This review highlights the dual nature of R-loops in #GeneRegulation and #GenomeInstability, emphasizing their impact on #DNADamage responses and potential as #therapeutic targets. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
November 2, 2025 at 12:51 AM
This review highlights the dual nature of R-loops in #GeneRegulation and #GenomeInstability, emphasizing their impact on #DNADamage responses and potential as #therapeutic targets. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
My former student Josh just had his paper accepted at #Genetics showing that #pombe diploids have intrinsic #genomeinstability . Be identified ploidy-essential genes and a remarkable loss of heterozygosity phenotype that may identify specific fragile sites.
🧬
@genetics-gsa.bsky.social
🧬
@genetics-gsa.bsky.social
April 19, 2025 at 3:04 PM
My former student Josh just had his paper accepted at #Genetics showing that #pombe diploids have intrinsic #genomeinstability . Be identified ploidy-essential genes and a remarkable loss of heterozygosity phenotype that may identify specific fragile sites.
🧬
@genetics-gsa.bsky.social
🧬
@genetics-gsa.bsky.social
Our study highlights RNA as a direct template for DNA repair, revealing RT-DSBR as a previously unrecognized and potentially mutagenic pathway. Huge thanks to the incredible team who made this work possible! (5/5)
🔗 www.nature.com/articles/s41...
#GenomeInstability #DNARepair #RNA #CRISPR #DSB
🔗 www.nature.com/articles/s41...
#GenomeInstability #DNARepair #RNA #CRISPR #DSB
RNA transcripts serve as a template for double-strand break repair in human cells - Nature Communications
DNA double-stranded breaks threaten genome stability. Here, the authors show that transcript RNA serves as a repair template in human cells and identify Polζ as a key factor in RNA-templated DSB repai...
www.nature.com
May 12, 2025 at 5:49 PM
Our study highlights RNA as a direct template for DNA repair, revealing RT-DSBR as a previously unrecognized and potentially mutagenic pathway. Huge thanks to the incredible team who made this work possible! (5/5)
🔗 www.nature.com/articles/s41...
#GenomeInstability #DNARepair #RNA #CRISPR #DSB
🔗 www.nature.com/articles/s41...
#GenomeInstability #DNARepair #RNA #CRISPR #DSB
Huge thanks to the incredible team who made this work possible! 🙌
Check out the full preprint here: 🔗 doi.org/10.1101/2025...
#GenomeInstability #DNARepair #RNA #CRISPR #DSB #Genomics
@agnelsfeir.bsky.social @hinashah.bsky.social
Check out the full preprint here: 🔗 doi.org/10.1101/2025...
#GenomeInstability #DNARepair #RNA #CRISPR #DSB #Genomics
@agnelsfeir.bsky.social @hinashah.bsky.social
doi.org
February 27, 2025 at 3:15 AM
Huge thanks to the incredible team who made this work possible! 🙌
Check out the full preprint here: 🔗 doi.org/10.1101/2025...
#GenomeInstability #DNARepair #RNA #CRISPR #DSB #Genomics
@agnelsfeir.bsky.social @hinashah.bsky.social
Check out the full preprint here: 🔗 doi.org/10.1101/2025...
#GenomeInstability #DNARepair #RNA #CRISPR #DSB #Genomics
@agnelsfeir.bsky.social @hinashah.bsky.social
Happy new year 🎊
For the first time on this platform, I am happy to share the latest collections of papers @biomednews.bsky.social about mitotic cell signalling!
Enjoy reading new cool methods and exciting findings about my favourite phase of the cell cycle!
#mitosis #cellcycle #genomeinstability
For the first time on this platform, I am happy to share the latest collections of papers @biomednews.bsky.social about mitotic cell signalling!
Enjoy reading new cool methods and exciting findings about my favourite phase of the cell cycle!
#mitosis #cellcycle #genomeinstability
January 2, 2025 at 12:17 PM
Happy new year 🎊
For the first time on this platform, I am happy to share the latest collections of papers @biomednews.bsky.social about mitotic cell signalling!
Enjoy reading new cool methods and exciting findings about my favourite phase of the cell cycle!
#mitosis #cellcycle #genomeinstability
For the first time on this platform, I am happy to share the latest collections of papers @biomednews.bsky.social about mitotic cell signalling!
Enjoy reading new cool methods and exciting findings about my favourite phase of the cell cycle!
#mitosis #cellcycle #genomeinstability
I would like to take this opportunity to use my first "tweet" to say that I am currently seeking a postdoctoral position.
#DDR #PTMs #GenomeInstability
#DDR #PTMs #GenomeInstability
November 16, 2024 at 12:40 PM
I would like to take this opportunity to use my first "tweet" to say that I am currently seeking a postdoctoral position.
#DDR #PTMs #GenomeInstability
#DDR #PTMs #GenomeInstability
Still new on 🦋 but thrilled to share that I will be chairing with @lopeslab.bsky.social the next series of virtual seminars from @genomeiinetwork.bsky.social! Join us for the most exciting, thought-provoking, latest findings in the field! 👇Please repost
#genomeinstability #DDR #Senescence #epigenome
#genomeinstability #DDR #Senescence #epigenome
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
March 18, 2025 at 9:22 AM
Still new on 🦋 but thrilled to share that I will be chairing with @lopeslab.bsky.social the next series of virtual seminars from @genomeiinetwork.bsky.social! Join us for the most exciting, thought-provoking, latest findings in the field! 👇Please repost
#genomeinstability #DDR #Senescence #epigenome
#genomeinstability #DDR #Senescence #epigenome
🔍 Before cancer starts, biology leaves clues.
The #ESMO25 session “The hallmarks of pre-cancer” unveils them
📅 17 Oct | 16:00–17:30 | Hall 5.2
🔗 buff.ly/33jC7nK
#GenomeInstability #PhenotypicPlasticity #inflammationa
The #ESMO25 session “The hallmarks of pre-cancer” unveils them
📅 17 Oct | 16:00–17:30 | Hall 5.2
🔗 buff.ly/33jC7nK
#GenomeInstability #PhenotypicPlasticity #inflammationa
October 15, 2025 at 8:01 AM
🔍 Before cancer starts, biology leaves clues.
The #ESMO25 session “The hallmarks of pre-cancer” unveils them
📅 17 Oct | 16:00–17:30 | Hall 5.2
🔗 buff.ly/33jC7nK
#GenomeInstability #PhenotypicPlasticity #inflammationa
The #ESMO25 session “The hallmarks of pre-cancer” unveils them
📅 17 Oct | 16:00–17:30 | Hall 5.2
🔗 buff.ly/33jC7nK
#GenomeInstability #PhenotypicPlasticity #inflammationa
4/ Strikingly, T. gondii-induced DNA damage begins just 15 minutes post-infection. This damage, marked by γH2AX foci, predominantly affects cells in the S-phase and is independent of reactive oxygen species (ROS).
#GenomeInstability
#GenomeInstability
December 16, 2024 at 2:02 PM
4/ Strikingly, T. gondii-induced DNA damage begins just 15 minutes post-infection. This damage, marked by γH2AX foci, predominantly affects cells in the S-phase and is independent of reactive oxygen species (ROS).
#GenomeInstability
#GenomeInstability
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases. #Chromatin #GenomeInstability #CellularSenescence #Ageing #Genomics #BioSky #SciSky 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases - Nature Reviews Molecular Cell Biology
Heterochromatin loss, telomere attrition and DNA damage induce cellular senescence by eliciting genome instability and innate immunity responses, thereby promoting ageing and age-related diseases. Thi...
www.nature.com
November 16, 2024 at 3:10 PM
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases. #Chromatin #GenomeInstability #CellularSenescence #Ageing #Genomics #BioSky #SciSky 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...