Emilie Brasset
@emiliebrasset.bsky.social
Transposable Element, piRNA & Drosophila #GReD #UCA, #Clermont-Ferrand
Reposted by Emilie Brasset
(1/9) Join us in Bern, Switzerland (8–11 Feb 2026) for our EMBO Workshop on Molecular Mechanisms of Selfish Elements and Strategies!
Organized with Tanja Schwander, Laura Ross (@laurarossevo.bsky.social) and Axel Imhof.
meetings.embo.org/event/26-sel...
#EMBOselfishElements #EMBOevents
Organized with Tanja Schwander, Laura Ross (@laurarossevo.bsky.social) and Axel Imhof.
meetings.embo.org/event/26-sel...
#EMBOselfishElements #EMBOevents
Molecular mechanisms of selfish elements and strategies
Certain genes, chromosomes, organelles, or entire sets of chromosomes can bias their transmission to the next generation, propagating themselves at the expense of the rest of the genome. Referred to …
meetings.embo.org
October 27, 2025 at 5:37 PM
(1/9) Join us in Bern, Switzerland (8–11 Feb 2026) for our EMBO Workshop on Molecular Mechanisms of Selfish Elements and Strategies!
Organized with Tanja Schwander, Laura Ross (@laurarossevo.bsky.social) and Axel Imhof.
meetings.embo.org/event/26-sel...
#EMBOselfishElements #EMBOevents
Organized with Tanja Schwander, Laura Ross (@laurarossevo.bsky.social) and Axel Imhof.
meetings.embo.org/event/26-sel...
#EMBOselfishElements #EMBOevents
Reposted by Emilie Brasset
Some impressions from the rather fabulous #EMBOmobilegenome Mobile Genome meeting in Heidelberg
Morning walk through the woods, exciting panel discussion, flash talks, lab community, drosophila friends, …
@events.embl.org
The transposon community is going very strong. see you all again in 2027!!
Morning walk through the woods, exciting panel discussion, flash talks, lab community, drosophila friends, …
@events.embl.org
The transposon community is going very strong. see you all again in 2027!!
November 7, 2025 at 7:38 AM
Some impressions from the rather fabulous #EMBOmobilegenome Mobile Genome meeting in Heidelberg
Morning walk through the woods, exciting panel discussion, flash talks, lab community, drosophila friends, …
@events.embl.org
The transposon community is going very strong. see you all again in 2027!!
Morning walk through the woods, exciting panel discussion, flash talks, lab community, drosophila friends, …
@events.embl.org
The transposon community is going very strong. see you all again in 2027!!
Reposted by Emilie Brasset
great to be at the #EMBOMobileGenome meeting in Heidelberg with a wonderful bunch of colleagues, speakers and attendees.
this meeting is a good reflection of the excitement and collegiality in the transposon field.
kindly sponsored by @embo.org
this meeting is a good reflection of the excitement and collegiality in the transposon field.
kindly sponsored by @embo.org
Welcome to Day 1 of 'The mobile genome: genetic and physiological impacts of transposable elements'! 🧬
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
November 4, 2025 at 8:25 PM
great to be at the #EMBOMobileGenome meeting in Heidelberg with a wonderful bunch of colleagues, speakers and attendees.
this meeting is a good reflection of the excitement and collegiality in the transposon field.
kindly sponsored by @embo.org
this meeting is a good reflection of the excitement and collegiality in the transposon field.
kindly sponsored by @embo.org
Reposted by Emilie Brasset
Glad to share our latest work showing that #drosophila epigenetic enzyme TET controls muscle development independently of its catalytic activity but prevents muscle aging in a catalytic-dependent manner!
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
TET exhibits enzymatic-independent and-dependent functions during Drosophila flight muscle development and aging - Skeletal Muscle
Background Enzymes of the Ten-Eleven Translocation family are responsible for 5-methylcytosine (5mC) oxidation and play a key role in regulating DNA demethylation during various developmental processe...
links.springernature.com
October 27, 2025 at 3:23 PM
Glad to share our latest work showing that #drosophila epigenetic enzyme TET controls muscle development independently of its catalytic activity but prevents muscle aging in a catalytic-dependent manner!
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
Reposted by Emilie Brasset
On the cover - Congrats @jeromeavellaneda.bsky.social @nunoluis.bsky.social
flies fly! @fly-eds.bsky.social www.cell.com/developmenta...
flies fly! @fly-eds.bsky.social www.cell.com/developmenta...
November 3, 2025 at 5:22 PM
On the cover - Congrats @jeromeavellaneda.bsky.social @nunoluis.bsky.social
flies fly! @fly-eds.bsky.social www.cell.com/developmenta...
flies fly! @fly-eds.bsky.social www.cell.com/developmenta...
Reposted by Emilie Brasset
When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
October 14, 2025 at 8:34 PM
When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
Reposted by Emilie Brasset
It is today and tomorrow! #IBENS International Symposium on Epigenetic Inheritance will bring together leading international experts in the field and pay tribute to Vincent Colot and Eric Meyer, two pioneers of epigenetics and eminent colleagues, on the occasion of their retirement.
October 13, 2025 at 11:51 AM
It is today and tomorrow! #IBENS International Symposium on Epigenetic Inheritance will bring together leading international experts in the field and pay tribute to Vincent Colot and Eric Meyer, two pioneers of epigenetics and eminent colleagues, on the occasion of their retirement.
Reposted by Emilie Brasset
Love RNA biology?
Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).
PhD student/postdoc position co-supervised by Clemens Plaschka & myself.
DM or email us if you’d like to know more!
@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).
PhD student/postdoc position co-supervised by Clemens Plaschka & myself.
DM or email us if you’d like to know more!
@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
September 18, 2025 at 2:34 PM
Love RNA biology?
Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).
PhD student/postdoc position co-supervised by Clemens Plaschka & myself.
DM or email us if you’d like to know more!
@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).
PhD student/postdoc position co-supervised by Clemens Plaschka & myself.
DM or email us if you’d like to know more!
@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
Reposted by Emilie Brasset
🌿⚖️ Growth or defense? A new study in Science Advances
shows how the PAF1 complex helps plants toggle between growth and immune responses by regulating gene expression.
📖 science.org/doi/10.1126/...
🔬 Collaboration between Wuhan Univesity & @cnrs.fr
shows how the PAF1 complex helps plants toggle between growth and immune responses by regulating gene expression.
📖 science.org/doi/10.1126/...
🔬 Collaboration between Wuhan Univesity & @cnrs.fr
October 6, 2025 at 6:45 AM
🌿⚖️ Growth or defense? A new study in Science Advances
shows how the PAF1 complex helps plants toggle between growth and immune responses by regulating gene expression.
📖 science.org/doi/10.1126/...
🔬 Collaboration between Wuhan Univesity & @cnrs.fr
shows how the PAF1 complex helps plants toggle between growth and immune responses by regulating gene expression.
📖 science.org/doi/10.1126/...
🔬 Collaboration between Wuhan Univesity & @cnrs.fr
Reposted by Emilie Brasset
Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included.
training.institut-curie.org/courses/deve...
training.institut-curie.org/courses/deve...
June 13, 2025 at 4:55 PM
Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included.
training.institut-curie.org/courses/deve...
training.institut-curie.org/courses/deve...
Reposted by Emilie Brasset
Novel insights into the silencing of an understudied transposable element - check out our latest preprint by @jakobschnabl.bsky.social and colleagues
📖 Happy to share our recent preprint! www.biorxiv.org/content/10.1... We discovered how SINEs are kept silent: the ChAHP protein complex acts as a molecular brake on POL III transcription retrotransposons. A 🧵:
ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment
Short interspersed nuclear elements (SINEs) are abundant non-autonomous transposable elements derived from RNA polymerase III (POL III)-transcribed short non-coding RNAs. SINEs retain sequence feature...
www.biorxiv.org
July 3, 2025 at 6:33 AM
Novel insights into the silencing of an understudied transposable element - check out our latest preprint by @jakobschnabl.bsky.social and colleagues
A little late to share, but still thrilled 🤗!
What started as two independent stories, one in Clermont-Ferrand (@igred.fr) and one in Cambridge (Hannon’s group @cruk-mi.bsky.social ), turned into a joint adventure to decode how Rhino picks its favorite piRNA clusters.
When forces unite…
👇👇👇
What started as two independent stories, one in Clermont-Ferrand (@igred.fr) and one in Cambridge (Hannon’s group @cruk-mi.bsky.social ), turned into a joint adventure to decode how Rhino picks its favorite piRNA clusters.
When forces unite…
👇👇👇
New online: Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks
Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks
Nature Structural & Molecular Biology, Published online: 17 June 2025; doi:10.1038/s41594-025-01584-8The authors reveal that, in fruit fly ovaries, the protein Rhino is guided to specific regions of the genome by a combination of two histone modifications, enhancing understanding of how cells protect their DNA from harmful virus-like elements.
go.nature.com
July 2, 2025 at 3:09 PM
A little late to share, but still thrilled 🤗!
What started as two independent stories, one in Clermont-Ferrand (@igred.fr) and one in Cambridge (Hannon’s group @cruk-mi.bsky.social ), turned into a joint adventure to decode how Rhino picks its favorite piRNA clusters.
When forces unite…
👇👇👇
What started as two independent stories, one in Clermont-Ferrand (@igred.fr) and one in Cambridge (Hannon’s group @cruk-mi.bsky.social ), turned into a joint adventure to decode how Rhino picks its favorite piRNA clusters.
When forces unite…
👇👇👇
Reposted by Emilie Brasset
Did you know…
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...
April 9, 2025 at 2:32 PM
Did you know…
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...
Reposted by Emilie Brasset
Very excited to have joined the @mpi-ie.bsky.social !
Thank you for the warm welcome 🤩🤩
Thank you for the warm welcome 🤩🤩
We are excited to officially welcome a new group leader at the MPI-IE in #Freiburg. 🎉
Dr Juliane Glaser 🥳 – she studies epigenetic mechanisms of embryonic development, with a focus on transposable elements. 👉 Interview: www.ie-freiburg.mpg.de/6043545/2025...
Welcome, @julianeg.bsky.social!
Dr Juliane Glaser 🥳 – she studies epigenetic mechanisms of embryonic development, with a focus on transposable elements. 👉 Interview: www.ie-freiburg.mpg.de/6043545/2025...
Welcome, @julianeg.bsky.social!
June 27, 2025 at 11:35 AM
Very excited to have joined the @mpi-ie.bsky.social !
Thank you for the warm welcome 🤩🤩
Thank you for the warm welcome 🤩🤩
Reposted by Emilie Brasset
Nice write up on @joshdubnau.bsky.social's "transposon storm" hypothesis: Alzheimer’s and ALS may be triggered by reawakened viral-like jumping genes that spark inflammation and kill neurons. Antiviral drugs could stop the storm.
knowablemagazine.org/content/arti...
knowablemagazine.org/content/arti...
How rogue jumping genes can spur Alzheimer’s, ALS
Our genomes are peppered with DNA segments called retrotransposons that can move from place to place. When unleashed, some can kill nerves and promote inflammation — a discovery that may inspire treat...
knowablemagazine.org
June 18, 2025 at 3:37 PM
Nice write up on @joshdubnau.bsky.social's "transposon storm" hypothesis: Alzheimer’s and ALS may be triggered by reawakened viral-like jumping genes that spark inflammation and kill neurons. Antiviral drugs could stop the storm.
knowablemagazine.org/content/arti...
knowablemagazine.org/content/arti...
Reposted by Emilie Brasset
The Chromatin And Development lab are hiring a postdoc!
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...
lms.mrc.ac.uk
June 26, 2025 at 3:19 PM
The Chromatin And Development lab are hiring a postdoc!
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
Reposted by Emilie Brasset
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
May 13, 2025 at 7:55 PM
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
Reposted by Emilie Brasset
Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 6:23 PM
Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...
Reposted by Emilie Brasset
Complete ape genomes! 🦍🦧 Our closest relatives get the deluxe sequencing treatment, resolving the most complex & often most interesting parts of the genome.
Happy to make a tiny contribution alongside @panpan100.bsky.social to awesome teamwork & fantastic resource.
www.nature.com/articles/s41...
Happy to make a tiny contribution alongside @panpan100.bsky.social to awesome teamwork & fantastic resource.
www.nature.com/articles/s41...
May 8, 2025 at 7:47 AM
Complete ape genomes! 🦍🦧 Our closest relatives get the deluxe sequencing treatment, resolving the most complex & often most interesting parts of the genome.
Happy to make a tiny contribution alongside @panpan100.bsky.social to awesome teamwork & fantastic resource.
www.nature.com/articles/s41...
Happy to make a tiny contribution alongside @panpan100.bsky.social to awesome teamwork & fantastic resource.
www.nature.com/articles/s41...
Reposted by Emilie Brasset
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound
of TE-derived sequences repurposed for organismal function. ...
www.pnas.org
April 30, 2025 at 10:45 AM
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Reposted by Emilie Brasset
👉 IMBA is hiring a Junior Group Leader in the molecular life sciences. Apply by May 18: imba.science/beagroupleader
#hiring #biology #research #groupleader #europe
#hiring #biology #research #groupleader #europe
imba.science/beagroupleader
imba.science
April 25, 2025 at 1:00 PM
👉 IMBA is hiring a Junior Group Leader in the molecular life sciences. Apply by May 18: imba.science/beagroupleader
#hiring #biology #research #groupleader #europe
#hiring #biology #research #groupleader #europe
Reposted by Emilie Brasset
DFAM (database of transposable elements) 3.9 is out! A lot of cool new stuff and a special update for Drosophila melanogaster... 1/2 #Transposon #DFAM
Today we released Dfam 3.9 with many new community submissions and the result of a thorough curation and update of the Drosophila Melanogaster library. www.dfam.org (release notes: www.dfam.org/releases/Dfa...)
Dfam
Open database of transposable elements and repetitive DNA families
www.dfam.org
March 10, 2025 at 9:20 PM
DFAM (database of transposable elements) 3.9 is out! A lot of cool new stuff and a special update for Drosophila melanogaster... 1/2 #Transposon #DFAM
Reposted by Emilie Brasset
🎉 so excited to share my first first-author paper is out in @Nature.com, from my PhD work in the Gallio Lab! we uncover the neurobiological mechanisms that drive the evolution of temperature preference behavior in flies of the genus Drosophila 👇
go.nature.com/4i1VQn9
go.nature.com/4i1VQn9
Evolution of temperature preference in flies of the genus Drosophila - Nature
A study using flies of the genus Drosophila adapted to life in diverse thermal environments shows how evolution has shaped temperature preference by acting on both molecular heat receptors and th...
go.nature.com
March 6, 2025 at 2:51 PM
🎉 so excited to share my first first-author paper is out in @Nature.com, from my PhD work in the Gallio Lab! we uncover the neurobiological mechanisms that drive the evolution of temperature preference behavior in flies of the genus Drosophila 👇
go.nature.com/4i1VQn9
go.nature.com/4i1VQn9
Reposted by Emilie Brasset
Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
Tenthorey et al. compare the effects of missense and indel mutations on the acquisition
of functional novelty by the rapidly evolving antiviral protein TRIM5α. They find
that single indel mutations al...
www.cell.com
March 27, 2025 at 9:36 PM
Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Reposted by Emilie Brasset
A selfish gene in Drosophila has met its match: Trailblazer.
“An innovation in host responses to escalating genomic conflicts”
by @emilianomarti.bsky.social & Amanda Larracuente
highlights work from @peiwei-chen.bsky.social et al in PNAS.
FREE till May 24 at
authors.elsevier.com/a/1ktQOcQbJF...
“An innovation in host responses to escalating genomic conflicts”
by @emilianomarti.bsky.social & Amanda Larracuente
highlights work from @peiwei-chen.bsky.social et al in PNAS.
FREE till May 24 at
authors.elsevier.com/a/1ktQOcQbJF...
April 4, 2025 at 1:45 PM
A selfish gene in Drosophila has met its match: Trailblazer.
“An innovation in host responses to escalating genomic conflicts”
by @emilianomarti.bsky.social & Amanda Larracuente
highlights work from @peiwei-chen.bsky.social et al in PNAS.
FREE till May 24 at
authors.elsevier.com/a/1ktQOcQbJF...
“An innovation in host responses to escalating genomic conflicts”
by @emilianomarti.bsky.social & Amanda Larracuente
highlights work from @peiwei-chen.bsky.social et al in PNAS.
FREE till May 24 at
authors.elsevier.com/a/1ktQOcQbJF...