dennis hernaus
@dhernaus.bsky.social
Associate prof @ Maastricht University. Neuroscience, drums & hardcore punk.
Reposted by dennis hernaus
𝗳𝗠𝗥𝗜 (𝗕𝗢𝗟𝗗) 𝘁𝗿𝗼𝘂𝗯𝗹𝗲𝘀 𝗮𝗴𝗮𝗶𝗻?
Something that everyone using fMRI will be hoping is not very solid, please please...
Please BOLD don't go down if oxygen metabolism (neurons?) goes up...
And it had to affect "default" regions???
doi.org/10.1038/s415...
#neuroskyence
Something that everyone using fMRI will be hoping is not very solid, please please...
Please BOLD don't go down if oxygen metabolism (neurons?) goes up...
And it had to affect "default" regions???
doi.org/10.1038/s415...
#neuroskyence
December 22, 2025 at 6:19 PM
𝗳𝗠𝗥𝗜 (𝗕𝗢𝗟𝗗) 𝘁𝗿𝗼𝘂𝗯𝗹𝗲𝘀 𝗮𝗴𝗮𝗶𝗻?
Something that everyone using fMRI will be hoping is not very solid, please please...
Please BOLD don't go down if oxygen metabolism (neurons?) goes up...
And it had to affect "default" regions???
doi.org/10.1038/s415...
#neuroskyence
Something that everyone using fMRI will be hoping is not very solid, please please...
Please BOLD don't go down if oxygen metabolism (neurons?) goes up...
And it had to affect "default" regions???
doi.org/10.1038/s415...
#neuroskyence
Reposted by dennis hernaus
This is an important study but psilocybin potentially promoting brain tumor growth is consistent with human studies suggesting SSRIs may worsen survival outcomes in glioma
🐁 Very concerning finding: Psilocybin promotes brain tumour growth
Authors caution against use of 5-HT2A agonists like psilocybin in patients with glioma, "given the profound and sustained tumor growth-promoting effects observed."
Extends to other serotonergic drugs like LSD.
Authors caution against use of 5-HT2A agonists like psilocybin in patients with glioma, "given the profound and sustained tumor growth-promoting effects observed."
Extends to other serotonergic drugs like LSD.
December 16, 2025 at 3:54 AM
This is an important study but psilocybin potentially promoting brain tumor growth is consistent with human studies suggesting SSRIs may worsen survival outcomes in glioma
Reposted by dennis hernaus
You will find this paper interesting and relevant too:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Misinterpreting the horseshoe effect in neuroscience
Dimensionality reduction methods are frequently used to analyze high-dimensional activity of cortical neuron populations during behavior. The resulting oscillatory trajectories that consistently emerg...
www.biorxiv.org
November 2, 2025 at 10:14 AM
You will find this paper interesting and relevant too:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by dennis hernaus
New ENIGMA-CHR study examining network topology differences in 1282 controls and 1582 individuals with clinical high risk for psychosis, led by Drs Siwei Liu, Helen Juan Zhou, Jimmy Lee with @dhernaus.bsky.social, Maria Jalbrzikowski and colleagues. Link to article: www.nature.com/articles/s41...
Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study - Molecular Psychiatry
Molecular Psychiatry - Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study
www.nature.com
October 23, 2025 at 6:44 PM
New ENIGMA-CHR study examining network topology differences in 1282 controls and 1582 individuals with clinical high risk for psychosis, led by Drs Siwei Liu, Helen Juan Zhou, Jimmy Lee with @dhernaus.bsky.social, Maria Jalbrzikowski and colleagues. Link to article: www.nature.com/articles/s41...
Reposted by dennis hernaus
A new take on the limitations of "psychometric networks" now out in Nature Human Behavior. You don't want to put too much confidence in individual edges. Something we cautioned against in 2017.
1/2
www.nature.com/articles/s41...
1/2
www.nature.com/articles/s41...
Statistical evidence in psychological networks - Nature Human Behaviour
Psychometric network models have become increasingly popular in psychology and the social sciences. Huth et al. show that a large proportion of reported network findings are based on weak or inconclusive evidence inviting caution when interpreting results.
www.nature.com
October 12, 2025 at 11:08 AM
A new take on the limitations of "psychometric networks" now out in Nature Human Behavior. You don't want to put too much confidence in individual edges. Something we cautioned against in 2017.
1/2
www.nature.com/articles/s41...
1/2
www.nature.com/articles/s41...
Reposted by dennis hernaus
Published now (after long last & 10 citations). Although tVNS does not alter food reward ratings in healthy people, it acutely improved liking ratings in patients with MDD (also correlated with anhedonia). #neuroskyence 🩺
Work w/ @akuehnel.bsky.social
www.sciencedirect.com/science/arti...
Work w/ @akuehnel.bsky.social
www.sciencedirect.com/science/arti...
October 11, 2025 at 11:40 AM
Published now (after long last & 10 citations). Although tVNS does not alter food reward ratings in healthy people, it acutely improved liking ratings in patients with MDD (also correlated with anhedonia). #neuroskyence 🩺
Work w/ @akuehnel.bsky.social
www.sciencedirect.com/science/arti...
Work w/ @akuehnel.bsky.social
www.sciencedirect.com/science/arti...
Reposted by dennis hernaus
With over 7000 participants @ecnp.eu annual meeting in Amsterdam is kicked off by President @martienkas.bsky.social - Congrats to program chair Barbara Franke on an excellent program starting with an impactful keynote from Eveline Crone on the mysterious adolescent brain. #ecnp2025
October 11, 2025 at 1:43 PM
With over 7000 participants @ecnp.eu annual meeting in Amsterdam is kicked off by President @martienkas.bsky.social - Congrats to program chair Barbara Franke on an excellent program starting with an impactful keynote from Eveline Crone on the mysterious adolescent brain. #ecnp2025
Reposted by dennis hernaus
This one looks intriguing. Arousal "embedding" whole-brain dynamics. 🤯
#neuroskyence #compneurosky
doi.org/10.1038/s415...
#neuroskyence #compneurosky
doi.org/10.1038/s415...
Arousal as a universal embedding for spatiotemporal brain dynamics - Nature
Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.
doi.org
September 25, 2025 at 6:03 AM
This one looks intriguing. Arousal "embedding" whole-brain dynamics. 🤯
#neuroskyence #compneurosky
doi.org/10.1038/s415...
#neuroskyence #compneurosky
doi.org/10.1038/s415...
Reposted by dennis hernaus
'Memento', but it's every plot you make in R
September 16, 2025 at 6:47 PM
'Memento', but it's every plot you make in R
Reposted by dennis hernaus
somehow I missed this!
Dopamine represents a domain-general teaching signal:
www.science.org/doi/full/10....
Dopamine represents a domain-general teaching signal:
www.science.org/doi/full/10....
Striatal dopamine signals errors in prediction across different informational domains
Dopamine reflects prediction errors not only about reward but also about valueless stimuli, challenging many current theories.
www.science.org
September 16, 2025 at 7:44 PM
somehow I missed this!
Dopamine represents a domain-general teaching signal:
www.science.org/doi/full/10....
Dopamine represents a domain-general teaching signal:
www.science.org/doi/full/10....
Reposted by dennis hernaus
Lab’s latest is out in Imaging Neuroscience, led by Kirsten Peterson: “Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding”, where we demonstrate a major improvement to standard fMRI functional connectivity (correlation) 1/n
September 14, 2025 at 9:34 PM
Lab’s latest is out in Imaging Neuroscience, led by Kirsten Peterson: “Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding”, where we demonstrate a major improvement to standard fMRI functional connectivity (correlation) 1/n
Reposted by dennis hernaus
New preprint...and this one is truly EPIC 🚨.
Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
August 30, 2025 at 8:30 AM
New preprint...and this one is truly EPIC 🚨.
Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
Reposted by dennis hernaus
Discovery of a brain center (BNST) that controls consumption (including sweets, fats, salt and other foods) in mice
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A brain center that controls consummatory responses
The BNST brain region integrates a broad range of external and internal signals to
flexibly regulate consumption, revealing a unified control over consummatory responses.
www.cell.com
September 10, 2025 at 2:56 PM
Discovery of a brain center (BNST) that controls consumption (including sweets, fats, salt and other foods) in mice
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by dennis hernaus
This was a fun piece to write
SPM as a cornerstone of an open source software ecosystem for neuroimaging
Abstract. The SPM software package played a major role in the establishment of open source software practices within the field of neuroimaging. I outline i
track.smtpsendmail.com
September 10, 2025 at 4:37 PM
This was a fun piece to write
In our new paper 📖🔥, we conducted a pooled analysis (n=443; 5 studies) to test if state affect (momentary mood) or trait dispositions (approach/avoidance) predict cortisol reactivity beyond biological & contextual factors. (1/4)
#neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
#neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
Unpacking cortisol stress reactivity: Associations with psychological state and trait data in a pooled data sample
Prior research suggests that cortisol responses to acute stress induction paradigms (i.e., “cortisol stress reactivity”) likely arise from complex int…
www.sciencedirect.com
September 10, 2025 at 10:57 AM
In our new paper 📖🔥, we conducted a pooled analysis (n=443; 5 studies) to test if state affect (momentary mood) or trait dispositions (approach/avoidance) predict cortisol reactivity beyond biological & contextual factors. (1/4)
#neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
#neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
Reposted by dennis hernaus
Hello hivemind! I haven't seen one of these in a while but I know that back-in-the-day they were all the rage: does anyone have a funky spreadsheet of MH/psych/neuro-relevant grants/fellowships for ECRs that they wouldn't mind me sharing with my lab?
a donkey is standing on a dirt field and asking for something .
ALT: a donkey is standing on a dirt field and asking for something .
media.tenor.com
September 4, 2025 at 2:39 PM
Hello hivemind! I haven't seen one of these in a while but I know that back-in-the-day they were all the rage: does anyone have a funky spreadsheet of MH/psych/neuro-relevant grants/fellowships for ECRs that they wouldn't mind me sharing with my lab?
Reposted by dennis hernaus
check out Jake Russin's new paper on how the interplay between in-context and in-weight learning in neural nets can explain tradeoffs in human learning!
pnas.org/doi/epdf/10....
pnas.org/doi/epdf/10....
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
September 4, 2025 at 2:42 PM
check out Jake Russin's new paper on how the interplay between in-context and in-weight learning in neural nets can explain tradeoffs in human learning!
pnas.org/doi/epdf/10....
pnas.org/doi/epdf/10....
Reposted by dennis hernaus
My latest: a short review on latent variable models to help uncover trial-to-trial structure in perceptual decision-making strategies
authors.elsevier.com/a/1lMiv4sIRv...
authors.elsevier.com/a/1lMiv4sIRv...
July 4, 2025 at 2:08 PM
My latest: a short review on latent variable models to help uncover trial-to-trial structure in perceptual decision-making strategies
authors.elsevier.com/a/1lMiv4sIRv...
authors.elsevier.com/a/1lMiv4sIRv...
Reposted by dennis hernaus
I am delighted to announce registration and abstract submission is open for "The Mechanistic Basis of Foraging 2025" to be held at the Edgbaston Park Hotel, University of Birmingham, UK on 3-5th November 2025. uobevents.eventsair.com/the-mechanis...
Homepage - The Mechanistic Basis of Foraging
uobevents.eventsair.com
July 4, 2025 at 8:50 AM
I am delighted to announce registration and abstract submission is open for "The Mechanistic Basis of Foraging 2025" to be held at the Edgbaston Park Hotel, University of Birmingham, UK on 3-5th November 2025. uobevents.eventsair.com/the-mechanis...
Reposted by dennis hernaus
Alert!!!!
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
June 26, 2025 at 1:29 PM
Alert!!!!
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
Reposted by dennis hernaus
Our big behavioral precision mapping preprint is out. Based on 1,486,950 observed choices in a reward learning task, we show that BMI is associated with higher and more variable learning rates. Binge eating was associated with lower reward sensitivity. #neuroskyence 🩺
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
June 21, 2025 at 7:33 AM
Our big behavioral precision mapping preprint is out. Based on 1,486,950 observed choices in a reward learning task, we show that BMI is associated with higher and more variable learning rates. Binge eating was associated with lower reward sensitivity. #neuroskyence 🩺
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by dennis hernaus
An Analysis of 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure-function coupling and behavior prediction highlights their effectiveness for neurophysiological applications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Benchmarking methods for mapping functional connectivity in the brain - Nature Methods
In this Analysis, Liu et al. benchmark more than 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure–function coupling and behavio...
www.nature.com
June 6, 2025 at 3:51 PM
An Analysis of 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure-function coupling and behavior prediction highlights their effectiveness for neurophysiological applications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by dennis hernaus
When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...
The history and future of resting-state functional magnetic resonance imaging - Nature
This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...
www.nature.com
May 28, 2025 at 3:52 PM
When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...
Still open for expressions of interest until June 15th! Do reach out directly (or see link) if you're interested in developing an MSCA-Postdoc. Fellowship application on the (cognitive) neuroscience of motivation/goal-directed behaviour 🧠
👇
#cognitiveneuroscience #Neuroscience
#postdoc #cogsci
👇
#cognitiveneuroscience #Neuroscience
#postdoc #cogsci
MSCA-PF in Cognitive Neuroscience with Dr Dennis Hernaus
euraxess.ec.europa.eu
May 28, 2025 at 12:42 PM
Still open for expressions of interest until June 15th! Do reach out directly (or see link) if you're interested in developing an MSCA-Postdoc. Fellowship application on the (cognitive) neuroscience of motivation/goal-directed behaviour 🧠
👇
#cognitiveneuroscience #Neuroscience
#postdoc #cogsci
👇
#cognitiveneuroscience #Neuroscience
#postdoc #cogsci
Reposted by dennis hernaus
A Reinforcement Learning and Decision-Making framework for understanding Mental Disorders: https://osf.io/s58jh
April 17, 2025 at 4:43 AM
A Reinforcement Learning and Decision-Making framework for understanding Mental Disorders: https://osf.io/s58jh