔputP
#microsky #MEvoSky
Teaser: Increased proline in ΔputP
#microsky #MEvoSky
After two rounds of "peer review" at Scientific reports 😵💫
"Runctitiononal features"? "Medical fymblal"? "1 Tol Line storee"? This gets worse the longer you look at it. But it's got to be good, because it was published in Nature Scientific Reports last week: www.nature.com/articles/s41... h/t @asa.tsbalans.se
November 28, 2025 at 11:55 AM
After two rounds of "peer review" at Scientific reports 😵💫
Great to see the increased use of genome-scale models in microbial ecology. Here is another recent example: www.nature.com/articles/s41...
But why is no one questioning the often implicit assumption that growth-optimization at the community level is the driving force of cross-feeding?
But why is no one questioning the often implicit assumption that growth-optimization at the community level is the driving force of cross-feeding?
Substrate utilization and cross-feeding synergistically determine microbiome resistance to pathogen invasion - Nature Ecology & Evolution
Combining genome-scale metabolic modelling with in vitro and in planta experiments, the authors show that cross-feeding metabolites and substrate utilization synergistically determine microbial commun...
www.nature.com
November 26, 2025 at 12:09 PM
Great to see the increased use of genome-scale models in microbial ecology. Here is another recent example: www.nature.com/articles/s41...
But why is no one questioning the often implicit assumption that growth-optimization at the community level is the driving force of cross-feeding?
But why is no one questioning the often implicit assumption that growth-optimization at the community level is the driving force of cross-feeding?
Great opportunity with a very nice PI👇
I am excited to announce two PhD opportunities! Come and join our interdisciplinary team in Sheffield, UK.
- Destroying forever chemicals with microbes and cold plasma: tinyurl.com/mth8ymx5
- Learning how motile bacteria make decisions: tinyurl.com/2hmc9a8u
UK and overseas students welcome to apply!
- Destroying forever chemicals with microbes and cold plasma: tinyurl.com/mth8ymx5
- Learning how motile bacteria make decisions: tinyurl.com/2hmc9a8u
UK and overseas students welcome to apply!
ECOSOLUTIONS DFA - Harnessing microbes and cold plasma to concentrate and destroy ‘forever chemicals’ in food associated ecosystems at University of Sheffield on FindAPhD.com
PhD Project - ECOSOLUTIONS DFA - Harnessing microbes and cold plasma to concentrate and destroy ‘forever chemicals’ in food associated ecosystems at University of Sheffield, listed on Find...
tinyurl.com
October 30, 2025 at 9:04 PM
Great opportunity with a very nice PI👇
A beautiful review of the factors influencing spatial organization of microbiomes
Deciphering microbial spatial organization: insights from synthetic and engineered communities url: academic.oup.com/ismecommun/a...
Deciphering microbial spatial organization: insights from synthetic and engineered communities
Abstract. Microbial communities are frequently organized into complex spatial structures, shaped by intrinsic cellular traits, interactions between communi
academic.oup.com
September 11, 2025 at 12:04 PM
A beautiful review of the factors influencing spatial organization of microbiomes
Excited to share the first results from my postdoc at @dmf-unil.bsky.social with @saramitri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Microbes release lower-value metabolites at higher rates
Microbes release a wide range of metabolites into their environment, yet the reasons for this release and the factors that influence release rates are not well understood. Here, using a combination of...
www.biorxiv.org
August 20, 2025 at 8:31 AM
Excited to share the first results from my postdoc at @dmf-unil.bsky.social with @saramitri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...