Sean Fanning
@docfanning.bsky.social
I am an Assistant Professor of Cancer Biology at Loyola University Chicago Stritch School of Medicine (www.fanninglab.com). The Fanning lab studies how allostery governs estrogen receptor-dependent transcriptional programs in breast cancer.
Reposted by Sean Fanning
🔊 Nova publicació del Dpt @bqbiomedmolub.bsky.social pel grup liderat per la Dra Eva Estébanez-Perpiñá @estebanezlab.bsky.social @ibub-ub.bsky.social @biologiaub.bsky.social
Enhorabona! 👋👋
Enhorabona! 👋👋
🎯 We are incredibly thrilled to share our newest paper on #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization 👇
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
The multimerization pathway of the glucocorticoid receptor
Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf
academic.oup.com
October 22, 2025 at 11:07 AM
🔊 Nova publicació del Dpt @bqbiomedmolub.bsky.social pel grup liderat per la Dra Eva Estébanez-Perpiñá @estebanezlab.bsky.social @ibub-ub.bsky.social @biologiaub.bsky.social
Enhorabona! 👋👋
Enhorabona! 👋👋
Reposted by Sean Fanning
I know & trust that NIH staff will get this round of reviews done. Yet having done my own CSR reviews 'for nothing' & with my own R01 sitting unreviewed now, working on another NIH grant has never felt so painful and futile. A quiet impact on science, perhaps, robbing the joy from looking ahead.
If you are serving on NIH study sections that have been cancelled, PLEASE continue to work on your reviews. NIH will do everything their power to ensure the meetings happen eventually, and the more prepared you are when those meetings are rescheduled, the better.
Welp. Thanks to the Republican gov shutdown I have a bunch of hours back in my week due to a NIH study section not meeting.
These poor applicants. They will be waiting week by week for government to reopen and to find out what will happen to their grant application.
These poor applicants. They will be waiting week by week for government to reopen and to find out what will happen to their grant application.
October 20, 2025 at 3:52 PM
I know & trust that NIH staff will get this round of reviews done. Yet having done my own CSR reviews 'for nothing' & with my own R01 sitting unreviewed now, working on another NIH grant has never felt so painful and futile. A quiet impact on science, perhaps, robbing the joy from looking ahead.
Reposted by Sean Fanning
Democracy in action, Illinois.
Proud of our state for peacefully showing up and speaking out together in one voice to fight back against Donald Trump’s takeover of our democracy.
Proud of our state for peacefully showing up and speaking out together in one voice to fight back against Donald Trump’s takeover of our democracy.
October 19, 2025 at 12:24 AM
Democracy in action, Illinois.
Proud of our state for peacefully showing up and speaking out together in one voice to fight back against Donald Trump’s takeover of our democracy.
Proud of our state for peacefully showing up and speaking out together in one voice to fight back against Donald Trump’s takeover of our democracy.
Just wrapped up my medical school teaching for the year. I happened to have an exceptionally awesome group of M1s. I’m excited to see where they’ll go from here!
September 11, 2025 at 5:14 PM
Just wrapped up my medical school teaching for the year. I happened to have an exceptionally awesome group of M1s. I’m excited to see where they’ll go from here!
Reposted by Sean Fanning
RFK Jr. and Trump tell us they want to Make America Healthy Again.
Great slogan. I agree. Unfortunately, they are doing the exact opposite.
Vaccines work. They are safe. They save lives.
No more conspiracy theories. Kennedy must resign.
Great slogan. I agree. Unfortunately, they are doing the exact opposite.
Vaccines work. They are safe. They save lives.
No more conspiracy theories. Kennedy must resign.
“Robert F. Kennedy Jr., the secretary of health and human services, is endangering the health of the American people now and into the future. He must resign,” Senator Bernie Sanders writes.
Opinion | Bernie Sanders: Kennedy Must Resign
The health secretary is endangering the lives of American people now and into the future.
nyti.ms
September 2, 2025 at 8:47 PM
RFK Jr. and Trump tell us they want to Make America Healthy Again.
Great slogan. I agree. Unfortunately, they are doing the exact opposite.
Vaccines work. They are safe. They save lives.
No more conspiracy theories. Kennedy must resign.
Great slogan. I agree. Unfortunately, they are doing the exact opposite.
Vaccines work. They are safe. They save lives.
No more conspiracy theories. Kennedy must resign.
Fanning Lab BBQ 2025! Another good year in the books thanks to this exceptional group! Also, they wanted me to make ribs and brisket, they know I look for any excuse to do a cook.
August 28, 2025 at 12:27 AM
Fanning Lab BBQ 2025! Another good year in the books thanks to this exceptional group! Also, they wanted me to make ribs and brisket, they know I look for any excuse to do a cook.
I had a wonderful time at Endo2025, catching up with great colleagues doing fantastic and important work in endocrinology. I particularly enjoyed chairing the session on Nuclear Receptor Structural Biology where @dougkojetin.bsky.social gave a powerhouse performance! 1/3
July 16, 2025 at 6:33 PM
I had a wonderful time at Endo2025, catching up with great colleagues doing fantastic and important work in endocrinology. I particularly enjoyed chairing the session on Nuclear Receptor Structural Biology where @dougkojetin.bsky.social gave a powerhouse performance! 1/3
Reposted by Sean Fanning
New review from us on radiation in #lobular breast cancer!
www.nature.com/articles/s41...
Lots of anecdote that ILC is highly responsive to XRT (despite ~chemoresistance), but do we have the data?
led by Dr. Michael Boysen (now resident at Trinity Health Ann Arbor), w Dr. Corey Speers @ UAB. 🧵1/n
www.nature.com/articles/s41...
Lots of anecdote that ILC is highly responsive to XRT (despite ~chemoresistance), but do we have the data?
led by Dr. Michael Boysen (now resident at Trinity Health Ann Arbor), w Dr. Corey Speers @ UAB. 🧵1/n
Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity - npj Breast Cancer
npj Breast Cancer - Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity
www.nature.com
July 10, 2025 at 3:33 PM
New review from us on radiation in #lobular breast cancer!
www.nature.com/articles/s41...
Lots of anecdote that ILC is highly responsive to XRT (despite ~chemoresistance), but do we have the data?
led by Dr. Michael Boysen (now resident at Trinity Health Ann Arbor), w Dr. Corey Speers @ UAB. 🧵1/n
www.nature.com/articles/s41...
Lots of anecdote that ILC is highly responsive to XRT (despite ~chemoresistance), but do we have the data?
led by Dr. Michael Boysen (now resident at Trinity Health Ann Arbor), w Dr. Corey Speers @ UAB. 🧵1/n
Reposted by Sean Fanning
Finished another bronze of a T-cell attacking a cancer cell. This one is heading to Max Krummel at UCSF, who did some of the early studies on CTLA4 immunotherapy. #sciart.
July 10, 2025 at 12:13 AM
Finished another bronze of a T-cell attacking a cancer cell. This one is heading to Max Krummel at UCSF, who did some of the early studies on CTLA4 immunotherapy. #sciart.
Very proud of Sofia for successfully defending her Master’s thesis today!! She’s starting her PhD in biomedicine at UMiami next year. Can’t wait to see what she’ll accomplish! I’m a proud PI!
June 27, 2025 at 10:47 PM
Very proud of Sofia for successfully defending her Master’s thesis today!! She’s starting her PhD in biomedicine at UMiami next year. Can’t wait to see what she’ll accomplish! I’m a proud PI!
Reposted by Sean Fanning
A careers feature in Nature Biotechnology provides some keys to a successful transition from a career in academia to one in industry. #Academicsky 🧪
Thinking about a move from academia to industry? Look before you leap - Nature Biotechnology
To those considering a change in careers from academia to the pharmaceutical industry, here are the keys to a successful transition.
go.nature.com
June 26, 2025 at 10:07 PM
A careers feature in Nature Biotechnology provides some keys to a successful transition from a career in academia to one in industry. #Academicsky 🧪
Reposted by Sean Fanning
#Illinois researchers have successfully treated a common type of colorectal cancer tumor with a cholesterol inhibitor drug, demonstrating a promising treatment for the disease in animal experiments.
The study was published in Nature Chemical Biology:
go.mcb.illinois.edu/623
@nelsonlab.bsky.social
The study was published in Nature Chemical Biology:
go.mcb.illinois.edu/623
@nelsonlab.bsky.social
Colorectal cancer treated with cholesterol inhibitor in U. of I. study | School of Molecular & Cellular Biology | Illinois
University of Illinois researchers have successfully treated a common type of colorectal cancer tumor with a cholesterol inhibitor drug, demonstrating a promising treatment for the disease in animal experiments.
mcb.illinois.edu
June 25, 2025 at 4:55 PM
#Illinois researchers have successfully treated a common type of colorectal cancer tumor with a cholesterol inhibitor drug, demonstrating a promising treatment for the disease in animal experiments.
The study was published in Nature Chemical Biology:
go.mcb.illinois.edu/623
@nelsonlab.bsky.social
The study was published in Nature Chemical Biology:
go.mcb.illinois.edu/623
@nelsonlab.bsky.social
Reposted by Sean Fanning
We did a thing w @jostrander.bsky.social!
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
June 25, 2025 at 5:26 PM
We did a thing w @jostrander.bsky.social!
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
Reposted by Sean Fanning
CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
June 23, 2025 at 12:46 AM
CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
Reposted by Sean Fanning
CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
June 23, 2025 at 12:50 AM
Reposted by Sean Fanning
Trump bombing Iran was illegal and unjustified.
I ran for Congress to make sure our leaders consider the true costs of war.
And I will be in the Senate, standing on my titanium legs, demanding answers from Trump.
My statement:
I ran for Congress to make sure our leaders consider the true costs of war.
And I will be in the Senate, standing on my titanium legs, demanding answers from Trump.
My statement:
June 22, 2025 at 3:27 AM
Trump bombing Iran was illegal and unjustified.
I ran for Congress to make sure our leaders consider the true costs of war.
And I will be in the Senate, standing on my titanium legs, demanding answers from Trump.
My statement:
I ran for Congress to make sure our leaders consider the true costs of war.
And I will be in the Senate, standing on my titanium legs, demanding answers from Trump.
My statement:
Reposted by Sean Fanning
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes. #NEJM
"zimislecel can restore physiologic islet function"
Reference
www.nejm.org/doi/full/10....
"zimislecel can restore physiologic islet function"
Reference
www.nejm.org/doi/full/10....
June 22, 2025 at 2:19 AM
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes. #NEJM
"zimislecel can restore physiologic islet function"
Reference
www.nejm.org/doi/full/10....
"zimislecel can restore physiologic islet function"
Reference
www.nejm.org/doi/full/10....
Reposted by Sean Fanning
Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity https://www.biorxiv.org/content/10.1101/2025.06.16.659976v1
June 21, 2025 at 12:46 PM
Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity https://www.biorxiv.org/content/10.1101/2025.06.16.659976v1
Reposted by Sean Fanning
Congrats Xiuxiu Li on her story out JBC! HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer - Journal of Biological Chemistry @asbmb.bsky.social 🧪https://www.jbc.org/article/S0021-9258%2825%2902255-0/fulltext
HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer
Endocrine resistance is a major challenge in the treatment of estrogen receptor-positive
(ER+) breast cancer, often leading to disease recurrence and metastasis. 3β-Hydroxysteroid
dehydrogenase 1 (3βH...
www.jbc.org
June 21, 2025 at 12:44 PM
Congrats Xiuxiu Li on her story out JBC! HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer - Journal of Biological Chemistry @asbmb.bsky.social 🧪https://www.jbc.org/article/S0021-9258%2825%2902255-0/fulltext
Reposted by Sean Fanning
Reposted by Sean Fanning
Today I’m leading 152 House Democrats in challenging Trump's devastating cuts to life-saving NIH research grants. Congress—not Trump—controls federal spending.
Trump must do his job, “faithfully execute” the laws and stop violating the Constitution to undercut public health.
Trump must do his job, “faithfully execute” the laws and stop violating the Constitution to undercut public health.
June 17, 2025 at 8:43 PM
Today I’m leading 152 House Democrats in challenging Trump's devastating cuts to life-saving NIH research grants. Congress—not Trump—controls federal spending.
Trump must do his job, “faithfully execute” the laws and stop violating the Constitution to undercut public health.
Trump must do his job, “faithfully execute” the laws and stop violating the Constitution to undercut public health.
Reposted by Sean Fanning
Congrats to Team Bitler—Drs. Bitler, Corr, Sikora, Clauset, and many others—2025 CU ASPIRE Awardees🎉Their SPORE effort to advance ovarian cancer care with novel therapies & population science. #OvarianCancer #CUAnschutz @uccc-gorg.bsky.social @mjsikora.bsky.social View details here: Bit.ly/4mWBRsO
June 17, 2025 at 3:47 PM
Congrats to Team Bitler—Drs. Bitler, Corr, Sikora, Clauset, and many others—2025 CU ASPIRE Awardees🎉Their SPORE effort to advance ovarian cancer care with novel therapies & population science. #OvarianCancer #CUAnschutz @uccc-gorg.bsky.social @mjsikora.bsky.social View details here: Bit.ly/4mWBRsO
Reposted by Sean Fanning
The Illinois General Assembly and I are working to make life more affordable for working families.
Unlike the Trump administration, we're balancing a budget while maintaining programs our people rely on — and we're investing in our children and building them a brighter future.
Unlike the Trump administration, we're balancing a budget while maintaining programs our people rely on — and we're investing in our children and building them a brighter future.
June 16, 2025 at 9:53 PM
The Illinois General Assembly and I are working to make life more affordable for working families.
Unlike the Trump administration, we're balancing a budget while maintaining programs our people rely on — and we're investing in our children and building them a brighter future.
Unlike the Trump administration, we're balancing a budget while maintaining programs our people rely on — and we're investing in our children and building them a brighter future.
Reposted by Sean Fanning
BREAKING: A federal judge reversed National Institutes of Health's terminations of hundreds of critical research grants that were canceled because of their alleged connection to disfavored topics, including diversity, equity, inclusion, and gender identity.
This is a major win for public health.
This is a major win for public health.
June 16, 2025 at 9:46 PM
BREAKING: A federal judge reversed National Institutes of Health's terminations of hundreds of critical research grants that were canceled because of their alleged connection to disfavored topics, including diversity, equity, inclusion, and gender identity.
This is a major win for public health.
This is a major win for public health.
Reposted by Sean Fanning
Excited to share that our EndoMap project is now out! A fun collaboration with Miguel Gonzalez-Lozano from the @harperlabhms.bsky.social. Explore our #AlphaFold structural interactome of #XLMS complexes in endosomes-> endomap.hms.harvard.edu
and read about it here->
www.nature.com/articles/s41...
and read about it here->
www.nature.com/articles/s41...
EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
www.nature.com
May 28, 2025 at 5:09 PM
Excited to share that our EndoMap project is now out! A fun collaboration with Miguel Gonzalez-Lozano from the @harperlabhms.bsky.social. Explore our #AlphaFold structural interactome of #XLMS complexes in endosomes-> endomap.hms.harvard.edu
and read about it here->
www.nature.com/articles/s41...
and read about it here->
www.nature.com/articles/s41...