Emilio Lecona
@emlecona.bsky.social
Reposted by Emilio Lecona
Como describe Ginés Morata: "Antonio García-Bellido fue uno de los muy pocos pioneros científicos que ha producido España”.
elpais.com/ciencia/2025...
elpais.com/ciencia/2025...
Muere Antonio García-Bellido, descubridor de las fronteras invisibles dentro de los seres vivos
El biólogo, fallecido a los 89 años, deja un legado científico que roza las alturas de los nobeles Santiago Ramón y Cajal y Severo Ochoa
elpais.com
November 11, 2025 at 1:15 PM
Como describe Ginés Morata: "Antonio García-Bellido fue uno de los muy pocos pioneros científicos que ha producido España”.
elpais.com/ciencia/2025...
elpais.com/ciencia/2025...
Reposted by Emilio Lecona
What Rosalind Franklin truly contributed to the discovery of DNA’s structure.
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 10, 2025 at 9:48 AM
What Rosalind Franklin truly contributed to the discovery of DNA’s structure.
Reposted by Emilio Lecona
🧬 List of 2026 DNA repair and genome stability conferences, now updated. Please let me know if there is anything missing!
docs.google.com/spreadsheets...
docs.google.com/spreadsheets...
DNA REPAIR/GENOME STABILITY CONFERENCES
docs.google.com
November 9, 2025 at 10:33 PM
🧬 List of 2026 DNA repair and genome stability conferences, now updated. Please let me know if there is anything missing!
docs.google.com/spreadsheets...
docs.google.com/spreadsheets...
Reposted by Emilio Lecona
Escuchar a Alfonso Valencia hoy en el CBM ha sido una oportunidad para reflexionar sobre el futuro de la biología.
Su visión desde el Barcelona Supercomputing Centre @bsc-cns.bsky.social mostró cómo la integración entre IA, datos masivos y biología está redefiniendo la investigación.
Su visión desde el Barcelona Supercomputing Centre @bsc-cns.bsky.social mostró cómo la integración entre IA, datos masivos y biología está redefiniendo la investigación.
November 7, 2025 at 1:08 PM
Escuchar a Alfonso Valencia hoy en el CBM ha sido una oportunidad para reflexionar sobre el futuro de la biología.
Su visión desde el Barcelona Supercomputing Centre @bsc-cns.bsky.social mostró cómo la integración entre IA, datos masivos y biología está redefiniendo la investigación.
Su visión desde el Barcelona Supercomputing Centre @bsc-cns.bsky.social mostró cómo la integración entre IA, datos masivos y biología está redefiniendo la investigación.
Reposted by Emilio Lecona
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:43 PM
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
Reposted by Emilio Lecona
In case anyone is wondering if Watson was really THAT bad, @lpachter.bsky.social compiled a list of quotes that are absolutely not for the faint of heart.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
November 7, 2025 at 10:18 PM
In case anyone is wondering if Watson was really THAT bad, @lpachter.bsky.social compiled a list of quotes that are absolutely not for the faint of heart.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
Reposted by Emilio Lecona
Queridos y queridas colegas, es un verdadero honor invitaros al 48º Congreso Internacional de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM), que celebraremos en la ciudad de Tarragona del 7 al 10 de septiembre de 2026.
¡Reservad vuestras fechas!
¡Reservad vuestras fechas!
November 7, 2025 at 3:03 PM
Queridos y queridas colegas, es un verdadero honor invitaros al 48º Congreso Internacional de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM), que celebraremos en la ciudad de Tarragona del 7 al 10 de septiembre de 2026.
¡Reservad vuestras fechas!
¡Reservad vuestras fechas!
Reposted by Emilio Lecona
SUMO interactions: the 1st of two reviews which Aanchal (@origichals.bsky.social), El Hadji, and I have recently written on non-covalent interactions of SUMO is now out. The 1st covers interactions with E1, E2, and deSUMOylating enzymes; the 2nd - on interactions with SIMs etc. - will appear soon.
Non-covalent SUMO interactions with (de)conjugation enzymes
SUMOylation – a protein post-translational modification (PTM) related to ubiquitylation – involves the reversible covalent attachment of the small ubiquitin-like modifier (SUMO) to proteins. During th...
portlandpress.com
November 5, 2025 at 1:44 PM
SUMO interactions: the 1st of two reviews which Aanchal (@origichals.bsky.social), El Hadji, and I have recently written on non-covalent interactions of SUMO is now out. The 1st covers interactions with E1, E2, and deSUMOylating enzymes; the 2nd - on interactions with SIMs etc. - will appear soon.
Reposted by Emilio Lecona
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ten essential tips for robust statistics in cell biology - Nature Cell Biology
Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...
www.nature.com
November 4, 2025 at 7:23 PM
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Emilio Lecona
Mil gracias a Julia Otero y todo el equipo de @juliaenlaonda.bsky.social por contar a vuestra audiencia lo que hacemos en el CBM, lo que llevamos haciendo 50 años siguiendo la estela de Severo Ochoa. ¡Por otros cincuenta años más del CBM y de #JELO! @ondacero.es @csic.es @uam.es
November 1, 2025 at 11:45 AM
Mil gracias a Julia Otero y todo el equipo de @juliaenlaonda.bsky.social por contar a vuestra audiencia lo que hacemos en el CBM, lo que llevamos haciendo 50 años siguiendo la estela de Severo Ochoa. ¡Por otros cincuenta años más del CBM y de #JELO! @ondacero.es @csic.es @uam.es
Reposted by Emilio Lecona
Very interesting!
Nature research paper: Evidence for improved DNA repair in long-lived bowhead whale
go.nature.com/4oNJSAG
go.nature.com/4oNJSAG
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.
go.nature.com
October 30, 2025 at 11:13 AM
Very interesting!
Reposted by Emilio Lecona
What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity?
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
October 29, 2025 at 4:26 PM
What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity?
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Reposted by Emilio Lecona
H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....
October 27, 2025 at 1:27 PM
H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....
Reposted by Emilio Lecona
I have a very bad feeling about this...
October 27, 2025 at 4:51 PM
I have a very bad feeling about this...
Reposted by Emilio Lecona
En Viena hay seis torres nazis de hormigón: colosales, indestructibles. Fueron fortalezas antiaéreas, pero hoy son acuarios o miradores.
Porque la ciudad ha entendido lo que hacer con su pasado: transformar la máquina de guerra en memoria.
Os lo cuento en #LaBrasaTorrijos 🧵⤵️
Porque la ciudad ha entendido lo que hacer con su pasado: transformar la máquina de guerra en memoria.
Os lo cuento en #LaBrasaTorrijos 🧵⤵️
October 27, 2025 at 11:38 AM
En Viena hay seis torres nazis de hormigón: colosales, indestructibles. Fueron fortalezas antiaéreas, pero hoy son acuarios o miradores.
Porque la ciudad ha entendido lo que hacer con su pasado: transformar la máquina de guerra en memoria.
Os lo cuento en #LaBrasaTorrijos 🧵⤵️
Porque la ciudad ha entendido lo que hacer con su pasado: transformar la máquina de guerra en memoria.
Os lo cuento en #LaBrasaTorrijos 🧵⤵️
Reposted by Emilio Lecona
What specific targets & roles are there for all distinct polyubiquitin chain types?
Niels Mailand, Robert Shearer et al profile a panel of #ubiquitin replacement cell lines, implicating K29 chains in chromatin regulation via SUV39H1 destabilization
www.embopress.org/doi/full/10....
Niels Mailand, Robert Shearer et al profile a panel of #ubiquitin replacement cell lines, implicating K29 chains in chromatin regulation via SUV39H1 destabilization
www.embopress.org/doi/full/10....
October 27, 2025 at 11:51 AM
What specific targets & roles are there for all distinct polyubiquitin chain types?
Niels Mailand, Robert Shearer et al profile a panel of #ubiquitin replacement cell lines, implicating K29 chains in chromatin regulation via SUV39H1 destabilization
www.embopress.org/doi/full/10....
Niels Mailand, Robert Shearer et al profile a panel of #ubiquitin replacement cell lines, implicating K29 chains in chromatin regulation via SUV39H1 destabilization
www.embopress.org/doi/full/10....
Reposted by Emilio Lecona
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 23, 2025 at 6:07 PM
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
Reposted by Emilio Lecona
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.
The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR
candidate.hr-manager.net
October 23, 2025 at 4:18 PM
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
Reposted by Emilio Lecona
A follow-up PhD project is now available: www.findaphd.com/phds/project...
October 21, 2025 at 11:43 AM
A follow-up PhD project is now available: www.findaphd.com/phds/project...
Y después de la ciencia, se disfruta un poco de Sevilla.
October 18, 2025 at 2:36 PM
Y después de la ciencia, se disfruta un poco de Sevilla.
Great workshop!
We are very happy with the GenomaHub @csic.es Workshop on "Genome dynamics from development to disease" held at our institute was a great success. Organized by @nestorgarciarod.bsky.social , @romangp.bsky.social , Cristina Gonzalez-Aguilera and Belén Gómez-González. Thanks to all the participants!
October 17, 2025 at 10:56 PM
Great workshop!
Reposted by Emilio Lecona
Hasta el 85 funcionó. Hasta 1985.
Patronato de Protección a la Mujer: un reformatorio franquista para lesbianas que funcionó en democracia
La lucha de su viuda logra que el Gobierno reconozca por primera vez como víctima de la dictadura a una mujer que fue recluida en centros religiosos de 1978 a 1985
elpais.com
October 16, 2025 at 10:32 PM
Hasta el 85 funcionó. Hasta 1985.
Reposted by Emilio Lecona
Let me tell you a story about how a 17th century painter accidentally made one of the most powerful pieces of intersex representation in art, whilst (probably) trying to make an offensive joke for horny nerds...
October 16, 2025 at 8:43 AM
Let me tell you a story about how a 17th century painter accidentally made one of the most powerful pieces of intersex representation in art, whilst (probably) trying to make an offensive joke for horny nerds...