It's Valve, so they're probably still stuck on T2T
November 13, 2025 at 10:41 PM
It's Valve, so they're probably still stuck on T2T
10/10 – What now? Well, there are still a few gaps, and I invite anyone to read our comprehensive discussion. In particular, I’d like to point out our LD score regression analysis predicting how much heritability is captured by T2T genome builds but currently missed by hg38.
November 12, 2025 at 5:57 PM
10/10 – What now? Well, there are still a few gaps, and I invite anyone to read our comprehensive discussion. In particular, I’d like to point out our LD score regression analysis predicting how much heritability is captured by T2T genome builds but currently missed by hg38.
#T2T #TLSky #EduSKy #kidlit
YAY. IT’S NATIONAL DRAGON MONTH! Dragon story #2. “Messenger’s Plight” By Robyn McGrew. 30 minutes. Grades 3 & Up
Listen: tinyurl.com/Mmessengers
More stories for listening: tinyurl.com/Sstoriesllis...
Share love, share reading
YAY. IT’S NATIONAL DRAGON MONTH! Dragon story #2. “Messenger’s Plight” By Robyn McGrew. 30 minutes. Grades 3 & Up
Listen: tinyurl.com/Mmessengers
More stories for listening: tinyurl.com/Sstoriesllis...
Share love, share reading
November 8, 2025 at 11:39 PM
#T2T #TLSky #EduSKy #kidlit
YAY. IT’S NATIONAL DRAGON MONTH! Dragon story #2. “Messenger’s Plight” By Robyn McGrew. 30 minutes. Grades 3 & Up
Listen: tinyurl.com/Mmessengers
More stories for listening: tinyurl.com/Sstoriesllis...
Share love, share reading
YAY. IT’S NATIONAL DRAGON MONTH! Dragon story #2. “Messenger’s Plight” By Robyn McGrew. 30 minutes. Grades 3 & Up
Listen: tinyurl.com/Mmessengers
More stories for listening: tinyurl.com/Sstoriesllis...
Share love, share reading
While I am appreciative of what the T2T Foundation has done for 9/11 First Responders, I think it's doing half of what it could be. This is why I am creating the T4T Foundation to *a big cane drags me offstage*
October 27, 2025 at 8:44 PM
While I am appreciative of what the T2T Foundation has done for 9/11 First Responders, I think it's doing half of what it could be. This is why I am creating the T4T Foundation to *a big cane drags me offstage*
October 18, 2025 at 9:44 PM
Love this paper by leogdlima.bsky.social et al. We discussed the pre-print in an internal meeting months ago and it was so cool to see people getting excited about what T2T can bring in understanding how genome architecture impacts disease and evolution. Exciting times for genomics (:
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse
YouTube video by Stowers Institute for Medical Research
youtu.be
October 18, 2025 at 12:48 PM
Love this paper by leogdlima.bsky.social et al. We discussed the pre-print in an internal meeting months ago and it was so cool to see people getting excited about what T2T can bring in understanding how genome architecture impacts disease and evolution. Exciting times for genomics (:
New Article: "Pan-centromere landscape and dynamic evolution in Brassica plants" rdcu.be/eLtOL
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
October 17, 2025 at 10:23 AM
New Article: "Pan-centromere landscape and dynamic evolution in Brassica plants" rdcu.be/eLtOL
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
Pan-centromere landscape and evolutionary dynamics in Brassica. T2T genome assemblies of multiple morphotypes shedding light on centromere evolution during domestication.
JL: T2T released first complete human genome, with addtional 200 Mbp, using new tech like PacBio HiFi and Oxford Nanopore sequencing #ASHG25
October 17, 2025 at 9:26 PM
JL: T2T released first complete human genome, with addtional 200 Mbp, using new tech like PacBio HiFi and Oxford Nanopore sequencing #ASHG25
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature
A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-...
www.nature.com
October 16, 2025 at 7:49 AM
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The T2T zebra finch genome has hatched! 🐣 🧬 @vertebrategenomes.bsky.social
The complete genome of a songbird https://www.biorxiv.org/content/10.1101/2025.10.14.682431v1
October 15, 2025 at 1:08 PM
The T2T zebra finch genome has hatched! 🐣 🧬 @vertebrategenomes.bsky.social
The pangenome resources and genome assembly/inference approaches we are building will eventually enable complete, personalized “T2T” genomes for everyone. This is the thesis of the Q100 project (www.biorxiv.org/content/10.1...) and what my group is currently working towards. Stay tuned... [10/10]
A complete diploid human genome benchmark for personalized genomics
Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...
www.biorxiv.org
October 13, 2025 at 8:17 PM
The pangenome resources and genome assembly/inference approaches we are building will eventually enable complete, personalized “T2T” genomes for everyone. This is the thesis of the Q100 project (www.biorxiv.org/content/10.1...) and what my group is currently working towards. Stay tuned... [10/10]
October 12, 2025 at 12:12 PM
#kidlil #T2T #EduSky #TLSky
A little humor in these trying times. Read Me a Story, Ink is thrilled to have permission to offer SciFi/Fantasy humorist, Robert Asprin’s “You Never Call,” both audio and print. 11 mins. Family, Mother’s Day, Space Adventure.
Listen or read: tinyurl.com/YouNnever
A little humor in these trying times. Read Me a Story, Ink is thrilled to have permission to offer SciFi/Fantasy humorist, Robert Asprin’s “You Never Call,” both audio and print. 11 mins. Family, Mother’s Day, Space Adventure.
Listen or read: tinyurl.com/YouNnever
October 12, 2025 at 4:52 PM
#kidlil #T2T #EduSky #TLSky
A little humor in these trying times. Read Me a Story, Ink is thrilled to have permission to offer SciFi/Fantasy humorist, Robert Asprin’s “You Never Call,” both audio and print. 11 mins. Family, Mother’s Day, Space Adventure.
Listen or read: tinyurl.com/YouNnever
A little humor in these trying times. Read Me a Story, Ink is thrilled to have permission to offer SciFi/Fantasy humorist, Robert Asprin’s “You Never Call,” both audio and print. 11 mins. Family, Mother’s Day, Space Adventure.
Listen or read: tinyurl.com/YouNnever
If that’s not enough, we threw in a complete, T2T giraffe genome! Giraffe genomes are pretty cool. Almost all of their chromosomes are Robertsonian fusions of the typically telocentric ruminant chromosomes. 🐄 vs. 🦒...
October 10, 2025 at 3:26 PM
If that’s not enough, we threw in a complete, T2T giraffe genome! Giraffe genomes are pretty cool. Almost all of their chromosomes are Robertsonian fusions of the typically telocentric ruminant chromosomes. 🐄 vs. 🦒...
Someone contacted me after CHM13 came out claiming that our assembly must be contaminated by Fetal Bovine Serum because they found cow DNA in it ... I had to break it to them that it was their cow sequences that were contaminated with human. DB contamination is an insidious problem. T2T genomes help
October 10, 2025 at 6:30 PM
Someone contacted me after CHM13 came out claiming that our assembly must be contaminated by Fetal Bovine Serum because they found cow DNA in it ... I had to break it to them that it was their cow sequences that were contaminated with human. DB contamination is an insidious problem. T2T genomes help
“Finishing a complete giraffe genome from telomere to telomere with Verkko-Fillet” walks you through the process of finishing a complete T2T genome using a new Python toolkit developed by Juhyun Kim that makes Verkko output more accessible... www.biorxiv.org/content/10.1...
Finishing a complete giraffe genome from telomere to telomere with Verkko-Fillet
High-quality genome assemblies are essential for understanding speciation, evolution, and for building reference genomes and pan-genomes. Despite major advances in long-read sequencing technologies an...
www.biorxiv.org
October 10, 2025 at 3:26 PM
“Finishing a complete giraffe genome from telomere to telomere with Verkko-Fillet” walks you through the process of finishing a complete T2T genome using a new Python toolkit developed by Juhyun Kim that makes Verkko output more accessible... www.biorxiv.org/content/10.1...
Having a complete, personalized reference genome of the sample you are analyzing allows for investigations like this in the most complex regions of the genome without having to worry about reference bias. More “matched” T2T assemblies are on the way for commonly used iPSC lines like KOLF2.1J...
October 10, 2025 at 3:27 PM
Having a complete, personalized reference genome of the sample you are analyzing allows for investigations like this in the most complex regions of the genome without having to worry about reference bias. More “matched” T2T assemblies are on the way for commonly used iPSC lines like KOLF2.1J...
Congratulations! I wanted to mention that there has been previous research on SST1/NBL2 prior T2T that might be relevant. For example, their localization to the short arms of acrocentric chromosomes and transcription upon hypomethylation (doi.org/10.1093/nar/gky263), along with some earlier work.
A novel long non-coding RNA from NBL2 pericentromeric macrosatellite forms a perinucleolar aggregate structure in colon cancer
Abstract. Primate-specific NBL2 macrosatellite is hypomethylated in several types of tumors, yet the consequences of this DNA hypomethylation remain unknow
doi.org
October 8, 2025 at 7:33 PM
Congratulations! I wanted to mention that there has been previous research on SST1/NBL2 prior T2T that might be relevant. For example, their localization to the short arms of acrocentric chromosomes and transcription upon hypomethylation (doi.org/10.1093/nar/gky263), along with some earlier work.
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse
YouTube video by Stowers Institute for Medical Research
youtu.be
September 24, 2025 at 6:48 PM
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
Clinically routine T2T genomes are finally in sight! 🧪🧬💯 @genomeinabottle.bsky.social [14/14]
September 22, 2025 at 5:07 PM
Clinically routine T2T genomes are finally in sight! 🧪🧬💯 @genomeinabottle.bsky.social [14/14]
I did too, after having one at a fountain soda shop.
Looks like you can get a case shipped
drinkarizona.com/products/t2t...
Looks like you can get a case shipped
drinkarizona.com/products/t2t...
T2T Sparkling Chocolate Fudge Cream | 22oz / 12-pack
Enjoy the perfect balance of sweet and tart with a bit of carbonation. Sip today.
drinkarizona.com
September 20, 2025 at 8:48 PM
I did too, after having one at a fountain soda shop.
Looks like you can get a case shipped
drinkarizona.com/products/t2t...
Looks like you can get a case shipped
drinkarizona.com/products/t2t...
Our software ULTRA, for finding/masking tandem repeats in genomic sequence, has been out in beta form for a while (and was used in the human T2T analysis). Now the 1.0 version is out with extra features. Greater coverage w/ low false label rate, better repeat labeling, easy to use. bit.ly/4fesEHT
ULTRA-Effective labeling of tandem repeats in genomic sequence
Abstract. In the age of long read sequencing, genomics researchers now have access to accurate repetitive DNA sequence (including satellites) that, due to
bit.ly
October 20, 2024 at 3:47 AM
Our software ULTRA, for finding/masking tandem repeats in genomic sequence, has been out in beta form for a while (and was used in the human T2T analysis). Now the 1.0 version is out with extra features. Greater coverage w/ low false label rate, better repeat labeling, easy to use. bit.ly/4fesEHT
Can I use a T2T reference for cancer analyses yet?
Are there meaningfully lifted over gene annotations / exon coordinates / transcriptomes / population variant datasets / cancer hotspot datasets / &c?
Are there meaningfully lifted over gene annotations / exon coordinates / transcriptomes / population variant datasets / cancer hotspot datasets / &c?
October 25, 2024 at 2:51 PM
Can I use a T2T reference for cancer analyses yet?
Are there meaningfully lifted over gene annotations / exon coordinates / transcriptomes / population variant datasets / cancer hotspot datasets / &c?
Are there meaningfully lifted over gene annotations / exon coordinates / transcriptomes / population variant datasets / cancer hotspot datasets / &c?
Thank YOU, Peg, for sharing your wisdom with the T2T community!
February 21, 2025 at 12:24 AM
Thank YOU, Peg, for sharing your wisdom with the T2T community!