dave dougan
@douganlab.bsky.social
Regulated proteolysis | N-degron | AAA+ machines | #Proteostasis #Ndegron https://scholar.google.com/citations?user=6LL-q08AAAAJ&hl=en … views my own
Reposted by dave dougan
And another paper with contribution from us. Here Sascha Amann solved the structure of the BORC complex. Due to its shape it is extremely challenging for cryo EM analysis but still he cracked it. Read the full story spearheaded by the Huber lab in Innsbruck: www.pnas.org/doi/10.1073/...
January 21, 2026 at 9:49 AM
And another paper with contribution from us. Here Sascha Amann solved the structure of the BORC complex. Due to its shape it is extremely challenging for cryo EM analysis but still he cracked it. Read the full story spearheaded by the Huber lab in Innsbruck: www.pnas.org/doi/10.1073/...
Reposted by dave dougan
The US is leaving some of the world’s oldest and most influential scientific networks involved in biodiversity research, climate science and conservation
go.nature.com/4a48Ney
go.nature.com/4a48Ney
The US is quitting 66 global agencies: what does it mean for science?
The United States is leaving some of the world’s oldest and most influential scientific networks involved in biodiversity research, climate science and conservation. Affected organizations tell Nature that their work continues.
go.nature.com
January 21, 2026 at 11:18 AM
The US is leaving some of the world’s oldest and most influential scientific networks involved in biodiversity research, climate science and conservation
go.nature.com/4a48Ney
go.nature.com/4a48Ney
[476084-quiet-morning-calm].
January 20, 2026 at 4:06 AM
[476084-quiet-morning-calm].
Reposted by dave dougan
I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
A phage protein screen identifies triggers of the bacterial innate immune system - Nature Microbiology
A library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.
www.nature.com
January 18, 2026 at 10:45 PM
I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
Reposted by dave dougan
Using complexes obtained through PINK1 pulldown, researchers determine the cryo-EM structures of the human Hsp90-Cdc37-PINK1 complex at 2.84 Å, Hsp90-FKBP51-PINK1 at approximately 6 Å, & Hsp90- PINK1 at 2.98 Å
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 2, 2025 at 9:25 PM
Using complexes obtained through PINK1 pulldown, researchers determine the cryo-EM structures of the human Hsp90-Cdc37-PINK1 complex at 2.84 Å, Hsp90-FKBP51-PINK1 at approximately 6 Å, & Hsp90- PINK1 at 2.98 Å
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by dave dougan
Save the CSIRO
Our national science & research agency is now facing more job cuts than under Tony Abbott
Call on the Albanese Govt to fund the scientists & research we need to tackle big issues we face from climate to food security and everything in between
www.davidpocock.com.au/save_our_csiro
Our national science & research agency is now facing more job cuts than under Tony Abbott
Call on the Albanese Govt to fund the scientists & research we need to tackle big issues we face from climate to food security and everything in between
www.davidpocock.com.au/save_our_csiro
November 19, 2025 at 9:49 AM
Save the CSIRO
Our national science & research agency is now facing more job cuts than under Tony Abbott
Call on the Albanese Govt to fund the scientists & research we need to tackle big issues we face from climate to food security and everything in between
www.davidpocock.com.au/save_our_csiro
Our national science & research agency is now facing more job cuts than under Tony Abbott
Call on the Albanese Govt to fund the scientists & research we need to tackle big issues we face from climate to food security and everything in between
www.davidpocock.com.au/save_our_csiro
Reposted by dave dougan
Add this to the CSIRO cuts and uni cuts generally and the picture is unmistakable
The success rate for NHMRC Ideas Grants announced yesterday was just over 8%. That means 11 of every 12 people who applied got rejected. This is a culture changing level of rejection and frankly a point of national shame. This is a crisis for research.
I will not rest until we see this resolved.
I will not rest until we see this resolved.
November 26, 2025 at 9:04 PM
Add this to the CSIRO cuts and uni cuts generally and the picture is unmistakable
Reposted by dave dougan
We are all mosaics: vast genetic diversity found between cells in a single person @nature.com
www.nature.com/articles/d41...
@biorxivpreprint.bsky.social @mayoclinic.org @harvardmed.bsky.social @timcoorens.bsky.social @emblebi.bsky.social
www.biorxiv.org/content/10.1...
www.nature.com/articles/d41...
@biorxivpreprint.bsky.social @mayoclinic.org @harvardmed.bsky.social @timcoorens.bsky.social @emblebi.bsky.social
www.biorxiv.org/content/10.1...
November 26, 2025 at 3:16 PM
We are all mosaics: vast genetic diversity found between cells in a single person @nature.com
www.nature.com/articles/d41...
@biorxivpreprint.bsky.social @mayoclinic.org @harvardmed.bsky.social @timcoorens.bsky.social @emblebi.bsky.social
www.biorxiv.org/content/10.1...
www.nature.com/articles/d41...
@biorxivpreprint.bsky.social @mayoclinic.org @harvardmed.bsky.social @timcoorens.bsky.social @emblebi.bsky.social
www.biorxiv.org/content/10.1...
Reposted by dave dougan
A triple-action PROTAC for wild-type p53 cancer therapy @cp-cellrepmed.bsky.social @lorenwalensky.bsky.social @danafarber.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
November 26, 2025 at 8:28 PM
A triple-action PROTAC for wild-type p53 cancer therapy @cp-cellrepmed.bsky.social @lorenwalensky.bsky.social @danafarber.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by dave dougan
🏔️🌧️ 🧬 We wrote this Expert View on oxygen sensing, you can read it here! 👇🏼
Recent advances in the mechanism, transduction and function of oxygen sensing in plants
#nendrule #hypoxia #plantscience
academic.oup.com/jxb/advance-...
#nendrule #hypoxia #plantscience
academic.oup.com/jxb/advance-...
Recent advances in the mechanism, transduction and function of oxygen sensing in plants
Abstract. Response to reduced ambient oxygen is a key component of plant adaptation in natural and farmed environments and is regulated by oxygen dependent
academic.oup.com
November 23, 2025 at 1:21 PM
🏔️🌧️ 🧬 We wrote this Expert View on oxygen sensing, you can read it here! 👇🏼
Reposted by dave dougan
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
November 23, 2025 at 3:47 PM
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
Reposted by dave dougan
Through proteomic profiling of our proprietary compound library, our team identified a selective, fast, and potent molecular glue degrader that induces cereblon degradation via a novel mechanism.
Read the full paper in @natcomms.nature.com: rdcu.be/eQKQk
Read the full paper in @natcomms.nature.com: rdcu.be/eQKQk
November 19, 2025 at 3:28 PM
Through proteomic profiling of our proprietary compound library, our team identified a selective, fast, and potent molecular glue degrader that induces cereblon degradation via a novel mechanism.
Read the full paper in @natcomms.nature.com: rdcu.be/eQKQk
Read the full paper in @natcomms.nature.com: rdcu.be/eQKQk
Reposted by dave dougan
Structural basis for co-translational assembly of homo-oligomeric proteins www.biorxiv.org/content/10.1101/2025.11.12.687954v1 #cryoem
November 14, 2025 at 12:14 PM
Structural basis for co-translational assembly of homo-oligomeric proteins www.biorxiv.org/content/10.1101/2025.11.12.687954v1 #cryoem
Reposted by dave dougan
📝 Online now - the Spotlight "Unlocking the protein code: how our organs age across a lifetime" from Dongxue Wang and Jing Yang.
#Proteostasis #Aging #BiologicalClocks #Proteomics
Read it here: authors.elsevier.com/a/1m7Ts3S6Gf...
#Proteostasis #Aging #BiologicalClocks #Proteomics
Read it here: authors.elsevier.com/a/1m7Ts3S6Gf...
November 18, 2025 at 9:35 PM
📝 Online now - the Spotlight "Unlocking the protein code: how our organs age across a lifetime" from Dongxue Wang and Jing Yang.
#Proteostasis #Aging #BiologicalClocks #Proteomics
Read it here: authors.elsevier.com/a/1m7Ts3S6Gf...
#Proteostasis #Aging #BiologicalClocks #Proteomics
Read it here: authors.elsevier.com/a/1m7Ts3S6Gf...
Ribonuclease toxin RelE1 inhibits growth of Mycobacterium tuberculosis through specific cleavage of the ribosomal anti-Shine–Dalgarno region: academic.oup.com/nar/article/...
Validate User
academic.oup.com
November 18, 2025 at 11:36 PM
Ribonuclease toxin RelE1 inhibits growth of Mycobacterium tuberculosis through specific cleavage of the ribosomal anti-Shine–Dalgarno region: academic.oup.com/nar/article/...
Development of a targeted BioPROTAC degrader selective for misfolded SOD1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Development of a targeted BioPROTAC degrader selective for misfolded SOD1 - Nature Communications
Conventional PROTACs have limited capacity for misfolded proteins. Here, authors develop a BioPROTAC containing an scFv specifically targeting misfolded SOD1, fused to an E3 ligase, and demonstrate a ...
www.nature.com
November 18, 2025 at 11:33 PM
Development of a targeted BioPROTAC degrader selective for misfolded SOD1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by dave dougan
A fluorescent probe enables direct visualization and measurement of membrane tension in live bacteria, offering new insights into how bacteria interact with and respond to different surfaces. doi.org/hbbsxk
How bacteria 'feel' surfaces: Fluorescent probe visualizes and quantifies membrane tension
In natural environments, bacteria rarely live as free-swimming cells but are attached to surfaces as biofilms in medical devices, mobile phones or human tissue.
phys.org
November 18, 2025 at 8:02 PM
A fluorescent probe enables direct visualization and measurement of membrane tension in live bacteria, offering new insights into how bacteria interact with and respond to different surfaces. doi.org/hbbsxk
Reposted by dave dougan
ICYMI: New online: Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1
Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1
Nature Structural & Molecular Biology, Published online: 06 November 2025; doi:10.1038/s41594-025-01695-2The authors use time-resolved cryo-electron microscopy to reveal the interactions of the redox-active cofactor TXNL1 with the human 26S proteasome and detect ATPase motor states that indicate burst-like mechanisms for hand-over-hand substrate translocation.
go.nature.com
November 7, 2025 at 11:45 AM
ICYMI: New online: Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1
Reposted by dave dougan
The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation www.biorxiv.org/content/10.1101/2025.11.08.687396v1 #cryoem
November 10, 2025 at 1:56 PM
The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation www.biorxiv.org/content/10.1101/2025.11.08.687396v1 #cryoem
How Pathogens Maintain Proteostasis During Infection
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
How Pathogens Maintain Proteostasis During Infection
Differential ribosome association of protein chaperones trigger factor and DnaK under sufficient and low cytoplasmic Mg2+ conditions. Trigger factor (TF) associates with ribosomes and cotranslational...
onlinelibrary.wiley.com
November 10, 2025 at 3:59 AM
How Pathogens Maintain Proteostasis During Infection
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
In situ characterization of mitochondrial Hsp60-Hsp10 chaperone complex under folding stress | Science Advances www.science.org/doi/10.1126/...
In situ characterization of mitochondrial Hsp60-Hsp10 chaperone complex under folding stress
The mitochondrial Hsp60-Hsp10 complex clusters and shifts conformation in response to protein-folding stress.
www.science.org
October 27, 2025 at 12:17 AM
In situ characterization of mitochondrial Hsp60-Hsp10 chaperone complex under folding stress | Science Advances www.science.org/doi/10.1126/...
Reposted by dave dougan
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com/4hj9NNV
go.nature.com/4hj9NNV
Economics Nobel prize won by researchers who showed how science boosts growth
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com
October 13, 2025 at 8:37 PM
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com/4hj9NNV
go.nature.com/4hj9NNV
Arctic seals face extinction and birds in decline globally, but there is some good news about green sea turtles www.cnn.com/2025/10/10/s...
Arctic seals face extinction and birds in decline globally, according to new Red List | CNN
More than a quarter of all animals, plants and fungi assessed are at risk of extinction, according to the latest IUCN Red List of Threatened Species.
www.cnn.com
October 13, 2025 at 11:31 PM
Arctic seals face extinction and birds in decline globally, but there is some good news about green sea turtles www.cnn.com/2025/10/10/s...
Well-exercised male mice appear to pass fitness to their male offspring | Science | AAAS www.science.org/content/arti...
Well-exercised male mice appear to pass fitness to their male offspring
Surprising epigenetic effect relies on snippets of RNA packaged within sperm
www.science.org
October 9, 2025 at 3:28 AM
Well-exercised male mice appear to pass fitness to their male offspring | Science | AAAS www.science.org/content/arti...