Danny Gale
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dannygale.bsky.social
Danny Gale
@dannygale.bsky.social
900 followers 800 following 3 posts
Nephrologist @RoyalFreeNHS and rare disease researcher @UCL using genomics to understand kidney disease. @RenalRaDaR director.
https://www.ucl.ac.uk/medicine/research/genetics-and-genomics
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Reposted by Danny Gale
dgmacarthur.bsky.social
Awesome work by @zornitza.bsky.social and collaborators showing the immediate value of WGS for newborn screening in a cohort of 1,000 Australian babies. Now we need larger, more diverse cohorts to show this approach can achieve population scale!
zornitza.bsky.social Zornitza Stark @zornitza.bsky.social · Oct 9
🤗 Out now @naturemedicine.bsky.social results of our genomic NBS study BabyScreen+ 👶🧬

👉 www.nature.com/articles/s41...

1,000 babies
WGS using existing cards
600+ conditions
13 day TAT
16 diagnoses (vs 1 in std NBS)
High clinical impact
High parental acceptability
October 14, 2025 at 9:54 PM
dannygale.bsky.social
If you’re interested in learning about all things genetic in nephrology, come to our Renal Genomics course in London, 5-6 March 2026!
renalgenomics.bsky.social UCL Renal Genomics @renalgenomics.bsky.social · Sep 28
We are proud to be organising the inaugural UCL Renal Genomics Course 5-6 March 2026! (London + Online). Practical genomics for the clinic: test choice, VUS, counselling & real cases across all aspects of rare renal disease.
Book 👉 ucl.ac.uk/short-course...

#Genomics #rarerenal #nephsky
Renal Genomics Course
A two-day course providing a practical, clinically‑focused update on the principles and practice of genomic medicine in kidney disease.
ucl.ac.uk
October 2, 2025 at 2:55 PM
Reposted by Danny Gale
lastwalsh.bsky.social
Int Society of Nephrology Glomerular Disease fellowships! Our program is not on the small ISN list but can host ISN fellows. We offer glomerular disease clinics, vasculitis clinics, genetics clinics, onconeph clinics and research opportunities. DM if interested!
www.theisn.org/in-action/gr...
Fellowships - International Society of Nephrology
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www.theisn.org
August 12, 2025 at 3:05 PM
Reposted by Danny Gale
jeffminerphd.bsky.social
Thrilled to have this finally published! If you are interested in learning about the collagen IV diseases Gould syndrome and Alport syndrome, add this to your reading list. www.nature.com/articles/s41...
Collagen IV in Gould syndrome and Alport syndrome
Nature Reviews Nephrology - In this Review, the authors focus on the role of collagen IV in Gould syndrome and Alport syndrome. They discuss the molecular and phenotypic similarities and...
www.nature.com
July 31, 2025 at 2:44 PM
Reposted by Danny Gale
nephtimes.bsky.social
⚠️ The FDA has approved pegcetacoplan (Empaveli) for treating C3G and IC-MPGN. #kidneydisease #nephrology #nephsky #c3g www.docwirenews.com/post/fda-app...
FDA Approves Pegcetacoplan for C3G and IC-MPGN | Docwire News
The FDA approved pegcetacoplan for treating C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN in patients age 12 and older.
www.docwirenews.com
July 30, 2025 at 7:28 PM
Reposted by Danny Gale
neilturn.bsky.social
The Alport Workshop in Beijing in September is looking tremendous! Agenda to be added soon, but register now at tinyurl.com/5674vckz @alportuk.bsky.social @dannygale.bsky.social @rheaultm.bsky.social @rachellennon.bsky.social‬
May 30, 2025 at 5:07 PM
Reposted by Danny Gale
vasculitides.bsky.social
Proteinuria Trajectory and Disease Progression in Children and Adults with IgA Nephropathy/Vasculitis
https://pubmed.ncbi.nlm.nih.gov/40208688
Image
April 11, 2025 at 10:07 AM
Reposted by Danny Gale
kidneyint.bsky.social
Treatment of patients with IgA nephropathy: a call for a new paradigm

doi.org/10.1016/j.kint.2025.01.014

#KIReview #OpenAccess #MedSky #NephSky #IgAN #IgAnephropathy
April 17, 2025 at 8:34 PM
Reposted by Danny Gale
zornitza.bsky.social
As @ausgenomics.bsky.social comes to an end: what have we learned? 🇦🇺🧬 @naturemedicine.bsky.social
👉 rdcu.be/eeuAN
Change is hard! Key for success: working across disciplines; jurisdictions; and all leadership levels🏆
@stephaniebest.bsky.social @iliasgoranitis.bsky.social @andrewmallett8.bsky.social
Using implementation science to navigate the complexity of integrating genomics into healthcare
Nature Medicine - Australian Genomics led a country-level, longitudinal project to deliver and evaluate the impact of genomics in routine healthcare.
rdcu.be
March 24, 2025 at 4:56 AM
dannygale.bsky.social
Statistician wanted! The UK National Registry of Rare Kidney Diseases (RaDaR) is looking for a statistician to join our team using patient data to unlock improvements in care for people with rare kidney diseases. If you are interested click here shortlink.is/fzNsRD or message me.
Senior Statistician
Are you an experienced statistician with the expertise to work independently and lead impactful research? Do you want to apply your skills to shape cr
shortlink.is
March 12, 2025 at 4:09 PM
Reposted by Danny Gale
rheaultm.bsky.social
Prospective Cohort Study in #Alport Syndrome Patients under Standard Therapy - the ATHENA study www.kireports.org/article/S246...
Prospective Cohort Study in Alport Syndrome Patients under Standard Therapy
Patients with Alport syndrome, a common genetic kidney disease, exhibit variable rates of decline in kidney function. Consequently, this global, multicenter, prospective observational study aimed to g...
www.kireports.org
March 8, 2025 at 4:08 PM
Reposted by Danny Gale
ajkd.bsky.social
#NephMadness 2025: Minimal Change Disease Region

buff.ly/qk4LG8w

Teams:
- MCD Diagnosis and Pathogenesis
- MCD Relapse

Expert: Susan Samuel
Writers: Mallory Downie & Robert Myette
Execs: Ana Catalina Alvarez-Elías & @nephrosparks.bsky.social
#NephMadness 2025: Minimal Change Disease Region
Submit your picks! | @NephMadness | @nephmadness.bsky.social | NephMadness 2025 Selection Committee Member: Susan Samuel @drsusansamuel Susan Samuel is a Clinician Scientist and Pediatric Nephrolog…
buff.ly
March 1, 2025 at 2:02 PM
Reposted by Danny Gale
theisn.org
Globally, 150+ rare kidney diseases affect 60–80 people per 100,000. Many are hereditary, with inherited kidney disease seen in 10% of adults & most children on #KRT. Yet, barriers to diagnosis & treatment persist, especially in LMICs. On #RareDiseaseDay, we call for action! #KidneyHealthMatters
February 28, 2025 at 8:00 AM
Reposted by Danny Gale
grahamabra.bsky.social
Somehow missed this excellent VA of the RaDaR study that has changed hearts and minds in IgA Nephropathy, breaking the sound barrier of 1g/day of proteinuria as are standard for high risk of progression
February 27, 2025 at 5:08 AM
Reposted by Danny Gale
alportuk.bsky.social
Exciting progress in Alport research! 🎉 The Alport Research Hub, led by Prof. Rachel Lennon, is uniting experts and patients to improve diagnosis, treatment & care.

Watch the video to learn all about The Alport Research Hub

@rachellennon.bsky.social
@kidneyresearchuk.org
February 25, 2025 at 3:12 PM
Reposted by Danny Gale
ksusztak.bsky.social
🎇Our new paper in @ScienceMagazine
: Kidney Multiome-Based Genetic Scorecard Reveals Convergent Coding and Regulatory Variants.
@Hongbo919Liu science.org/doi/10.1126/...
Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants
Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted a multiancestry genome-wide association study in 2.2 million individuals and...
science.org
February 7, 2025 at 2:25 PM
Reposted by Danny Gale
rheaultm.bsky.social
Genotype-First Analysis in an Unselected Health System–Based Population and Phenotypic Severity of COL4A5 Variants.

tl;dr The spectrum of kidney disease in those with COL4A5 variants is broad and under diagnosed. journals.lww.com/jasn/abstrac...
Genotype-First Analysis in an Unselected Health... : Journal of the American Society of Nephrology
udy, an unselected health system-based cohort with exome sequencing and electronic health records. Patients with COL4A5 variants reported as pathogenic or likely pathogenic in ClinVar, or protein-trun...
journals.lww.com
December 14, 2024 at 2:48 PM
Reposted by Danny Gale
brendonneuen.bsky.social
The PARASOL initiative started after the DUPLEX trial results were presented by @rheaultm.bsky.social in 2023

On #kidneycompass, Laura Mariani shares how remarkable progress can be possible in a short time when groups work together towards a common goal #FSGS

www.hcplive.com/view/kidney-...
Kidney Compass: PARASOL Background and FSGS Landscape
In part 2 of 4 from this episode, the discussion focuses on the groundbreaking work of the RADAR Registry and the PARASOL Initiative.
www.hcplive.com
December 12, 2024 at 2:40 AM
Reposted by Danny Gale
imperialtxgroup.bsky.social
Congratulations Steph Chong and colleagues at UCL renal on this important work.

www.thelancet.com/journals/ebi...
Composition of the neutralising antibody response predicts risk of BK virus DNAaemia in recipients of kidney transplants
BKV nAb mismatch predicts post-transplant BKV DNAaemia. Specific mismatches in nAb, rather than total seroreactivity, are key indicators of BKV risk post-transplant. This has the potential to risk-str...
www.thelancet.com
November 26, 2024 at 7:51 PM
Reposted by Danny Gale
emiliewigdor.bsky.social
📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣

Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
a couple of cartoon characters standing next to each other with one wearing a purple earring
Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring
media.tenor.com
November 20, 2024 at 4:03 PM