Edoardo Melilli
@edoardomelilli.bsky.social
no man is an island.. an italian nephrologist living and working in barcelona. Medicine, food, and sports are my interests
Reposted by Edoardo Melilli
5/10
A figure paints🖼️ a 1000 words!
Emerging evidence from APRIL/BAFF–axis trials underscores how central this pathway is to IgAN biology. Let’s put ORIGIN side by side with the others and see what we learn!
A figure paints🖼️ a 1000 words!
Emerging evidence from APRIL/BAFF–axis trials underscores how central this pathway is to IgAN biology. Let’s put ORIGIN side by side with the others and see what we learn!
November 20, 2025 at 12:35 AM
5/10
A figure paints🖼️ a 1000 words!
Emerging evidence from APRIL/BAFF–axis trials underscores how central this pathway is to IgAN biology. Let’s put ORIGIN side by side with the others and see what we learn!
A figure paints🖼️ a 1000 words!
Emerging evidence from APRIL/BAFF–axis trials underscores how central this pathway is to IgAN biology. Let’s put ORIGIN side by side with the others and see what we learn!
Reposted by Edoardo Melilli
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: The Impact of Donor and Recipient Diabetes on Patient and Graft Survival in Kidney Transplant Recipients www.kireports.org/ar...
November 21, 2025 at 6:00 AM
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: The Impact of Donor and Recipient Diabetes on Patient and Graft Survival in Kidney Transplant Recipients www.kireports.org/ar...
Reposted by Edoardo Melilli
Maintaining a moderate level of physical activity approximately 17 MET-hours/week (ie, 5 hours of brisk walking or 2 hours of running each week) over 3 decades was sufficient to achieve optimal benefit in reducing Digestive System Cancer risk.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Consistent Adherence to Physical Activity Guidelines and Digestive System Cancer Risk and Mortality
This cohort study using data from 3 large US prospective cohorts assesses whether adherence to the recommended physical activity level measured in metabolic equivalent task over time is associated wit...
jamanetwork.com
November 16, 2025 at 11:41 AM
Maintaining a moderate level of physical activity approximately 17 MET-hours/week (ie, 5 hours of brisk walking or 2 hours of running each week) over 3 decades was sufficient to achieve optimal benefit in reducing Digestive System Cancer risk.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Edoardo Melilli
2025 AJKD Editors' Choice Award winning article: Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study
bit.ly/3WeEZ72
#VisualAbstract
bit.ly/3WeEZ72
#VisualAbstract
November 16, 2025 at 5:01 PM
2025 AJKD Editors' Choice Award winning article: Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study
bit.ly/3WeEZ72
#VisualAbstract
bit.ly/3WeEZ72
#VisualAbstract
Reposted by Edoardo Melilli
A follow-up report showed that the overall benefit of machine perfusion over cold storage in kidney graft survival remained present 10 years after transplantation. Read the full report: nej.md/4hDQNK4
#MedSky #Nephrology #Surgery
#MedSky #Nephrology #Surgery
November 10, 2025 at 6:31 PM
A follow-up report showed that the overall benefit of machine perfusion over cold storage in kidney graft survival remained present 10 years after transplantation. Read the full report: nej.md/4hDQNK4
#MedSky #Nephrology #Surgery
#MedSky #Nephrology #Surgery
Reposted by Edoardo Melilli
📘 “Responsible Use of Artificial Intelligence to Improve Kidney Care”
🧩 Journal of the American Society of Nephrology (JASN) – Published online November 7, 2025 @asnkidney.bsky.social
@asnpublications.bsky.social
journals.lww.com/jasn/fulltex...
🧩 Journal of the American Society of Nephrology (JASN) – Published online November 7, 2025 @asnkidney.bsky.social
@asnpublications.bsky.social
journals.lww.com/jasn/fulltex...
journals.lww.com
November 11, 2025 at 2:29 PM
📘 “Responsible Use of Artificial Intelligence to Improve Kidney Care”
🧩 Journal of the American Society of Nephrology (JASN) – Published online November 7, 2025 @asnkidney.bsky.social
@asnpublications.bsky.social
journals.lww.com/jasn/fulltex...
🧩 Journal of the American Society of Nephrology (JASN) – Published online November 7, 2025 @asnkidney.bsky.social
@asnpublications.bsky.social
journals.lww.com/jasn/fulltex...
Reposted by Edoardo Melilli
🚨🧬 Registrations for the IV Bootcamp are now open! Limited to 30 spots—first come, first served. Acces the link in this thread.
November 11, 2025 at 4:29 PM
🚨🧬 Registrations for the IV Bootcamp are now open! Limited to 30 spots—first come, first served. Acces the link in this thread.
Reposted by Edoardo Melilli
The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele?
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 11, 2025 at 3:20 PM
The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele?
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Edoardo Melilli
Chronic kidney disease currently affects 850 million people
@mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...
@mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...
November 11, 2025 at 7:30 PM
Chronic kidney disease currently affects 850 million people
@mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...
@mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...
Reposted by Edoardo Melilli
Late breakers that included children:
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
November 8, 2025 at 8:27 PM
Late breakers that included children:
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
Reposted by Edoardo Melilli
Get this: Coffee suppressed atrial fibrillation!
Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF
#AHA25 @jama.com
jamanetwork.com/journals/jam...
Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF
#AHA25 @jama.com
jamanetwork.com/journals/jam...
November 9, 2025 at 2:51 PM
Get this: Coffee suppressed atrial fibrillation!
Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF
#AHA25 @jama.com
jamanetwork.com/journals/jam...
Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF
#AHA25 @jama.com
jamanetwork.com/journals/jam...
Reposted by Edoardo Melilli
💬 @jama.com Editorial: The LIBERATE-D trial shows conservative dialysis—guided by A-E-I-O-U indications and asking "Why"—promotes earlier kidney recovery and fewer dialysis sessions in AKI.
#KidneyWK @asnkidney.bsky.social
ja.ma/4hOkM1W
#KidneyWK @asnkidney.bsky.social
ja.ma/4hOkM1W
November 8, 2025 at 12:20 AM
💬 @jama.com Editorial: The LIBERATE-D trial shows conservative dialysis—guided by A-E-I-O-U indications and asking "Why"—promotes earlier kidney recovery and fewer dialysis sessions in AKI.
#KidneyWK @asnkidney.bsky.social
ja.ma/4hOkM1W
#KidneyWK @asnkidney.bsky.social
ja.ma/4hOkM1W
Reposted by Edoardo Melilli
Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.
November 7, 2025 at 4:43 PM
Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.
Reposted by Edoardo Melilli
After empa-kidney, it still wasn’t clear what to do for patients with CKD without diabetes or albuminuria. This meta-analysis suggests you use flozins. #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria
This meta-analysis examines whether estimated glomerular filtration rate or degree of albuminuria, as measured by urinary albumin to creatinine ratio, modifies the effects of sodium-glucose cotranspor...
jamanetwork.com
November 8, 2025 at 12:31 AM
After empa-kidney, it still wasn’t clear what to do for patients with CKD without diabetes or albuminuria. This meta-analysis suggests you use flozins. #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Edoardo Melilli
Now live in #ASNJASN, simultaneously published with #KidneyWk: "Immunosuppression in Older Kidney Transplant Recipients: A Randomized Controlled Trial"
Read more: kidney.pub/JASN0924
Read more: kidney.pub/JASN0924
November 7, 2025 at 5:30 PM
Now live in #ASNJASN, simultaneously published with #KidneyWk: "Immunosuppression in Older Kidney Transplant Recipients: A Randomized Controlled Trial"
Read more: kidney.pub/JASN0924
Read more: kidney.pub/JASN0924
Reposted by Edoardo Melilli
Air pollution doesn’t just harm the lungs and heart — it also accelerates kidney disease.
A new @ClinKidneyJ review links exposure to fine particulate matter (PM2.5) and black carbon with faster progression of glomerular diseases.
🔗 academic.oup.com/ckj/article/...
A new @ClinKidneyJ review links exposure to fine particulate matter (PM2.5) and black carbon with faster progression of glomerular diseases.
🔗 academic.oup.com/ckj/article/...
Elevated exposure to air pollutants accelerates primary glomerular disease progression
ABSTRACT. Air pollution is a global problem and a major contributor to adverse health outcomes in patients of all ages. Most research has focused on the ad
academic.oup.com
October 27, 2025 at 4:20 PM
Air pollution doesn’t just harm the lungs and heart — it also accelerates kidney disease.
A new @ClinKidneyJ review links exposure to fine particulate matter (PM2.5) and black carbon with faster progression of glomerular diseases.
🔗 academic.oup.com/ckj/article/...
A new @ClinKidneyJ review links exposure to fine particulate matter (PM2.5) and black carbon with faster progression of glomerular diseases.
🔗 academic.oup.com/ckj/article/...
Reposted by Edoardo Melilli
In patients with chronic coronary syndrome taking oral anticoagulants, adding aspirin led to higher risks of cardiovascular events, major bleeding, and death from any cause than anticoagulation alone. Full AQUATIC trial results and Research Summary: nej.md/45AU4Wp
#MedSky #CardioSky
#MedSky #CardioSky
October 27, 2025 at 1:04 PM
In patients with chronic coronary syndrome taking oral anticoagulants, adding aspirin led to higher risks of cardiovascular events, major bleeding, and death from any cause than anticoagulation alone. Full AQUATIC trial results and Research Summary: nej.md/45AU4Wp
#MedSky #CardioSky
#MedSky #CardioSky
Reposted by Edoardo Melilli
How do mRNA vaccines help fight cancer?
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
How mRNA Vaccines Can Help Fight Cancer
Turning "cold" tumors "hot"
erictopol.substack.com
October 22, 2025 at 3:19 PM
How do mRNA vaccines help fight cancer?
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
Reposted by Edoardo Melilli
A meta-analysis of 13 studies comparing health care professionals vs generative A.I. showed the latter was more likely to be perceived as more empathetic in all but 1 study
academic.oup.com/bmb/article/...
academic.oup.com/bmb/article/...
October 22, 2025 at 6:46 PM
A meta-analysis of 13 studies comparing health care professionals vs generative A.I. showed the latter was more likely to be perceived as more empathetic in all but 1 study
academic.oup.com/bmb/article/...
academic.oup.com/bmb/article/...
Reposted by Edoardo Melilli
A new Nature study found that people with cancer who received an mRNA COVID vaccine while on immunotherapy lived nearly twice as long. Median survival jumped from 20.6 to 37.3 months.
That’s not a typo. Let’s talk about how, and why, that might be. 🧵
That’s not a typo. Let’s talk about how, and why, that might be. 🧵
October 22, 2025 at 3:26 PM
A new Nature study found that people with cancer who received an mRNA COVID vaccine while on immunotherapy lived nearly twice as long. Median survival jumped from 20.6 to 37.3 months.
That’s not a typo. Let’s talk about how, and why, that might be. 🧵
That’s not a typo. Let’s talk about how, and why, that might be. 🧵
Reposted by Edoardo Melilli
Frailty and sarcopenia double mortality in liver transplant candidates and impair recovery. Early detection, nutritional optimization, and personalized (p)rehabilitation are essential to improve outcomes. @BirminghamBRC #TXPforAll #LiverTransplantation tinyurl.com/4u4rr689
October 20, 2025 at 12:00 PM
Frailty and sarcopenia double mortality in liver transplant candidates and impair recovery. Early detection, nutritional optimization, and personalized (p)rehabilitation are essential to improve outcomes. @BirminghamBRC #TXPforAll #LiverTransplantation tinyurl.com/4u4rr689
Reposted by Edoardo Melilli
What does the naked mole rat’s extreme healthspan have to do with ongoing clinical trials?
open.substack.com/pub/erictopo...
open.substack.com/pub/erictopo...
A Long-Awaited Longevity Mystery Solved
Spotlighting an essential human biologic pathway targeted by drugs in clinical trials
open.substack.com
October 13, 2025 at 12:46 PM
What does the naked mole rat’s extreme healthspan have to do with ongoing clinical trials?
open.substack.com/pub/erictopo...
open.substack.com/pub/erictopo...
Reposted by Edoardo Melilli
Really interesting study. I would be curious to know what the average travel distance is for in centre hemodialysis given the 36% estimated contribution from travel to the overall carbon footprint
www.ajkd.org/article/S027...
www.ajkd.org/article/S027...
Carbon Emissions From Different Dialysis Modalities: A Life Cycle Assessment
As the health impacts of climate change intensify, the health care sector faces growing
pressure to minimize its carbon footprint. Achieving this goal requires understanding
of the carbon impact of wi...
www.ajkd.org
October 7, 2025 at 8:08 PM
Really interesting study. I would be curious to know what the average travel distance is for in centre hemodialysis given the 36% estimated contribution from travel to the overall carbon footprint
www.ajkd.org/article/S027...
www.ajkd.org/article/S027...
Reposted by Edoardo Melilli
#weekendReads from the #EditorsChoice
Does Reserpine deserve a Relook for Resistant Hypertension?
academic.oup.com/ajh/article/...
#Free
Does Reserpine deserve a Relook for Resistant Hypertension?
academic.oup.com/ajh/article/...
#Free
Reserpine Substantially Lowers Blood Pressure in Patients With Refractory Hypertension: A Proof-of-Concept Study
AbstractBACKGROUND. Refractory hypertension (RfHTN), a phenotype of antihypertensive treatment failure, is defined as uncontrolled automated office blood p
academic.oup.com
October 5, 2025 at 3:02 PM
#weekendReads from the #EditorsChoice
Does Reserpine deserve a Relook for Resistant Hypertension?
academic.oup.com/ajh/article/...
#Free
Does Reserpine deserve a Relook for Resistant Hypertension?
academic.oup.com/ajh/article/...
#Free