Oliver Hofmann
@fiamh.bsky.social
Cancer genomics in Melbourne, Australia, at day. Board games - https://instagram.com/fiamh_bgg - and dog training - https://instagram.com/totoro.the.lappie - at other times. He/him.
Reposted by Oliver Hofmann
I think it's best for everyone to understand that the unified class project of billionaires right now is to do to white collar workers what globalization and neoliberalism did to blue collar workers.
February 4, 2026 at 7:41 PM
I think it's best for everyone to understand that the unified class project of billionaires right now is to do to white collar workers what globalization and neoliberalism did to blue collar workers.
Reposted by Oliver Hofmann
I've been in SF for four days and on each day I've had multiple conversations where people (self included) express deep feelings, fear, wonder and worry about their skills being replaced or (this is less named explicitly but an assumed driver I think) no longer valued by others. Big threats to feel
February 5, 2026 at 4:53 PM
I've been in SF for four days and on each day I've had multiple conversations where people (self included) express deep feelings, fear, wonder and worry about their skills being replaced or (this is less named explicitly but an assumed driver I think) no longer valued by others. Big threats to feel
Reposted by Oliver Hofmann
was banging my head against a bug (VEP classifying my in-exon variants as 'downstream') that Claude Sonnet 4.5 fixed in about 5 minutes. I can understand the scepticism on LLMs being jammed into every corner of life, but there's merit in these tools
February 3, 2026 at 1:46 AM
was banging my head against a bug (VEP classifying my in-exon variants as 'downstream') that Claude Sonnet 4.5 fixed in about 5 minutes. I can understand the scepticism on LLMs being jammed into every corner of life, but there's merit in these tools
Reposted by Oliver Hofmann
Reminder for everyone operating at situationally-diminished capacity.
January 3, 2026 at 3:40 PM
Reminder for everyone operating at situationally-diminished capacity.
Reposted by Oliver Hofmann
Getting older is like being out on the ocean in the Ship of Theseus but then at some point the guys just decided against replacing the decayed parts.
December 29, 2025 at 4:25 PM
Getting older is like being out on the ocean in the Ship of Theseus but then at some point the guys just decided against replacing the decayed parts.
Reposted by Oliver Hofmann
The comments on this are all about how sweet it is and I feel insane. Using AI to make fake memories of your grandma with dementia and telling her they happened and then filming her reaction
December 26, 2025 at 3:23 AM
The comments on this are all about how sweet it is and I feel insane. Using AI to make fake memories of your grandma with dementia and telling her they happened and then filming her reaction
Reposted by Oliver Hofmann
Pipeline release! nf-core/oncoanalyser v2.3.0 - 2.3.0 - Spotted Nightjar!
Please see the changelog: https://github.com/nf-core/oncoanalyser/releases/tag/2.3.0
Please see the changelog: https://github.com/nf-core/oncoanalyser/releases/tag/2.3.0
Release 2.3.0 - Spotted Nightjar · nf-core/oncoanalyser
What's Changed
Post release bump by @scwatts in #246
Improve samplesheet validation by @scwatts in #247
Important! Template update for nf-core/tools v3.5.1 by @scwatts @nf-core-bot in #266
Apply H...
github.com
December 11, 2025 at 5:58 AM
Pipeline release! nf-core/oncoanalyser v2.3.0 - 2.3.0 - Spotted Nightjar!
Please see the changelog: https://github.com/nf-core/oncoanalyser/releases/tag/2.3.0
Please see the changelog: https://github.com/nf-core/oncoanalyser/releases/tag/2.3.0
Reposted by Oliver Hofmann
I recently discovered Conventional Comments (conventionalcomments.org) for providing a pseudo-standard set of labels for feedback and just tried it for an article review and it was really helpful to specify issues vs. thoughts vs. suggestions, etc. Hopefully it's helpful for the authors too!
November 17, 2025 at 3:52 PM
I recently discovered Conventional Comments (conventionalcomments.org) for providing a pseudo-standard set of labels for feedback and just tried it for an article review and it was really helpful to specify issues vs. thoughts vs. suggestions, etc. Hopefully it's helpful for the authors too!
Reposted by Oliver Hofmann
Join the Clinical Genomics Laboratory Community (CGLC) meeting on 24 November. This session will explore how artificial intelligence and large language models (LLMs) are transforming variant interpretation. Register for the meeting: us02web.zoom.us/meeting/regi...
Welcome! You are invited to join a meeting: Clinical Genomics Laboratory Meeting. After registering, you will receive a confirmation email about joining the meeting.
The topic for this meeting will be AI and LLMs in Variant Classification
us02web.zoom.us
November 17, 2025 at 4:22 PM
Join the Clinical Genomics Laboratory Community (CGLC) meeting on 24 November. This session will explore how artificial intelligence and large language models (LLMs) are transforming variant interpretation. Register for the meeting: us02web.zoom.us/meeting/regi...
Reposted by Oliver Hofmann
You have to wonder if White House staffers are simply showing him AI videos at this point and he thinks it's reality.
Trump: "The people of Chicago are walking around with MAGA hats. You have women, beautiful Black women, walking around with MAGA hats. 'Please let the president in and we don't care how he does it ... bring in the Marines.'"
October 15, 2025 at 8:35 PM
You have to wonder if White House staffers are simply showing him AI videos at this point and he thinks it's reality.
Reposted by Oliver Hofmann
Reminder: a large (2.5M+) sibling control study found "no evidence of increased risk of autism, ADHD, or intellectual disability associated with acetaminophen use". Precisely the kind of data that requires serious consideration before declaring mission accomplished.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability
This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.
jamanetwork.com
September 22, 2025 at 9:03 PM
Reminder: a large (2.5M+) sibling control study found "no evidence of increased risk of autism, ADHD, or intellectual disability associated with acetaminophen use". Precisely the kind of data that requires serious consideration before declaring mission accomplished.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Oliver Hofmann
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
September 15, 2025 at 8:40 AM
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
Reposted by Oliver Hofmann
Breaking Google up was one of the last best hopes for preventing the free press from getting squeezed into oblivion and harvested into AI slop, and for saving the open web. The ruling that effectively lets Google continue operating as a monopoly isn't just disappointing, it's a disaster.
One of the last, best hopes for saving the open web and a free press is dead
The Google ruling is a disaster. Let the AI slop flow and the writers, journalists and creators get squeezed.
www.bloodinthemachine.com
September 4, 2025 at 8:22 PM
Breaking Google up was one of the last best hopes for preventing the free press from getting squeezed into oblivion and harvested into AI slop, and for saving the open web. The ruling that effectively lets Google continue operating as a monopoly isn't just disappointing, it's a disaster.
Reposted by Oliver Hofmann
At scale, the way that we store (and process) data matters! Many may think that the way we keep data, the file formats we adopt, and the way that we compress data are unimportant details, but they are, in fact, critical considerations to allow science to move forward at scale!
I can't believe the biggest bottleneck in my lab right now is scrounging to afford more storage for processing data, not sequencing costs, technique or analysis difficulty.
August 26, 2025 at 2:45 PM
At scale, the way that we store (and process) data matters! Many may think that the way we keep data, the file formats we adopt, and the way that we compress data are unimportant details, but they are, in fact, critical considerations to allow science to move forward at scale!
Reposted by Oliver Hofmann
I do not know when or how this became a KPop Demon Hunters stan account, yet here we are
www.billboard.com/lists/huntr-...
www.billboard.com/lists/huntr-...
Led by HUNTR/X’s ‘Golden’ at No. 1, ‘KPop Demon Hunters’ Becomes First Soundtrack With Four Simultaneous Hot 100 Top 10s
Led by HUNTR/X’s “Golden” at No. 1, “KPop Demon Hunters” becomes the first soundtrack ever with four simultaneous Billboard Hot 100 top 10s.
www.billboard.com
August 25, 2025 at 6:50 PM
I do not know when or how this became a KPop Demon Hunters stan account, yet here we are
www.billboard.com/lists/huntr-...
www.billboard.com/lists/huntr-...
Reposted by Oliver Hofmann
August 21, 2025 at 10:32 AM
Reposted by Oliver Hofmann
He's gonna buy up the only remaining left leaning outlets, give them the WaPo treatment which means more people are gonna end up launching substacks and I'm gonna walk into the sea
Bezos rumored to be buying Condé Nast, which would include Vogue, Teen Vogue, The New Yorker, GQ, Vanity Fair, Wired, Architectural Digest, and Ars Technica.
Wired and Teen Vogue have done some of the best reporting in the Trump era. Ars Technica one of a handful of good remaining tech pubs.
Wired and Teen Vogue have done some of the best reporting in the Trump era. Ars Technica one of a handful of good remaining tech pubs.
Bezos to buy Vogue as a gift to new wife? Insiders link deal to Sanchez’s cover shoot, could cost him billions
Rumors are swirling that Jeff Bezos might acquire Condé Nast, Vogue's parent company, as a wedding gift for Lauren Sanchez. This speculation is fueled by Sanchez's recent Vogue cover, hand-picked atti...
economictimes.indiatimes.com
July 11, 2025 at 2:24 PM
He's gonna buy up the only remaining left leaning outlets, give them the WaPo treatment which means more people are gonna end up launching substacks and I'm gonna walk into the sea
Reposted by Oliver Hofmann
happy birthday to bill watterson who gave me the gift of encapsulating my entire ethical approach in one comic panel.
July 5, 2025 at 8:12 AM
happy birthday to bill watterson who gave me the gift of encapsulating my entire ethical approach in one comic panel.
Reposted by Oliver Hofmann
It’s a good thing Congress isn’t alive to see this
June 22, 2025 at 12:47 AM
It’s a good thing Congress isn’t alive to see this
Reposted by Oliver Hofmann
I still can't get past the idea that people in America are now supposed to accept that this is a valid form of law enforcement and just assume it's fine when random dudes in groups with face-coverings, no ID, no warrant, & no uniform grab people off the street and force them into unmarked vehicles
Not an original point but worth saying again - there is not a single element in this picture that identifies any of these folks as law enforcement agents. No badges, no uniforms, no vests. Out of context it just looks like a bunch of random guys are kidnapping a mayoral candidate.
Breaking News: Brad Lander, the New York City comptroller who is running for mayor, was detained by ICE agents at an immigration court as he tried to escort a migrant out of the courthouse to prevent his arrest. nyti.ms/4jWkANE
June 17, 2025 at 6:59 PM
I still can't get past the idea that people in America are now supposed to accept that this is a valid form of law enforcement and just assume it's fine when random dudes in groups with face-coverings, no ID, no warrant, & no uniform grab people off the street and force them into unmarked vehicles
Reposted by Oliver Hofmann
this is a day for those of us who have spent the last six months terminally online. this is for us and honestly, we deserve it.
June 5, 2025 at 7:42 PM
this is a day for those of us who have spent the last six months terminally online. this is for us and honestly, we deserve it.
Reposted by Oliver Hofmann
Do not give them an INCH!
It's not: Well, maybe there are some areas where DEI has become too much a focus.
It's: FREE COUNTRIES DON'T SEND OUT BANNED WORDS LISTS TO THEIR SCIENTISTS
It's not: Well, science isn't perfect...
It's: FREE COUNTRIES DO NOT HAVE SCIENCE COMMISSARS
It's not: Well, maybe there are some areas where DEI has become too much a focus.
It's: FREE COUNTRIES DON'T SEND OUT BANNED WORDS LISTS TO THEIR SCIENTISTS
It's not: Well, science isn't perfect...
It's: FREE COUNTRIES DO NOT HAVE SCIENCE COMMISSARS
May 25, 2025 at 4:11 PM
Do not give them an INCH!
It's not: Well, maybe there are some areas where DEI has become too much a focus.
It's: FREE COUNTRIES DON'T SEND OUT BANNED WORDS LISTS TO THEIR SCIENTISTS
It's not: Well, science isn't perfect...
It's: FREE COUNTRIES DO NOT HAVE SCIENCE COMMISSARS
It's not: Well, maybe there are some areas where DEI has become too much a focus.
It's: FREE COUNTRIES DON'T SEND OUT BANNED WORDS LISTS TO THEIR SCIENTISTS
It's not: Well, science isn't perfect...
It's: FREE COUNTRIES DO NOT HAVE SCIENCE COMMISSARS
Reposted by Oliver Hofmann
We dodged right-wing populism this time because of Trump. We won't dodge it a second time if everyone's day-to-day living is still shit and the progressive side of politics hasn't offered real, courageous solutions.
May 6, 2025 at 12:51 AM
We dodged right-wing populism this time because of Trump. We won't dodge it a second time if everyone's day-to-day living is still shit and the progressive side of politics hasn't offered real, courageous solutions.
Reposted by Oliver Hofmann
one of the radicalizing incidents of my youth was when the NYPD brutalized a judge who was volunteering as a legal observer at a protest. I'm afraid that "Feds arrest judge" is the incident that has fully broken my brain
April 25, 2025 at 5:27 PM
one of the radicalizing incidents of my youth was when the NYPD brutalized a judge who was volunteering as a legal observer at a protest. I'm afraid that "Feds arrest judge" is the incident that has fully broken my brain
Reposted by Oliver Hofmann
All the games I played on game day ranked. Top spot is Signal by @dvcgames.bsky.social In the game you’re experts trying to communicate with aliens. A great deduction game similar to First Contact but instead of words you work with objects. Really great fun especially if you’re drinking wine 😆
April 25, 2025 at 11:15 AM
All the games I played on game day ranked. Top spot is Signal by @dvcgames.bsky.social In the game you’re experts trying to communicate with aliens. A great deduction game similar to First Contact but instead of words you work with objects. Really great fun especially if you’re drinking wine 😆
