Stefano Di Talia
@ditalialab.bsky.social
Quantitative Developmental Biology @Duke
@sushantbangru.bsky.social and @rdiegmiller.bsky.social new review on regeneration is out in Nature Reviews Molecular Cell Biology. A fun piece to write and another great collaboration with @kenposs.bsky.social.
New Online! Signal control during tissue regeneration in adult animals
Signal control during tissue regeneration in adult animals
Nature Reviews Molecular Cell Biology, Published online: 11 November 2025; doi:10.1038/s41580-025-00917-1The ability to track single cells in vivo, combined with insights into chromatin structure, immune–tissue crosstalk, bioelectric and metabolic cues and quantitative modelling, is changing our understanding of how tissues are repaired and renewed. This Review discusses how signals are regulated during regeneration and future directions for a more quantitative understanding of regenerative biology.
bit.ly
November 13, 2025 at 8:48 PM
@sushantbangru.bsky.social and @rdiegmiller.bsky.social new review on regeneration is out in Nature Reviews Molecular Cell Biology. A fun piece to write and another great collaboration with @kenposs.bsky.social.
We are hiring!
Please repost!!:
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology - Durham, North Carolina (US) job with Duke University School of Medicine | 12844591
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology
www.nature.com
October 25, 2025 at 9:58 PM
We are hiring!
Just got back from a great visit to Vienna, spending time both at @impvienna.bsky.social and @istaresearch.bsky.social. Followed by a great visit to @embl.org. Amazing science, great and supportive colleagues and most notably incredible young trainees. It was so much fun to meet everyone.
September 28, 2025 at 1:58 PM
Just got back from a great visit to Vienna, spending time both at @impvienna.bsky.social and @istaresearch.bsky.social. Followed by a great visit to @embl.org. Amazing science, great and supportive colleagues and most notably incredible young trainees. It was so much fun to meet everyone.
Thanks, Paul! Means a lot coming from you, as your papers have been great inspiration for this study
Super impressive study by the group of Stefano di Talia on the segmentation of zebrafish notochord. There might even be a SNIC ! www.biorxiv.org/content/10.1...
Tissue-wide, synchronous Erk oscillations time the segmentation of the zebrafish notochord
The generation of a periodic body plan is a fundamental property of vertebrates. While biological oscillators provide a mechanism for timing the formation of repeated structures, few examples of signa...
www.biorxiv.org
September 9, 2025 at 12:21 PM
Thanks, Paul! Means a lot coming from you, as your papers have been great inspiration for this study
Reposted by Stefano Di Talia
🍽️🧬 How do diet and gut microbes shape fertility across generations? 🪱🔬 Our Laboratory at #InstitutPasteur is recruiting a PhD student to study epigenetic inheritance of fertility using C. elegans. Fully funded via the International PPU program. Apply now! 🌍 #PhDposition #Epigenetics #Inheritance
🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry.
Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, PPU-@ox.ac.uk, PPU-EID @upcite.bsky.social & more 🧬
Register now ✍️ www.pasteur.fr/en/education...
Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, PPU-@ox.ac.uk, PPU-EID @upcite.bsky.social & more 🧬
Register now ✍️ www.pasteur.fr/en/education...
September 7, 2025 at 10:49 AM
🍽️🧬 How do diet and gut microbes shape fertility across generations? 🪱🔬 Our Laboratory at #InstitutPasteur is recruiting a PhD student to study epigenetic inheritance of fertility using C. elegans. Fully funded via the International PPU program. Apply now! 🌍 #PhDposition #Epigenetics #Inheritance
Reposted by Stefano Di Talia
Tissue 'tectonic' collision is detrimental, but flies found two distinct solutions! Gratifying and grateful to be included in this collective effort, w/ Steffen Lemke, to crack the (or 'a') code of #cephalicfurrow, now out in @nature.com, all with @paveltomancak.bsky.social at the helm. (1/9)
September 4, 2025 at 5:18 PM
Tissue 'tectonic' collision is detrimental, but flies found two distinct solutions! Gratifying and grateful to be included in this collective effort, w/ Steffen Lemke, to crack the (or 'a') code of #cephalicfurrow, now out in @nature.com, all with @paveltomancak.bsky.social at the helm. (1/9)
Priyom's preprint is out on biorxiv. See below for a detailed thread. In a nutshell, she has discovered and characterized the oscillator that times notochord and spine segmentation in zebrafish. Turns out that there are uniform Erk oscillations across the entire tissue that act as timekeepers!
Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below
Additional thread below
September 2, 2025 at 5:34 PM
Priyom's preprint is out on biorxiv. See below for a detailed thread. In a nutshell, she has discovered and characterized the oscillator that times notochord and spine segmentation in zebrafish. Turns out that there are uniform Erk oscillations across the entire tissue that act as timekeepers!
Reposted by Stefano Di Talia
Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below
Additional thread below
September 2, 2025 at 4:46 PM
Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below
Additional thread below
Heartfelt obituary of Ben Shilo by Stas Shvartsman
Ben-Zion Shilo (1951–2025)
Ben-Zion Shilo, a distinguished Israeli geneticist (Figure 1), passed away this April
at the age of 73 at his home in Rehovot. Benny, as he was known to his friends and
colleagues around the world, ma...
www.cell.com
August 19, 2025 at 10:38 AM
Heartfelt obituary of Ben Shilo by Stas Shvartsman
Reposted by Stefano Di Talia
Just noticed a super nice preview of our paper by @ditalialab.bsky.social and Alexandra Hiestand. As always, good editorial experience with @cp-cellsystems.bsky.social
www.cell.com/cell-systems...
www.cell.com/cell-systems...
July 17, 2025 at 3:23 AM
Just noticed a super nice preview of our paper by @ditalialab.bsky.social and Alexandra Hiestand. As always, good editorial experience with @cp-cellsystems.bsky.social
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Great dinner with current and former members of the lab, as well as current and former Duke members and friends of the lab. Great to catch up with @ceriweber.bsky.social ,Ben, @woonyunghur.bsky.social and share stories. Great @socdevbio.bsky.social meeting!
June 22, 2025 at 2:53 AM
Great dinner with current and former members of the lab, as well as current and former Duke members and friends of the lab. Great to catch up with @ceriweber.bsky.social ,Ben, @woonyunghur.bsky.social and share stories. Great @socdevbio.bsky.social meeting!
Excited to see @drsusanna.bsky.social 's work out as a preprint. Please read the thread below for some more information or check the paper out on biorxiv.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share the bulk of my postdocotoral work from the @ditalialab.bsky.social on how cells interpret dynamic morphogen signaling during development! Many thanks to our collaborators & coauthors @shelbyflies.bsky.social, Massimo Vergassola, Jacqueline Janssen, and Anna Chao.
June 10, 2025 at 5:25 PM
Excited to see @drsusanna.bsky.social 's work out as a preprint. Please read the thread below for some more information or check the paper out on biorxiv.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Stefano Di Talia
A heartfelt thank you to @izfs.bsky.social for this incredible honor! I'm so grateful to receive an award in memory of Dr. Chi-Bin Chien, an inspiring scientist and pioneer in the zebrafish community 🐟💙
We are excited to announce the winner of the Chi-Bin Chien Award, Dr. Victoria Deneke! See more about Dr. Deneke and the CBC Award here: www.izfs.org/news/congrat...
@impvienna.bsky.social @vdeneke.bsky.social
@impvienna.bsky.social @vdeneke.bsky.social
June 4, 2025 at 6:11 AM
A heartfelt thank you to @izfs.bsky.social for this incredible honor! I'm so grateful to receive an award in memory of Dr. Chi-Bin Chien, an inspiring scientist and pioneer in the zebrafish community 🐟💙
Very much looking forward to this meeting!
🔈 We’re pleased to welcome Stefano Di Talia @ditalialab.bsky.social as an invited speaker at #ICDB2025!
His work combines imaging and quantitative models to understand cell cycle coordination during embryonic development. 📊🧪
His work combines imaging and quantitative models to understand cell cycle coordination during embryonic development. 📊🧪
May 14, 2025 at 11:43 AM
Very much looking forward to this meeting!
Highly recommended! A great lab and wonderful mentor.
👩🔬Curious about #fertilisation and #development? Join Andrea Pauli’s group through the Vienna BioCenter #PhD Program!
⏳Deadline: 15 April training.vbc.ac.at/phd-program/
📽️Watch Andi's 'Scientist Snapshot': www.youtube.com/watch?v=X9FN...
@pauligroup.bsky.social
⏳Deadline: 15 April training.vbc.ac.at/phd-program/
📽️Watch Andi's 'Scientist Snapshot': www.youtube.com/watch?v=X9FN...
@pauligroup.bsky.social
March 17, 2025 at 11:58 AM
Highly recommended! A great lab and wonderful mentor.
Reposted by Stefano Di Talia
We are hiring!
Interested in X chromosome inactivation, cell biology, and epigenetics?
Funded postdoctoral position in our lab at the Koç University Mol Bio and Genetics Department, in Istanbul Türkiye. DM for more details.
Interested in X chromosome inactivation, cell biology, and epigenetics?
Funded postdoctoral position in our lab at the Koç University Mol Bio and Genetics Department, in Istanbul Türkiye. DM for more details.
March 1, 2025 at 11:22 AM
We are hiring!
Interested in X chromosome inactivation, cell biology, and epigenetics?
Funded postdoctoral position in our lab at the Koç University Mol Bio and Genetics Department, in Istanbul Türkiye. DM for more details.
Interested in X chromosome inactivation, cell biology, and epigenetics?
Funded postdoctoral position in our lab at the Koç University Mol Bio and Genetics Department, in Istanbul Türkiye. DM for more details.
Our paper, led by @argo-mkhrji.bsky.social and @woonyunghur.bsky.social, on cortical migration of nuclei in drosophila embryos came out today in @naturephysics.bsky.social. Argo wrote a comprehensive thread below. A great collaboration with Massimo Vergassola and @streichan.bsky.social.
1/n Wanted to share this latest piece of work that came online today on how Scale-independent and Topological interactions govern the spindle orientation and in turn the decision to become embryonic/yolk nuclei.
Freely available to read here:
rdcu.be/ebb0l
Freely available to read here:
rdcu.be/ebb0l
Topological interactions drive the first fate decision in the Drosophila embryo
Nature Physics - Early positioning of the embryo nuclei is not well understood. Now, experiments show that the orientation of the mitotic spindle is controlled by topological interactions, which...
rdcu.be
February 26, 2025 at 12:15 AM
Our paper, led by @argo-mkhrji.bsky.social and @woonyunghur.bsky.social, on cortical migration of nuclei in drosophila embryos came out today in @naturephysics.bsky.social. Argo wrote a comprehensive thread below. A great collaboration with Massimo Vergassola and @streichan.bsky.social.
Great new paper on spatiotemporal organization of cell division in zebrafish embryos. The mitotic waves preceding the ZGA are phase waves set by differences in N/C ratio, driven by geometry-induced asymmetric divisions. Important new insights and very interesting addition to the field.
📢‼️ Exciting new preprint from the lab by @nikhil-mishra.bsky.social et al, now out on @biorxivpreprint.bsky.social, reveals that the early embryo geometry spatiotemporally patterns zygotic genome activation (ZGA) in zebrafish. 🐟 tinyurl.com/Biorxiv-nmis...
Read on to learn more... 👇
Read on to learn more... 👇
February 7, 2025 at 4:29 PM
Great new paper on spatiotemporal organization of cell division in zebrafish embryos. The mitotic waves preceding the ZGA are phase waves set by differences in N/C ratio, driven by geometry-induced asymmetric divisions. Important new insights and very interesting addition to the field.
What an awesome paper from Olga showing how in zebrafish the scaling of anaphase movements is controlled by cytoplasmic flows! Love to see a new role for cytoplasmic flows ;) and excited to learn that scaling of anaphase is controlled so differently in fly and fish embryos.
New paper alert! ‼️‼️
Super happy to share that my postdoc paper is finally out!
1/3 We looked at scaling of chromosome separation during anaphase in zebrafish embryos.
Super happy to share that my postdoc paper is finally out!
1/3 We looked at scaling of chromosome separation during anaphase in zebrafish embryos.
February 4, 2025 at 11:26 AM
What an awesome paper from Olga showing how in zebrafish the scaling of anaphase movements is controlled by cytoplasmic flows! Love to see a new role for cytoplasmic flows ;) and excited to learn that scaling of anaphase is controlled so differently in fly and fish embryos.
Very nice dispatch describing Yitong's paper from Akihiro Tanaka and Yuta Shimamoto.
www.cell.com/current-biol...
www.cell.com/current-biol...
Chromosome segregation: Scaling speed with time and space
Spatiotemporal control of subcellular events is crucial for embryogenesis. A new study
in fruit flies reports that the speed of chromosome segregation upon nuclear division
robustly scales with spindl...
www.cell.com
February 3, 2025 at 5:04 PM
Very nice dispatch describing Yitong's paper from Akihiro Tanaka and Yuta Shimamoto.
www.cell.com/current-biol...
www.cell.com/current-biol...
Ashley's postdoc work is now posted on bioRxiv.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration
Regeneration of an amputated salamander limb or fish fin restores pre-injury size and structure, illustrating the phenomenon of positional memory. Although appreciated for centuries, the identity of p...
www.biorxiv.org
January 27, 2025 at 3:23 PM
Ashley's postdoc work is now posted on bioRxiv.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Stefano Di Talia
📣 Excited to receive the 💥 NSF CAREER 💥 Award. Our group is looking for PhD students and postdocs interested in the Nonlinear Dynamics and the Physics of Living Systems, with support from NSF, HFSP, and other sources. We’d appreciate your help in spreading the word! @ucsdphysci.bsky.social
January 16, 2025 at 9:08 PM
📣 Excited to receive the 💥 NSF CAREER 💥 Award. Our group is looking for PhD students and postdocs interested in the Nonlinear Dynamics and the Physics of Living Systems, with support from NSF, HFSP, and other sources. We’d appreciate your help in spreading the word! @ucsdphysci.bsky.social
Reposted by Stefano Di Talia
Join us next week for another western/evening 🌙 session seminar! Our speakers will be:
Stefano Di Talia @ditalialab.bsky.social and
Chaitanya Dingare
🗓️ Thursday, January 23rd at
⏰ 09:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET
Stefano Di Talia @ditalialab.bsky.social and
Chaitanya Dingare
🗓️ Thursday, January 23rd at
⏰ 09:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET
January 15, 2025 at 3:47 PM
Join us next week for another western/evening 🌙 session seminar! Our speakers will be:
Stefano Di Talia @ditalialab.bsky.social and
Chaitanya Dingare
🗓️ Thursday, January 23rd at
⏰ 09:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET
Stefano Di Talia @ditalialab.bsky.social and
Chaitanya Dingare
🗓️ Thursday, January 23rd at
⏰ 09:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET
Reposted by Stefano Di Talia
How did microtubules adapt to support life across 🐸 species at divergent thermal niches?
Now online & OA @currentbiology.bsky.social
Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL 🙌
Enjoy reading! 👉 www.cell.com/current-biol...
Now online & OA @currentbiology.bsky.social
Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL 🙌
Enjoy reading! 👉 www.cell.com/current-biol...
Mechanistic basis of temperature adaptation in microtubule dynamics across frog species
Despite tubulin’s evolutionary conservation, microtubule dynamics are highly temperature sensitive. Troman et al. use natural tubulin variants from closely related Xenopus species to show that a decrease in tubulin’s apparent activation energy and weakening of lateral lattice contacts stabilize microtubules in cold-adapted frogs.
www.cell.com
January 10, 2025 at 4:40 PM
How did microtubules adapt to support life across 🐸 species at divergent thermal niches?
Now online & OA @currentbiology.bsky.social
Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL 🙌
Enjoy reading! 👉 www.cell.com/current-biol...
Now online & OA @currentbiology.bsky.social
Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL 🙌
Enjoy reading! 👉 www.cell.com/current-biol...