🏥 🧬 Criticial work will be led by colleagues & co-investigators:
🐝 @cruk-mi.bsky.social
🐝 @mcrcnews.bsky.social
🐝 @cruknbc.bsky.social
🐝 The Christie
6️⃣ months in: Finally feel like I have arrived - presented my PhD work & also showcased @manifest-cirrp.bsky.social.
@mcrcnews.bsky.social
@giampazolias.bsky.social
@santiagozelenay.bsky.social
🏥 🧬 Criticial work will be led by colleagues & co-investigators:
🐝 @cruk-mi.bsky.social
🐝 @mcrcnews.bsky.social
🐝 @cruknbc.bsky.social
🐝 The Christie
The true definition of #TeamScience 🧬 in the delivery of this work!
Journey not over yet, and hopefully much more to come!
@manifest-cirrp.bsky.social
Very proud of you & all your incredible achievements over the past few years! Looking forward to seeing you continue to shine 🤩🌟.
@manifest-cirrp.bsky.social
@icr.ac.uk
@crick.ac.uk
The true definition of #TeamScience 🧬 in the delivery of this work!
Journey not over yet, and hopefully much more to come!
@manifest-cirrp.bsky.social
I sincerely hope this is a temporary technical glitch and not reflective of the political change ongoing in the US.
I sincerely hope this is a temporary technical glitch and not reflective of the political change ongoing in the US.
🩸PBMC derived immune signatures can predict ICI response & tox!
🧑💻 Hugely collaborative effort led by @maxemmerichderm.bsky.social & Turajlic Lab in conjunction with #IMUBiosciences
📍Watch this space for multimodal composite biomarkers
🩸PBMC derived immune signatures can predict ICI response & tox!
🧑💻 Hugely collaborative effort led by @maxemmerichderm.bsky.social & Turajlic Lab in conjunction with #IMUBiosciences
📍Watch this space for multimodal composite biomarkers
Need for:
📊 Sample & Data Harmonisation
🔴 Overcome pervasive heterogeneity
🩸Incorporation of dynamic measures
🧠 Collaborative efforts
➡️ Generation of multimodal biomarker signatures
🧑💻: manifest-io.org.uk
Need for:
📊 Sample & Data Harmonisation
🔴 Overcome pervasive heterogeneity
🩸Incorporation of dynamic measures
🧠 Collaborative efforts
➡️ Generation of multimodal biomarker signatures
🧑💻: manifest-io.org.uk
Final Survival Analysis: COSMIC-313
💉Continued PFS benefit for the triplet of Ipi/Nivo/Cabo
❌ Nil OS Benefit
‼️ Triplet limited by Tox:
⬇️ ICI # No & Dose
🔬⬆️ M2 macrophages identifies a subgroup benefitting from triplet!
Final Survival Analysis: COSMIC-313
💉Continued PFS benefit for the triplet of Ipi/Nivo/Cabo
❌ Nil OS Benefit
‼️ Triplet limited by Tox:
⬇️ ICI # No & Dose
🔬⬆️ M2 macrophages identifies a subgroup benefitting from triplet!
🔴 Emerging role as a surrogate for path response & survival ‼️
Need for:
💉 Prospective efforts w/ embedded sampling timepoints
🧑💻 Combinatorial Biomarkers
📊 Data Harmonisation
#GU25
🔴 Emerging role as a surrogate for path response & survival ‼️
Need for:
💉 Prospective efforts w/ embedded sampling timepoints
🧑💻 Combinatorial Biomarkers
📊 Data Harmonisation
#GU25
🧬 Aiming to generate multimodal biomarker signatures incl & beyond ctDNA & PD-L1 expression in Bladder Ca
🧑🏾💻 manifest-io.org.uk
#GU25
🔍 Role of peri-op IO in MIBC: #CM274 & #NIAGRA
🧬 Biomarker need to optimise stratification and minimise risk of over-treatment
➡️ Emerging risk adapted integrated biomarker driven studies (MODERN)
🧬 Aiming to generate multimodal biomarker signatures incl & beyond ctDNA & PD-L1 expression in Bladder Ca
🧑🏾💻 manifest-io.org.uk
#GU25
🔍 Role of peri-op IO in MIBC: #CM274 & #NIAGRA
🧬 Biomarker need to optimise stratification and minimise risk of over-treatment
➡️ Emerging risk adapted integrated biomarker driven studies (MODERN)
🔍 Role of peri-op IO in MIBC: #CM274 & #NIAGRA
🧬 Biomarker need to optimise stratification and minimise risk of over-treatment
➡️ Emerging risk adapted integrated biomarker driven studies (MODERN)
Critical to this will be a strong theme of cross-collaboration 🏥🧬 & knowledge-sharing 🧠
Great to see members of the consortium together at #Immuno25
A comprehensive overview from the amazing @zaydtippu.bsky.social, who managed to package a complex field into 20mins 🙌.
Excited to see how @manifest-cirrp.bsky.social will hopefully contribute going forwards!
Critical to this will be a strong theme of cross-collaboration 🏥🧬 & knowledge-sharing 🧠
Great to see members of the consortium together at #Immuno25
Great to be a small part of a fantastic programme at #Immuno25 🏥🧑⚕️🧬
Reflecting the ongoing evolution across the Immune-oncology landscape 💊💉
Follow @manifest-cirrp.bsky.social to keep abreast of some of these developments!
A comprehensive overview from the amazing @zaydtippu.bsky.social, who managed to package a complex field into 20mins 🙌.
Excited to see how @manifest-cirrp.bsky.social will hopefully contribute going forwards!
Great to be a small part of a fantastic programme at #Immuno25 🏥🧑⚕️🧬
Reflecting the ongoing evolution across the Immune-oncology landscape 💊💉
Follow @manifest-cirrp.bsky.social to keep abreast of some of these developments!
That’s a wrap 🙌! Such a fantastic day getting to discuss all about #CancerImmunotherapy, alongside fellow enthusiasts & friends.
@zaydtippu.bsky.social
@annaob.bsky.social
@beckilee.bsky.social
@ikshinchin1.bsky.social
@mcrcnews.bsky.social
That’s a wrap 🙌! Such a fantastic day getting to discuss all about #CancerImmunotherapy, alongside fellow enthusiasts & friends.
@zaydtippu.bsky.social
@annaob.bsky.social
@beckilee.bsky.social
@ikshinchin1.bsky.social
@mcrcnews.bsky.social
➡️ Join a growing team of computational & cancer biologists
💊Immune-Oncology Biomarker Discovery
📍@TurajlicLab @crick.ac.uk
🧑💻manifest-io.org.uk
Link 👇
Join the Cancer Dynamics Lab @crick.ac.uk, led by Samra Turajlic, to advance imaging pipelines & multiomic profiling for immunotherapy research.
📍 London
⏳ 4-year role
💻 Apply now: www.crick.ac.uk/careers-stud...
➡️ Join a growing team of computational & cancer biologists
💊Immune-Oncology Biomarker Discovery
📍@TurajlicLab @crick.ac.uk
🧑💻manifest-io.org.uk
Link 👇
The findings were led by Angel Fernandez Sanroman with senior author Samra Turajlic
www.crick.ac.uk/news-and-rep...
The findings were led by Angel Fernandez Sanroman with senior author Samra Turajlic
www.crick.ac.uk/news-and-rep...
We are looking for:
💻 ML engineer
🔬 Senior Laboratory Research Scientist (Spatial Profiling)
🧑🔬 Senior Laboratory Research Scientist (Flow Cytometry)
Apply now 👉 www.crick.ac.uk/careers-and-...
We are looking for:
💻 ML engineer
🔬 Senior Laboratory Research Scientist (Spatial Profiling)
🧑🔬 Senior Laboratory Research Scientist (Flow Cytometry)
Apply now 👉 www.crick.ac.uk/careers-and-...
🐝 Why not visit us in Manchester & join us in our flagship #CancerImmunotherapy event. Programme now finalised & speakers confirmed 🤩!
🗓️ 2 days: 24 & 27 Jan 2025 (hybrid)
To register (discount code - IMMUNO10):
www.eventbrite.co.uk/e/the-cancer...
🐝 Why not visit us in Manchester & join us in our flagship #CancerImmunotherapy event. Programme now finalised & speakers confirmed 🤩!
🗓️ 2 days: 24 & 27 Jan 2025 (hybrid)
To register (discount code - IMMUNO10):
www.eventbrite.co.uk/e/the-cancer...
Privileged to reperesent team MANIFEST, lots to come in 2025!
👩💻 manifest-io.org.uk
📧 manifest-io@crick.ac.uk
Excited to get going with delivery in 2025!
@crick.ac.uk
@icrlondon.bsky.social
@cruk-mi.bsky.social
@mcrcnews.bsky.social
Privileged to reperesent team MANIFEST, lots to come in 2025!
👩💻 manifest-io.org.uk
📧 manifest-io@crick.ac.uk
Builds on themes of
👨💻 Sample, assay & data harmonisation
➡️For generation of multi-modal/composite biomarkers
🚨Job opportunities across the platform!
👇
manifest-io.org.uk
Builds on themes of
👨💻 Sample, assay & data harmonisation
➡️For generation of multi-modal/composite biomarkers
🚨Job opportunities across the platform!
👇
manifest-io.org.uk
Come and say 👋🏾 at Poster 40P!
👨🏾💻Additional info at
manifest-io.org.uk
#ESMOImmuno24
📣 Special shout out to ZAYD 🙌 @zaydtippu.bsky.social - who will be presenting our work:
"MANIFEST: A Multiomic Profiling Platform for Immuno-Oncology Biomarker Discovery"
Go say hi - Poster: 40P!
Come and say 👋🏾 at Poster 40P!
👨🏾💻Additional info at
manifest-io.org.uk
#ESMOImmuno24
If you are presenting your work at #ESMOImmuno24, and potentially looking for a home for your research work, please consider submitting to our ESMO IOTECH journal:
🔗 esmoiotech.org
If you are presenting your work at #ESMOImmuno24, and potentially looking for a home for your research work, please consider submitting to our ESMO IOTECH journal:
🔗 esmoiotech.org
🔴 Heterogeneity in data, samples and assay types
🧬 Need for cross-study harmonisation & tailored composite biomarkers
💊 Neoadj. trials & PDTF’s offer opportunities for biomarker discovery!
🔴 Heterogeneity in data, samples and assay types
🧬 Need for cross-study harmonisation & tailored composite biomarkers
💊 Neoadj. trials & PDTF’s offer opportunities for biomarker discovery!
🏥 6 NHS Foundation Trusts
🧬 14 Academic Institutions
💊 Commercial Backing
Opportunities to help shape and drive the programme! 👇🏾
We are hiring 2⃣ Laboratory Research Scientists to support our MANIFEST consortium (manifest-io.org.uk). These roles will focus on sample reception and processing, based at @thecrick.bsky.social (London).
🗓️ Deadline: 6th Dec 2024
🗳️ To apply:
www.crick.ac.uk/careers-stud...
🏥 6 NHS Foundation Trusts
🧬 14 Academic Institutions
💊 Commercial Backing
Opportunities to help shape and drive the programme! 👇🏾
Massive kudos to the brilliant and the inspiring leadership of Samra Turajlic! @thecrick.bsky.social 🧬 🏥
📢 👀 Stay tuned for updates at www.manifest-io.org.uk.
The platform received £20m+ in public and industry investment and will involve thousands of people from across the UK receiving immunotherapy
🔗 crick.ac.uk/news-and-rep...
Massive kudos to the brilliant and the inspiring leadership of Samra Turajlic! @thecrick.bsky.social 🧬 🏥
📢 👀 Stay tuned for updates at www.manifest-io.org.uk.
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
….but same excellent team 🩺👨🏽⚕️🧬
👇🏾Would highly recommend for any budding Phase 1 trialists/ cell therapy enthusiasts!
🧑⚕️Interested in novel IO & #CellTherapy in solid cancer? Keen to gain experience in early phase trials?
Come join Fiona, me & our amazing team as a ‘Clinical Fellow in Advanced Immunotherapy & Cell Therapy’.
@mcrcnews.bsky.social
App might close early👇
healthjobsuk.com/job/v6778827
….but same excellent team 🩺👨🏽⚕️🧬
👇🏾Would highly recommend for any budding Phase 1 trialists/ cell therapy enthusiasts!