Dan Brierley
@drdanbrierley.bsky.social
Gut-Brain Neuroscientist (mostly focused on the brain end) | Wellcome Trust Sir Henry Dale Fellow | Group leader of UCL Gut-Brain Neurophysiology & Ingestive Behaviour lab | http://brierley-lab.org
Pinned
Dan Brierley
@drdanbrierley.bsky.social
· Jan 21
GLP-1 and the Neurobiology of Eating Control: Recent Advances
Abstract. Obesity is now considered a chronic relapsing progressive disease, associated with increased all-cause mortality that scales with body weight, af
academic.oup.com
Really proud to start the year by sharing our new review in @endosocjournals.bsky.social on the roles of GLP-1 in eating and obesity treatment, led by superstar postdoc @laurenjonesucl.bsky.social!
academic.oup.com/endo/article...
🧪🧠📈 #neuroscience #neuroskyence #GLP-1 #obesity #wegovy #ozempic
academic.oup.com/endo/article...
🧪🧠📈 #neuroscience #neuroskyence #GLP-1 #obesity #wegovy #ozempic
Reposted by Dan Brierley
How do VTA DA neurons sculpt downstream representations to reinforce actions? VERY excited about our new preprint (by Alex Pan Vazquez & @czimmerman.bsky.social )
VTA dopamine neuron activity produces spatially organized value representations https://www.biorxiv.org/content/10.1101/2025.11.04.685995v1
November 7, 2025 at 8:46 PM
How do VTA DA neurons sculpt downstream representations to reinforce actions? VERY excited about our new preprint (by Alex Pan Vazquez & @czimmerman.bsky.social )
Reposted by Dan Brierley
👉 We generated a starter pack for #neurogastroenterology and enteric #neuroscience!
Let's connect and bring gut-brain research and clinical neurogastroenterology to the next level! 🌐
go.bsky.app/3Z82PbH
Let's connect and bring gut-brain research and clinical neurogastroenterology to the next level! 🌐
go.bsky.app/3Z82PbH
November 1, 2025 at 6:37 PM
👉 We generated a starter pack for #neurogastroenterology and enteric #neuroscience!
Let's connect and bring gut-brain research and clinical neurogastroenterology to the next level! 🌐
go.bsky.app/3Z82PbH
Let's connect and bring gut-brain research and clinical neurogastroenterology to the next level! 🌐
go.bsky.app/3Z82PbH
Reposted by Dan Brierley
The interaction of GLP-1 medicines with the immune system is complex, enabled by direct and indirect actions, including neural inter organ communication. These studies have been led @SinaiHealth by CK Wong. His latest perspective here in the JCI www.jci.org/articles/vie...
November 4, 2025 at 11:56 AM
The interaction of GLP-1 medicines with the immune system is complex, enabled by direct and indirect actions, including neural inter organ communication. These studies have been led @SinaiHealth by CK Wong. His latest perspective here in the JCI www.jci.org/articles/vie...
Reposted by Dan Brierley
I interviewed Prof Anne White for the BSN on her research at our annual meeting in Bradford this year. Something that struck me was her investment in the #Postdoc members of her team, using profits from #commercialisation of her work.
"I could take the money personally but I put it into my research" - Prof White on how she invests money from commercial enterprise.
Watch Anne's full lecture on Melanocortin neuropeptides as a BSN member (login to mySociety):
my.neuroendo.org.uk/...
Watch Anne's full lecture on Melanocortin neuropeptides as a BSN member (login to mySociety):
my.neuroendo.org.uk/...
October 24, 2025 at 3:27 PM
I interviewed Prof Anne White for the BSN on her research at our annual meeting in Bradford this year. Something that struck me was her investment in the #Postdoc members of her team, using profits from #commercialisation of her work.
Reposted by Dan Brierley
Such a nice collection of brain-body interaction articles in the special issue of @currentbiology.bsky.social. Love the beautiful vagus nerve on the cover by Andreas Vesalius www.cell.com/current-biol...
October 22, 2025 at 6:44 PM
Such a nice collection of brain-body interaction articles in the special issue of @currentbiology.bsky.social. Love the beautiful vagus nerve on the cover by Andreas Vesalius www.cell.com/current-biol...
Reposted by Dan Brierley
Out today in Nature: We uncover a neural mechanism for the integration of two internal states - hunger and estrous state - and how this integration shapes pup-directed behaviors in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Integration of hunger and hormonal state gates infant-directed aggression - Nature
Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups...
www.nature.com
October 22, 2025 at 3:30 PM
Out today in Nature: We uncover a neural mechanism for the integration of two internal states - hunger and estrous state - and how this integration shapes pup-directed behaviors in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dan Brierley
Our Primer on Sickness and the Brain: how are inflammatory signals and the brain coordinate to make us sick?
in the new issue of Current Biology www.cell.com/current-biol...
together with @Zuri A. Sullivan
in the new issue of Current Biology www.cell.com/current-biol...
together with @Zuri A. Sullivan
Sickness and the brain
Zuri Sullivan and Catherine Dulac discuss the reciprocal communication between the
brain and the immune system in sickness behavior.
www.cell.com
October 20, 2025 at 5:58 PM
Our Primer on Sickness and the Brain: how are inflammatory signals and the brain coordinate to make us sick?
in the new issue of Current Biology www.cell.com/current-biol...
together with @Zuri A. Sullivan
in the new issue of Current Biology www.cell.com/current-biol...
together with @Zuri A. Sullivan
Reposted by Dan Brierley
New essay in @currentbiology.bsky.social special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing @champalimaudf.bsky.social discovery ↔️ clinic at its best. www.cell.com/current-biol...
From cognition in the body to the body in cognition
Carlos Ribeiro and Albino Oliveira-Maia propose how brain–body interactions may inform
the study of ‘higher’ cognitive functions such as learning and memory across model
systems.
www.cell.com
October 20, 2025 at 4:40 PM
New essay in @currentbiology.bsky.social special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing @champalimaudf.bsky.social discovery ↔️ clinic at its best. www.cell.com/current-biol...
Reposted by Dan Brierley
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 5:35 PM
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Reposted by Dan Brierley
A fantastic first day of the 47th conference of the Societe de Neuroendocrinologie in beautiful Lausanne, Switzerland! Great science and wonderful interactions! Thank you @sebastienbouret.bsky.social Sophie Crozier and rest of the organizers, it’s a true pleasure to be here @jne-editor.bsky.social
Delighted to give the welcome words as President of this friendly and scientifically stimulating society @sneuroendo.bsky.social
October 8, 2025 at 9:57 PM
A fantastic first day of the 47th conference of the Societe de Neuroendocrinologie in beautiful Lausanne, Switzerland! Great science and wonderful interactions! Thank you @sebastienbouret.bsky.social Sophie Crozier and rest of the organizers, it’s a true pleasure to be here @jne-editor.bsky.social
Reposted by Dan Brierley
A reminder that the PhD program for EMBL is open for winter recruitment round. If you want to understand life at a molecular level and have a quantitative science (you don't have to have done biology - we love our mathematicians/physcists/chemists!) apply www.embl.org/about/info/e...
Application – EMBL International PhD Programme
www.embl.org
October 9, 2025 at 4:51 AM
A reminder that the PhD program for EMBL is open for winter recruitment round. If you want to understand life at a molecular level and have a quantitative science (you don't have to have done biology - we love our mathematicians/physcists/chemists!) apply www.embl.org/about/info/e...
Reposted by Dan Brierley
A framework from @easoobesity.bsky.social to guide pharmacological treatment of 'fat mass diseases' versus 'sick fat diseases' 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Framework for the pharmacological treatment of obesity and its complications from the European Association for the Study of Obesity (EASO) - Nature Medicine
Obesity and associated complications can be managed by obesity medications, prompting the revision of criteria for the diagnosis and staging of this disease.
www.nature.com
October 7, 2025 at 6:43 AM
A framework from @easoobesity.bsky.social to guide pharmacological treatment of 'fat mass diseases' versus 'sick fat diseases' 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dan Brierley
Thread of things I'm learning as I read The Discovery of Insulin by Michael Bliss
October 5, 2025 at 6:34 PM
Thread of things I'm learning as I read The Discovery of Insulin by Michael Bliss
Reposted by Dan Brierley
We’re hiring!
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...
Sign In
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myhr.northwestern.edu
September 30, 2025 at 10:32 PM
We’re hiring!
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...
Reposted by Dan Brierley
In case you missed this article, it will definitely put you off drinking these! And it links to the authors' full paper in Journal of Nutritional Physiology, one of the new journals at @physoc.bsky.social
theconversation.com/we-fed-peopl...
theconversation.com/we-fed-peopl...
We fed people a milkshake with 130g of fat to see what it did to their brains – here’s what we learned
We fed people milkshakes containing 130g of fat to see what it did to their brains.
theconversation.com
September 24, 2025 at 12:27 PM
In case you missed this article, it will definitely put you off drinking these! And it links to the authors' full paper in Journal of Nutritional Physiology, one of the new journals at @physoc.bsky.social
theconversation.com/we-fed-peopl...
theconversation.com/we-fed-peopl...
🤯
Latest imaging data from our completely re-designed ExA-SPIM system.
Expansion-assisted imaging (3X expansion, 0.3 NA) enables brain-wide imaging with high-contrast and <400 nm effective resolution.
Expansion-assisted imaging (3X expansion, 0.3 NA) enables brain-wide imaging with high-contrast and <400 nm effective resolution.
September 29, 2025 at 4:10 PM
🤯
Reposted by Dan Brierley
The gut-brain connection
Glia cells mediate cytokine signalling between the gut and the brain, linking sleep to inflammation in the gut.
Glia cells mediate cytokine signalling between the gut and the brain, linking sleep to inflammation in the gut.
The gut-brain connection
Glia cells mediate cytokine signaling between the gut and the brain, linking sleep to inflammation in the gut.
buff.ly
September 27, 2025 at 10:44 PM
The gut-brain connection
Glia cells mediate cytokine signalling between the gut and the brain, linking sleep to inflammation in the gut.
Glia cells mediate cytokine signalling between the gut and the brain, linking sleep to inflammation in the gut.
Reposted by Dan Brierley
Thanks to @dkthomp.bsky.social for inviting @juliabelluz.bsky.social and I on the Plain English podcast to discuss our food system, nutrition science & our new book FOOD INTELLIGENCE.
www.theringer.com/podcasts/pla...
www.theringer.com/podcasts/pla...
What’s the Matter With America’s Food? - The Ringer
If you really want to understand why Americans are so unhealthy, you have to see that the problem is not just our willpower, and it’s not just our food itself. It’s our food policies.
www.theringer.com
September 26, 2025 at 6:40 PM
Thanks to @dkthomp.bsky.social for inviting @juliabelluz.bsky.social and I on the Plain English podcast to discuss our food system, nutrition science & our new book FOOD INTELLIGENCE.
www.theringer.com/podcasts/pla...
www.theringer.com/podcasts/pla...
Reposted by Dan Brierley
From the lizard venom and John Eng, in licensing to clinical development and approval April 28 2005. The remarkable story of Amylin Pharma and exenatide www.nature.com/articles/s42...
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals - Nature Metabolism
The glucagon-like peptide 1 receptor agonist (GLP-1RA) class of medicines has emerged as transformative for the treatment of diabetes, obesity and other diseases. On the twentieth anniversary of the approval of exenatide (Byetta), three former employees of Amylin Pharmaceuticals acknowledge the contributions of some of the individuals and the innovation responsible for delivering the first approved GLP-1RA — the forerunner to the modern blockbuster drugs.
www.nature.com
September 25, 2025 at 10:20 AM
From the lizard venom and John Eng, in licensing to clinical development and approval April 28 2005. The remarkable story of Amylin Pharma and exenatide www.nature.com/articles/s42...
Reposted by Dan Brierley
Applications are now open for the SWC Systems Neuroscience PhD Programme.
Join us in London!
🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social
Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
Join us in London!
🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social
Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
September 24, 2025 at 6:42 PM
Reposted by Dan Brierley
There is no clear evidence that paracetamol has any harmful effects on an unborn baby.
It’s OK to use paracetamol in pregnancy. Here’s what the science says about the link with autism
It’s safe for pregnant women to take paracetamol at any stage of pregnancy. Here’s what the research says about the risk of autism.
tcnv.link
September 23, 2025 at 10:06 AM
There is no clear evidence that paracetamol has any harmful effects on an unborn baby.
Reposted by Dan Brierley
Even after recovery, relapse is heartbreakingly common in anorexia nervosa. Could the answer lie in the gut’s hidden signals? 🧵
September 22, 2025 at 8:14 PM
Even after recovery, relapse is heartbreakingly common in anorexia nervosa. Could the answer lie in the gut’s hidden signals? 🧵
Great scheme!
Our ECR Mentor Scheme is open for enrolment!
"I got so much great guidance about postdoc applications ✍️, how to network efficiently 🤝 and ECR awards 🏆 to apply for.” – Celine Camon
Find your mentor: www.neuroendo.org.uk...
Closes 30 September 2025
"I got so much great guidance about postdoc applications ✍️, how to network efficiently 🤝 and ECR awards 🏆 to apply for.” – Celine Camon
Find your mentor: www.neuroendo.org.uk...
Closes 30 September 2025
September 22, 2025 at 10:06 AM
Great scheme!
Reposted by Dan Brierley
Are you working on an exciting neuroendocrine research project?
Get up to £8k support for consumables/other research costs to enable you to carry out the best possible research project.
Deadline 1 Oct 2025
(All members eligible to apply!)
Apply: www.neuroendo.org.uk...
Get up to £8k support for consumables/other research costs to enable you to carry out the best possible research project.
Deadline 1 Oct 2025
(All members eligible to apply!)
Apply: www.neuroendo.org.uk...
September 21, 2025 at 8:40 AM
Are you working on an exciting neuroendocrine research project?
Get up to £8k support for consumables/other research costs to enable you to carry out the best possible research project.
Deadline 1 Oct 2025
(All members eligible to apply!)
Apply: www.neuroendo.org.uk...
Get up to £8k support for consumables/other research costs to enable you to carry out the best possible research project.
Deadline 1 Oct 2025
(All members eligible to apply!)
Apply: www.neuroendo.org.uk...