Lydia Daboussi
@daboussi.bsky.social
Assistant Professor @UCLA - Department of Neurobiology.
#newPI
“I’m in the field for real, UCLA Bruins” -KL (GNX)
Looking for a postdoc? #hiring (contact info in lab website)
https://daboussilab.healthsciences.ucla.edu
#newPI
“I’m in the field for real, UCLA Bruins” -KL (GNX)
Looking for a postdoc? #hiring (contact info in lab website)
https://daboussilab.healthsciences.ucla.edu
Pinned
Lydia Daboussi
@daboussi.bsky.social
· Dec 7
Late addition for #fluorescencefriday
Cultured neurons (red/yellow) interacting with glia (green).
Imaged by the talented undergraduate researcher Grace Haroun.
Cultured neurons (red/yellow) interacting with glia (green).
Imaged by the talented undergraduate researcher Grace Haroun.
Reposted by Lydia Daboussi
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
October 29, 2025 at 3:01 PM
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Reposted by Lydia Daboussi
New tenure track faculty position in glia and/or neurovascular coupling! Please come join us!
academicjobsonline.org/ajo/jobs/30864
#neurosky #neuroskyence #glia #neurojobs
academicjobsonline.org/ajo/jobs/30864
#neurosky #neuroskyence #glia #neurojobs
University of Oregon, Department of Human Physiology
Job #AJO30864, Assistant/Associate Professor of Human Physiology with a Glia and Neurovascular focus, Department of Human Physiology, University of Oregon, Eugene, Oregon, US
academicjobsonline.org
October 15, 2025 at 5:40 PM
New tenure track faculty position in glia and/or neurovascular coupling! Please come join us!
academicjobsonline.org/ajo/jobs/30864
#neurosky #neuroskyence #glia #neurojobs
academicjobsonline.org/ajo/jobs/30864
#neurosky #neuroskyence #glia #neurojobs
It’s so exciting to see this. These tools will be game changing.
In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me!
Hope this tool helps more people see it too.
Hope this tool helps more people see it too.
OASIS: in vivo AAV-mediated transduction and genome editing of adult oligodendrocytes https://www.biorxiv.org/content/10.1101/2025.10.20.683551v1
October 22, 2025 at 2:31 AM
It’s so exciting to see this. These tools will be game changing.
Reposted by Lydia Daboussi
If you think your field needs a collection of curated reviews and protocols, let me know! Let's create it and help the community.
I'm always looking for ideas for CSH Protocols.
If you know of a field that would benefit from a curated and authoritative collection of review articles and step-by-step protocols, please let me know! 🧬🧪
We've recently done one on fly neurobiology, bacterial genetics, xenopus, and more!
If you know of a field that would benefit from a curated and authoritative collection of review articles and step-by-step protocols, please let me know! 🧬🧪
We've recently done one on fly neurobiology, bacterial genetics, xenopus, and more!
October 21, 2025 at 1:05 PM
If you think your field needs a collection of curated reviews and protocols, let me know! Let's create it and help the community.
Reposted by Lydia Daboussi
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
October 9, 2025 at 6:06 PM
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
Reposted by Lydia Daboussi
The first (of hopefully many) reports to come from our collaboration with @hjp.bsky.social
We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.
We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.
Cell villages and Dirichlet modeling map human cell fitness genetics https://www.biorxiv.org/content/10.1101/2025.09.26.678880v1
September 30, 2025 at 7:17 PM
The first (of hopefully many) reports to come from our collaboration with @hjp.bsky.social
We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.
We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.
Wow! This is really exciting!
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…
www.sciencedirect.com
August 26, 2025 at 4:12 PM
Wow! This is really exciting!
Reposted by Lydia Daboussi
🚨
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
August 19, 2025 at 3:32 PM
🚨
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
It was great to co-teach today’s Academic Skills workshop with the amazing @debiaselm.bsky.social 🧪✨
May 7, 2025 at 10:03 PM
It was great to co-teach today’s Academic Skills workshop with the amazing @debiaselm.bsky.social 🧪✨
Reposted by Lydia Daboussi
Check out our recent progress using 🧬 PAINT kinetics to decode molecular tension in super-resolution force imaging! 🔬 Great team effort from Seongho, Adam, Irving, and Kevin! 👏
#DNA-PAINT #tension #integrin #superresolution #adhesion
doi.org/10.1002/advs...
#DNA-PAINT #tension #integrin #superresolution #adhesion
doi.org/10.1002/advs...
Quantitative Super‐Resolution Imaging of Molecular Tension
Quantitative tension PAINT (qtPAINT) is a new method to quantify molecular tension at super-resolution by exploiting force-dependent DNA oligonucleotide dissociation kinetics. Combining hairpin tensi....
doi.org
April 18, 2025 at 8:00 AM
Check out our recent progress using 🧬 PAINT kinetics to decode molecular tension in super-resolution force imaging! 🔬 Great team effort from Seongho, Adam, Irving, and Kevin! 👏
#DNA-PAINT #tension #integrin #superresolution #adhesion
doi.org/10.1002/advs...
#DNA-PAINT #tension #integrin #superresolution #adhesion
doi.org/10.1002/advs...
Reposted by Lydia Daboussi
Please spread the word about the glia networks world-wide 🙃
@astrocytenet.bsky.social @astrocytecafe.bsky.social @ukglia.bsky.social @glialclub.bsky.social @gliameeting.bsky.social @warsawgliacomm.bsky.social @italianglianetwork.bsky.social @canglia.bsky.social
@astrocytenet.bsky.social @astrocytecafe.bsky.social @ukglia.bsky.social @glialclub.bsky.social @gliameeting.bsky.social @warsawgliacomm.bsky.social @italianglianetwork.bsky.social @canglia.bsky.social
⭐️ Starterpack for networks and organisations fostering collaborations of glia enthustiasts ⭐️
go.bsky.app/JaGgbrT
go.bsky.app/JaGgbrT
March 20, 2025 at 11:49 AM
Please spread the word about the glia networks world-wide 🙃
@astrocytenet.bsky.social @astrocytecafe.bsky.social @ukglia.bsky.social @glialclub.bsky.social @gliameeting.bsky.social @warsawgliacomm.bsky.social @italianglianetwork.bsky.social @canglia.bsky.social
@astrocytenet.bsky.social @astrocytecafe.bsky.social @ukglia.bsky.social @glialclub.bsky.social @gliameeting.bsky.social @warsawgliacomm.bsky.social @italianglianetwork.bsky.social @canglia.bsky.social
Reposted by Lydia Daboussi
Come join our lab as Postdoctoral Fellow! The project will investigate the maturation of spinal circuits and their plasticity within chronic widespread pain states.
Apply here: www.ucl.ac.uk/work-at-ucl/... until 11th April.
@ucllifesciences.bsky.social @uclnpp.bsky.social @jobrxiv.bsky.social
Apply here: www.ucl.ac.uk/work-at-ucl/... until 11th April.
@ucllifesciences.bsky.social @uclnpp.bsky.social @jobrxiv.bsky.social
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
March 14, 2025 at 12:47 PM
Come join our lab as Postdoctoral Fellow! The project will investigate the maturation of spinal circuits and their plasticity within chronic widespread pain states.
Apply here: www.ucl.ac.uk/work-at-ucl/... until 11th April.
@ucllifesciences.bsky.social @uclnpp.bsky.social @jobrxiv.bsky.social
Apply here: www.ucl.ac.uk/work-at-ucl/... until 11th April.
@ucllifesciences.bsky.social @uclnpp.bsky.social @jobrxiv.bsky.social
It was a pleasure hosting Ritchie Ho for this weeks Neural Repair seminar and hearing about his amazing work to understand pathogenic mechanisms of ALS @ucla @ritchieholab.bsky.social
January 25, 2025 at 10:05 PM
It was a pleasure hosting Ritchie Ho for this weeks Neural Repair seminar and hearing about his amazing work to understand pathogenic mechanisms of ALS @ucla @ritchieholab.bsky.social
Reposted by Lydia Daboussi
UCLA scientists led by Dr. Hilary Coller have found that quiescent cells express transcription factors that act as "master switches" to regulate genes that suppress cell cycle progression, prevent the adoption of irreversible fates and reorganize their metabolism. www.nature.com/articles/s41...
Transcription factor networks in cellular quiescence - Nature Cell Biology
Recent developments in single-cell technologies have increased our understanding of how the coordinated activities of transcription factors in different quiescent cells and differentiated cells mainta...
www.nature.com
January 24, 2025 at 12:09 AM
UCLA scientists led by Dr. Hilary Coller have found that quiescent cells express transcription factors that act as "master switches" to regulate genes that suppress cell cycle progression, prevent the adoption of irreversible fates and reorganize their metabolism. www.nature.com/articles/s41...
✨UCLA is an amazing place for science! ✨
📢 Tenure Track position open at UCLA!
This is a very broad search in the Biomathematics, Biological Chemistry, Human Genetics, Molecular & Medical Pharmacology, Neurobiology, Physiology departments. 🔬✨
recruit.apo.ucla.edu/JPF10062
📢 Tenure Track position open at UCLA!
This is a very broad search in the Biomathematics, Biological Chemistry, Human Genetics, Molecular & Medical Pharmacology, Neurobiology, Physiology departments. 🔬✨
recruit.apo.ucla.edu/JPF10062
Open Rank Faculty Position in David Geffen School of Medicine at UCLA
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
January 18, 2025 at 12:22 AM
✨UCLA is an amazing place for science! ✨
📢 Tenure Track position open at UCLA!
This is a very broad search in the Biomathematics, Biological Chemistry, Human Genetics, Molecular & Medical Pharmacology, Neurobiology, Physiology departments. 🔬✨
recruit.apo.ucla.edu/JPF10062
📢 Tenure Track position open at UCLA!
This is a very broad search in the Biomathematics, Biological Chemistry, Human Genetics, Molecular & Medical Pharmacology, Neurobiology, Physiology departments. 🔬✨
recruit.apo.ucla.edu/JPF10062
✨Tenure Track position open at UCLA! This is a very broad search in the Biomathematics, Biological Chemistry, Human Genetics, Molecular & Medical Pharmacology, Neurobiology, Physiology departments. 🧪🔬
recruit.apo.ucla.edu/JPF10062
recruit.apo.ucla.edu/JPF10062
Open Rank Faculty Position in David Geffen School of Medicine at UCLA
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
January 17, 2025 at 9:11 PM
✨Tenure Track position open at UCLA! This is a very broad search in the Biomathematics, Biological Chemistry, Human Genetics, Molecular & Medical Pharmacology, Neurobiology, Physiology departments. 🧪🔬
recruit.apo.ucla.edu/JPF10062
recruit.apo.ucla.edu/JPF10062
Reposted by Lydia Daboussi
Check out this paper and tool that we worked on with @sloanlab.bsky.social and Ye Zhang.
Think of it as 'the Barres datasets 2.0'
Lots of input and feedback from the amazing #Glia community.
Think of it as 'the Barres datasets 2.0'
Lots of input and feedback from the amazing #Glia community.
Hi #neuroscience community! This is one of my favorite posts ever. In close collaboration with @liddelowsa.bsky.social and Ye Zhang, we've built a new tool that we are eager to share! www.webseq.net
WEBseq
share freely
www.webseq.net
January 15, 2025 at 4:29 PM
Check out this paper and tool that we worked on with @sloanlab.bsky.social and Ye Zhang.
Think of it as 'the Barres datasets 2.0'
Lots of input and feedback from the amazing #Glia community.
Think of it as 'the Barres datasets 2.0'
Lots of input and feedback from the amazing #Glia community.
📢UCLA is recruiting an open rank, tenure-track/tenured faculty position in the basic sciences! (see link below)
#AcademicSky
💫✨
recruit.apo.ucla.edu/JPF10062
#AcademicSky
💫✨
recruit.apo.ucla.edu/JPF10062
Open Rank Faculty Position in David Geffen School of Medicine at UCLA
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
December 20, 2024 at 2:19 AM
📢UCLA is recruiting an open rank, tenure-track/tenured faculty position in the basic sciences! (see link below)
#AcademicSky
💫✨
recruit.apo.ucla.edu/JPF10062
#AcademicSky
💫✨
recruit.apo.ucla.edu/JPF10062
📢UCLA is recruiting an open rank, tenure-track/tenured faculty position in the basic sciences! (see link below)
#AcademicTwitter
💫✨
recruit.apo.ucla.edu/JPF10062
#AcademicTwitter
💫✨
recruit.apo.ucla.edu/JPF10062
Open Rank Faculty Position in David Geffen School of Medicine at UCLA
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
December 20, 2024 at 1:25 AM
📢UCLA is recruiting an open rank, tenure-track/tenured faculty position in the basic sciences! (see link below)
#AcademicTwitter
💫✨
recruit.apo.ucla.edu/JPF10062
#AcademicTwitter
💫✨
recruit.apo.ucla.edu/JPF10062
Reposted by Lydia Daboussi
so nice to see this amazing study out - huge congrats to @franckp.bsky.social & coll.!
Delighted to highlight our new paper in
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
Synaptic basis of feature selectivity in hippocampal neurons - Nature
A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.
www.nature.com
December 19, 2024 at 6:50 PM
so nice to see this amazing study out - huge congrats to @franckp.bsky.social & coll.!
📢UCLA is recruiting an open rank, tenure-track/tenured faculty position in the basic sciences! (see link below)
#AcademicTwitter
💫✨
recruit.apo.ucla.edu/JPF10062
🧪🔬
#AcademicTwitter
💫✨
recruit.apo.ucla.edu/JPF10062
🧪🔬
Open Rank Faculty Position in David Geffen School of Medicine at UCLA
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
December 19, 2024 at 10:28 PM
📢UCLA is recruiting an open rank, tenure-track/tenured faculty position in the basic sciences! (see link below)
#AcademicTwitter
💫✨
recruit.apo.ucla.edu/JPF10062
🧪🔬
#AcademicTwitter
💫✨
recruit.apo.ucla.edu/JPF10062
🧪🔬
Reposted by Lydia Daboussi
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
rdcu.be
December 18, 2024 at 10:40 PM
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵