Isaac Li
@isaacli.bsky.social
Single-molecule biophysicist, building force-responsive DNA to study biology, love space exploration real & sci-fi. 🔬🧬🧫🌟🪐🚀
Associate Professor of Chemistry at UBC Okanagan, Canada Research Chair, Michael Smith Scholar 🍁🇨🇦
https://lilab.ok.ubc.ca/
Associate Professor of Chemistry at UBC Okanagan, Canada Research Chair, Michael Smith Scholar 🍁🇨🇦
https://lilab.ok.ubc.ca/
We just uploaded a preprint on a new massively parallel single-molecule force spectroscopy method. No beads, no messy calibration - just pure DNA tethers pulling individual molecules while we watch them in real-time with fluorescence.
Check it out: www.biorxiv.org/content/10.1...
Check it out: www.biorxiv.org/content/10.1...
September 17, 2025 at 11:29 PM
We just uploaded a preprint on a new massively parallel single-molecule force spectroscopy method. No beads, no messy calibration - just pure DNA tethers pulling individual molecules while we watch them in real-time with fluorescence.
Check it out: www.biorxiv.org/content/10.1...
Check it out: www.biorxiv.org/content/10.1...
Latest from the lab: 🧬 Decoy DNA 🧬 can extend the lifetime of DNA-based tension probes >24h by outcompeting DNases and preserving signal integrity in live-cell tension imaging. This is a simple, general strategy for robust mechanobiology in DNase-rich environments. doi.org/10.1002/anie...
June 25, 2025 at 8:03 PM
Latest from the lab: 🧬 Decoy DNA 🧬 can extend the lifetime of DNA-based tension probes >24h by outcompeting DNases and preserving signal integrity in live-cell tension imaging. This is a simple, general strategy for robust mechanobiology in DNase-rich environments. doi.org/10.1002/anie...
Wonderful visit to the University of Lethbridge -many thanks to Trushar @trushar7.bsky.social and Dylan for the kind hosting! Great discussions with researchers at the Chemistry and Biochemistry Department! 👍
June 24, 2025 at 6:00 AM
Wonderful visit to the University of Lethbridge -many thanks to Trushar @trushar7.bsky.social and Dylan for the kind hosting! Great discussions with researchers at the Chemistry and Biochemistry Department! 👍
Taking the group out for fun outside of the #BSC2025 @biophyscanada.bsky.social annual meeting, visited Niagara Falls, ran into a filming of a featured film, good times!
May 24, 2025 at 12:53 PM
Taking the group out for fun outside of the #BSC2025 @biophyscanada.bsky.social annual meeting, visited Niagara Falls, ran into a filming of a featured film, good times!
Congratulations 🎉 to Ryan, David, and Irving for winning two poster and a travel award at the @biophyscanada.bsky.social annual meeting! 👏
May 24, 2025 at 12:47 PM
Congratulations 🎉 to Ryan, David, and Irving for winning two poster and a travel award at the @biophyscanada.bsky.social annual meeting! 👏
Reposted by Isaac Li
Congratulations to all the trainee award winners at the BSC 2025!
May 24, 2025 at 12:24 PM
Congratulations to all the trainee award winners at the BSC 2025!
Reposted by Isaac Li
The 10th BSC annual meeting just wrapped up. We sincerely thank Cecile Fradin and the team of local organizers and volunteers at McMaster for making this a successful event! Looking forward to next year in Winnipeg!
May 24, 2025 at 12:19 PM
The 10th BSC annual meeting just wrapped up. We sincerely thank Cecile Fradin and the team of local organizers and volunteers at McMaster for making this a successful event! Looking forward to next year in Winnipeg!
Reposted by Isaac Li
Congratulations to @sfuphysics.bsky.social professor Nancy Forde who has received the @canadianphysicists.bsky.social Medal for Excellence in Undergraduate Teaching, recognizing her innovative teaching methods, curriculum development and undergraduate research mentorship. cap.ca/programs/rec...
April 29, 2025 at 7:42 PM
Congratulations to @sfuphysics.bsky.social professor Nancy Forde who has received the @canadianphysicists.bsky.social Medal for Excellence in Undergraduate Teaching, recognizing her innovative teaching methods, curriculum development and undergraduate research mentorship. cap.ca/programs/rec...
Check out our recent progress using 🧬 PAINT kinetics to decode molecular tension in super-resolution force imaging! 🔬 Great team effort from Seongho, Adam, Irving, and Kevin! 👏
#DNA-PAINT #tension #integrin #superresolution #adhesion
doi.org/10.1002/advs...
#DNA-PAINT #tension #integrin #superresolution #adhesion
doi.org/10.1002/advs...
Quantitative Super‐Resolution Imaging of Molecular Tension
Quantitative tension PAINT (qtPAINT) is a new method to quantify molecular tension at super-resolution by exploiting force-dependent DNA oligonucleotide dissociation kinetics. Combining hairpin tensi....
doi.org
April 18, 2025 at 8:00 AM
Check out our recent progress using 🧬 PAINT kinetics to decode molecular tension in super-resolution force imaging! 🔬 Great team effort from Seongho, Adam, Irving, and Kevin! 👏
#DNA-PAINT #tension #integrin #superresolution #adhesion
doi.org/10.1002/advs...
#DNA-PAINT #tension #integrin #superresolution #adhesion
doi.org/10.1002/advs...
Reposted by Isaac Li
The 10th annual BSC meeting is coming up in Hamilton!
Don't miss the April 15 deadline for early registration, abstract submission, and travel awards.
Details & program: event.fourwaves.com/bsc2025/ #BSC2025
Don't miss the April 15 deadline for early registration, abstract submission, and travel awards.
Details & program: event.fourwaves.com/bsc2025/ #BSC2025
April 2, 2025 at 8:29 PM
The 10th annual BSC meeting is coming up in Hamilton!
Don't miss the April 15 deadline for early registration, abstract submission, and travel awards.
Details & program: event.fourwaves.com/bsc2025/ #BSC2025
Don't miss the April 15 deadline for early registration, abstract submission, and travel awards.
Details & program: event.fourwaves.com/bsc2025/ #BSC2025
Reposted by Isaac Li
The 10th annual meeting of the Biophysical Society of Canada will be held May 20-23 at McMaster University in Hamilton, ON.
Check out the speaker lineup and programs here: event.fourwaves.com/bsc2025/
Early registration and abstract submission deadlines are April 15. #BSC2025
Check out the speaker lineup and programs here: event.fourwaves.com/bsc2025/
Early registration and abstract submission deadlines are April 15. #BSC2025
April 2, 2025 at 8:34 PM
The 10th annual meeting of the Biophysical Society of Canada will be held May 20-23 at McMaster University in Hamilton, ON.
Check out the speaker lineup and programs here: event.fourwaves.com/bsc2025/
Early registration and abstract submission deadlines are April 15. #BSC2025
Check out the speaker lineup and programs here: event.fourwaves.com/bsc2025/
Early registration and abstract submission deadlines are April 15. #BSC2025
David Bakker from my group is talking to middle school students about our research on DNA and optical tweezers!🧬Great job, David, for bringing the latest science from UBCO to the grade 6-10 classrooms! career.sd83.bc.ca/2025/03/14/f...
#biophysics #outreach @ubcokanagan.bsky.social
#biophysics #outreach @ubcokanagan.bsky.social
From SAS to Biochemistry and Back
Former Salmon Arm Secondary student David Bakker (left) and Grade 10 JL Jackson student Sabrina Wilson (right) demonstrate what happens when DNA strings are stretched while Teacher David Hollatz wa…
career.sd83.bc.ca
March 15, 2025 at 12:23 AM
David Bakker from my group is talking to middle school students about our research on DNA and optical tweezers!🧬Great job, David, for bringing the latest science from UBCO to the grade 6-10 classrooms! career.sd83.bc.ca/2025/03/14/f...
#biophysics #outreach @ubcokanagan.bsky.social
#biophysics #outreach @ubcokanagan.bsky.social
We just published a review of the very recent progress in integrin force loading rate measurement using various molecular tension probes. Learn more about how this has advanced the field and what potential improvement lies ahead here: doi.org/10.1017/qrd....
#mechanobiology #integrin #tensionprobes
#mechanobiology #integrin #tensionprobes
March 12, 2025 at 7:57 PM
We just published a review of the very recent progress in integrin force loading rate measurement using various molecular tension probes. Learn more about how this has advanced the field and what potential improvement lies ahead here: doi.org/10.1017/qrd....
#mechanobiology #integrin #tensionprobes
#mechanobiology #integrin #tensionprobes
Heading to @biophysicalsoc.bsky.social for #bps2025! Looking forward to catching up with everyone!
February 15, 2025 at 8:18 PM
Heading to @biophysicalsoc.bsky.social for #bps2025! Looking forward to catching up with everyone!
Reposted by Isaac Li
A online environment for playing interactively with reaction-diffusion systems from Karl Sims
karlsims.com/rdtool.html
karlsims.com/rdtool.html
December 21, 2024 at 11:19 AM
A online environment for playing interactively with reaction-diffusion systems from Karl Sims
karlsims.com/rdtool.html
karlsims.com/rdtool.html
Confronting risks of mirror life
Broad discussion is needed to chart a path forward.
www.science.org
December 17, 2024 at 4:09 PM
Reposted by Isaac Li
Not a new paper, but still helps (1/2)
PhD survival guide @embopress.org
#PhD #PhDlife #academics #scisky #medsky
PhD survival guide @embopress.org
#PhD #PhDlife #academics #scisky #medsky
November 30, 2024 at 2:21 PM
Not a new paper, but still helps (1/2)
PhD survival guide @embopress.org
#PhD #PhDlife #academics #scisky #medsky
PhD survival guide @embopress.org
#PhD #PhDlife #academics #scisky #medsky
This is immensely fun to read
doi.org/10.1016/j.ij...
doi.org/10.1016/j.ij...
November 18, 2024 at 4:52 PM
This is immensely fun to read
doi.org/10.1016/j.ij...
doi.org/10.1016/j.ij...
Coffee…made
Matlab…opened
Meetings…none
It’s gonna be a great day!
Matlab…opened
Meetings…none
It’s gonna be a great day!
November 15, 2024 at 5:18 PM
Coffee…made
Matlab…opened
Meetings…none
It’s gonna be a great day!
Matlab…opened
Meetings…none
It’s gonna be a great day!