Tumour-associated blood vessels are abnormal in structure and function, and this can limit immune cell infiltration into tumours and contribute to the immunosuppressive tumour microenvironment. This R...

Chromatin structure is a key determinant of gene expression in eukaryotes, but it has not been possible to define the structure of cis-regulatory elem…

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

Signaling networks may provide greater return for the investment in cancer research.

Nature Reviews Genetics, Published online: 03 November 2025; doi:10.1038/s41576-025-00914-2In this Journal Club, Peter Koo reflects on the 2021 publication of Enformer and its impact on the use of deep learning for modelling the regulatory genome.

The accurate representation of data is essential in science communication, however, colour maps that visually distort data through uneven colour gradients or are unreadable to those with colour vision...

AbstractBackground. Technological advances in sequencing and computation have allowed deep exploration of the molecular basis of diseases. Biological netwo

Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.

Nature Reviews Genetics, Published online: 22 October 2025; doi:10.1038/s41576-025-00905-3Jean Fan recounts a 2015 paper by Martincorena et al. that revealed oncogenic mutations in normal tissues, also highlighting how the latest spatial technologies can now be used to study the spatial contextual impact of these mutations.

Survival analysis often relies on Cox models, assuming both linearity and proportional hazards (PH). This study evaluates machine and deep learning me…

Nature Reviews Genetics, Published online: 24 September 2025; doi:10.1038/s41576-025-00895-2Haplotype phasing and genotype imputation improve genomic analyses by determining which variants occur together on a chromosome and inferring unobserved varants, respectively. In this Review, Sun and Li describe how tools for haplotype phasing and genotype imputation have evolved to accommodate increasingly larger genomic datasets and new sequencing technologies.

p21 acts as a rheostat of DNA replication speed controlling PrimPol- and Pol kappa–dependent nascent DNA synthesis.

The tool that snaps mercurial design into mechanical focus.