Edward Pimentel
@edwardpimentel.bsky.social
Stanford Postdoc (Soh Lab) 🧬
UW-Madison PhD (Martell Group) 🧪
Loves Chemistry, Books, Bread, Bikes and Plants.
🇺🇸 🇧🇦 🇷🇴 🇳🇱 🇸🇩 🇧🇪
UW-Madison PhD (Martell Group) 🧪
Loves Chemistry, Books, Bread, Bikes and Plants.
🇺🇸 🇧🇦 🇷🇴 🇳🇱 🇸🇩 🇧🇪
Reposted by Edward Pimentel
And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm!
elifesciences.org/articles/88794
colab.research.google.com/github/Masaa...
elifesciences.org/articles/88794
colab.research.google.com/github/Masaa...
February 15, 2026 at 3:03 AM
And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm!
elifesciences.org/articles/88794
colab.research.google.com/github/Masaa...
elifesciences.org/articles/88794
colab.research.google.com/github/Masaa...
Reposted by Edward Pimentel
Follow @inprep.bsky.social for the best #ScienceSatire anywhere!
January 31, 2026 at 12:40 AM
Follow @inprep.bsky.social for the best #ScienceSatire anywhere!
Amazing work by my former labmate, Ashley and collaborators in the @chembiobryan.bsky.social group!
The final version of our new paper is out now - and open access @acs.org Central Science!!
Such a fun collaboration!
pubs.acs.org/doi/10.1021/...
Such a fun collaboration!
pubs.acs.org/doi/10.1021/...
January 26, 2026 at 6:59 AM
Amazing work by my former labmate, Ashley and collaborators in the @chembiobryan.bsky.social group!
Reposted by Edward Pimentel
Did you know that narratives can generate interest in your research? @storycollider.bsky.social provides #CASFutureLeaders with skills for effective storytelling. If you're a Ph.D. student or postdoc, apply for the 2026 program by January 25. www.cas.org/about/future... youtu.be/3J9LvBqM8XY?...
How Scientists Learn to Tell Their Research Story | CAS Future Leaders™
YouTube video by CAS, a division of the American Chemical Society
youtu.be
January 21, 2026 at 7:08 PM
Did you know that narratives can generate interest in your research? @storycollider.bsky.social provides #CASFutureLeaders with skills for effective storytelling. If you're a Ph.D. student or postdoc, apply for the 2026 program by January 25. www.cas.org/about/future... youtu.be/3J9LvBqM8XY?...
Reposted by Edward Pimentel
Researchers have developed a light-driven catalytic method to hydrolyze furans, offering a more efficient way to exploit them in biorefineries. cen.acs.org/synthesis/gr... #chemsky 🧪
Lighting a better path for biobased furans
Photocatalytic hydrolysis offers a shortcut for renewable chemicals
cen.acs.org
January 20, 2026 at 9:25 PM
Researchers have developed a light-driven catalytic method to hydrolyze furans, offering a more efficient way to exploit them in biorefineries. cen.acs.org/synthesis/gr... #chemsky 🧪
Reposted by Edward Pimentel
Dissolved in poly(alpha-olefin) oil, the reagents don’t ignite or smoke in air, making them easier to handle and less prone to degradation on storage, while maintaining performance across a range of reaction types.
New reagents take the burn out of butyllithium
Merck KGaA's non-pyrophoric butyllithium in poly(α-olefin) oil make BuLi stable to air and water
www.chemistryworld.com
January 20, 2026 at 4:18 PM
Dissolved in poly(alpha-olefin) oil, the reagents don’t ignite or smoke in air, making them easier to handle and less prone to degradation on storage, while maintaining performance across a range of reaction types.
Lucky manufacturing glitch of the week: finding 0.5 mL centrifuge tubes mixed in with the 1.5 mL tubes we ordered. It's like finding the plastic baby figurine in your slice of the king cake! @eppendorf.bsky.social #chemchat 🧪
January 20, 2026 at 6:37 AM
Lucky manufacturing glitch of the week: finding 0.5 mL centrifuge tubes mixed in with the 1.5 mL tubes we ordered. It's like finding the plastic baby figurine in your slice of the king cake! @eppendorf.bsky.social #chemchat 🧪
Amazing work from the @aliceyting.bsky.social lab! Especially cool to see the functional effect of the conformational biasing on enzyme activity. www.science.org/doi/10.1126/...
Computational design of conformation-biasing mutations to alter protein functions
Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...
www.science.org
January 9, 2026 at 10:33 PM
Amazing work from the @aliceyting.bsky.social lab! Especially cool to see the functional effect of the conformational biasing on enzyme activity. www.science.org/doi/10.1126/...
Reposted by Edward Pimentel
Cool new chemistry for covalent ligand development targeting arginine 👏
Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines
Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...
www.biorxiv.org
January 6, 2026 at 5:15 PM
Cool new chemistry for covalent ligand development targeting arginine 👏
Very cool work in this preprint from the Krishnan lab!
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 4:50 AM
Very cool work in this preprint from the Krishnan lab!
Amazing to see two of my Soh Lab teammates on the #ForbesUnder30 Science list today: Congratulations Yihang and Yahao! www.forbes.com/30-under-30/...
Forbes 30 Under 30 2025: Science
Inventing the future from the atom up
www.forbes.com
December 2, 2025 at 7:54 PM
Amazing to see two of my Soh Lab teammates on the #ForbesUnder30 Science list today: Congratulations Yihang and Yahao! www.forbes.com/30-under-30/...
This is an amazing program. Check it out and apply!
Are you an early-career scientist ready to take the next steps in your leadership journey? The 2026 #CASFutureLeaders program is now accepting applications! Learn more and apply by Sunday, January 25, 2026. www.cas.org/about/future...
December 1, 2025 at 6:22 PM
This is an amazing program. Check it out and apply!
Reposted by Edward Pimentel
Check out our review on DNA-scaffolded catalysis! This link provides free full text access until the end of 2025: authors.elsevier.com/a/1m43W9CpcY.... Big thanks to co-authors @edwardpimentel.bsky.social , Ashley Ogorek, @ethan-hartman-125.bsky.social , and Caleb Cox
November 13, 2025 at 3:21 AM
Check out our review on DNA-scaffolded catalysis! This link provides free full text access until the end of 2025: authors.elsevier.com/a/1m43W9CpcY.... Big thanks to co-authors @edwardpimentel.bsky.social , Ashley Ogorek, @ethan-hartman-125.bsky.social , and Caleb Cox
Our mini-review on DNA-scaffolded catalysis is out today in @cp-trendschem.bsky.social! It's an interesting look at this unique intersection of catalysis, DNA nanotechnology and supramolecular chemistry. Give it a read! #chemsky doi.org/10.1016/j.tr...
Redirecting
doi.org
November 9, 2025 at 5:26 AM
Our mini-review on DNA-scaffolded catalysis is out today in @cp-trendschem.bsky.social! It's an interesting look at this unique intersection of catalysis, DNA nanotechnology and supramolecular chemistry. Give it a read! #chemsky doi.org/10.1016/j.tr...
Just stumbled across Orca Sciences' technical articles. Interesting reads! www.orcasciences.com/reading-diff...
Orca Sciences
www.orcasciences.com
November 1, 2025 at 11:16 PM
Just stumbled across Orca Sciences' technical articles. Interesting reads! www.orcasciences.com/reading-diff...
Interesting article about RNA structure prediction - we're always wishing we had better structure prediction tools for aptamers, and this article sums up the challenges very neatly! www.owlposting.com/p/rna-struct...
RNA structure prediction is hard. How much does that matter?
4.8k words, 22 minute reading time
www.owlposting.com
September 26, 2025 at 10:09 PM
Interesting article about RNA structure prediction - we're always wishing we had better structure prediction tools for aptamers, and this article sums up the challenges very neatly! www.owlposting.com/p/rna-struct...
Reposted by Edward Pimentel
In @science.org this week @zachwickens.bsky.social and collaborators find a way to do Z-selective elimination using thianthrenium chemistry in a versatile route to Z olefins.
chemsky 🧪
www.science.org/doi/10.1126/...
chemsky 🧪
www.science.org/doi/10.1126/...
Stereo-reversed E2 unlocks Z-selective C–H functionalization
The stereoselective functionalization of C–H bonds represents a central challenge in modern organic synthesis. Despite decades of innovation in C–H activation chemistry, methods for Z-selective functi...
www.science.org
September 18, 2025 at 10:14 PM
In @science.org this week @zachwickens.bsky.social and collaborators find a way to do Z-selective elimination using thianthrenium chemistry in a versatile route to Z olefins.
chemsky 🧪
www.science.org/doi/10.1126/...
chemsky 🧪
www.science.org/doi/10.1126/...
Reposted by Edward Pimentel
Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...
An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis
Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...
pubs.acs.org
September 16, 2025 at 10:42 PM
Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...
New preprint from the Soh lab! Nice work by my labmate Haji - new highly specific steroid aptamers identified using our modified sequencer platform! These don't have the 3wj structure and promiscuity of previous aptamers - I've used it myself! #chemsky www.biorxiv.org/content/10.1...
Discovery of high-specificity DNA aptamers for progesterone using a high-throughput array platform
Aptamer-based biosensors offer several advantages for detecting small molecules, including chemical stability and compatibility with diverse sensing formats. However, developing highly specific DNA ap...
www.biorxiv.org
September 16, 2025 at 4:31 PM
New preprint from the Soh lab! Nice work by my labmate Haji - new highly specific steroid aptamers identified using our modified sequencer platform! These don't have the 3wj structure and promiscuity of previous aptamers - I've used it myself! #chemsky www.biorxiv.org/content/10.1...
Reposted by Edward Pimentel
#chemsky 🧪
What's up with today's #GoogleDoodle? @maxhenrybarnhart.bsky.social has all the juicy deets on DNA for @cenmag.bsky.social cen.acs.org/articles/103...
Google Doodle features DNA chemistry to mark start of school year
Guanine, a phosphate backbone, and a double helix get the Doodle treatment
cen.acs.org
September 10, 2025 at 10:34 PM
#chemsky 🧪
Reposted by Edward Pimentel
Great perspective by @dereklowe.bsky.social on recent advances in cell surface #glycoRNA biology, including new work from @raflynn5.bsky.social and collaborators identifying an immune silencing effect of N-glycans on activation of TLRs by Acp3U-RNA (www.nature.com/articles/s41...)
September 9, 2025 at 6:19 PM
Great perspective by @dereklowe.bsky.social on recent advances in cell surface #glycoRNA biology, including new work from @raflynn5.bsky.social and collaborators identifying an immune silencing effect of N-glycans on activation of TLRs by Acp3U-RNA (www.nature.com/articles/s41...)
Fascinating work by @philiplampkin.bsky.social from the Gellman lab about preorganization in bifunctional catalysts! Controls like the alkyl-tethered catalysts in this paper are important for assessing the role of the supramolecular scaffold, but rarely investigated. Give it a read!
My work assessing the effect of preorganization on dihydrazide activity is out in @jacs.acspublications.org. We find that dihydrazides with flexible tethers can replicate much of the catalytic activity of complex dihydrazides with preorganized foldamer scaffolds. #Chemsky
doi.org/10.1021/jacs...
doi.org/10.1021/jacs...
Bifunctional Catalysis of Aldol Reactions by Foldamer Dihydrazides: Assessment of Conformational Preorganization
We previously reported that molecules containing two cyclic hydrazide units connected by a polymethylene linker could catalyze aldol condensations via a bifunctional mechanism. One hydrazide apparentl...
doi.org
September 8, 2025 at 9:04 PM
Fascinating work by @philiplampkin.bsky.social from the Gellman lab about preorganization in bifunctional catalysts! Controls like the alkyl-tethered catalysts in this paper are important for assessing the role of the supramolecular scaffold, but rarely investigated. Give it a read!
Reposted by Edward Pimentel
A very apt Venn diagram (dunno original source)
August 29, 2025 at 7:48 PM
A very apt Venn diagram (dunno original source)
I loved reading about the Dickinson lab's masked acylating reagent approach to proximity labeling in Nature Chemistry last year (www.nature.com/articles/s41...), and was really excited when @jeffmartell.bsky.social and my labmate Ashley got involved. Check the pre-print out!
Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr...
1/n
1/n
Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling
Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...
chemrxiv.org
August 29, 2025 at 12:22 AM
I loved reading about the Dickinson lab's masked acylating reagent approach to proximity labeling in Nature Chemistry last year (www.nature.com/articles/s41...), and was really excited when @jeffmartell.bsky.social and my labmate Ashley got involved. Check the pre-print out!
Cool grant program by ACS that supports graduate students whose Masters/PhD is being impacted by canceled grants: www.acs.org/funding/gran...
ACS Graduate Student Success Grant - American Chemical Society
To support graduate students (M.S. and Ph.D.), within one year of degree completion, whose education and training were disrupted due to recent termination or cancellation of research grants. Funding w...
www.acs.org
August 22, 2025 at 8:43 PM
Cool grant program by ACS that supports graduate students whose Masters/PhD is being impacted by canceled grants: www.acs.org/funding/gran...