George Lund
@georgelund.bsky.social
Postdoc @Rothamsted in Microbial Natural Product Discovery.
Microbial interactions (Pseudomonas & Zymoseptoria tritici), Bioinformatics, Secondary Metabolism.
Microbial interactions (Pseudomonas & Zymoseptoria tritici), Bioinformatics, Secondary Metabolism.
Pinned
George Lund
@georgelund.bsky.social
· Jun 3
Development of a bioassay guided genome mining approach for antifungal natural product discovery from pseudomonads
Zymoseptoria tritici causes Septoria Leaf Blotch disease of wheat and has evolved to overcome most chemical and genetic control methods. As such, new tools are required for future disease control.
We...
doi.org
🚨 New preprint!
We've developed a bioassay-guided genome mining approach to identify bacterial secondary metabolites that inhibit Zymoseptoria tritici — a major fungal pathogen of wheat.
Available now on bioRxiv: doi.org/10.1101/2025...
We've developed a bioassay-guided genome mining approach to identify bacterial secondary metabolites that inhibit Zymoseptoria tritici — a major fungal pathogen of wheat.
Available now on bioRxiv: doi.org/10.1101/2025...
Reposted by George Lund
Congratulations to Katerina Velchova for successfully defending her PhD thesis today, with no corrections! 👏 Thank you to examiners Jim Harris (Cranfield Uni) and Ute Voß (University of Nottingham) for the great discussions.
February 11, 2026 at 4:15 PM
Congratulations to Katerina Velchova for successfully defending her PhD thesis today, with no corrections! 👏 Thank you to examiners Jim Harris (Cranfield Uni) and Ute Voß (University of Nottingham) for the great discussions.
Reposted by George Lund
Have you ever used a #bioinformatics #database and were frustrated by its lack of coverage? Did you ever think about starting your own resource? We just published a new strategy for community-driven #biocuration, based on our experiences with the #MIBiG database (1/8)! doi.org/10.1093/bib/...
Strategies for community-sourced biocuration in bioinformatics: a case study on MIBiG 4.0
Abstract. Biocuration is essential to transform molecular sequence data into standardized, machine-readable resources. Such curated datasets enable compara
doi.org
December 11, 2025 at 7:19 PM
Have you ever used a #bioinformatics #database and were frustrated by its lack of coverage? Did you ever think about starting your own resource? We just published a new strategy for community-driven #biocuration, based on our experiences with the #MIBiG database (1/8)! doi.org/10.1093/bib/...
Reposted by George Lund
Now out in @asm.org #mSystems! journals.asm.org/doi/10.1128/...
Congratulations to Robert and thanks to all collaborators. See thread below for a summary of the work, exploring the use of cross-species coexpression analyses to predict primary and secondary metabolic interactions in microbiomes.
Congratulations to Robert and thanks to all collaborators. See thread below for a summary of the work, exploring the use of cross-species coexpression analyses to predict primary and secondary metabolic interactions in microbiomes.
December 10, 2025 at 8:35 AM
Now out in @asm.org #mSystems! journals.asm.org/doi/10.1128/...
Congratulations to Robert and thanks to all collaborators. See thread below for a summary of the work, exploring the use of cross-species coexpression analyses to predict primary and secondary metabolic interactions in microbiomes.
Congratulations to Robert and thanks to all collaborators. See thread below for a summary of the work, exploring the use of cross-species coexpression analyses to predict primary and secondary metabolic interactions in microbiomes.
Reposted by George Lund
The pre print of my PhD research is out! 📣 Check it out for some cool results on high-throuhput microbial isolation, #SynComs and #Tree #Microbiome 🌳🧫
doi.org/10.1101/2025...
#PhDone 💯
doi.org/10.1101/2025...
#PhDone 💯
November 19, 2025 at 8:39 PM
The pre print of my PhD research is out! 📣 Check it out for some cool results on high-throuhput microbial isolation, #SynComs and #Tree #Microbiome 🌳🧫
doi.org/10.1101/2025...
#PhDone 💯
doi.org/10.1101/2025...
#PhDone 💯
Reposted by George Lund
🧵 1/ New preprint alert! From the FUTURE OAK project, led by the super talented @alejandra1909.bsky.social
Large-scale culturing of the tree microbiome enables targeted disease suppression
Here's what we found... 👇
www.biorxiv.org/content/10.1...
Large-scale culturing of the tree microbiome enables targeted disease suppression
Here's what we found... 👇
www.biorxiv.org/content/10.1...
Large-scale culturing of the tree microbiome enables targeted disease suppression
The tree microbiome is essential for host health and pathogen suppression. Synthetic microbial communities (SynComs) are emerging as important tools to understand microbiome dynamics and engineer micr...
www.biorxiv.org
November 19, 2025 at 3:05 PM
🧵 1/ New preprint alert! From the FUTURE OAK project, led by the super talented @alejandra1909.bsky.social
Large-scale culturing of the tree microbiome enables targeted disease suppression
Here's what we found... 👇
www.biorxiv.org/content/10.1...
Large-scale culturing of the tree microbiome enables targeted disease suppression
Here's what we found... 👇
www.biorxiv.org/content/10.1...
Reposted by George Lund
New publication: #Serotonin modulation of #metabolism and #stress response in Pseudomonas fluorescens, by @gillesvanwezel.bsky.social and others.
doi.org/10.1186/s129...
doi.org/10.1186/s129...
November 14, 2025 at 8:31 AM
New publication: #Serotonin modulation of #metabolism and #stress response in Pseudomonas fluorescens, by @gillesvanwezel.bsky.social and others.
doi.org/10.1186/s129...
doi.org/10.1186/s129...
Reposted by George Lund
👩🔬 Want to team up with us to expand the #SEVA collection?
Contribute your own constructs to our open plasmid repository and help make #SynBio more reproducible for everyone.
✨ Check out our contribution guidelines and join the mission!👇👇
seva-plasmids.com
Contribute your own constructs to our open plasmid repository and help make #SynBio more reproducible for everyone.
✨ Check out our contribution guidelines and join the mission!👇👇
seva-plasmids.com
Home - SEVA plasmids - Standard European Vector Architecture
Standard European Vector Architecture 4.0 Welcome to the CNB-hosted database and material repository of standard and modular plasmid vectors for (de/re) constructing complex bacterial phenotypes WHAT…
seva-plasmids.com
November 12, 2025 at 11:01 AM
👩🔬 Want to team up with us to expand the #SEVA collection?
Contribute your own constructs to our open plasmid repository and help make #SynBio more reproducible for everyone.
✨ Check out our contribution guidelines and join the mission!👇👇
seva-plasmids.com
Contribute your own constructs to our open plasmid repository and help make #SynBio more reproducible for everyone.
✨ Check out our contribution guidelines and join the mission!👇👇
seva-plasmids.com
Reposted by George Lund
Still using 16S/ITS profiling? You might want to reconsider👀
Our new paper presents pangenome-informed amplicons that provide up to 10× higher phylogenetic resolution than full-length ribosomal markers- while remaining cost effective and scalable!
microbiomejournal.biomedcentral.com/articles/10....
Our new paper presents pangenome-informed amplicons that provide up to 10× higher phylogenetic resolution than full-length ribosomal markers- while remaining cost effective and scalable!
microbiomejournal.biomedcentral.com/articles/10....
High-resolution profiling of bacterial and fungal communities using pangenome-informed taxon-specific long-read amplicons - Microbiome
Background High-throughput sequencing technologies have greatly advanced our understanding of microbiomes, but resolving microbial communities at species and strain levels remains challenging. Results...
microbiomejournal.biomedcentral.com
October 30, 2025 at 1:32 PM
Still using 16S/ITS profiling? You might want to reconsider👀
Our new paper presents pangenome-informed amplicons that provide up to 10× higher phylogenetic resolution than full-length ribosomal markers- while remaining cost effective and scalable!
microbiomejournal.biomedcentral.com/articles/10....
Our new paper presents pangenome-informed amplicons that provide up to 10× higher phylogenetic resolution than full-length ribosomal markers- while remaining cost effective and scalable!
microbiomejournal.biomedcentral.com/articles/10....
Reposted by George Lund
Polyunsaturated fatty acid (PUFA) synthase enzymes turn out to be far more versatile than we ever imagined! In our new preprint, we reveal a largely untapped biosynthetic space where they team up with PKSs and NRPSs to create new types of bioactive amphiphilic metabolites.
👉http://bit.ly/4hzUUak
👉http://bit.ly/4hzUUak
Charting the biosynthetic landscape of hybrid polyketide-nonribosomal peptide-specialized lipids
Polyunsaturated fatty acid (PUFA) synthase-like enzymes are best known for their role in membrane lipid biosynthesis in marine bacteria, but have also been repurposed for the assembly of specialized l...
bit.ly
October 27, 2025 at 9:56 AM
Polyunsaturated fatty acid (PUFA) synthase enzymes turn out to be far more versatile than we ever imagined! In our new preprint, we reveal a largely untapped biosynthetic space where they team up with PKSs and NRPSs to create new types of bioactive amphiphilic metabolites.
👉http://bit.ly/4hzUUak
👉http://bit.ly/4hzUUak
Reposted by George Lund
Interested in Python programming and good software engineering practices? Check out my newest blog post where I introduce a "modern Python" GitHub repository template and talk about my motivation for its creation! mmzdouc.github.io/posts/2025/1...
Modern Python Project GitHub Template
TL;DR: I created a freely available template to facilitate setting up “modern” Python projects.
mmzdouc.github.io
October 22, 2025 at 2:06 PM
Interested in Python programming and good software engineering practices? Check out my newest blog post where I introduce a "modern Python" GitHub repository template and talk about my motivation for its creation! mmzdouc.github.io/posts/2025/1...
Reposted by George Lund
📣 I’m excited to share two open positions in my lab @leibniz-hki.de. For this interdisciplinary project with @luziagyr.bsky.social, I’m seeking (1) an enthusiastic PhD student interested in fungal natural product research and genetic engineering, as well as (2) a technical assistant 👇🏻
October 21, 2025 at 2:48 PM
📣 I’m excited to share two open positions in my lab @leibniz-hki.de. For this interdisciplinary project with @luziagyr.bsky.social, I’m seeking (1) an enthusiastic PhD student interested in fungal natural product research and genetic engineering, as well as (2) a technical assistant 👇🏻
Reposted by George Lund
We are looking for a 3-year postdoc to work with Daniel Probst, Justin van der Hooft and myself on an exciting project involving federated learning and integrative omics for discovery of new antibiotics from natural products.
Apply here: www.wur.nl/en/vacancy/p...
Please share!
Apply here: www.wur.nl/en/vacancy/p...
Please share!
www.wur.nl
September 8, 2025 at 9:07 AM
We are looking for a 3-year postdoc to work with Daniel Probst, Justin van der Hooft and myself on an exciting project involving federated learning and integrative omics for discovery of new antibiotics from natural products.
Apply here: www.wur.nl/en/vacancy/p...
Please share!
Apply here: www.wur.nl/en/vacancy/p...
Please share!
Reposted by George Lund
Now out as preprint: versions 2.0 of both BiG-SCAPE and BiG-SLiCE have been released! With significant speed and accuracy increases, as well as new interactive functionalities. www.biorxiv.org/content/10.1...
BiG-SCAPE 2.0 and BiG-SLiCE 2.0: scalable, accurate and interactive sequence clustering of metabolic gene clusters
Microbial metabolic gene clusters encode the biosynthesis or catabolism of metabolites that facilitate ecological specialization, mediate microbiome interactions and constitute a major source of medic...
www.biorxiv.org
September 1, 2025 at 10:35 PM
Now out as preprint: versions 2.0 of both BiG-SCAPE and BiG-SLiCE have been released! With significant speed and accuracy increases, as well as new interactive functionalities. www.biorxiv.org/content/10.1...
Reposted by George Lund
Are you a theoretical biologist that is intererested in the ecology and evolution of metabolic interactions among microorganisms?
Do you like to cooperate with experimentalists?
Do you have a PhD and experience in modelling and statistics?
Then this position might be for you👇:
shorturl.at/iiiOv
Do you like to cooperate with experimentalists?
Do you have a PhD and experience in modelling and statistics?
Then this position might be for you👇:
shorturl.at/iiiOv
August 22, 2025 at 8:25 AM
Are you a theoretical biologist that is intererested in the ecology and evolution of metabolic interactions among microorganisms?
Do you like to cooperate with experimentalists?
Do you have a PhD and experience in modelling and statistics?
Then this position might be for you👇:
shorturl.at/iiiOv
Do you like to cooperate with experimentalists?
Do you have a PhD and experience in modelling and statistics?
Then this position might be for you👇:
shorturl.at/iiiOv
Reposted by George Lund
New paper out now in @britmycolsoc.org.uk Fungal Biology Reviews. Learning from fungicide resistance: Evolutionary insights to guide RNAi-based control of fungal crop pathogens. www.sciencedirect.com/science/arti...
Learning from fungicide resistance: Evolutionary insights to guide RNAi-based control of fungal crop pathogens
Crop protection against fungal pathogens is essential to prevent crop losses and maintain food security. Current crop protection relies heavily on che…
www.sciencedirect.com
August 11, 2025 at 4:48 PM
New paper out now in @britmycolsoc.org.uk Fungal Biology Reviews. Learning from fungicide resistance: Evolutionary insights to guide RNAi-based control of fungal crop pathogens. www.sciencedirect.com/science/arti...
Reposted by George Lund
Great to see our manuscript on skDER & CiDDER - programs for selection of representative microbial genomes - now published.
Please give them a try and if you have any feature requests or issues, just let us know.
www.microbiologyresearch.org/content/jour...
github.com/raufs/skDER
Please give them a try and if you have any feature requests or issues, just let us know.
www.microbiologyresearch.org/content/jour...
github.com/raufs/skDER
skDER and CiDDER: two scalable approaches for microbial genome dereplication
An abundance of microbial genomes have been sequenced in the past two decades. For fundamental comparative genomic investigations, where the goal is to determine the major gain and loss events shaping...
www.microbiologyresearch.org
July 11, 2025 at 8:14 PM
Great to see our manuscript on skDER & CiDDER - programs for selection of representative microbial genomes - now published.
Please give them a try and if you have any feature requests or issues, just let us know.
www.microbiologyresearch.org/content/jour...
github.com/raufs/skDER
Please give them a try and if you have any feature requests or issues, just let us know.
www.microbiologyresearch.org/content/jour...
github.com/raufs/skDER
Reposted by George Lund
🎯 New antibiotic target in TB!
👉 Small-molecule inhibitor targeting PurF, the first enzyme in the mycobacterial de novo purine biosynthesis pathway.
👉 Effective vs drug-resistant Mycobacterium tuberculosis in vivo (in mice)
#TBSky #IDSky #MedSky 🧪
@nature.com
www.nature.com/articles/s41...
👉 Small-molecule inhibitor targeting PurF, the first enzyme in the mycobacterial de novo purine biosynthesis pathway.
👉 Effective vs drug-resistant Mycobacterium tuberculosis in vivo (in mice)
#TBSky #IDSky #MedSky 🧪
@nature.com
www.nature.com/articles/s41...
Targeting de novo purine biosynthesis for tuberculosis treatment - Nature
The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.
www.nature.com
June 19, 2025 at 5:15 PM
🎯 New antibiotic target in TB!
👉 Small-molecule inhibitor targeting PurF, the first enzyme in the mycobacterial de novo purine biosynthesis pathway.
👉 Effective vs drug-resistant Mycobacterium tuberculosis in vivo (in mice)
#TBSky #IDSky #MedSky 🧪
@nature.com
www.nature.com/articles/s41...
👉 Small-molecule inhibitor targeting PurF, the first enzyme in the mycobacterial de novo purine biosynthesis pathway.
👉 Effective vs drug-resistant Mycobacterium tuberculosis in vivo (in mice)
#TBSky #IDSky #MedSky 🧪
@nature.com
www.nature.com/articles/s41...
Reposted by George Lund
Proud to share our latest pre-print manuscript entitled 'Downy mildew disease-suppressive soils transmit a protective core microbiome to the phyllosphere' (lnkd.in/dBk28gnT). Super cool to see the final chapter of my PhD at the Plant-Microbe Interactions group of Universiteit Utrecht now online!
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
June 17, 2025 at 8:31 PM
Proud to share our latest pre-print manuscript entitled 'Downy mildew disease-suppressive soils transmit a protective core microbiome to the phyllosphere' (lnkd.in/dBk28gnT). Super cool to see the final chapter of my PhD at the Plant-Microbe Interactions group of Universiteit Utrecht now online!
Reposted by George Lund
In the past decade or so, new techniques have enabled a resurgence of antimicrobial discovery. A new golden age of antibiotics may be upon us, though getting a drug candidate into the clinic isn’t so easy: cen.acs.org/pharmaceutic... #chemsky 🧪
Bioprospectors mine microbial genomes for antibiotic gold
But turning what they find into drugs isn’t so easy
cen.acs.org
June 11, 2025 at 1:41 PM
In the past decade or so, new techniques have enabled a resurgence of antimicrobial discovery. A new golden age of antibiotics may be upon us, though getting a drug candidate into the clinic isn’t so easy: cen.acs.org/pharmaceutic... #chemsky 🧪
🚨 New preprint!
We've developed a bioassay-guided genome mining approach to identify bacterial secondary metabolites that inhibit Zymoseptoria tritici — a major fungal pathogen of wheat.
Available now on bioRxiv: doi.org/10.1101/2025...
We've developed a bioassay-guided genome mining approach to identify bacterial secondary metabolites that inhibit Zymoseptoria tritici — a major fungal pathogen of wheat.
Available now on bioRxiv: doi.org/10.1101/2025...
Development of a bioassay guided genome mining approach for antifungal natural product discovery from pseudomonads
Zymoseptoria tritici causes Septoria Leaf Blotch disease of wheat and has evolved to overcome most chemical and genetic control methods. As such, new tools are required for future disease control.
We...
doi.org
June 3, 2025 at 8:08 AM
🚨 New preprint!
We've developed a bioassay-guided genome mining approach to identify bacterial secondary metabolites that inhibit Zymoseptoria tritici — a major fungal pathogen of wheat.
Available now on bioRxiv: doi.org/10.1101/2025...
We've developed a bioassay-guided genome mining approach to identify bacterial secondary metabolites that inhibit Zymoseptoria tritici — a major fungal pathogen of wheat.
Available now on bioRxiv: doi.org/10.1101/2025...
Reposted by George Lund
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
May 22, 2025 at 12:42 PM
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
Reposted by George Lund
#FERMO Prioritization of metabolite signals and metabolomics samples by streamlined data integration! 😎
#metabolomics #CompMetabolomics
www.linkedin.com/posts/jjjvan...
#metabolomics #CompMetabolomics
www.linkedin.com/posts/jjjvan...
#ms2query #antismash #metabolomics #compmetabolomics #prioritization… | Justin J.J. van der Hooft
🚨 Preprint (update) alert 🚨 --> Prioritizing Metabolite Features with FERMO
Very proud of Mitja Zdouc, PhD, Hannah Augustijn 😊👏, and all colleagues and collaborators involved: the FERMO preprint...
www.linkedin.com
May 20, 2025 at 9:54 AM
#FERMO Prioritization of metabolite signals and metabolomics samples by streamlined data integration! 😎
#metabolomics #CompMetabolomics
www.linkedin.com/posts/jjjvan...
#metabolomics #CompMetabolomics
www.linkedin.com/posts/jjjvan...
Reposted by George Lund
The best day ever!! Thank you so much to everyone who has been involved in this in project and came out to celebrate today. A moment I will never forget!
May 20, 2025 at 6:38 AM
The best day ever!! Thank you so much to everyone who has been involved in this in project and came out to celebrate today. A moment I will never forget!
Reposted by George Lund
Happy to announce that our „newest old tool“ autoMLST2.0 is out and published. You need an accurate and easy to use tool to build #phylogenetictrees from #bacterialgenomes: academic.oup.com/nar/advance-...
AutoMLST2: a web server for phylogeny and microbial taxonomy
Abstract. Accurate and accessible phylogenetic analysis is essential for understanding microbial taxonomy and evolution, which are integral to microbiology
academic.oup.com
May 13, 2025 at 6:34 PM
Happy to announce that our „newest old tool“ autoMLST2.0 is out and published. You need an accurate and easy to use tool to build #phylogenetictrees from #bacterialgenomes: academic.oup.com/nar/advance-...