CCMN
@ccmnlondon.bsky.social
Centre for Cardiovascular and Metabolic Neuroscience | UCL | WHRI | QMUL
ucl.ac.uk/ccmn/
https://www.ucl.ac.uk/biosciences/neuroscience-physiology-and-pharmacology/facilities/ccmn-lecture-series
ucl.ac.uk/ccmn/
https://www.ucl.ac.uk/biosciences/neuroscience-physiology-and-pharmacology/facilities/ccmn-lecture-series
Reposted by CCMN
Thanks to @theiups.bsky.social 2025 meeting for a great Vascular Health and Function session where I was pleased to share exciting new data!
Another day, another excellent talk from a @ccmnlondon.bsky.social member. Dr. Anna Robert’s from @adriaenssenslab.bsky.social lab presented her work on GIP and vascular health here at @theiups.bsky.social 2025 meeting in Frankfurt.
September 14, 2025 at 7:45 AM
Thanks to @theiups.bsky.social 2025 meeting for a great Vascular Health and Function session where I was pleased to share exciting new data!
Reposted by CCMN
Dr Cecilia Skoug presenting the latest mouse behaviour data from the Trapp lab at @theiups.bsky.social. Great presence from @ccmnlondon.bsky.social at a fantastic meeting!
September 13, 2025 at 4:19 PM
Dr Cecilia Skoug presenting the latest mouse behaviour data from the Trapp lab at @theiups.bsky.social. Great presence from @ccmnlondon.bsky.social at a fantastic meeting!
Reposted by CCMN
Another day, another excellent talk from a @ccmnlondon.bsky.social member. Dr. Anna Robert’s from @adriaenssenslab.bsky.social lab presented her work on GIP and vascular health here at @theiups.bsky.social 2025 meeting in Frankfurt.
September 13, 2025 at 3:05 PM
Another day, another excellent talk from a @ccmnlondon.bsky.social member. Dr. Anna Robert’s from @adriaenssenslab.bsky.social lab presented her work on GIP and vascular health here at @theiups.bsky.social 2025 meeting in Frankfurt.
Reposted by CCMN
More @ccmnlondon.bsky.social representation at #IUPS2025; Philippa Wittenberg, PhD student in Prof. Alex Gourine’s group presented her work on the baroreceptor mechanism.
September 12, 2025 at 3:45 PM
More @ccmnlondon.bsky.social representation at #IUPS2025; Philippa Wittenberg, PhD student in Prof. Alex Gourine’s group presented her work on the baroreceptor mechanism.
Reposted by CCMN
Last conference for the year for me is IUPS 2025. Yesterday was the well-attended symposium ”GLP-1 Receptor Agonists - a Magic Bullet Beyond Diabetes and Obesity?” Chaired by Prof. Stefan Trapp @trapp-lab.bsky.social Maybe I’m
biased but a great symposium indeed! @ccmnlondon.bsky.social
biased but a great symposium indeed! @ccmnlondon.bsky.social
September 12, 2025 at 11:30 AM
Last conference for the year for me is IUPS 2025. Yesterday was the well-attended symposium ”GLP-1 Receptor Agonists - a Magic Bullet Beyond Diabetes and Obesity?” Chaired by Prof. Stefan Trapp @trapp-lab.bsky.social Maybe I’m
biased but a great symposium indeed! @ccmnlondon.bsky.social
biased but a great symposium indeed! @ccmnlondon.bsky.social
Reposted by CCMN
Proud PI moment #1:
@phoebeclax.bsky.social doing a stellar job in her first ever conference poster session, presenting data generated during her @bsneuroendo.bsky.social funded undergraduate summer lab experience project.
#BSNBradford2025
@phoebeclax.bsky.social doing a stellar job in her first ever conference poster session, presenting data generated during her @bsneuroendo.bsky.social funded undergraduate summer lab experience project.
#BSNBradford2025
September 1, 2025 at 3:03 PM
Proud PI moment #1:
@phoebeclax.bsky.social doing a stellar job in her first ever conference poster session, presenting data generated during her @bsneuroendo.bsky.social funded undergraduate summer lab experience project.
#BSNBradford2025
@phoebeclax.bsky.social doing a stellar job in her first ever conference poster session, presenting data generated during her @bsneuroendo.bsky.social funded undergraduate summer lab experience project.
#BSNBradford2025
Reposted by CCMN
Proud PI moment #2:
Superstar postdoc @laurenjonesucl.bsky.social absolutely smashing her first conference presentation of her fascinating data on #semaglutide mechanism of action.
#BSNBradford2025
Superstar postdoc @laurenjonesucl.bsky.social absolutely smashing her first conference presentation of her fascinating data on #semaglutide mechanism of action.
#BSNBradford2025
September 1, 2025 at 3:08 PM
Proud PI moment #2:
Superstar postdoc @laurenjonesucl.bsky.social absolutely smashing her first conference presentation of her fascinating data on #semaglutide mechanism of action.
#BSNBradford2025
Superstar postdoc @laurenjonesucl.bsky.social absolutely smashing her first conference presentation of her fascinating data on #semaglutide mechanism of action.
#BSNBradford2025
Reposted by CCMN
Pleased to share a new paper that I'm proud to have contributed to 🌟 Grateful for the chance to work with such a talented team 🙌
Interested in brain access for Tirzepatide-based drugs? Have a look at the fluorescent Tirzepatide analogue developed by Johannes Broichhagen and David Hodson @daveyboyhod.bsky.social out now in Nature Metabolism www.nature.com/articles/s42.... Proud to contribute to this great multi-lab effort.
Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain - Nature Metabolism
A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors, and are used to image receptor binding activities in tissues and animals.
www.nature.com
August 19, 2025 at 2:32 PM
Pleased to share a new paper that I'm proud to have contributed to 🌟 Grateful for the chance to work with such a talented team 🙌
Reposted by CCMN
Really enjoyed working on this - big thanks to everyone involved!
Online now: Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism
Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism
Hansford et al. show that GIPR, a target of new weight-loss drugs, is found in brain cells called oligodendrocytes. GIPR helps these drugs access the brain and boosts weight loss. Without GIPR in these cells, the drugs are less effective, revealing a new mechanism behind their action.
dlvr.it
August 14, 2025 at 10:36 AM
Really enjoyed working on this - big thanks to everyone involved!
Reposted by CCMN
Interested in brain access for Tirzepatide-based drugs? Have a look at the fluorescent Tirzepatide analogue developed by Johannes Broichhagen and David Hodson @daveyboyhod.bsky.social out now in Nature Metabolism www.nature.com/articles/s42.... Proud to contribute to this great multi-lab effort.
Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain - Nature Metabolism
A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors, and are used to image receptor binding activities in tissues and animals.
www.nature.com
August 19, 2025 at 9:56 AM
Interested in brain access for Tirzepatide-based drugs? Have a look at the fluorescent Tirzepatide analogue developed by Johannes Broichhagen and David Hodson @daveyboyhod.bsky.social out now in Nature Metabolism www.nature.com/articles/s42.... Proud to contribute to this great multi-lab effort.
📣 New paper out exploring brain access of Tirzepatide based fluorescent analogues! We are proud to have contributed to this multi-lab effort.
August 19, 2025 at 4:24 PM
📣 New paper out exploring brain access of Tirzepatide based fluorescent analogues! We are proud to have contributed to this multi-lab effort.
Reposted by CCMN
Unbelievably proud of @nataliefigueredob.bsky.social for winning the prestigious Bogue Fellowship 🌟 She'll be heading across the pond to train with the @zknight.bsky.social lab for 3 months. Exciting things to come for this bright young scientist 🧠. @uclnpp.bsky.social @ccmnlondon.bsky.social
June 24, 2025 at 12:43 PM
Unbelievably proud of @nataliefigueredob.bsky.social for winning the prestigious Bogue Fellowship 🌟 She'll be heading across the pond to train with the @zknight.bsky.social lab for 3 months. Exciting things to come for this bright young scientist 🧠. @uclnpp.bsky.social @ccmnlondon.bsky.social
Can targeting GLP-1 in the brain revolutionise obesity treatment? 🧠💉
Check out Professor Stefan Trapp’s take on how central GLP-1 pathways could transform the future of obesity care.
www.drugtargetreview.com/article/1606...
Check out Professor Stefan Trapp’s take on how central GLP-1 pathways could transform the future of obesity care.
www.drugtargetreview.com/article/1606...
Targeting GLP-1 in the brain could transform obesity care
Explore the role of GLP-1 in regulating hunger and appetite, uncovering its complex mechanisms in the brain and gut.
www.drugtargetreview.com
June 6, 2025 at 11:23 AM
Can targeting GLP-1 in the brain revolutionise obesity treatment? 🧠💉
Check out Professor Stefan Trapp’s take on how central GLP-1 pathways could transform the future of obesity care.
www.drugtargetreview.com/article/1606...
Check out Professor Stefan Trapp’s take on how central GLP-1 pathways could transform the future of obesity care.
www.drugtargetreview.com/article/1606...
📣 New publication alert!
“Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity” is now out!
Read the full article here:
www.nature.com/articles/s41...
“Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity” is now out!
Read the full article here:
www.nature.com/articles/s41...
Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity - Nature Reviews Cardiology
The physiological phenomenon whereby heart rate varies in phase with breathing in vertebrates has been known as ‘respiratory sinus arrhythmia’. In this Expert Recommendation, the authors argue that th...
www.nature.com
May 12, 2025 at 8:09 PM
📣 New publication alert!
“Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity” is now out!
Read the full article here:
www.nature.com/articles/s41...
“Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity” is now out!
Read the full article here:
www.nature.com/articles/s41...
Reposted by CCMN
It's a big week for GIPR pharmacology! Two great studies out in @natmetabolism.nature.com from Gutgesell et al (www.nature.com/articles/s42...) and Liu et al (www.nature.com/articles/s42...) revealing divergent neural mechanisms engaged by GIPR agonism vs antagonism. Commentary here: rdcu.be/ejPSA
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice - Nature Metabolism
This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...
www.nature.com
April 29, 2025 at 1:20 PM
It's a big week for GIPR pharmacology! Two great studies out in @natmetabolism.nature.com from Gutgesell et al (www.nature.com/articles/s42...) and Liu et al (www.nature.com/articles/s42...) revealing divergent neural mechanisms engaged by GIPR agonism vs antagonism. Commentary here: rdcu.be/ejPSA
Reposted by CCMN
We are recruiting! If you are interested in working as a post-doctoral Research Fellow in the heart of London contributing to MRC-funded research into GLP-1 action within the brain, please look at this link and apply if interested: www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
March 6, 2025 at 1:57 PM
We are recruiting! If you are interested in working as a post-doctoral Research Fellow in the heart of London contributing to MRC-funded research into GLP-1 action within the brain, please look at this link and apply if interested: www.ucl.ac.uk/work-at-ucl/...
📣Join the Trapp lab as a Postdoctoral Research Fellow!
The Trapp lab is seeking for a highly motivated Research Fellow to explore the role of GLP-1 action within the brain. If you are interested we encourage you to apply!
📍 Location: UCL, London
📆 Application deadline: March 19th
The Trapp lab is seeking for a highly motivated Research Fellow to explore the role of GLP-1 action within the brain. If you are interested we encourage you to apply!
📍 Location: UCL, London
📆 Application deadline: March 19th
March 7, 2025 at 9:00 AM
📣Join the Trapp lab as a Postdoctoral Research Fellow!
The Trapp lab is seeking for a highly motivated Research Fellow to explore the role of GLP-1 action within the brain. If you are interested we encourage you to apply!
📍 Location: UCL, London
📆 Application deadline: March 19th
The Trapp lab is seeking for a highly motivated Research Fellow to explore the role of GLP-1 action within the brain. If you are interested we encourage you to apply!
📍 Location: UCL, London
📆 Application deadline: March 19th
📣 Professor Stefan Trapp will be giving a talk as part of the webinar titled Harnessing Hormones for Health: Taking GLP-1 from Research to Reality hosted by @chemistryworld.com
Join to learn all about the groundbreaking science behind obesity drugs on March 6th at 3:00pm.
Join to learn all about the groundbreaking science behind obesity drugs on March 6th at 3:00pm.
March 5, 2025 at 6:08 PM
📣 Professor Stefan Trapp will be giving a talk as part of the webinar titled Harnessing Hormones for Health: Taking GLP-1 from Research to Reality hosted by @chemistryworld.com
Join to learn all about the groundbreaking science behind obesity drugs on March 6th at 3:00pm.
Join to learn all about the groundbreaking science behind obesity drugs on March 6th at 3:00pm.
📣 New study from @AcklandLab and CCMN in #EHJ! This randomized, double-blind, sham-controlled, crossover trial in healthy volunteers shows that vagal stimulation increases peak O₂ consumption and power output during exercise and has a strong anti-inflammatory effect.
February 21, 2025 at 1:23 PM
📣 New study from @AcklandLab and CCMN in #EHJ! This randomized, double-blind, sham-controlled, crossover trial in healthy volunteers shows that vagal stimulation increases peak O₂ consumption and power output during exercise and has a strong anti-inflammatory effect.
CCMN is off to an amazing start this year. Here are some highlights you don’t want to miss ✨
February 19, 2025 at 7:49 PM
CCMN is off to an amazing start this year. Here are some highlights you don’t want to miss ✨
Reposted by CCMN
Fantastic departmental seminar by @zknight.bsky.social, followed by craft beer and bowling for xmas party with the @ccmnlondon.bsky.social crew.
Definitely a Good Science Day.
Definitely a Good Science Day.
December 4, 2024 at 11:10 PM
Fantastic departmental seminar by @zknight.bsky.social, followed by craft beer and bowling for xmas party with the @ccmnlondon.bsky.social crew.
Definitely a Good Science Day.
Definitely a Good Science Day.
📣 We are excited to launch this year’s CCMN Lecture Series with Dr. @zknight.bsky.social! Join us to learn about his latest work on:
In vivo imaging of brainstem neurons in response to nutrient intake.
🗓️ Wednesday, Dec 4, 2024
🕐 13:00
📍 H O Schild Lecture Theatre, Medical Sciences Building
In vivo imaging of brainstem neurons in response to nutrient intake.
🗓️ Wednesday, Dec 4, 2024
🕐 13:00
📍 H O Schild Lecture Theatre, Medical Sciences Building
December 2, 2024 at 8:54 PM
📣 We are excited to launch this year’s CCMN Lecture Series with Dr. @zknight.bsky.social! Join us to learn about his latest work on:
In vivo imaging of brainstem neurons in response to nutrient intake.
🗓️ Wednesday, Dec 4, 2024
🕐 13:00
📍 H O Schild Lecture Theatre, Medical Sciences Building
In vivo imaging of brainstem neurons in response to nutrient intake.
🗓️ Wednesday, Dec 4, 2024
🕐 13:00
📍 H O Schild Lecture Theatre, Medical Sciences Building
Reposted by CCMN
The Trapp Lab has moved to BlueSky. No better way to start this than with a new paper.
We are excited to alert you to the latest study on the involvement of brain GLP-1 in stress responses led by our @CCMN_London and Trapp Lab
alumni @MKBHolt
Read the details at doi.org/10.1016/j.mo....
We are excited to alert you to the latest study on the involvement of brain GLP-1 in stress responses led by our @CCMN_London and Trapp Lab
alumni @MKBHolt
Read the details at doi.org/10.1016/j.mo....
Redirecting
doi.org
November 27, 2024 at 12:03 PM
The Trapp Lab has moved to BlueSky. No better way to start this than with a new paper.
We are excited to alert you to the latest study on the involvement of brain GLP-1 in stress responses led by our @CCMN_London and Trapp Lab
alumni @MKBHolt
Read the details at doi.org/10.1016/j.mo....
We are excited to alert you to the latest study on the involvement of brain GLP-1 in stress responses led by our @CCMN_London and Trapp Lab
alumni @MKBHolt
Read the details at doi.org/10.1016/j.mo....
📣 New paper out today from the Rinaman lab in collaboration with the Trapp lab. Go check it out to gain insights on how PPG neurons modulate stress-related behaviour. Congratulations to former CCMN member, Marie K Holt, for leading this interesting project!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Modulation of stress-related behaviour by preproglucagon neurons and hypothalamic projections to the nucleus of the solitary tract
Stress-induced behaviours are driven by complex neural circuits and some neuronal populations concurrently modulate diverse behavioural and physiologi…
www.sciencedirect.com
November 27, 2024 at 10:34 AM
📣 New paper out today from the Rinaman lab in collaboration with the Trapp lab. Go check it out to gain insights on how PPG neurons modulate stress-related behaviour. Congratulations to former CCMN member, Marie K Holt, for leading this interesting project!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...