Di Antonio Research Group
@diantoniogroup.bsky.social
We are a Chemical-Biology group investigating DNA structures and dynamics based at Imperial College Chemistry.
https://www.imperial.ac.uk/diantonio-research-group
https://www.imperial.ac.uk/diantonio-research-group
Reposted by Di Antonio Research Group
⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
December 22, 2025 at 3:48 PM
⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
Reposted by Di Antonio Research Group
🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/...
#NARBreakthrough #RibosomeBiogenesis
#NARBreakthrough #RibosomeBiogenesis
December 15, 2025 at 4:25 PM
🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/...
#NARBreakthrough #RibosomeBiogenesis
#NARBreakthrough #RibosomeBiogenesis
Reposted by Di Antonio Research Group
Impressive number of Lister community members in
@clarivate.com's Highly Cited Researchers 2025. Our first shoutout to current #ListerFellows
🥇 Marco di Antonio @diantoniogroup.bsky.social
🥇 Ravi Gupta
Congrats on your highly influential research 👏
clarivate.com/highly-cited...
@clarivate.com's Highly Cited Researchers 2025. Our first shoutout to current #ListerFellows
🥇 Marco di Antonio @diantoniogroup.bsky.social
🥇 Ravi Gupta
Congrats on your highly influential research 👏
clarivate.com/highly-cited...
November 24, 2025 at 9:01 AM
Impressive number of Lister community members in
@clarivate.com's Highly Cited Researchers 2025. Our first shoutout to current #ListerFellows
🥇 Marco di Antonio @diantoniogroup.bsky.social
🥇 Ravi Gupta
Congrats on your highly influential research 👏
clarivate.com/highly-cited...
@clarivate.com's Highly Cited Researchers 2025. Our first shoutout to current #ListerFellows
🥇 Marco di Antonio @diantoniogroup.bsky.social
🥇 Ravi Gupta
Congrats on your highly influential research 👏
clarivate.com/highly-cited...
Reposted by Di Antonio Research Group
📣 Announcement 📣
We are delighted to announce that the 2025 Supramolecular Chemistry Award 🏆 goes to Prof Dr Job Boekhoven from TU Munich.
Congratulations, Job! @boekhovenlab.bsky.social
Thanks @cellpress.bsky.social for generously sponsoring the award!
(1/3)
We are delighted to announce that the 2025 Supramolecular Chemistry Award 🏆 goes to Prof Dr Job Boekhoven from TU Munich.
Congratulations, Job! @boekhovenlab.bsky.social
Thanks @cellpress.bsky.social for generously sponsoring the award!
(1/3)
November 5, 2025 at 3:44 PM
📣 Announcement 📣
We are delighted to announce that the 2025 Supramolecular Chemistry Award 🏆 goes to Prof Dr Job Boekhoven from TU Munich.
Congratulations, Job! @boekhovenlab.bsky.social
Thanks @cellpress.bsky.social for generously sponsoring the award!
(1/3)
We are delighted to announce that the 2025 Supramolecular Chemistry Award 🏆 goes to Prof Dr Job Boekhoven from TU Munich.
Congratulations, Job! @boekhovenlab.bsky.social
Thanks @cellpress.bsky.social for generously sponsoring the award!
(1/3)
It was a pleasure @mcgalanlab.bsky.social and congratulations again to Nina for the lovely viva. Next time hopefully catch up in person!
Many congratulations to @NinaMaiAllen @BristolChem @BCS_CDT on passing her PhD viva today. Many thanks to Chris @Willis_Group and Marco @diantoniogroup.bsky.social for examining 🥳
November 11, 2025 at 1:48 PM
It was a pleasure @mcgalanlab.bsky.social and congratulations again to Nina for the lovely viva. Next time hopefully catch up in person!
Well done guys!
October 9, 2025 at 6:22 AM
Well done guys!
Reposted by Di Antonio Research Group
As promised, we run the town and gown 10k! In the photos are group members @rogerrubiosanchez.bsky.social Juliette Bucci, Brian Ng, Cathrine Fan, Sebastian Krauss and Lorenzo (the old one). Thanks to all who supported us with donations to @mdukcharity.bsky.social
October 8, 2025 at 8:06 PM
As promised, we run the town and gown 10k! In the photos are group members @rogerrubiosanchez.bsky.social Juliette Bucci, Brian Ng, Cathrine Fan, Sebastian Krauss and Lorenzo (the old one). Thanks to all who supported us with donations to @mdukcharity.bsky.social
Reposted by Di Antonio Research Group
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre
The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…
www.jic.ac.uk
October 3, 2025 at 4:06 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Reposted by Di Antonio Research Group
With motor neurone disease (MND, aka ALS) hitting the headlines, here's a story about how two #ListerFellows @patanilab.bsky.social and @diantoniogroup.bsky.social teamed up to investigate how RNA might start aggregations and trigger disease.
lister-institute.org.uk/two-lister-f...
lister-institute.org.uk/two-lister-f...
October 7, 2025 at 8:26 AM
With motor neurone disease (MND, aka ALS) hitting the headlines, here's a story about how two #ListerFellows @patanilab.bsky.social and @diantoniogroup.bsky.social teamed up to investigate how RNA might start aggregations and trigger disease.
lister-institute.org.uk/two-lister-f...
lister-institute.org.uk/two-lister-f...
Reposted by Di Antonio Research Group
Hey! Some group members and I are running a 10k race in Cambridge this Sunday, and raining some funds for @mdukcharity.bsky.social
Please donate and share!
@ceb.cam.ac.uk @pembroke1347.bsky.social
sportsgiving.co.uk/sponsorship/...
Please donate and share!
@ceb.cam.ac.uk @pembroke1347.bsky.social
sportsgiving.co.uk/sponsorship/...
SportsGiving - Entry: Lorenzo Di Michele
Lorenzo Di Michele is fundraising for charity. Visit their fundraising page to sponsor them online now!
sportsgiving.co.uk
September 29, 2025 at 5:02 PM
Hey! Some group members and I are running a 10k race in Cambridge this Sunday, and raining some funds for @mdukcharity.bsky.social
Please donate and share!
@ceb.cam.ac.uk @pembroke1347.bsky.social
sportsgiving.co.uk/sponsorship/...
Please donate and share!
@ceb.cam.ac.uk @pembroke1347.bsky.social
sportsgiving.co.uk/sponsorship/...
Have fun guys and leave nothing behind! push push push!
September 30, 2025 at 8:14 AM
Have fun guys and leave nothing behind! push push push!
We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 4:51 PM
We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Reposted by Di Antonio Research Group
John Iredale kicking off our annual meeting. Auditorium is packed 😀 Record attendance!
September 11, 2025 at 2:42 PM
John Iredale kicking off our annual meeting. Auditorium is packed 😀 Record attendance!
Reposted by Di Antonio Research Group
Thank you @beckyneuro.bsky.social @therad-lab.bsky.social and @thav-lab.bsky.social for kicking off our annual meeting with such inspiring insights from your research. Impressive examples of career-long commitment to a cause, opportunistic curiosity and always aspiration for clinical application 👏
September 12, 2025 at 8:02 AM
Thank you @beckyneuro.bsky.social @therad-lab.bsky.social and @thav-lab.bsky.social for kicking off our annual meeting with such inspiring insights from your research. Impressive examples of career-long commitment to a cause, opportunistic curiosity and always aspiration for clinical application 👏
Reposted by Di Antonio Research Group
Marco Di Antonio - his fantastic science is always challenging dogma, but first a bit about Italy ❤️ 🤌🤌🤌
@diantoniogroup.bsky.social
@diantoniogroup.bsky.social
September 6, 2025 at 11:49 AM
Marco Di Antonio - his fantastic science is always challenging dogma, but first a bit about Italy ❤️ 🤌🤌🤌
@diantoniogroup.bsky.social
@diantoniogroup.bsky.social
I would say that the expert on intrinsically toxic sequences is @costerlab.bsky.social
September 2, 2025 at 8:35 AM
I would say that the expert on intrinsically toxic sequences is @costerlab.bsky.social
One of which is the HoD :)
August 11, 2025 at 10:30 AM
One of which is the HoD :)
Reposted by Di Antonio Research Group
Proud to share our latest research in #NatureCommunication on #Gquadruplexes in #M_Tuberculosis as a new defense mechanism against oxidation
🔗https://www.nature.com/articles/s41467-025-62485-4
🧬🦠All-female collaboration from #DMM_Unipd
#SaraNRichter_ @irenezanin.bsky.social
#Tuberculosis
🔗https://www.nature.com/articles/s41467-025-62485-4
🧬🦠All-female collaboration from #DMM_Unipd
#SaraNRichter_ @irenezanin.bsky.social
#Tuberculosis
CUT&Tag reveals unconventional G-quadruplex landscape in Mycobacterium tuberculosis in response to oxidative stress - Nature Communications
In this study, the authors demonstrate that cleavage under targets and tagmentation (CUT&Tag) can be employed to map G-quadruplexes (G4s) in Mycobacterium tuberculosis, which may serve as pot...
www.nature.com
August 8, 2025 at 10:34 AM
Proud to share our latest research in #NatureCommunication on #Gquadruplexes in #M_Tuberculosis as a new defense mechanism against oxidation
🔗https://www.nature.com/articles/s41467-025-62485-4
🧬🦠All-female collaboration from #DMM_Unipd
#SaraNRichter_ @irenezanin.bsky.social
#Tuberculosis
🔗https://www.nature.com/articles/s41467-025-62485-4
🧬🦠All-female collaboration from #DMM_Unipd
#SaraNRichter_ @irenezanin.bsky.social
#Tuberculosis
Reposted by Di Antonio Research Group
Please share - this year's #ListerPrize is open for applications for another month!
🔎 Read about what winning it mean to some of our former Fellows like Dr Stineke Van Houte here: lister-institute.org.uk/what-it-mean...
🙋 Find out more about how to apply: lister-institute.org.uk/how-to-apply/
🔎 Read about what winning it mean to some of our former Fellows like Dr Stineke Van Houte here: lister-institute.org.uk/what-it-mean...
🙋 Find out more about how to apply: lister-institute.org.uk/how-to-apply/
July 30, 2025 at 12:14 PM
Please share - this year's #ListerPrize is open for applications for another month!
🔎 Read about what winning it mean to some of our former Fellows like Dr Stineke Van Houte here: lister-institute.org.uk/what-it-mean...
🙋 Find out more about how to apply: lister-institute.org.uk/how-to-apply/
🔎 Read about what winning it mean to some of our former Fellows like Dr Stineke Van Houte here: lister-institute.org.uk/what-it-mean...
🙋 Find out more about how to apply: lister-institute.org.uk/how-to-apply/
Reposted by Di Antonio Research Group
⭐NAR Breakthrough!⭐
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.
tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa
Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di
doi.org
July 28, 2025 at 8:12 AM
⭐NAR Breakthrough!⭐
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.
Reposted by Di Antonio Research Group
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 9:10 AM
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Happy to share our latest preprint describing the first genome-wide mapping of G4s in T.Brucei, led by the amazing Ludovica Monti. We found that G4s accumulate in coding regions of the parasite, causing transcriptional perturbation upon treatment with G4-ligands.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions
G-quadruplexes (G4s) are non-canonical DNA structures formed in guanine-rich sequences that are proposed to act as regulatory elements in trypanosomatid parasites, including Trypanosoma brucei, the ca...
www.biorxiv.org
July 24, 2025 at 6:57 AM
Happy to share our latest preprint describing the first genome-wide mapping of G4s in T.Brucei, led by the amazing Ludovica Monti. We found that G4s accumulate in coding regions of the parasite, causing transcriptional perturbation upon treatment with G4-ligands.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Di Antonio Research Group
BBC News - Babies made using three people's DNA are born free of hereditary disease
www.bbc.com/news/article...
www.bbc.com/news/article...
Babies from three people's DNA prevents heriditary disease
The method was pioneered by UK scientists to overcome devastating, sometimes fatal inherited diseases.
www.bbc.com
July 16, 2025 at 10:38 PM
BBC News - Babies made using three people's DNA are born free of hereditary disease
www.bbc.com/news/article...
www.bbc.com/news/article...
Reposted by Di Antonio Research Group
Congratulations to all the prize winners from the Nucleic Acids Forum 2025! An amazing selection of talks and posters to choose from! Thank you to our prize sponsors Chemgenes and RSC Chemical Biology!
@rscchembio.rsc.org
@mikeboothlab.bsky.social
@rscchembio.rsc.org
@mikeboothlab.bsky.social
July 16, 2025 at 11:00 AM
Congratulations to all the prize winners from the Nucleic Acids Forum 2025! An amazing selection of talks and posters to choose from! Thank you to our prize sponsors Chemgenes and RSC Chemical Biology!
@rscchembio.rsc.org
@mikeboothlab.bsky.social
@rscchembio.rsc.org
@mikeboothlab.bsky.social
Reposted by Di Antonio Research Group
📣NAR Breakthrough Article!📣
✂️ Removal of a single tRNA^Gly gene copy in Staphylococcus aureus via CRISPR weakens the cell wall, biofilm formation and increases antibiotic susceptibility💊
📖 doi.org/10.1093/nar/...
#Microbiology #CRISPR #tRNA #AntibioticResearch #BacterialGenetics
✂️ Removal of a single tRNA^Gly gene copy in Staphylococcus aureus via CRISPR weakens the cell wall, biofilm formation and increases antibiotic susceptibility💊
📖 doi.org/10.1093/nar/...
#Microbiology #CRISPR #tRNA #AntibioticResearch #BacterialGenetics
July 14, 2025 at 3:47 PM
📣NAR Breakthrough Article!📣
✂️ Removal of a single tRNA^Gly gene copy in Staphylococcus aureus via CRISPR weakens the cell wall, biofilm formation and increases antibiotic susceptibility💊
📖 doi.org/10.1093/nar/...
#Microbiology #CRISPR #tRNA #AntibioticResearch #BacterialGenetics
✂️ Removal of a single tRNA^Gly gene copy in Staphylococcus aureus via CRISPR weakens the cell wall, biofilm formation and increases antibiotic susceptibility💊
📖 doi.org/10.1093/nar/...
#Microbiology #CRISPR #tRNA #AntibioticResearch #BacterialGenetics