David Davies-Payne
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d2p.bsky.social
David Davies-Payne
@d2p.bsky.social
Paediatric Radiologist, Aotearoa New Zealand
Following more immunologists than radiologists
#MECFS #LongCOVID and a bit of #MacDev #iOSDev
he/him
https://ddp.nz | https://dysimmune.nz
Pinned
📌 I've made a page for some key recent scientific papers for #MECFS and #LongCovid. Nearly all have accessible PDF links (open-access or via PubMedCentral).

Aiming to keep updated as new papers drop, but with limited numbers.

www.ddp.nz/me-cfs-lc/re...
ME/CFS and LC References
www.ddp.nz
Multi-omics identifies lipid accumulation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cell lines: a case-control study

@danielmissailidis.bsky.social et al.

#MECFS

link.springer.com/article/10.1...
January 9, 2026 at 6:11 AM
Reposted by David Davies-Payne
“This year, renewables surpassed coal as a source of electricity worldwide, and solar and wind energy grew fast enough to cover the entire increase in global electricity use from January to June according to energy think tank Ember“
@science.org’s Breakthrough of the Year is the growth of renewables
Science has named the seemingly unstoppable growth of renewable energy worldwide as the 2025 Breakthrough of the Year.

Learn more about this year's #BOTY and other big advances in science: https://scim.ag/493Tpgx
December 18, 2025 at 8:30 PM
Reposted by David Davies-Payne
More evidence-based disease mechanisms = less #stigma for Long COVID patients! 👇👇👇👇
Human #genetics implicate thromboembolism in the pathogenesis of #LongCOVID in individuals of European ancestry.
www.nature.com/articles/s44...
Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry - Nature Cardiovascular Research
Schuermans et al. discovered that genetic predisposition to thromboembolism is associated with a greater risk of post-acute sequelae after SARS-CoV-2 infection, including long COVID, and downstream an...
www.nature.com
December 16, 2025 at 8:19 PM
Reposted by David Davies-Payne
fMRI signals “up,” but neural metabolism might be going “down.”

In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.

rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
December 16, 2025 at 3:43 PM
Reposted by David Davies-Payne
Well done & thanks to these healthcare professionals (PTs)/similar ( @sunsopeningband.bsky.social @profmarkfaghy.bsky.social et al) for this new e-letter 👏

"In the Long Run, Misleading Participants Will Harm More Than Help in Long COVID Research"

bmjopen.bmj.com/content/15/1...

#LongCOVID #PEM
December 9, 2025 at 11:51 PM
Reposted by David Davies-Payne
I’m excited to share my latest work, “The Small Life.” It explores the little things that still bring me joy as I navigate #LongCovid and #MECFS. #ChronicIllness

substack.com/home/post/p-...
The Small Life
Calculating Worth with Diminished Returns
substack.com
December 1, 2025 at 9:28 PM
This blog post is a very accurate characterisation of the experience of living with #PostExertionalMalaise #PEM.

Recommended reading for healthcare professionals who want to understand #MECFS and #LongCovid.

You generally only see these patients when they're at their best — not in the aftermath.
Here’s a quote from my piece, Why I Can’t Just Meet You for Dinner, about post-exertional malaise. This is after work while I’m in the middle of a PEM crash. #PEM #MECFS #LongCovid #ChronicIllness #Disabled

substack.com/home/post/p-...
November 24, 2025 at 10:32 PM
Reposted by David Davies-Payne
I never met Alice Wong in person, but like so many great writers I felt like I knew her - and unlike many, when I emailed she emailed right back. ❤️

Peds neurologist @dianacejasmd.bsky.social has a beautiful essay in Wong's Disability Visibility collection - I recommend it to physicians. #neurosky
November 15, 2025 at 6:32 PM
Reposted by David Davies-Payne
After some hardcore protesting in Germany!! Well done‼️‼️🇩🇪🇩🇪

"The coalition plans to invest 500 million euros by 2036 in the fight against #LongCovid and chronic fatigue syndrome (#MECFS)."

www.spiegel.de/politik/karl...
(S+) Ex-Gesundheitsminister Lauterbach: Forschung gegen ME/CFS wird ausgeweitet
Union und SPD wollen mehr Geld in die Erforschung postinfektiöser Erkrankungen wie Long Covid stecken. Deutschland könne damit zum weltweiten Vorreiter werden, sagt Ex-Gesundheitsminister Lauterbach.
www.spiegel.de
November 13, 2025 at 11:18 PM
Reposted by David Davies-Payne
From Daniel Missailidis, PhD @danielmissailidis.bsky.social

(Victoria, Australia)
People with ME/CFS, Long Covid, and healthy volunteers sought

drive.google.com/drive/folder...

#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #LongCovid
November 13, 2025 at 2:09 PM
Reposted by David Davies-Payne
WTAF.
This is an absolute travesty. Teen Vogue has consistently been a light in the dark and once again the corporate overlords just end it all.
I was laid off from Teen Vogue today along with multiple other staffers, and today is my last day.

certainly more to come from me when the dust has settled more, but to my knowledge, after today, there will be no politics staffers at Teen Vogue.
November 3, 2025 at 10:34 PM
Reposted by David Davies-Payne
Long Covid Is Real — And It’s Changing an Entire Generation

Hundreds of thousands of kids in America are struggling with an illness that many doctors and schools refuse to recognize.e

Feature: www.rollingstone.com/culture/cult...
October 16, 2025 at 12:00 PM
"described for the first time widespread abnormalities in the function of unmyelinated C fibers, both somatosensory and sympathetic, that could represent a common pathophysiological mechanism explaining the multiplicity of symptoms in #longCOVID"

#MECFS

onlinelibrary.wiley.com/doi/10.1002/...
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Objective To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular, g.....
onlinelibrary.wiley.com
September 23, 2025 at 3:27 AM
WatchME for iPhone and Apple Watch
v2.8 now available

To help #pwME with daily pacing

iOS 17 | watchOS 10
Free. No data collected.

apps.apple.com/app/watchme/...
‎WatchME
‎For people with ME/CFS. This app helps you to pace and stay within your capacity envelope. Use your watch and phone to monitor your daily heart rate, steps and distance. Integrated with HealthKit....
apps.apple.com
September 21, 2025 at 5:45 AM
Reposted by David Davies-Payne
The Irish health service has initiated a process to develop a clinical guideline for ME (#MyalgicEncephalomyelitis). I am honoured to be part of its Steering Group

The process so far has been extremely progressive

I am hugely optimistic that a world-leading guideline will be produced

#pwME #MECFS
Myalgic Encephalomyelitis (ME) - HSE.ie
www.hse.ie
September 9, 2025 at 2:46 PM
Reposted by David Davies-Payne
“DecodeME shows the incredible level of support that the ME/CFS patient community can give to research that involves them on a deep and meaningful level. Without the community, we could not have achieved all that we have.” Andy Devereux-Cooke (PPI Member and Co-Investigator)
August 15, 2025 at 8:45 AM
Reposted by David Davies-Payne
"DecodeME is now calling on researchers worldwide to join us in accelerating ME/CFS research.” - Prof Chris Ponting (DecodeME Investigator).

We encourage researchers to explore and build on our findings. Apply for access to our rich dataset now shorturl.at/F8aOM
August 12, 2025 at 10:11 AM
Reposted by David Davies-Payne
My piece for The RCP Commentary Magazine for #SouthAsianHeritageMonth.

This is my lovely Mum and Dad in 1969.

Immigrants helped build the NHS

www.rcp.ac.uk/78702?utm_so...
Roots to Routes: why South Asian Heritage Month matters to the NHS
www.rcp.ac.uk
August 11, 2025 at 12:00 PM
"we identified significant differences in cfRNA contributions from multiple immune cell types. Notably, we observed a decrease in platelet-derived cfRNA and an increase in pDCs, monocytes, and certain T cell subset-derived cfRNA"

#MECFS

www.pnas.org/doi/10.1073/...
Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome | PNAS
People living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience heterogeneous and debilitating symptoms that lack suffici...
www.pnas.org
August 12, 2025 at 12:13 AM
"includes seven Tier 1 genes, with BTN2A2 and TRIM38 eQTLs colocalised with ME/CFS risk […] Complexes involving butyrophilin3 and -2 homologues […] allow innate-like Vγ9Vδ2 T cells to distinguish self-derived from non-self-derived pyrophosphate antigens"

#gdTcells #MECFS
@forum-gd.bsky.social
Our initial DNA results! DecodeME have discovered that people with an ME/CFS diagnosis have significant genetic differences compared to the general population.
-
Summary of our results: shorturl.at/pgsjk
Check out our full preprint paper: shorturl.at/VwN3s
August 7, 2025 at 1:01 AM
"The project is part of a “notable increase” in ME/CFS research in recent years, Bosch says—a trend he attributes to a mix of patient advocacy, the failure of psychological and behavioral explanations for the condition, and increasing awareness of #MECFS thanks to its similarities to #LongCovid."
August 6, 2025 at 9:06 PM
Reposted by David Davies-Payne
Proud to be on the Science Advisory Board for DecodeME, a peripheral role but a fantastic vantage point from which to witness such outstanding work by Chris Ponting @cgatist.bsky.social and colleagues

#MECFS #pwME

www.theguardian.com/society/2025...
Scientists find link between genes and ME/chronic fatigue syndrome
Large study suggests people’s genetics could ‘tip the balance’ on whether they would develop the illness
www.theguardian.com
August 6, 2025 at 8:16 PM
With clear evidence of a genetic predisposition linked to relevant biological pathways, these findings need to mark a turning point away from medicine's historic failure to correctly research this disease and meet its duty of patient care.

#MECFS #DecodeME
August 6, 2025 at 7:45 PM
Reposted by David Davies-Payne
DECODE ME has published its results.

Massive congratulations to @cgatist.bsky.social and team in Edinburgh.

Let’s hope this is the start of a paradigm shift in how we view, research and treat this dreadful illness.

www.decodeme.org.uk/initial-dna-...
Initial DecodeME DNA Results - DecodeME
06 August 2025 The DecodeME team is delighted to announce that the initial analysis of 15,579 DNA samples is complete, and we have important news to share. Main findings from our analysis  Your genes ...
www.decodeme.org.uk
August 6, 2025 at 6:50 PM