Prof. Zoë Waller
@drzoewaller.bsky.social
Professor in Drug Discovery at UCL School of Pharmacy. Mum of 3. Researching. Lecturing. Chemistry. Pharmacy. DNA. RNA. i-Motif. G-Quadruplex. Cycling. Commuting. Legs. Shoes.
New paper out!
i-Motif, not G-quadruplex, stability regulates insulin expression - published in @narjournal.bsky.social
Team effort driven by Dr Dilek Guneri supported by Dr Chris Morris, @timcraggs.bsky.social, @yiliangding.bsky.social and Prof Steve Smith
academic.oup.com/nar/article/...
i-Motif, not G-quadruplex, stability regulates insulin expression - published in @narjournal.bsky.social
Team effort driven by Dr Dilek Guneri supported by Dr Chris Morris, @timcraggs.bsky.social, @yiliangding.bsky.social and Prof Steve Smith
academic.oup.com/nar/article/...
Validate User
academic.oup.com
February 3, 2026 at 12:48 PM
New paper out!
i-Motif, not G-quadruplex, stability regulates insulin expression - published in @narjournal.bsky.social
Team effort driven by Dr Dilek Guneri supported by Dr Chris Morris, @timcraggs.bsky.social, @yiliangding.bsky.social and Prof Steve Smith
academic.oup.com/nar/article/...
i-Motif, not G-quadruplex, stability regulates insulin expression - published in @narjournal.bsky.social
Team effort driven by Dr Dilek Guneri supported by Dr Chris Morris, @timcraggs.bsky.social, @yiliangding.bsky.social and Prof Steve Smith
academic.oup.com/nar/article/...
Congratulations to Rob Yuan for passing his PhD viva! Many thanks to @hannongroup.bsky.social and David Shorthouse for examining!
January 23, 2026 at 10:57 AM
Congratulations to Rob Yuan for passing his PhD viva! Many thanks to @hannongroup.bsky.social and David Shorthouse for examining!
UCL School of Pharmacy Festive Window Competition
All entries can be viewed in this video:
vm.tiktok.com/ZNR2uARKY/
@ucllifesciences.bsky.social
All entries can be viewed in this video:
vm.tiktok.com/ZNR2uARKY/
@ucllifesciences.bsky.social
TikTok - Make Your Day
vm.tiktok.com
December 21, 2025 at 10:13 PM
UCL School of Pharmacy Festive Window Competition
All entries can be viewed in this video:
vm.tiktok.com/ZNR2uARKY/
@ucllifesciences.bsky.social
All entries can be viewed in this video:
vm.tiktok.com/ZNR2uARKY/
@ucllifesciences.bsky.social
Really great to attend the Faculty staff awards, organised by Steve Bunting. Loved the attention to detail in the hosting, kind jokes and the awards themselves, which Steve made himself!
School of Pharmacy did well in the awards, many congratulations to my colleagues @ucllifesciences.bsky.social
School of Pharmacy did well in the awards, many congratulations to my colleagues @ucllifesciences.bsky.social
December 20, 2025 at 8:58 AM
Really great to attend the Faculty staff awards, organised by Steve Bunting. Loved the attention to detail in the hosting, kind jokes and the awards themselves, which Steve made himself!
School of Pharmacy did well in the awards, many congratulations to my colleagues @ucllifesciences.bsky.social
School of Pharmacy did well in the awards, many congratulations to my colleagues @ucllifesciences.bsky.social
Cell organelles have different pHs- shown clearly in this preprint. Check out the very clear thread here for a summary ❤️
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 9:43 AM
Cell organelles have different pHs- shown clearly in this preprint. Check out the very clear thread here for a summary ❤️
Reposted by Prof. Zoë Waller
Mind blowing new preprint and Bluetorial by @krishnanyamuna.bsky.social! Shows how much we have yet to learn about cellular chemistry, the curtains get pulled back more and more with each new technology her lab invents! 👏 👏
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 3:38 AM
Mind blowing new preprint and Bluetorial by @krishnanyamuna.bsky.social! Shows how much we have yet to learn about cellular chemistry, the curtains get pulled back more and more with each new technology her lab invents! 👏 👏
Reposted by Prof. Zoë Waller
Super, super cool research design and findings! 👏👏👏
Another amazing paper with awesome tech.
Kudos to Yamuna and team. Such an easy read too. ⚡️⭐️
Another amazing paper with awesome tech.
Kudos to Yamuna and team. Such an easy read too. ⚡️⭐️
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 2:20 AM
Super, super cool research design and findings! 👏👏👏
Another amazing paper with awesome tech.
Kudos to Yamuna and team. Such an easy read too. ⚡️⭐️
Another amazing paper with awesome tech.
Kudos to Yamuna and team. Such an easy read too. ⚡️⭐️
Reposted by Prof. Zoë Waller
A continuing regress of complexity. I love it.
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 2:16 AM
A continuing regress of complexity. I love it.
Reposted by Prof. Zoë Waller
Amazing work by @krishnanyamuna.bsky.social and team. Great thread with pics.
🤯 a paper that will change how you think about cells - there are long-lived chemical microdomains within organelles!
🤯 a paper that will change how you think about cells - there are long-lived chemical microdomains within organelles!
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 1:05 AM
Amazing work by @krishnanyamuna.bsky.social and team. Great thread with pics.
🤯 a paper that will change how you think about cells - there are long-lived chemical microdomains within organelles!
🤯 a paper that will change how you think about cells - there are long-lived chemical microdomains within organelles!
Having a 4 hour delay on the train today has expedited writing a paper
a man sitting on a couch with the words swings ' n roundabouts innit written above him
Alt: a man sitting on a couch with the words swings ' n roundabouts innit written above him
media.tenor.com
December 17, 2025 at 2:24 AM
Having a 4 hour delay on the train today has expedited writing a paper
Reposted by Prof. Zoë Waller
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 12:46 AM
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
YES
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 2:22 AM
YES
We are recruiting! PDRA to work on a BBSRC funded position with Prof. Yiliang Ding and Dr. Tim Craggs. We are looking for someone with experience with cell culture and gene expression analysis - Please do share. Happy to answer any questions. Details below:
www.ucl.ac.uk/work-at-ucl/...
www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
December 16, 2025 at 11:49 AM
We are recruiting! PDRA to work on a BBSRC funded position with Prof. Yiliang Ding and Dr. Tim Craggs. We are looking for someone with experience with cell culture and gene expression analysis - Please do share. Happy to answer any questions. Details below:
www.ucl.ac.uk/work-at-ucl/...
www.ucl.ac.uk/work-at-ucl/...
Pretty but worrying... Daffodils in December
December 15, 2025 at 6:40 PM
Pretty but worrying... Daffodils in December
Papers papers papers papers papers papers papers papers
papers papers papers
SI
SI
papers papers papers
SI
SI
December 6, 2025 at 11:49 PM
Papers papers papers papers papers papers papers papers
papers papers papers
SI
SI
papers papers papers
SI
SI
The inevitable outcome of playing "What do you Meme?" with your research group
December 3, 2025 at 7:46 PM
The inevitable outcome of playing "What do you Meme?" with your research group
It was a pleasure to examine Bella! Really interesting work. Congratulations 🎊
Many congratulations to Bella Law from @Spencer_D60 jointly with our group @BristolChem on passing her MRes Viva today 🥳. Many thanks to @drzoewaller.bsky.social and Angela Nobbs for examining. Wish I could have been there in person to celebrate with you. 🍾
November 24, 2025 at 6:07 PM
It was a pleasure to examine Bella! Really interesting work. Congratulations 🎊
White coat ceremony for UCL School of Pharmacy underway @ucllifesciences.bsky.social
November 19, 2025 at 3:31 PM
White coat ceremony for UCL School of Pharmacy underway @ucllifesciences.bsky.social
So wonderful to finally meet Prof Angela Russell today - and see her final stop on her RSC Jeremy Knowles Prize tour. Absolutely inspirational talk about her experiences in the drug development process. Grateful for her insights and advice.
November 19, 2025 at 3:23 PM
So wonderful to finally meet Prof Angela Russell today - and see her final stop on her RSC Jeremy Knowles Prize tour. Absolutely inspirational talk about her experiences in the drug development process. Grateful for her insights and advice.
Congratulations to all the prize winners 🏆 👏
Join us for a celebration of this year’s Education Prizes winners!
We are honouring inspirational, innovative and dedicated people working in primary, secondary, further and higher education. Follow the thread and learn about all 12 winners of our #RSCPrizes as we congratulate… #ChemSky
We are honouring inspirational, innovative and dedicated people working in primary, secondary, further and higher education. Follow the thread and learn about all 12 winners of our #RSCPrizes as we congratulate… #ChemSky
November 19, 2025 at 8:25 AM
Congratulations to all the prize winners 🏆 👏
Reposted by Prof. Zoë Waller
#Gquadruplexes can form within fungal pathogens and represent new #antifungal targets ➡️ doi.org/10.1038/s443...
By G. Middleton, F. Mahamud, I. Storer, Z. Waller, S. Bidula & colleagues at @ucl.ac.uk & @uniofeastanglia.bsky.social
By G. Middleton, F. Mahamud, I. Storer, Z. Waller, S. Bidula & colleagues at @ucl.ac.uk & @uniofeastanglia.bsky.social
November 17, 2025 at 4:43 PM
#Gquadruplexes can form within fungal pathogens and represent new #antifungal targets ➡️ doi.org/10.1038/s443...
By G. Middleton, F. Mahamud, I. Storer, Z. Waller, S. Bidula & colleagues at @ucl.ac.uk & @uniofeastanglia.bsky.social
By G. Middleton, F. Mahamud, I. Storer, Z. Waller, S. Bidula & colleagues at @ucl.ac.uk & @uniofeastanglia.bsky.social
New paper!
Evidence that G-quadruplexes form in pathogenic fungi and represent promising antifungal targets
@ucllifesciences.bsky.social
| EMBO Molecular Medicine
www.embopress.org/doi/full/10....
Evidence that G-quadruplexes form in pathogenic fungi and represent promising antifungal targets
@ucllifesciences.bsky.social
| EMBO Molecular Medicine
www.embopress.org/doi/full/10....
Evidence that G-quadruplexes form in pathogenic fungi and represent promising antifungal targets | EMBO Molecular Medicine
imageimageIn this study, we show that G-quadruplexes can form within fungal pathogens and represent
new antifungal targets. PhenDC3 and/or pyridostatin are antifungal against Aspergillus fumigatus, C...
www.embopress.org
November 17, 2025 at 8:55 PM
New paper!
Evidence that G-quadruplexes form in pathogenic fungi and represent promising antifungal targets
@ucllifesciences.bsky.social
| EMBO Molecular Medicine
www.embopress.org/doi/full/10....
Evidence that G-quadruplexes form in pathogenic fungi and represent promising antifungal targets
@ucllifesciences.bsky.social
| EMBO Molecular Medicine
www.embopress.org/doi/full/10....
Dr Chris Morris and I have a new paper in Nucleic Acids Research.
This paper has been a long time in the making & was affected by COVID so we are proud to have it published!
@shozebhaider.bsky.social
@effrosynialexandr.bsky.social
@chriswaudby.bsky.social
academic.oup.com/nar/article/...
This paper has been a long time in the making & was affected by COVID so we are proud to have it published!
@shozebhaider.bsky.social
@effrosynialexandr.bsky.social
@chriswaudby.bsky.social
academic.oup.com/nar/article/...
Affinity-selected peptide ligands specifically bind i-motif DNA and modulate c-Myc gene expression
Abstract. c-Myc is an oncogene that is dysregulated in ∼70% of cancers. Its multifaceted function complicates effective drug targeting of the protein. i-Mo
academic.oup.com
November 7, 2025 at 4:34 PM
Dr Chris Morris and I have a new paper in Nucleic Acids Research.
This paper has been a long time in the making & was affected by COVID so we are proud to have it published!
@shozebhaider.bsky.social
@effrosynialexandr.bsky.social
@chriswaudby.bsky.social
academic.oup.com/nar/article/...
This paper has been a long time in the making & was affected by COVID so we are proud to have it published!
@shozebhaider.bsky.social
@effrosynialexandr.bsky.social
@chriswaudby.bsky.social
academic.oup.com/nar/article/...
Congratulations to Yaxuan for passing your upgrade viva - many thanks to @cjserpell.bsky.social and Chris Morris for examining
November 6, 2025 at 8:06 PM
Congratulations to Yaxuan for passing your upgrade viva - many thanks to @cjserpell.bsky.social and Chris Morris for examining
In my sadness that Irregular Choice is going out of business I'm making more effort to wear my collection - today are black flats with Queen and Corgi #irregularchoice
October 17, 2025 at 9:25 AM
In my sadness that Irregular Choice is going out of business I'm making more effort to wear my collection - today are black flats with Queen and Corgi #irregularchoice