Scott Soderling
@scottsoderling.bsky.social
Neuroscientist-cell biologist, proteomics developer, deep learning collaborator, tackling brain disorders. PI @Duke. Chair of Cell Biology and Biochem. Founder, Triangle Protein Design.
http://soderlinglab.cellbio.duke.edu
http://soderlinglab.cellbio.duke.edu
Sounds very exciting
Congratulations to @swcanner.bsky.social for the successful defense of his thesis, “The Protein Sugar Interactome”! Leveraging deep learning and AI, he created tools and uncovered putative structural interactions underlying intercellular communication. He will receive his diploma in December.
November 3, 2025 at 3:43 PM
Sounds very exciting
Reposted by Scott Soderling
The published version of our study on the early-life transition from isolation USVs to adult-like USVs in juvenile mice is out in Animal Behaviour!
authors.elsevier.com/a/1m1YDmjMA4GP
bsky.app/profile/kati...
authors.elsevier.com/a/1m1YDmjMA4GP
bsky.app/profile/kati...
November 3, 2025 at 1:49 PM
The published version of our study on the early-life transition from isolation USVs to adult-like USVs in juvenile mice is out in Animal Behaviour!
authors.elsevier.com/a/1m1YDmjMA4GP
bsky.app/profile/kati...
authors.elsevier.com/a/1m1YDmjMA4GP
bsky.app/profile/kati...
Deadline for applications- November 1st!
Duke Cell Biology is hiring in AI/ML! @scottsoderling.bsky.social, @rohitsingh8080.bsky.social, and others are building a very active community around ML for discovery science, and Duke is a great place to be.
academicjobsonline.org/ajo/jobs/30509
academicjobsonline.org/ajo/jobs/30509
Duke University, Cell Biology/Duke University Medical Center
Job #AJO30509, 24903 Tenure - Track Assistant Professor Position - AI/ML for Biology, Cell Biology/Duke University Medical Center, Duke University, Durham, North Carolina, US
academicjobsonline.org
October 27, 2025 at 6:07 PM
Deadline for applications- November 1st!
Reposted by Scott Soderling
We are hiring!
Please repost!!:
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology - Durham, North Carolina (US) job with Duke University School of Medicine | 12844591
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology
www.nature.com
October 25, 2025 at 9:58 PM
We are hiring!
Please repost!!:
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology - Durham, North Carolina (US) job with Duke University School of Medicine | 12844591
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology
www.nature.com
October 25, 2025 at 3:11 PM
Please repost!!:
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
Reposted by Scott Soderling
I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...
October 10, 2025 at 10:28 PM
I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...
Cool new work- DynamicsPLM adds prot conformational dynamics to LMs: fuses seq with per-residue structure-token distributions from an ensemble (no averaging) → state-aware embeddings. Gains: +4% HumanPPI, +11% on multi-state proteins. Firing this up in the lab soon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
October 8, 2025 at 1:17 AM
Cool new work- DynamicsPLM adds prot conformational dynamics to LMs: fuses seq with per-residue structure-token distributions from an ensemble (no averaging) → state-aware embeddings. Gains: +4% HumanPPI, +11% on multi-state proteins. Firing this up in the lab soon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Scott Soderling
Duke Cell Biology is hiring in AI/ML! @scottsoderling.bsky.social, @rohitsingh8080.bsky.social, and others are building a very active community around ML for discovery science, and Duke is a great place to be.
academicjobsonline.org/ajo/jobs/30509
academicjobsonline.org/ajo/jobs/30509
Duke University, Cell Biology/Duke University Medical Center
Job #AJO30509, 24903 Tenure - Track Assistant Professor Position - AI/ML for Biology, Cell Biology/Duke University Medical Center, Duke University, Durham, North Carolina, US
academicjobsonline.org
September 7, 2025 at 5:24 PM
Duke Cell Biology is hiring in AI/ML! @scottsoderling.bsky.social, @rohitsingh8080.bsky.social, and others are building a very active community around ML for discovery science, and Duke is a great place to be.
academicjobsonline.org/ajo/jobs/30509
academicjobsonline.org/ajo/jobs/30509
Duke is recruiting a tenure-track Assistant Professor in AI/ML for Biology—joint Discovery AI Initiative × Cell Biology Search. Building models for protein design, single-cell/spatial omics, imaging, proteomics, genomics? Apply: academicjobsonline.org/ajo/jobs/30509
#hiring #AIforBio #CompBio
#hiring #AIforBio #CompBio
September 7, 2025 at 7:47 PM
Duke is recruiting a tenure-track Assistant Professor in AI/ML for Biology—joint Discovery AI Initiative × Cell Biology Search. Building models for protein design, single-cell/spatial omics, imaging, proteomics, genomics? Apply: academicjobsonline.org/ajo/jobs/30509
#hiring #AIforBio #CompBio
#hiring #AIforBio #CompBio
Reposted by Scott Soderling
Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below
Additional thread below
September 2, 2025 at 4:46 PM
Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below
Additional thread below
Reposted by Scott Soderling
Priyom's preprint is out on biorxiv. See below for a detailed thread. In a nutshell, she has discovered and characterized the oscillator that times notochord and spine segmentation in zebrafish. Turns out that there are uniform Erk oscillations across the entire tissue that act as timekeepers!
Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below
Additional thread below
September 2, 2025 at 5:34 PM
Priyom's preprint is out on biorxiv. See below for a detailed thread. In a nutshell, she has discovered and characterized the oscillator that times notochord and spine segmentation in zebrafish. Turns out that there are uniform Erk oscillations across the entire tissue that act as timekeepers!
Reposted by Scott Soderling
Duke researchers have uncovered a promising path to potentially treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA).
🔗: https://mgm.duke.edu/news/fundamental-cell-molecule-could-help-fight-rare-brain-disorders
#AcademicSky #MedSky
🔗: https://mgm.duke.edu/news/fundamental-cell-molecule-could-help-fight-rare-brain-disorders
#AcademicSky #MedSky
Fundamental Cell Molecule Could Help Fight Rare Brain Disorders | Duke Department of Molecular Genetics and Microbiology
Duke researchers may have found a path to treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA). People with NBIA have extra iron accumulation ...
mgm.duke.edu
August 20, 2025 at 4:07 PM
Duke researchers have uncovered a promising path to potentially treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA).
🔗: https://mgm.duke.edu/news/fundamental-cell-molecule-could-help-fight-rare-brain-disorders
#AcademicSky #MedSky
🔗: https://mgm.duke.edu/news/fundamental-cell-molecule-could-help-fight-rare-brain-disorders
#AcademicSky #MedSky
Another milestone for the amazing Munjal lab!
So happy for Kira! She also received NOA for her F32.
Congratulations to the @socdevbio.bsky.social 2025 West Coast Regional Meeting postdoc poster winners (left to right): 1st place- Celja Uebel (Villeneuve lab), 2nd place- Kira Heikes (Munjal lab), honorable mention- Hailey Edward's (Yelon lab)!
August 18, 2025 at 7:34 PM
Another milestone for the amazing Munjal lab!
Reposted by Scott Soderling
The order is the latest move by the Trump administration to assert control over US science
go.nature.com/3H6IxVr
go.nature.com/3H6IxVr
Trump order gives political appointees vast powers over research grants
Researchers are alarmed that the move might upend a long-standing tradition of peer-review for grants.
go.nature.com
August 11, 2025 at 2:18 PM
The order is the latest move by the Trump administration to assert control over US science
go.nature.com/3H6IxVr
go.nature.com/3H6IxVr
Reposted by Scott Soderling
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
August 10, 2025 at 1:19 PM
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
Great work from Huanghe Yang’s lab in Duke Biochemistry.
New research from Duke could transform how complications related to the placenta during pregnancy are detected and prevented.
This discovery may also lead to new insights into cancer, bone healing, and viral infections.
🔗 Read more: medschool.duke.edu/news/protein...
#AcademicSky #MedSky
This discovery may also lead to new insights into cancer, bone healing, and viral infections.
🔗 Read more: medschool.duke.edu/news/protein...
#AcademicSky #MedSky
The Protein That’s Crucial for a Healthy Pregnancy
Researchers have discovered for the first time that a particular protein plays a crucial role in the development of a normal placenta in the early stages of pregnancy. Learning more more about the pro...
medschool.duke.edu
August 7, 2025 at 12:39 PM
Great work from Huanghe Yang’s lab in Duke Biochemistry.
Congrats James! Loved hearing about this at an earlier CZI meeting!
⚡️Thrilled that #VirtualLab is published in @nature.com! www.nature.com/articles/s41...
We created a team of AI agents to mirror my Stanford lab 🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
We created a team of AI agents to mirror my Stanford lab 🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
July 29, 2025 at 7:29 PM
Congrats James! Loved hearing about this at an earlier CZI meeting!
I like o3 pro even better.
o3, an AI model developed by the creators of ChatGPT, has been ranked the best AI tool for answering science questions in multiple fields
go.nature.com/4lzaWlC
go.nature.com/4lzaWlC
OpenAI's o3 tops new AI league table for answering scientific questions
SciArena uses votes by researchers to evaluate large language models’ responses on technical topics.
go.nature.com
July 12, 2025 at 6:29 PM
I like o3 pro even better.
Reposted by Scott Soderling
Researchers are making ever more sophisticated mini organs in the lab — and now they can grow their own blood vessels
go.nature.com/4nNF3ri
go.nature.com/4nNF3ri
Mini hearts, lungs and livers made in lab now grow their own blood vessels
These sophisticated models will be used for human-development studies and drug testing.
go.nature.com
July 11, 2025 at 11:12 AM
Researchers are making ever more sophisticated mini organs in the lab — and now they can grow their own blood vessels
go.nature.com/4nNF3ri
go.nature.com/4nNF3ri
Reposted by Scott Soderling
The new Center of Excellence for Multiscale Immune Systems Modeling (MISM), launching soon by Duke University School of Medicine researchers, will transform how we understand and treat infectious and immune-related diseases.
#AcademicSky #MedSky
#AcademicSky #MedSky
A New Hub for Fighting Infectious Diseases with Smarter Models
Duke University School of Medicine researchers will launch a new national Center of Excellence for Multiscale Immune Systems Modeling (MISM), funded by a U54 grant from the National Institutes of Heal...
medschool.duke.edu
July 10, 2025 at 3:47 PM
The new Center of Excellence for Multiscale Immune Systems Modeling (MISM), launching soon by Duke University School of Medicine researchers, will transform how we understand and treat infectious and immune-related diseases.
#AcademicSky #MedSky
#AcademicSky #MedSky
Lab backpacking trip recently along the AT in NC. It's so nice to get away from it all, together.
July 4, 2025 at 7:12 PM
Lab backpacking trip recently along the AT in NC. It's so nice to get away from it all, together.
Reposted by Scott Soderling
In this essay in Hopkins Magazine, I talk about how NIH budget cuts will delay or stop the translation of basic science to the clinic and impact kids with intellectual disability, autism, and epilepsy. hub.jhu.edu/magazine/202...
Research funding cuts: What's at stake
Researchers like Richard Huganir are closing in on a cure for SYNGAP1-related disorders. But in the face of federal funding cuts, can they finish what they started?
hub.jhu.edu
June 30, 2025 at 6:13 PM
In this essay in Hopkins Magazine, I talk about how NIH budget cuts will delay or stop the translation of basic science to the clinic and impact kids with intellectual disability, autism, and epilepsy. hub.jhu.edu/magazine/202...
AI research in collaboration with cell biologists is transforming research at Duke. More discoveries coming soon!!
The AI tool Raygun (named as an homage to “Honey, I Shrunk the Kids”) is just one of several tools that a team led by Duke's Rohit Singh, PhD, has built to help scientists work both faster and smarter.
🔗 Read more: medschool.duke.edu/stories/hone...
#DukeB&B #DukeCellBiology #AcademicSky #MedSky
🔗 Read more: medschool.duke.edu/stories/hone...
#DukeB&B #DukeCellBiology #AcademicSky #MedSky
June 24, 2025 at 2:17 PM
AI research in collaboration with cell biologists is transforming research at Duke. More discoveries coming soon!!