Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to ...

Prebiotic and probiotic interventions can induce therapeutically relevant shifts in the human microbiome, but their effects are variable across individuals. This study shows that metabolic models can ...

Nature Reviews Gastroenterology & Hepatology, Published online: 18 February 2026; doi:10.1038/s41575-026-01176-xThis Consensus Statement provides a definition of the term ‘gut health’, as well as a discussion of the relevant domains that contribute to gut health and a framework for appropriate use of the term in the context of therapeutic interventions.

After decades, scientists have finally pieced together the 23-step biosynthetic pathway to produce this cancer drug

Covering: up to August 2025 Terpenoids constitute nature's largest and most structurally diverse class of natural products, with extensive applications in medicine, agriculture, and fragrance…

Bacteriophages (phages) are viruses that exclusively infect bacteria and cannot replicate within eukaryotic cells in the absence of their bacterial host. Discovered in 1915 (1, 2), more than 10 years ...

Bromotyrosine-containing natural products have been isolated from marine sponges. While studying the uptake of engineered bacterial strains by sponges, we observed the production of fistularin-3 in the sponge. To explore these results, we employed multimodal imaging to colocalize metabolites with fluorescent in situ hybridization (FISH) probes. Using mass spectrometry imaging (MSI), we measured fistularin-3 and mapped this against the FISH probes to locate the bacteria. A recent study reported that P. brasiliensis produced fistularin-3 in pure culture, but these data have not yet been reproduced. We employed MSI and FISH to colocalize the fistularin-3 spatial distribution with P. brasiliensis in sponge tissue.

The rise of Klebsiella pneumoniae combining antimicrobial resistance and virulence genes poses a major health threat, but the evolutionary routes and phenotypic consequences of this convergence are po...

Background Core genome multilocus sequence typing (cgMLST) is a powerful method for bacterial strain genotyping. However, the size of the core genome decreases as the phylogenetic breadth of the targe...

Abstract. From its earliest beginnings, life’s expansion into new habitats has been profoundly shaped by its reciprocal interactions with Earth’s changing

Staphylococcus aureus has undergone metabolic remodeling to adapt to the dairy niche.

Staphylococcus aureus lineages vary widely in the frequency of gene exchange and the diversity of genome content. Gorzynski and Harling-Lee et al. show that both host ecology and the horizontal acquis...