Davidmcmahon
@drdavidmcmahon.bsky.social
🇮🇪 Medical Oncologist
Post CSCST research fellow in thoracic oncology @ Royal Marsden Hospital
Arsenal fan (for my sins)
Post CSCST research fellow in thoracic oncology @ Royal Marsden Hospital
Arsenal fan (for my sins)
pubmed.ncbi.nlm.nih.gov/41609978/
Delighted to explore the complex landscape of EGFRm NSCLC in 2026 with @drsanjaypopat.bsky.social and @dralexiusjohn.bsky.social
Mechanisms of resistance
FLAURA vs MARIPOSA vs FLAURA 2
Decision making after these regimens
Genomic informed and agnostic approaches
Delighted to explore the complex landscape of EGFRm NSCLC in 2026 with @drsanjaypopat.bsky.social and @dralexiusjohn.bsky.social
Mechanisms of resistance
FLAURA vs MARIPOSA vs FLAURA 2
Decision making after these regimens
Genomic informed and agnostic approaches
Current and Emerging Treatment Landscape of Common EGFR-Mutated Advanced Non-small Cell Lung Cancer - PubMed
Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has been standard of care as monotherapy for EGFR-mutated advanced non-small cell lung cancer since reporting of the FLAURA phase III clinical trial, which demonstrated superiority over first-generatio …
pubmed.ncbi.nlm.nih.gov
January 30, 2026 at 7:26 PM
pubmed.ncbi.nlm.nih.gov/41609978/
Delighted to explore the complex landscape of EGFRm NSCLC in 2026 with @drsanjaypopat.bsky.social and @dralexiusjohn.bsky.social
Mechanisms of resistance
FLAURA vs MARIPOSA vs FLAURA 2
Decision making after these regimens
Genomic informed and agnostic approaches
Delighted to explore the complex landscape of EGFRm NSCLC in 2026 with @drsanjaypopat.bsky.social and @dralexiusjohn.bsky.social
Mechanisms of resistance
FLAURA vs MARIPOSA vs FLAURA 2
Decision making after these regimens
Genomic informed and agnostic approaches
Pleased to publish a case report exploring a number of interesting elements of ERBB2 (HER2) mutated NSCLC on @jtoonline.bsky.social with @drsanjaypopat.bsky.social and @dralexiusjohn.bsky.social
www.jtocrr.org/article/S266...
www.jtocrr.org/article/S266...
Acquired ERBB2 amplification and overexpression as on-target resistance mechanisms to zongertinib with subsequent response to trastuzumab deruxtecan; a case report
A number of drugs are in development for the treatment of ERBB2(HER2)-mutated Non-Small
Cell Lung Cancer (NSCLC) including antibody-drug conjugates (ADCs) such as trastuzumab
deruxtecan (T-DXd) and ty...
www.jtocrr.org
January 24, 2026 at 12:31 PM
Pleased to publish a case report exploring a number of interesting elements of ERBB2 (HER2) mutated NSCLC on @jtoonline.bsky.social with @drsanjaypopat.bsky.social and @dralexiusjohn.bsky.social
www.jtocrr.org/article/S266...
www.jtocrr.org/article/S266...
Reposted by Davidmcmahon
Due to directives on balance, the BBC are reporting that yes she was shot dead at close range, but in many belief systems death is not an end but a new beginning, part of a neverending cycle of change.
January 10, 2026 at 9:46 AM
Due to directives on balance, the BBC are reporting that yes she was shot dead at close range, but in many belief systems death is not an end but a new beginning, part of a neverending cycle of change.
Reposted by Davidmcmahon
Right. I need match highlights in about 78 different languages ASAP because I'm not falling asleep anytime soon.
April 8, 2025 at 9:31 PM
Right. I need match highlights in about 78 different languages ASAP because I'm not falling asleep anytime soon.
ascopubs.org/doi/10.1200/...
very impressive efficacy and safety (manageable TRK-specific AEs) data for taletrectinib in ROS1+ NSCLC.
ORR 88 and 56% (1L/2+L).
61% in the G2032R common resistance mutation.
76% intracranial response.
mPFS 44.6m in the untreated population 👏
very impressive efficacy and safety (manageable TRK-specific AEs) data for taletrectinib in ROS1+ NSCLC.
ORR 88 and 56% (1L/2+L).
61% in the G2032R common resistance mutation.
76% intracranial response.
mPFS 44.6m in the untreated population 👏
Taletrectinib in <i>ROS1</i>+ Non–Small Cell Lung Cancer: TRUST
PURPOSETaletrectinib is an oral, potent, CNS-active, selective, next-generation ROS1 tyrosine
kinase inhibitor (TKI). We report integrated efficacy and safety from registrational
taletrectinib studies...
ascopubs.org
April 6, 2025 at 8:56 AM
ascopubs.org/doi/10.1200/...
very impressive efficacy and safety (manageable TRK-specific AEs) data for taletrectinib in ROS1+ NSCLC.
ORR 88 and 56% (1L/2+L).
61% in the G2032R common resistance mutation.
76% intracranial response.
mPFS 44.6m in the untreated population 👏
very impressive efficacy and safety (manageable TRK-specific AEs) data for taletrectinib in ROS1+ NSCLC.
ORR 88 and 56% (1L/2+L).
61% in the G2032R common resistance mutation.
76% intracranial response.
mPFS 44.6m in the untreated population 👏
Reposted by Davidmcmahon
Arseblog will donate 100% of our Patreon revenue in April to four good causes:
🔴 The Arsenal Foundation
🔴 Oscar's Kids Ireland
🔴 UNICEF
🔴 Islington Foodbank
Get loads of extra content, and help people who really need it for just $6 per month (+ VAT where applicable) 🙏
www.patreon.com/c/arseblog
🔴 The Arsenal Foundation
🔴 Oscar's Kids Ireland
🔴 UNICEF
🔴 Islington Foodbank
Get loads of extra content, and help people who really need it for just $6 per month (+ VAT where applicable) 🙏
www.patreon.com/c/arseblog
April 3, 2025 at 2:08 PM
Arseblog will donate 100% of our Patreon revenue in April to four good causes:
🔴 The Arsenal Foundation
🔴 Oscar's Kids Ireland
🔴 UNICEF
🔴 Islington Foodbank
Get loads of extra content, and help people who really need it for just $6 per month (+ VAT where applicable) 🙏
www.patreon.com/c/arseblog
🔴 The Arsenal Foundation
🔴 Oscar's Kids Ireland
🔴 UNICEF
🔴 Islington Foodbank
Get loads of extra content, and help people who really need it for just $6 per month (+ VAT where applicable) 🙏
www.patreon.com/c/arseblog
nice data!
Please do check out Roxane Chen’s (my iBSc student - a medical student) poster on pan-immune inflammation scoring and outcomes in ALK positive lung cancer.
She worked so hard, and has been rewarded with the first abstract in the book, so no excuses not to engage, people! ❤️
No 1!! 🏅
#BTOG25
She worked so hard, and has been rewarded with the first abstract in the book, so no excuses not to engage, people! ❤️
No 1!! 🏅
#BTOG25
March 4, 2025 at 12:37 PM
nice data!
Reposted by Davidmcmahon
Great first day at #BTOG25!
An excellent advocates’ session in the afternoon, we presented our poster on real-world ALK+ #lungcancer treatment side effects & had valuable conversations with friends & colleagues.
Looking forward to lots more today! @btog.bsky.social #LCSM
An excellent advocates’ session in the afternoon, we presented our poster on real-world ALK+ #lungcancer treatment side effects & had valuable conversations with friends & colleagues.
Looking forward to lots more today! @btog.bsky.social #LCSM
March 4, 2025 at 7:46 AM
Great first day at #BTOG25!
An excellent advocates’ session in the afternoon, we presented our poster on real-world ALK+ #lungcancer treatment side effects & had valuable conversations with friends & colleagues.
Looking forward to lots more today! @btog.bsky.social #LCSM
An excellent advocates’ session in the afternoon, we presented our poster on real-world ALK+ #lungcancer treatment side effects & had valuable conversations with friends & colleagues.
Looking forward to lots more today! @btog.bsky.social #LCSM
Reposted by Davidmcmahon
Traveling to #BTOG25 today? Great thread from @tnewsomdavis.bsky.social on what you’ll experience. Get ready!
‼️ 1 day until #BTOG25 ‼️
Things to look forward to #12
Sandi Deans, Tuesday morning, on how to deliver genomics within a 2wk turnaround
Vital for all of our patients, and a huge challenge. Sandi is Deputy Director of the @nhsenglandldn.bsky.social Genomics Unit
Things to look forward to #12
Sandi Deans, Tuesday morning, on how to deliver genomics within a 2wk turnaround
Vital for all of our patients, and a huge challenge. Sandi is Deputy Director of the @nhsenglandldn.bsky.social Genomics Unit
March 2, 2025 at 11:02 AM
Traveling to #BTOG25 today? Great thread from @tnewsomdavis.bsky.social on what you’ll experience. Get ready!
Reposted by Davidmcmahon
Officially overtaken Arsene Wenger as the club's longest-serving manager.
February 27, 2025 at 11:56 AM
Officially overtaken Arsene Wenger as the club's longest-serving manager.
Delighted to share this review “Navigating the landscape of immune checkpoint inhibitors and novel immunotherapies in melanoma: long-term outcomes, progress, and challenges” from the renal and skin units of the royal Marsden.
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Navigating the landscape of immune checkpoint inhibitors and novel immunotherapies in melanoma: long-term outcomes, progress, and challenges
Melanoma has become the poster child for transformative outcomes in advanced malignancy from the use of immunotherapy over the last 10–15 years with median survival improving from ~ 1 to > 5 years....
www.tandfonline.com
February 6, 2025 at 8:31 PM
Delighted to share this review “Navigating the landscape of immune checkpoint inhibitors and novel immunotherapies in melanoma: long-term outcomes, progress, and challenges” from the renal and skin units of the royal Marsden.
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Reposted by Davidmcmahon
Myles Lewis-Skelly, gargantuan performance. 🫡
February 2, 2025 at 6:17 PM
Myles Lewis-Skelly, gargantuan performance. 🫡
Reposted by Davidmcmahon
Reposted by Davidmcmahon
Reposted by Davidmcmahon
What I'm calling Arsenal's Big Three -- Saka, Odegaard, Saliba -- have all been in the Premier League starting XI in 10 of 22 matches this season. Include Rice and it's just eight.
There has been one starting XI since August to contain White, Rice, Saka, Saliba and Odegaard (Chelsea, away).
There has been one starting XI since August to contain White, Rice, Saka, Saliba and Odegaard (Chelsea, away).
January 25, 2025 at 2:06 PM
What I'm calling Arsenal's Big Three -- Saka, Odegaard, Saliba -- have all been in the Premier League starting XI in 10 of 22 matches this season. Include Rice and it's just eight.
There has been one starting XI since August to contain White, Rice, Saka, Saliba and Odegaard (Chelsea, away).
There has been one starting XI since August to contain White, Rice, Saka, Saliba and Odegaard (Chelsea, away).
Reposted by Davidmcmahon
Premier League cumulative spending on net spend for transfers and wages 2019/20 to 2023/24
January 24, 2025 at 6:07 PM
Premier League cumulative spending on net spend for transfers and wages 2019/20 to 2023/24
Reposted by Davidmcmahon
Reposted by Davidmcmahon
Here's today's blog with a preview of tonight's game, and an explanation as to why Arseblog and Arseblog News will no longer post content to Twitter.
👇
👇
January 22, 2025 at 1:47 PM
Here's today's blog with a preview of tonight's game, and an explanation as to why Arseblog and Arseblog News will no longer post content to Twitter.
👇
👇
Reposted by Davidmcmahon
How does John Textor get away with it? After Nuamah, 'bought' by Molenbeek and sent straight to Lyon, here is Botafogo's record signing Thiago Almada also being sent out to the L1 club. For free. This is how multi-club ownership is allowed to skew fair competition.
www.lequipe.fr/Football/Act...
www.lequipe.fr/Football/Act...
Toulouse dépose une réclamation concernant la qualification de Thiago Almada, la dernière recrue de l'OL
Toulouse a déposé des réserves avant son match à Lyon (0-0), samedi, pour contester la qualification de Thiago Almada, arrivé de Botafogo. Il les confirmées ce lundi auprès de la LFP.
www.lequipe.fr
January 21, 2025 at 8:23 AM
How does John Textor get away with it? After Nuamah, 'bought' by Molenbeek and sent straight to Lyon, here is Botafogo's record signing Thiago Almada also being sent out to the L1 club. For free. This is how multi-club ownership is allowed to skew fair competition.
www.lequipe.fr/Football/Act...
www.lequipe.fr/Football/Act...
Reposted by Davidmcmahon
Israel has destroyed the last remaining hospital in northern Gaza.
We have witnessed the total decimation of Palestinian healthcare, met with silence from political leaders who refuse to acknowledge the horrors they have enabled.
This is the dehumanising reality of genocide.
We have witnessed the total decimation of Palestinian healthcare, met with silence from political leaders who refuse to acknowledge the horrors they have enabled.
This is the dehumanising reality of genocide.
December 27, 2024 at 7:46 PM
Israel has destroyed the last remaining hospital in northern Gaza.
We have witnessed the total decimation of Palestinian healthcare, met with silence from political leaders who refuse to acknowledge the horrors they have enabled.
This is the dehumanising reality of genocide.
We have witnessed the total decimation of Palestinian healthcare, met with silence from political leaders who refuse to acknowledge the horrors they have enabled.
This is the dehumanising reality of genocide.
Reposted by Davidmcmahon
I was fine with them fixing the hamstring, but amputating his left arm is too much. FFS.
December 28, 2024 at 8:05 PM
I was fine with them fixing the hamstring, but amputating his left arm is too much. FFS.
Reposted by Davidmcmahon
The decision (and it is a clear and conscious policy) of Howard Webb to totally disregard violent conduct and player safety and to fuss endlessly about shit that nobody cares about continues to irritate me profoundly.
João Pedro escapes red as Brighton’s winless run continues against Brentford
João Pedro escapes red as Brighton’s winless run continues against Brentford
When Brighton produced a stirring comeback to defeat Manchester City here at the start of November and move into the top four, Fabian Hürzeler could have been forgiven for thinking that being a Premier League manager is a pretty straightforward business.…
www.theguardian.com
December 28, 2024 at 12:41 PM
The decision (and it is a clear and conscious policy) of Howard Webb to totally disregard violent conduct and player safety and to fuss endlessly about shit that nobody cares about continues to irritate me profoundly.
Reposted by Davidmcmahon
We are hiring! #MANIFESTuk
3 more positions now open:
💻 Postdoctoral Fellow – Computational Modelling
🧬 Senior Bioinformatician (Genomics)
🔬 Senior Bioinformatician (Imaging)
@manifest-cirrp.bsky.social
@crick.ac.uk
Check out below for more info 👇
3 more positions now open:
💻 Postdoctoral Fellow – Computational Modelling
🧬 Senior Bioinformatician (Genomics)
🔬 Senior Bioinformatician (Imaging)
@manifest-cirrp.bsky.social
@crick.ac.uk
Check out below for more info 👇
📅 Deadline: 8th January 2025
📝 Apply here: crick.ac.uk/careers-and-...
💻 Find out more: manifest-io.org.uk/about
📝 Apply here: crick.ac.uk/careers-and-...
💻 Find out more: manifest-io.org.uk/about
Vacancies
Discover job opportunities at the Crick.
crick.ac.uk
December 20, 2024 at 1:58 PM
We are hiring! #MANIFESTuk
3 more positions now open:
💻 Postdoctoral Fellow – Computational Modelling
🧬 Senior Bioinformatician (Genomics)
🔬 Senior Bioinformatician (Imaging)
@manifest-cirrp.bsky.social
@crick.ac.uk
Check out below for more info 👇
3 more positions now open:
💻 Postdoctoral Fellow – Computational Modelling
🧬 Senior Bioinformatician (Genomics)
🔬 Senior Bioinformatician (Imaging)
@manifest-cirrp.bsky.social
@crick.ac.uk
Check out below for more info 👇
Reposted by Davidmcmahon
Delighted to share the MANIFEST platform at #ESMOImmuno24 led by Samra Turajlic
Builds on themes of
👨💻 Sample, assay & data harmonisation
➡️For generation of multi-modal/composite biomarkers
🚨Job opportunities across the platform!
👇
manifest-io.org.uk
Builds on themes of
👨💻 Sample, assay & data harmonisation
➡️For generation of multi-modal/composite biomarkers
🚨Job opportunities across the platform!
👇
manifest-io.org.uk
December 12, 2024 at 12:35 PM
Delighted to share the MANIFEST platform at #ESMOImmuno24 led by Samra Turajlic
Builds on themes of
👨💻 Sample, assay & data harmonisation
➡️For generation of multi-modal/composite biomarkers
🚨Job opportunities across the platform!
👇
manifest-io.org.uk
Builds on themes of
👨💻 Sample, assay & data harmonisation
➡️For generation of multi-modal/composite biomarkers
🚨Job opportunities across the platform!
👇
manifest-io.org.uk