Rauf Salamzade
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raufs.bsky.social
Rauf Salamzade
@raufs.bsky.social
Interested in microbial ecology & evolution. Views are only my own. (he/him)

🎓: https://scholar.google.com/citations?hl=en&user=OBPpZq4AAAAJ&view_op=list_works&sortby=pubdate
👨‍💻: https://github.com/raufs
Reposted by Rauf Salamzade
Ever struggled with a good SNP threshold for transmission analysis? As part of our paper, we made the bioinformatics pipeline available and we deeply investigated and developed new methods for this purpose. Check it out!
We’ve made our analytical pipeline THRESHER publicly available! Just provide your genomes and it handles strain and/or cluster composition, and generates quality visualizations for you. Easy to install,thoroughly documented,and validated on published datasets and simulations. Manuscript coming soon!
GitHub - microbialARC/THRESHER: THRESHER is a bacterial phylogenomics toolkit for strain and/or transmission clusters identification, genome profiling of substitution rates and MGEs, and bacterial evo...
THRESHER is a bacterial phylogenomics toolkit for strain and/or transmission clusters identification, genome profiling of substitution rates and MGEs, and bacterial evolution simulation. - microbia...
github.com
February 10, 2026 at 6:06 PM
Reposted by Rauf Salamzade
New in JB: Latimer, Agbavor & Cahoon discuss the HtrA protein, which serves double duty as a protease and chaperone and plays key roles in maintaining envelope integrity, stress resistance, and virulence in Gram-positive organisms.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
February 10, 2026 at 3:43 PM
Reposted by Rauf Salamzade
Reposted by Rauf Salamzade
The Journal of Infectious Diseases has just released a special collection of papers devoted to "Contemporary Research on #AMR", covering mechanisms of resistance and virulence, pharmacokinetics, drug development, and wastewater surveillance
@jidjournal.bsky.social
#IDEpi #MedSky #IDSky #AMS
Validate User
academic.oup.com
February 10, 2026 at 5:44 AM
Reposted by Rauf Salamzade
STEM Black History Fact 9/28

Dr. Jane Cooke Wright pioneered chemotherapy techniques and helped establish personalized cancer treatment as a scientific discipline.
Ten Black Scientists That Science Teachers Should Know About
Help your students see the possibilities of careers in STEM fields by providing them with diverse role models.
www.pbs.org
February 10, 2026 at 2:44 AM
Reposted by Rauf Salamzade
Now out & nicely formatted in @isme-microbes.bsky.social

A big analysis of ocean genomes & metagenomes co-led by former postdocs, now PIs, @gmdouglas.bsky.social & @cyanophage.bsky.social along with co-PIs @lbobay.bsky.social & Samuel Chaffron.

A few highlights... 🧵 (1/n)

doi.org/10.1093/isme...
Co-occurrence is associated with horizontal gene transfer across marine bacteria independent of phylogeny
Abstract. Understanding the drivers and consequences of horizontal gene transfer (HGT) is a key goal of microbial evolution research. Although co-occurring
doi.org
February 9, 2026 at 8:31 PM
Reposted by Rauf Salamzade
How do bacterial pangenomes evolve, what controls their dynamics, why do they exist?
Fitting a mechanistic model to 450 species from allthebacteria.org suggesting fast vs slow gene exchange (i.e. amount of MGEs) is a major differentiating factor, correlated with phylogeny rather than lifestyle
February 9, 2026 at 10:55 AM
Reposted by Rauf Salamzade
This study looks at microbiomes in aerial surfaces of plants and their roles in environmental processes, in order to advance microbiome utility across the bioeconomy. @ucmerced.bsky.social
🖥️🧬 🦠 🌱

https://jgi.doe.gov/user-science/science-stories/secrets-needles-what-microbes-do-conifer-leaves
Secrets of the Needles: What Microbes do on Conifer Leaves | Joint Genome Institute
Novel study looks at microbiomes in aerial surfaces of plants, and their roles in plant health and environmental processes
jgi.doe.gov
February 9, 2026 at 9:15 PM
Reposted by Rauf Salamzade
Just published: "Planetary microbiome structure and generalist-driven gene flow across disparate habitats" by @podlesny.bsky.social @chanyeong-kim.bsky.social and @jonas-bio.bsky.social www.cell.com/cell/fulltex...

See the quoted post below for a thread on the preprint!
February 9, 2026 at 5:08 PM
Reposted by Rauf Salamzade
Excited to share the newest paper from our team, where we uncovered a potential role of the uncultured gut #microbiome in health: www.cell.com/cell-host-mi.... Out now in @cp-cellhostmicrobe.bsky.social @cellpress.bsky.social. With Ana C. da Silva, Jacob Lapkin, Qi Yin and Efrat Muller.
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a candidate signature of health
Silva et al. perform a global analysis of over 11,000 gut microbiomes and reveal that uncultured bacteria are key markers of gut health. The uncultured genus CAG-170 is strongly linked to low gut dysb...
www.cell.com
February 9, 2026 at 4:46 PM
Reposted by Rauf Salamzade
Metabolic blueprints of monocultures enable prediction and design of synthetic microbial consortia

A nice demonstration of how cross-feeding shapes small microbial community compositions

From Segré lab @dsegre.bsky.social

www.biorxiv.org/content/10.6...
www.biorxiv.org
February 8, 2026 at 7:25 PM
Reposted by Rauf Salamzade
have you ever wondered how endosymbionts cope with the many pseudogenes in their genomes (before they generously reduce them by a factor of ~10)?
arkadiy describes a way, read his paper and learn the surprising role of TmRNA (10Sa RNA still when john @mcsymbiont.bsky.social ...

#SymbioSky #MicroSky
Happy to share a preprint—the last chapter of my dissertation with @mcsymbiont.bsky.social and Co—on what happens when bacterial endosymbionts accumulate huge numbers of pseudogenes during early genome reduction.

www.biorxiv.org/content/10.6...
February 9, 2026 at 1:55 AM
Reposted by Rauf Salamzade
Reading and really liking this #openaccess paper by Ary Hoffman and @brandonscooper.bsky.social

onlinelibrary.wiley.com/doi/full/10....

Describing endosymbiont–host interactions within the parasitism–mutualism continuum
Describing endosymbiont–host interactions within the parasitism–mutualism continuum
Bacteria that live inside the cells of arthropod hosts (“endosymbionts”) are gaining increasing interest as targets for pest control and for reducing the ability of arthropod vectors to transmit anim....
onlinelibrary.wiley.com
February 8, 2026 at 1:08 AM
Reposted by Rauf Salamzade
Excited for this new preprint from former postdoc @caitlinkowa.bsky.social identifying unexpected functions for the bacterial stringent response in antimicrobial fatty acid susceptibility in S. aureus #microsky
www.biorxiv.org
February 5, 2026 at 9:52 PM
Reposted by Rauf Salamzade
Evolutionary bioenergetics of sporulation

"energetic cost of sporulation in units of ATP by integrating time-resolved genome, transcriptome, and proteome profiles"
#Bsubtilis #MicroSky

#PNAS by @ckarakoc.bsky.social @shoestrapped.bsky.social @jaytlennon.bsky.social

www.pnas.org/doi/10.1073/...
Evolutionary bioenergetics of sporulation | PNAS
Energy is required for the expression and maintenance of complex traits. In many habitats, however, free energy available to support biosynthesis i...
www.pnas.org
February 7, 2026 at 11:25 AM
Reposted by Rauf Salamzade
Registration fee is only 175€, some of the invited speakers: Charles Rice, Yasmine Belkaid, Bonnie Bassler, Daniel Mucida, Joy Bergelson, Matthew Chang, Carolina Lucas, Jeff Barrick, Carolina Tropini, Roy Kishony and more... Save the date now!
GIMM Fest returns September 17–19 with three days dedicated to the future of science and health, this year focusing on microbes. 🦠

Join researchers and innovators for a programme designed to promote scientific exchange and collaboration.
February 6, 2026 at 6:51 PM
Reposted by Rauf Salamzade
meetings.embo.org/event/26-mic... Announcing the 2026 EMBO course in Computational and Experimental Microbiomics, to be held at Bath. The course brings together experiments and bioinformatics to study host-microbe interactions and co-evolution. Register now, or at least by 11 May, if interested :)
Computational and experimental microbiomics
The critical contribution of microbiota to animal, plant and environmental health is now widely accepted. Progress has been driven by two parallel approaches: in silico analyses of large -omics data …
meetings.embo.org
February 6, 2026 at 4:37 PM
Reposted by Rauf Salamzade
Weekend read! Structural proteome unfolds insight into gut microbiome:
Structure database of gut microbial proteins & structure-aware AI model for remote homolog detection. Reveals diversification of phage endolysins & bacterial enzymes in melatonin biosynthesis
www.cell.com/cell-host-mi...
Exploring functional insights into the human gut microbiome via the structural proteome
Liu et al. develop a structure database of human gut microbial proteins and a structure-aware AI model for remote homolog detection. They demonstrate the power of structure-guided approach in discover...
www.cell.com
February 6, 2026 at 5:02 PM
Reposted by Rauf Salamzade
What happened before the last universal common ancestor? Pre-LUCA evolution is hard to study. In our new Cell Genomics Perspective we spotlight how paralogous proteins open a window onto the deepest chapters of evolution. 🧬🌍

Out today!

--> www.cell.com/cell-genomic... @cellpress.bsky.social
Universal paralogs provide a window into evolution before the last universal common ancestor
Universal paralog protein families form due to gene duplications that occurred prior to the last universal common ancestor of life. This perspective describes how these protein families offer valuable...
www.cell.com
February 6, 2026 at 4:39 PM
Reposted by Rauf Salamzade
New blog post: ONT read QC strategies for assembly
rrwick.github.io/2026/02/05/r...

Mini-study comparing a few QC/subsampling approaches, plus practical notes from my experience.
ONT read QC strategies for assembly
a blog for miscellaneous bioinformatics stuff
rrwick.github.io
February 5, 2026 at 3:38 AM
Reposted by Rauf Salamzade
🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...
Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries
Eukaryotic gene expression is orchestrated by RNA polymerases (RNAPI, II, and III) and associated factors, yet their real-time dynamics remain obscure. Using single-molecule tracking in living yeast, ...
www.science.org
February 6, 2026 at 12:14 AM
Reposted by Rauf Salamzade
Mapping of the viral shunt across widespread coccolithophore blooms using metabolic biomarkers | PNAS https://www.pnas.org/doi/abs/10.1073/pnas.2424035123?af=R
February 5, 2026 at 10:53 PM
Reposted by Rauf Salamzade
What does competition for iron look like for pathogens in different environments? We had the chance to contribute to this great paper looking at Salmonella in the gut with the Cunrath Lab (UoStrasbourg). Salmonella relies on siderophore exploitation at low pH url: academic.oup.com/microlife/ar...
Salmonella relies on siderophore exploitation at low pH
Abstract. Salmonella enterica, a prominent enteric pathogen, employs sophisticated iron acquisition mechanisms to overcome host-imposed iron limitation, no
academic.oup.com
February 5, 2026 at 7:39 PM
Reposted by Rauf Salamzade
How does catalysis emerge from non-catalytic domains?

In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.

A striking case of catalysis evolving from binding.
October 8, 2025 at 2:32 PM