This Review discusses the expansion of glucagon-like peptide-1 (GLP-1) medicines beyond type 2 diabetes and obesity, outlining opportunities for new indications, key questions around benefits and long...

Visceral pain disorders, such as irritable bowel syndrome, exhibit a marked female prevalence. Enhanced signaling between enterochromaffin (EC) cells in the gut epithelium and mucosal sensory nerve fi...

A comprehensive neuronal molecular map spanning the entire murine gastrointestinal tract enables selective, in vivo investigation of the roles that genetically defined enteric neuron subtypes play in ...

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During the high-estradiol stages of their estrus cycle, female rats learn faster than they do during other stages—and than male rats overall—thanks to a boost in their dopaminergic response to reward…

On a gray November morning in London, ministers, scientists, and animal welfare advocates did something rare: they all applauded the same announcement. The UK government unveiled a sweeping roadmap to phase out animal testing, promising to accelerate the shift toward humane, high-tech alternatives that could redefine modern science itself. Backed by £75 million in new funding, the plan outlines a decade-long mission to replace regulatory animal testing with technologies such as organ-on-a-chip systems, artificial intelligence models, and 3D bioprinted tissues.