Casey Theriot
LightNews LightNews
banner
theriotmicrobe.bsky.social
Casey Theriot
@theriotmicrobe.bsky.social
670 followers 170 following 11 posts
Professor in Infectious Disease, microbiologist, C. difficile, gut microbiome, metabolomics, microbial mediated bile acids, amino acids
Posts Replies Media Videos
theriotmicrobe.bsky.social
Really nice work driven by postdocs Dr. Gancz in my lab and Dr. Zhang in Baker @erinbakerims.bsky.social lab at UNC, looking at novel lipids and how they might play a role in restoring colonization resistance against C. difficile in patients with rCDI post FMT.
www.researchsquare.com/article/rs-7...
Successful Fecal Microbiota Transplants in Post-antibiotic Treated Recurrent Clostridioides difficile Patients Induce Acylcarnitine and Sphingolipid Lipidomic Shifts
Clostridioides difficile infection (CDI) is an urgent public health threat in the United States, resulting on an annual basis in over half a million cases, more than 29,000 deaths, and $4.8 billion in...
www.researchsquare.com
November 3, 2025 at 1:29 PM
Reposted by Casey Theriot
smitslab.bsky.social
Leids ‘superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang www.universiteitleiden.nl/nieuws/2025/...
Leids ‘superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang
Het in Leiden ontwikkelde antibioticum EVG7 slaagt erin om met een minimale dosis de gevaarlijke darmbacterie C. difficile te bestrijden. Bovendien komt de bacterie minder gemakkelijk terug, wat bij b...
www.universiteitleiden.nl
October 13, 2025 at 2:31 PM
Reposted by Casey Theriot
smitslab.bsky.social
New paper alert! In this work, published in @natcomms.nature.com we show that a new antibiotic is effective against (r)CDI. www.nature.com/articles/s41...
Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications
Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.
www.nature.com
October 11, 2025 at 2:19 PM
theriotmicrobe.bsky.social
Really nice collaboration with the Martin and Smits labs at Leiden University Netherlands, designing and testing novel antimicrobials that target C. difficile but spare members of the microbiota, including Lachnospiraceae.
www.nature.com/articles/s41...
Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications
Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.
www.nature.com
October 10, 2025 at 12:14 PM
Reposted by Casey Theriot
peiferlabunc.bsky.social
Cool Postdoc opportunity alert! UNC SPIRE (Seeding Postdoctoral Innovators in Research & Education)-it provides scholars with both high quality research training & the opportunity to develop research based teaching skills that will inspire students across the sciences 1/n
spire.unc.edu/program-info/
About Seeding Postdoctoral Innovators in Research & Education (SPIRE) SPIRE’s Mission: 1) To provide scholars with both high quality research training and the opportunity to develop research based teaching skills that will inspire students across the sciences 2) To promote effective teaching and research partnerships between research intensive institutions and partner institutions with a large population of underrepresented students The four major components of the SPIRE Postdoctoral Fellowship Program include: Research Teaching Professional Development Additional Opportunities
October 1, 2025 at 2:31 PM
Reposted by Casey Theriot
leighknodler.bsky.social
"We became inconvenient".
NIH whistleblower details clash over childhood vaccines with Trump administration: "We became inconvenient"
A former NIH official says she was removed after clashes over vaccines, accusing RFK Jr. and his deputies of posing "a substantial and specific danger to public health and safety."
www.cbsnews.com
September 9, 2025 at 12:01 PM
Reposted by Casey Theriot
angierasmussen.bsky.social
If you believe that keeping your head down and being quiet will spare you from this fate, you are mistaken. This will be all of us.
jeremymberg.bsky.social Jeremy Berg @jeremymberg.bsky.social · Aug 24
New York Times story with profiles of researchers whose grants were terminated.

[Gift Link]

www.nytimes.com/2025/08/24/o...
Opinion | America First? Not When It Comes to Your Health.
www.nytimes.com
August 24, 2025 at 3:39 PM
Reposted by Casey Theriot
jkpfeiff.bsky.social
Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...
Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.
August 18, 2025 at 2:31 PM
Reposted by Casey Theriot
pieterdorrestein.bsky.social
The best of both worlds with awesome speakers that will focus on how the microbiome affects ecosystems at a mechanistic level. Can’t wait for this meeting.
August 12, 2025 at 11:35 PM
Reposted by Casey Theriot
jeffjacksonnc.bsky.social
A federal agency - which controls an enormous amount of money - is breaking the law to hide its decisions from you and avoid accountability.

Hey OMB, see you in court.
July 29, 2025 at 6:22 PM
Reposted by Casey Theriot
roycoopernc.bsky.social
I have thought on it and prayed about it, and I have decided: I am running to be the next U.S. Senator from North Carolina.
July 28, 2025 at 12:05 PM
Reposted by Casey Theriot
peiferlabunc.bsky.social
Thank you Senator Tillis! NC folks drop him an email or make a call and thank him
barrlab.bsky.social Maureen Barr @barrlab.bsky.social · Jul 26
From @aaas.org check-in with Sudip Parikh: a letter by 14 Republican senators urge the Office of Management and Budget to release NIH funding. If this includes your state (AL, ME, WV, SC, KY, KS, AR, PA, NC, IN, AK), Sudip recommends contacting & thanking them for being American science leaders.
Director Vought: We write to ask you to fully implement the Fiscal Year (FY) 2025 Full-Year Continuing Appropriations and Extensions Act, including funds appropriated for the National Institutes of Health (NIH). The continuing resolution supp011s NIH initiatives across a range of critical research areas­cancer, cardiovascular disease, rare pediatric disorders, and more. These vital efforts are not only necessary to Make America Healthy Again, but also have a direct impact on American families, biomedical innovation, our economy, and competing with Communist China. We are concerned by the slow disbursement rate of FY25 NIH funds, as it risks undermining critical research and the thousands of American jobs it supports. Suspension of these appropriated funds - whether formally withheld or functionally delayed - could threaten Americans' ability to access better treatments and limit our nation's leadership in biomedical science. It also risks inadve11ently severing ongoing NIH-funded research prior to actionable results. We share your commitment to ensuring NIH funds are used responsibly and not diverted to ideological or unaccountable programs. We are confident Secretary Kennedy and Director Bhattacharya are well positioned to uphold gold standard research by ensuring that NIH awards are grounded in transparency, scientific merit, and a clear alignment with national interests. Our shared goal is to restore public trust in the NIH precisely because its work is focused on results, accountability, and real-world impact. Withholding or suspending these funds would jeopardize that trust and hinder progress on critical health challenges facing our nation. Ultimately, this is about finding cures and seeing them through to fruition. We respectfully request that you ensure the timely release of all FY25 NIH appropriations in accordance with congressional intent. Doing so will ensure continued momentum in curing disease, supp011ing American innovation, and delivering result… Sincerely, Katie Boyd Britt John Boozman Shelly Moore Capito Bill Cassidy Susan Collins Lindsey O. Graham David H. McCormick Mitch McConnel Jerry Moran Lisa Murkowski Thom Tillis Todd Young Dan Sullivan Tim Scott
July 26, 2025 at 8:44 PM
Reposted by Casey Theriot
donmoyn.bsky.social
We’ve known for months now that Vought was illegally impounding funds with the goals of rescissions. Better late than never for GOP Senators to politely ask that he stop breaking the law.
elizabethjacobs.bsky.social Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · Jul 25
Wait, sometimes there are surprises. Apparently some Republicans have now grasped the immense damage to their communities caused by massive cuts to NIH funding.

We told them this beforehand, yet they still thoroughly enjoyed seeing the massive cuts…until it affected them directly.
14 Republican senators urge White House to release delayed NIH funds
Sen. Katie Britt (R-Ala.) is leading the letter making the ask of OMB director Russ Vought.
www.politico.com
July 26, 2025 at 12:29 AM
Reposted by Casey Theriot
biorxiv-microbiol.bsky.social
Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1
July 25, 2025 at 4:18 AM
Reposted by Casey Theriot
pieterdorrestein.bsky.social
I am so excited about this meeting. I will cover the discovery of 10,000s new metabolites, including an entirely new class of molecules. Looking forward to hearing and discussing your science on microbiome metabolites and metabolism.
keystonesymposia.bsky.social Keystone Symposia @keystonesymposia.bsky.social · Jul 21
⏳ Don’t miss it! Submit abstracts & scholarship apps for Microbiome Metabolism & Metabolites by Sept 23 (11:59 PM MT).
📍 Jan 19-22, 2026 | Banff, Canada
👉 keysym.us/KSMicroMetab26
#KSMicroMetab26 #Microbiome #Metabolomics @pieterdorrestein.bsky.social ‪@inesthiele.bsky.social
July 21, 2025 at 4:54 PM
theriotmicrobe.bsky.social
New paper is out from our lab showing that some probiotics can accelerate and prolong the return of colonization resistance to C. difficile after antibiotics.
news.ncsu.edu/2025/07/prob...
Probiotics Can Help or Hinder Gut Recovery After Antibiotic Treatment
news.ncsu.edu
July 21, 2025 at 4:52 PM
theriotmicrobe.bsky.social
Join us in Banff, CAN January 19-22 for the Keystone meeting on Microbiome Metabolism and Metabolites! Early scholarship deadline is September 23!
July 18, 2025 at 1:08 PM
Reposted by Casey Theriot
peiferlabunc.bsky.social
Thanks to WRAL for documenting the tremendous impact of the Trump administration efforts to end important research grants
www.wral.com/news/local/u...
100+ UNC research projects lose federal funding
UNC-Chapel Hill is navigating a significant $126 million reduction in federal grant funding compared to last fiscal year.
www.wral.com
June 27, 2025 at 2:34 PM
Reposted by Casey Theriot
theriotmicrobe.bsky.social
We are looking for a new postdoctoral fellow to join our team at NC State University College of Veterinary Medicine, near Research Triangle Park. If you are interested please DM me and or also apply here: jobs.ncsu.edu/postings/219...
PostDoc Research Fellow - Gut Microbiology - Theriot Lab
A postdoctoral scientist position (1+ years) is available in Prof. Casey Theriot’s group at North Carolina State University College of Veterinary Medicine (NCSU CVM).Duties and ResponsibilitiesThe suc...
jobs.ncsu.edu
June 17, 2025 at 2:00 PM
Reposted by Casey Theriot
joshuasweitz.bsky.social
The #SCIMaP team announces a major update: an analysis of the economic impacts of the White House's NIH FY26 budget.

Bottom-line, we estimate $46B in total economic loss, 202K lost jobs, and impacts in communities nationwide.

Interactive map and shareable report:
scienceimpacts.org/fy26

a 🧵
Economic loss due to NIH budget cuts by congressional district, scienceimpacts.org/fy26
June 23, 2025 at 7:10 PM
theriotmicrobe.bsky.social
We are looking for a new postdoctoral fellow to join our team at NC State University College of Veterinary Medicine, near Research Triangle Park. If you are interested please DM me and or also apply here: jobs.ncsu.edu/postings/219...
PostDoc Research Fellow - Gut Microbiology - Theriot Lab
A postdoctoral scientist position (1+ years) is available in Prof. Casey Theriot’s group at North Carolina State University College of Veterinary Medicine (NCSU CVM).Duties and ResponsibilitiesThe suc...
jobs.ncsu.edu
June 17, 2025 at 2:00 PM
Reposted by Casey Theriot
isakoditomassi.bsky.social
Incredible work, JP!

#McClintockLetters
June 16, 2025 at 6:41 PM
Reposted by Casey Theriot
pieterdorrestein.bsky.social
If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids
Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library containing hundreds of N-acyl lipids, including conjugates with short-chain fatty acids. This resource enabled the...
www.cell.com
June 12, 2025 at 5:56 PM
Reposted by Casey Theriot
gavinyamey.bsky.social
Jay Bhattacharya & Russ Vought are taking $566 million in NIH funding from my state (we are #2 in terminated grants)

The impact will be truly horrific, but these 2 men will rejoice 😡

Bhattacharya took $129 million from Duke’s HIV vaccine development efforts: www.dukechronicle.com/article/2025... 🤬
gregggonsalves.bsky.social Gregg Gonsalves @gregggonsalves.bsky.social · Jun 8
This is all on Russ Vought at Office of Management and Budget for his insane crusade against federal agencies and universities and on Jay Bhattacharya at NIH for acquiescing to all this. It's red and blue states. It's going to hurt local economies and our nation's health. There is no good here.
A table from the Association of American Medical Colleges (AAMC) titled “Impact on states”, showing the financial losses by U.S. states due to terminated NIH grants in 2025. The table is labeled Table 2: The Financial Impact of Terminated NIH Grants on U.S. States and ranks 45 states, the District of Columbia, and Puerto Rico by the amount of NIH funding lost. • Top 5 states by lost funding: 1. New York – $575,614,031 2. North Carolina – $566,096,741 3. California – $98,579,246 4. Texas – $71,809,080 5. Florida – $62,943,080 Other notable states: • Massachusetts (#6) – $54M • Maryland (#7) – $51.8M • Illinois (#8) – $46.8M • Georgia (#9) – $40.9M • Tennessee (#10) – $34.3M • Smallest losses are reported for: • Idaho (#45) – $281,335 • Puerto Rico (#44) – $363,997 • Indiana (#43) – $571,041 • Iowa (#42) – $667,894 • Kentucky (#41) – $773,937 A footnote clarifies that no terminated grants were reported for North Dakota, South Dakota, Wyoming, Kansas, West Virginia, or New Hampshire. Sources listed include: • Ross N, Delaney S, Barente A, Mairson E. NIH grant terminations in 2025 (via Grant Tracker, accessed May 5, 2025) • U.S. Department of Health and Human Services, NIH • ClinicalTrials.gov (accessed May 5, 2025) • A link to the methodology: https://www.aamc.org/media/83351/download The document is © 2025 AAMC.
June 8, 2025 at 8:39 PM
Reposted by Casey Theriot
gcrox.bsky.social
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
May 23, 2025 at 5:56 PM