Casey Theriot
@theriotmicrobe.bsky.social
Professor in Infectious Disease, microbiologist, C. difficile, gut microbiome, metabolomics, microbial mediated bile acids, amino acids
Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 18, 2025 at 2:26 PM
Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model
Reposted by Casey Theriot
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 18, 2025 at 2:07 PM
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
Really nice work driven by postdocs Dr. Gancz in my lab and Dr. Zhang in Baker @erinbakerims.bsky.social lab at UNC, looking at novel lipids and how they might play a role in restoring colonization resistance against C. difficile in patients with rCDI post FMT.
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
Successful Fecal Microbiota Transplants in Post-antibiotic Treated Recurrent Clostridioides difficile Patients Induce Acylcarnitine and Sphingolipid Lipidomic Shifts
Clostridioides difficile infection (CDI) is an urgent public health threat in the United States, resulting on an annual basis in over half a million cases, more than 29,000 deaths, and $4.8 billion in...
www.researchsquare.com
November 3, 2025 at 1:29 PM
Really nice work driven by postdocs Dr. Gancz in my lab and Dr. Zhang in Baker @erinbakerims.bsky.social lab at UNC, looking at novel lipids and how they might play a role in restoring colonization resistance against C. difficile in patients with rCDI post FMT.
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
Reposted by Casey Theriot
Leids ‘superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang www.universiteitleiden.nl/nieuws/2025/...
Leids ‘superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang
Het in Leiden ontwikkelde antibioticum EVG7 slaagt erin om met een minimale dosis de gevaarlijke darmbacterie C. difficile te bestrijden. Bovendien komt de bacterie minder gemakkelijk terug, wat bij b...
www.universiteitleiden.nl
October 13, 2025 at 2:31 PM
Leids ‘superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang www.universiteitleiden.nl/nieuws/2025/...
Reposted by Casey Theriot
New paper alert! In this work, published in @natcomms.nature.com we show that a new antibiotic is effective against (r)CDI. www.nature.com/articles/s41...
Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications
Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.
www.nature.com
October 11, 2025 at 2:19 PM
New paper alert! In this work, published in @natcomms.nature.com we show that a new antibiotic is effective against (r)CDI. www.nature.com/articles/s41...
Really nice collaboration with the Martin and Smits labs at Leiden University Netherlands, designing and testing novel antimicrobials that target C. difficile but spare members of the microbiota, including Lachnospiraceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications
Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.
www.nature.com
October 10, 2025 at 12:14 PM
Really nice collaboration with the Martin and Smits labs at Leiden University Netherlands, designing and testing novel antimicrobials that target C. difficile but spare members of the microbiota, including Lachnospiraceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Casey Theriot
Cool Postdoc opportunity alert! UNC SPIRE (Seeding Postdoctoral Innovators in Research & Education)-it provides scholars with both high quality research training & the opportunity to develop research based teaching skills that will inspire students across the sciences 1/n
spire.unc.edu/program-info/
spire.unc.edu/program-info/
October 1, 2025 at 2:31 PM
Cool Postdoc opportunity alert! UNC SPIRE (Seeding Postdoctoral Innovators in Research & Education)-it provides scholars with both high quality research training & the opportunity to develop research based teaching skills that will inspire students across the sciences 1/n
spire.unc.edu/program-info/
spire.unc.edu/program-info/
Reposted by Casey Theriot
"We became inconvenient".
NIH whistleblower details clash over childhood vaccines with Trump administration: "We became inconvenient"
A former NIH official says she was removed after clashes over vaccines, accusing RFK Jr. and his deputies of posing "a substantial and specific danger to public health and safety."
www.cbsnews.com
September 9, 2025 at 12:01 PM
"We became inconvenient".
Reposted by Casey Theriot
If you believe that keeping your head down and being quiet will spare you from this fate, you are mistaken. This will be all of us.
New York Times story with profiles of researchers whose grants were terminated.
[Gift Link]
www.nytimes.com/2025/08/24/o...
[Gift Link]
www.nytimes.com/2025/08/24/o...
Opinion | America First? Not When It Comes to Your Health.
www.nytimes.com
August 24, 2025 at 3:39 PM
If you believe that keeping your head down and being quiet will spare you from this fate, you are mistaken. This will be all of us.
Reposted by Casey Theriot
Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...
August 18, 2025 at 2:31 PM
Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...
Reposted by Casey Theriot
The best of both worlds with awesome speakers that will focus on how the microbiome affects ecosystems at a mechanistic level. Can’t wait for this meeting.
Two conferences, one reg! Sign up for Microbiome Metabolism & Metabolites + get Human Microbiome FREE. Joint keynotes: Emily P. Balskus & Mohamed S. Abou Donia. keysym.us/KSMicroMetab26 @pieterdorrestein.bsky.social @mfgrp.bsky.social @inesthiele.bsky.social #KSMicroMetab26 #KSMicrobiome26
Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease | Keystone Symposia
Join us at the Keystone Symposia on Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease, January 2026, in Banff, with field leaders!
keysym.us
August 12, 2025 at 11:35 PM
The best of both worlds with awesome speakers that will focus on how the microbiome affects ecosystems at a mechanistic level. Can’t wait for this meeting.
Reposted by Casey Theriot
A federal agency - which controls an enormous amount of money - is breaking the law to hide its decisions from you and avoid accountability.
Hey OMB, see you in court.
Hey OMB, see you in court.
July 29, 2025 at 6:22 PM
A federal agency - which controls an enormous amount of money - is breaking the law to hide its decisions from you and avoid accountability.
Hey OMB, see you in court.
Hey OMB, see you in court.
Reposted by Casey Theriot
I have thought on it and prayed about it, and I have decided: I am running to be the next U.S. Senator from North Carolina.
July 28, 2025 at 12:05 PM
I have thought on it and prayed about it, and I have decided: I am running to be the next U.S. Senator from North Carolina.
Reposted by Casey Theriot
Thank you Senator Tillis! NC folks drop him an email or make a call and thank him
From @aaas.org check-in with Sudip Parikh: a letter by 14 Republican senators urge the Office of Management and Budget to release NIH funding. If this includes your state (AL, ME, WV, SC, KY, KS, AR, PA, NC, IN, AK), Sudip recommends contacting & thanking them for being American science leaders.
July 26, 2025 at 8:44 PM
Thank you Senator Tillis! NC folks drop him an email or make a call and thank him
Reposted by Casey Theriot
We’ve known for months now that Vought was illegally impounding funds with the goals of rescissions. Better late than never for GOP Senators to politely ask that he stop breaking the law.
Wait, sometimes there are surprises. Apparently some Republicans have now grasped the immense damage to their communities caused by massive cuts to NIH funding.
We told them this beforehand, yet they still thoroughly enjoyed seeing the massive cuts…until it affected them directly.
We told them this beforehand, yet they still thoroughly enjoyed seeing the massive cuts…until it affected them directly.
14 Republican senators urge White House to release delayed NIH funds
Sen. Katie Britt (R-Ala.) is leading the letter making the ask of OMB director Russ Vought.
www.politico.com
July 26, 2025 at 12:29 AM
We’ve known for months now that Vought was illegally impounding funds with the goals of rescissions. Better late than never for GOP Senators to politely ask that he stop breaking the law.
Reposted by Casey Theriot
Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1
July 25, 2025 at 4:18 AM
Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1
Reposted by Casey Theriot
I am so excited about this meeting. I will cover the discovery of 10,000s new metabolites, including an entirely new class of molecules. Looking forward to hearing and discussing your science on microbiome metabolites and metabolism.
⏳ Don’t miss it! Submit abstracts & scholarship apps for Microbiome Metabolism & Metabolites by Sept 23 (11:59 PM MT).
📍 Jan 19-22, 2026 | Banff, Canada
👉 keysym.us/KSMicroMetab26
#KSMicroMetab26 #Microbiome #Metabolomics @pieterdorrestein.bsky.social @inesthiele.bsky.social
📍 Jan 19-22, 2026 | Banff, Canada
👉 keysym.us/KSMicroMetab26
#KSMicroMetab26 #Microbiome #Metabolomics @pieterdorrestein.bsky.social @inesthiele.bsky.social
July 21, 2025 at 4:54 PM
I am so excited about this meeting. I will cover the discovery of 10,000s new metabolites, including an entirely new class of molecules. Looking forward to hearing and discussing your science on microbiome metabolites and metabolism.
New paper is out from our lab showing that some probiotics can accelerate and prolong the return of colonization resistance to C. difficile after antibiotics.
news.ncsu.edu/2025/07/prob...
news.ncsu.edu/2025/07/prob...
Probiotics Can Help or Hinder Gut Recovery After Antibiotic Treatment
news.ncsu.edu
July 21, 2025 at 4:52 PM
New paper is out from our lab showing that some probiotics can accelerate and prolong the return of colonization resistance to C. difficile after antibiotics.
news.ncsu.edu/2025/07/prob...
news.ncsu.edu/2025/07/prob...
Join us in Banff, CAN January 19-22 for the Keystone meeting on Microbiome Metabolism and Metabolites! Early scholarship deadline is September 23!
July 18, 2025 at 1:08 PM
Join us in Banff, CAN January 19-22 for the Keystone meeting on Microbiome Metabolism and Metabolites! Early scholarship deadline is September 23!
Reposted by Casey Theriot
Thanks to WRAL for documenting the tremendous impact of the Trump administration efforts to end important research grants
www.wral.com/news/local/u...
www.wral.com/news/local/u...
100+ UNC research projects lose federal funding
UNC-Chapel Hill is navigating a significant $126 million reduction in federal grant funding compared to last fiscal year.
www.wral.com
June 27, 2025 at 2:34 PM
Thanks to WRAL for documenting the tremendous impact of the Trump administration efforts to end important research grants
www.wral.com/news/local/u...
www.wral.com/news/local/u...
Reposted by Casey Theriot
We are looking for a new postdoctoral fellow to join our team at NC State University College of Veterinary Medicine, near Research Triangle Park. If you are interested please DM me and or also apply here: jobs.ncsu.edu/postings/219...
PostDoc Research Fellow - Gut Microbiology - Theriot Lab
A postdoctoral scientist position (1+ years) is available in Prof. Casey Theriot’s group at North Carolina State University College of Veterinary Medicine (NCSU CVM).Duties and ResponsibilitiesThe suc...
jobs.ncsu.edu
June 17, 2025 at 2:00 PM
We are looking for a new postdoctoral fellow to join our team at NC State University College of Veterinary Medicine, near Research Triangle Park. If you are interested please DM me and or also apply here: jobs.ncsu.edu/postings/219...
Reposted by Casey Theriot
The #SCIMaP team announces a major update: an analysis of the economic impacts of the White House's NIH FY26 budget.
Bottom-line, we estimate $46B in total economic loss, 202K lost jobs, and impacts in communities nationwide.
Interactive map and shareable report:
scienceimpacts.org/fy26
a 🧵
Bottom-line, we estimate $46B in total economic loss, 202K lost jobs, and impacts in communities nationwide.
Interactive map and shareable report:
scienceimpacts.org/fy26
a 🧵
June 23, 2025 at 7:10 PM
The #SCIMaP team announces a major update: an analysis of the economic impacts of the White House's NIH FY26 budget.
Bottom-line, we estimate $46B in total economic loss, 202K lost jobs, and impacts in communities nationwide.
Interactive map and shareable report:
scienceimpacts.org/fy26
a 🧵
Bottom-line, we estimate $46B in total economic loss, 202K lost jobs, and impacts in communities nationwide.
Interactive map and shareable report:
scienceimpacts.org/fy26
a 🧵
We are looking for a new postdoctoral fellow to join our team at NC State University College of Veterinary Medicine, near Research Triangle Park. If you are interested please DM me and or also apply here: jobs.ncsu.edu/postings/219...
PostDoc Research Fellow - Gut Microbiology - Theriot Lab
A postdoctoral scientist position (1+ years) is available in Prof. Casey Theriot’s group at North Carolina State University College of Veterinary Medicine (NCSU CVM).Duties and ResponsibilitiesThe suc...
jobs.ncsu.edu
June 17, 2025 at 2:00 PM
We are looking for a new postdoctoral fellow to join our team at NC State University College of Veterinary Medicine, near Research Triangle Park. If you are interested please DM me and or also apply here: jobs.ncsu.edu/postings/219...
Reposted by Casey Theriot
So proud to be a part of @snapcoalition.bsky.social! We’ve worked hard on the McClintock Letters and are excited to read everyone’s pieces!
Check out 1/2 of my op-eds below:
indyweek.com/news/opinion...
Check out 1/2 of my op-eds below:
indyweek.com/news/opinion...
Op-Ed: What Science Funding Cuts Mean for NC
Recent decisions to slash science funding are threatening to uproot decades of innovation, education, and public health in our state.
indyweek.com
June 16, 2025 at 6:41 PM
Reposted by Casey Theriot
If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids
Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library
containing hundreds of N-acyl lipids, including conjugates with short-chain fatty
acids. This resource enabled the...
www.cell.com
June 12, 2025 at 5:56 PM
If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...