David Davies-Payne
@d2p.bsky.social
Paediatric Radiologist, Aotearoa New Zealand
Following more immunologists than radiologists
#MECFS #LongCOVID and a bit of #MacDev #iOSDev
he/him
https://ddp.nz | https://dysimmune.nz
Following more immunologists than radiologists
#MECFS #LongCOVID and a bit of #MacDev #iOSDev
he/him
https://ddp.nz | https://dysimmune.nz
Pinned
David Davies-Payne
@d2p.bsky.social
· Nov 16
ME/CFS and LC References
www.ddp.nz
📌 I've made a page for some key recent scientific papers for #MECFS and #LongCovid. Nearly all have accessible PDF links (open-access or via PubMedCentral).
Aiming to keep updated as new papers drop, but with limited numbers.
www.ddp.nz/me-cfs-lc/re...
Aiming to keep updated as new papers drop, but with limited numbers.
www.ddp.nz/me-cfs-lc/re...
Reposted by David Davies-Payne
I never met Alice Wong in person, but like so many great writers I felt like I knew her - and unlike many, when I emailed she emailed right back. ❤️
Peds neurologist @dianacejasmd.bsky.social has a beautiful essay in Wong's Disability Visibility collection - I recommend it to physicians. #neurosky
Peds neurologist @dianacejasmd.bsky.social has a beautiful essay in Wong's Disability Visibility collection - I recommend it to physicians. #neurosky
November 15, 2025 at 6:32 PM
I never met Alice Wong in person, but like so many great writers I felt like I knew her - and unlike many, when I emailed she emailed right back. ❤️
Peds neurologist @dianacejasmd.bsky.social has a beautiful essay in Wong's Disability Visibility collection - I recommend it to physicians. #neurosky
Peds neurologist @dianacejasmd.bsky.social has a beautiful essay in Wong's Disability Visibility collection - I recommend it to physicians. #neurosky
Reposted by David Davies-Payne
After some hardcore protesting in Germany!! Well done‼️‼️🇩🇪🇩🇪
"The coalition plans to invest 500 million euros by 2036 in the fight against #LongCovid and chronic fatigue syndrome (#MECFS)."
www.spiegel.de/politik/karl...
"The coalition plans to invest 500 million euros by 2036 in the fight against #LongCovid and chronic fatigue syndrome (#MECFS)."
www.spiegel.de/politik/karl...
(S+) Ex-Gesundheitsminister Lauterbach: Forschung gegen ME/CFS wird ausgeweitet
Union und SPD wollen mehr Geld in die Erforschung postinfektiöser Erkrankungen wie Long Covid stecken. Deutschland könne damit zum weltweiten Vorreiter werden, sagt Ex-Gesundheitsminister Lauterbach.
www.spiegel.de
November 13, 2025 at 11:18 PM
After some hardcore protesting in Germany!! Well done‼️‼️🇩🇪🇩🇪
"The coalition plans to invest 500 million euros by 2036 in the fight against #LongCovid and chronic fatigue syndrome (#MECFS)."
www.spiegel.de/politik/karl...
"The coalition plans to invest 500 million euros by 2036 in the fight against #LongCovid and chronic fatigue syndrome (#MECFS)."
www.spiegel.de/politik/karl...
Reposted by David Davies-Payne
From Daniel Missailidis, PhD @danielmissailidis.bsky.social
(Victoria, Australia)
People with ME/CFS, Long Covid, and healthy volunteers sought
drive.google.com/drive/folder...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #LongCovid
(Victoria, Australia)
People with ME/CFS, Long Covid, and healthy volunteers sought
drive.google.com/drive/folder...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #LongCovid
November 13, 2025 at 2:09 PM
From Daniel Missailidis, PhD @danielmissailidis.bsky.social
(Victoria, Australia)
People with ME/CFS, Long Covid, and healthy volunteers sought
drive.google.com/drive/folder...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #LongCovid
(Victoria, Australia)
People with ME/CFS, Long Covid, and healthy volunteers sought
drive.google.com/drive/folder...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #LongCovid
Reposted by David Davies-Payne
WTAF.
This is an absolute travesty. Teen Vogue has consistently been a light in the dark and once again the corporate overlords just end it all.
This is an absolute travesty. Teen Vogue has consistently been a light in the dark and once again the corporate overlords just end it all.
I was laid off from Teen Vogue today along with multiple other staffers, and today is my last day.
certainly more to come from me when the dust has settled more, but to my knowledge, after today, there will be no politics staffers at Teen Vogue.
certainly more to come from me when the dust has settled more, but to my knowledge, after today, there will be no politics staffers at Teen Vogue.
November 3, 2025 at 10:34 PM
WTAF.
This is an absolute travesty. Teen Vogue has consistently been a light in the dark and once again the corporate overlords just end it all.
This is an absolute travesty. Teen Vogue has consistently been a light in the dark and once again the corporate overlords just end it all.
Reposted by David Davies-Payne
Long Covid Is Real — And It’s Changing an Entire Generation
Hundreds of thousands of kids in America are struggling with an illness that many doctors and schools refuse to recognize.e
Feature: www.rollingstone.com/culture/cult...
Hundreds of thousands of kids in America are struggling with an illness that many doctors and schools refuse to recognize.e
Feature: www.rollingstone.com/culture/cult...
October 16, 2025 at 12:00 PM
Long Covid Is Real — And It’s Changing an Entire Generation
Hundreds of thousands of kids in America are struggling with an illness that many doctors and schools refuse to recognize.e
Feature: www.rollingstone.com/culture/cult...
Hundreds of thousands of kids in America are struggling with an illness that many doctors and schools refuse to recognize.e
Feature: www.rollingstone.com/culture/cult...
"described for the first time widespread abnormalities in the function of unmyelinated C fibers, both somatosensory and sympathetic, that could represent a common pathophysiological mechanism explaining the multiplicity of symptoms in #longCOVID"
#MECFS
onlinelibrary.wiley.com/doi/10.1002/...
#MECFS
onlinelibrary.wiley.com/doi/10.1002/...
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Objective
To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular, g.....
onlinelibrary.wiley.com
September 23, 2025 at 3:27 AM
"described for the first time widespread abnormalities in the function of unmyelinated C fibers, both somatosensory and sympathetic, that could represent a common pathophysiological mechanism explaining the multiplicity of symptoms in #longCOVID"
#MECFS
onlinelibrary.wiley.com/doi/10.1002/...
#MECFS
onlinelibrary.wiley.com/doi/10.1002/...
WatchME for iPhone and Apple Watch
v2.8 now available
To help #pwME with daily pacing
iOS 17 | watchOS 10
Free. No data collected.
apps.apple.com/app/watchme/...
v2.8 now available
To help #pwME with daily pacing
iOS 17 | watchOS 10
Free. No data collected.
apps.apple.com/app/watchme/...
WatchME
For people with ME/CFS. This app helps you to pace and stay within your capacity envelope. Use your watch and phone to monitor your daily heart rate, steps and distance.
Integrated with HealthKit....
apps.apple.com
September 21, 2025 at 5:45 AM
WatchME for iPhone and Apple Watch
v2.8 now available
To help #pwME with daily pacing
iOS 17 | watchOS 10
Free. No data collected.
apps.apple.com/app/watchme/...
v2.8 now available
To help #pwME with daily pacing
iOS 17 | watchOS 10
Free. No data collected.
apps.apple.com/app/watchme/...
Reposted by David Davies-Payne
The Irish health service has initiated a process to develop a clinical guideline for ME (#MyalgicEncephalomyelitis). I am honoured to be part of its Steering Group
The process so far has been extremely progressive
I am hugely optimistic that a world-leading guideline will be produced
#pwME #MECFS
The process so far has been extremely progressive
I am hugely optimistic that a world-leading guideline will be produced
#pwME #MECFS
Myalgic Encephalomyelitis (ME) - HSE.ie
www.hse.ie
September 9, 2025 at 2:46 PM
Reposted by David Davies-Payne
“DecodeME shows the incredible level of support that the ME/CFS patient community can give to research that involves them on a deep and meaningful level. Without the community, we could not have achieved all that we have.” Andy Devereux-Cooke (PPI Member and Co-Investigator)
August 15, 2025 at 8:45 AM
“DecodeME shows the incredible level of support that the ME/CFS patient community can give to research that involves them on a deep and meaningful level. Without the community, we could not have achieved all that we have.” Andy Devereux-Cooke (PPI Member and Co-Investigator)
Reposted by David Davies-Payne
"DecodeME is now calling on researchers worldwide to join us in accelerating ME/CFS research.” - Prof Chris Ponting (DecodeME Investigator).
We encourage researchers to explore and build on our findings. Apply for access to our rich dataset now shorturl.at/F8aOM
We encourage researchers to explore and build on our findings. Apply for access to our rich dataset now shorturl.at/F8aOM
August 12, 2025 at 10:11 AM
"DecodeME is now calling on researchers worldwide to join us in accelerating ME/CFS research.” - Prof Chris Ponting (DecodeME Investigator).
We encourage researchers to explore and build on our findings. Apply for access to our rich dataset now shorturl.at/F8aOM
We encourage researchers to explore and build on our findings. Apply for access to our rich dataset now shorturl.at/F8aOM
Reposted by David Davies-Payne
My piece for The RCP Commentary Magazine for #SouthAsianHeritageMonth.
This is my lovely Mum and Dad in 1969.
Immigrants helped build the NHS
www.rcp.ac.uk/78702?utm_so...
This is my lovely Mum and Dad in 1969.
Immigrants helped build the NHS
www.rcp.ac.uk/78702?utm_so...
Roots to Routes: why South Asian Heritage Month matters to the NHS
www.rcp.ac.uk
August 11, 2025 at 12:00 PM
My piece for The RCP Commentary Magazine for #SouthAsianHeritageMonth.
This is my lovely Mum and Dad in 1969.
Immigrants helped build the NHS
www.rcp.ac.uk/78702?utm_so...
This is my lovely Mum and Dad in 1969.
Immigrants helped build the NHS
www.rcp.ac.uk/78702?utm_so...
"we identified significant differences in cfRNA contributions from multiple immune cell types. Notably, we observed a decrease in platelet-derived cfRNA and an increase in pDCs, monocytes, and certain T cell subset-derived cfRNA"
#MECFS
www.pnas.org/doi/10.1073/...
#MECFS
www.pnas.org/doi/10.1073/...
Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome | PNAS
People living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience
heterogeneous and debilitating symptoms that lack suffici...
www.pnas.org
August 12, 2025 at 12:13 AM
"we identified significant differences in cfRNA contributions from multiple immune cell types. Notably, we observed a decrease in platelet-derived cfRNA and an increase in pDCs, monocytes, and certain T cell subset-derived cfRNA"
#MECFS
www.pnas.org/doi/10.1073/...
#MECFS
www.pnas.org/doi/10.1073/...
"includes seven Tier 1 genes, with BTN2A2 and TRIM38 eQTLs colocalised with ME/CFS risk […] Complexes involving butyrophilin3 and -2 homologues […] allow innate-like Vγ9Vδ2 T cells to distinguish self-derived from non-self-derived pyrophosphate antigens"
#gdTcells #MECFS
@forum-gd.bsky.social
#gdTcells #MECFS
@forum-gd.bsky.social
Our initial DNA results! DecodeME have discovered that people with an ME/CFS diagnosis have significant genetic differences compared to the general population.
-
Summary of our results: shorturl.at/pgsjk
Check out our full preprint paper: shorturl.at/VwN3s
-
Summary of our results: shorturl.at/pgsjk
Check out our full preprint paper: shorturl.at/VwN3s
August 7, 2025 at 1:01 AM
"includes seven Tier 1 genes, with BTN2A2 and TRIM38 eQTLs colocalised with ME/CFS risk […] Complexes involving butyrophilin3 and -2 homologues […] allow innate-like Vγ9Vδ2 T cells to distinguish self-derived from non-self-derived pyrophosphate antigens"
#gdTcells #MECFS
@forum-gd.bsky.social
#gdTcells #MECFS
@forum-gd.bsky.social
"The project is part of a “notable increase” in ME/CFS research in recent years, Bosch says—a trend he attributes to a mix of patient advocacy, the failure of psychological and behavioral explanations for the condition, and increasing awareness of #MECFS thanks to its similarities to #LongCovid."
Science magazine’s coverage of the DecodeME initial results : www.science.org/content/arti...
Possible genetic clues to ME/chronic fatigue syndrome identified in massive study
DNA analysis of more than 15,500 people with the debilitating condition identifies eight tentative “genetic signals”
www.science.org
August 6, 2025 at 9:06 PM
"The project is part of a “notable increase” in ME/CFS research in recent years, Bosch says—a trend he attributes to a mix of patient advocacy, the failure of psychological and behavioral explanations for the condition, and increasing awareness of #MECFS thanks to its similarities to #LongCovid."
Reposted by David Davies-Payne
Proud to be on the Science Advisory Board for DecodeME, a peripheral role but a fantastic vantage point from which to witness such outstanding work by Chris Ponting @cgatist.bsky.social and colleagues
#MECFS #pwME
www.theguardian.com/society/2025...
#MECFS #pwME
www.theguardian.com/society/2025...
Scientists find link between genes and ME/chronic fatigue syndrome
Large study suggests people’s genetics could ‘tip the balance’ on whether they would develop the illness
www.theguardian.com
August 6, 2025 at 8:16 PM
Proud to be on the Science Advisory Board for DecodeME, a peripheral role but a fantastic vantage point from which to witness such outstanding work by Chris Ponting @cgatist.bsky.social and colleagues
#MECFS #pwME
www.theguardian.com/society/2025...
#MECFS #pwME
www.theguardian.com/society/2025...
With clear evidence of a genetic predisposition linked to relevant biological pathways, these findings need to mark a turning point away from medicine's historic failure to correctly research this disease and meet its duty of patient care.
#MECFS #DecodeME
#MECFS #DecodeME
August 6, 2025 at 7:45 PM
Reposted by David Davies-Payne
DECODE ME has published its results.
Massive congratulations to @cgatist.bsky.social and team in Edinburgh.
Let’s hope this is the start of a paradigm shift in how we view, research and treat this dreadful illness.
www.decodeme.org.uk/initial-dna-...
Massive congratulations to @cgatist.bsky.social and team in Edinburgh.
Let’s hope this is the start of a paradigm shift in how we view, research and treat this dreadful illness.
www.decodeme.org.uk/initial-dna-...
Initial DecodeME DNA Results - DecodeME
06 August 2025 The DecodeME team is delighted to announce that the initial analysis of 15,579 DNA samples is complete, and we have important news to share. Main findings from our analysis Your genes ...
www.decodeme.org.uk
August 6, 2025 at 6:50 PM
DECODE ME has published its results.
Massive congratulations to @cgatist.bsky.social and team in Edinburgh.
Let’s hope this is the start of a paradigm shift in how we view, research and treat this dreadful illness.
www.decodeme.org.uk/initial-dna-...
Massive congratulations to @cgatist.bsky.social and team in Edinburgh.
Let’s hope this is the start of a paradigm shift in how we view, research and treat this dreadful illness.
www.decodeme.org.uk/initial-dna-...
Thank you Professor Chris Ponting @cgatist.bsky.social and the team at @decodemestudy.bsky.social
#MECFS #genomics
#MECFS #genomics
Our initial DNA results! DecodeME have discovered that people with an ME/CFS diagnosis have significant genetic differences compared to the general population.
-
Summary of our results: shorturl.at/pgsjk
Check out our full preprint paper: shorturl.at/VwN3s
-
Summary of our results: shorturl.at/pgsjk
Check out our full preprint paper: shorturl.at/VwN3s
August 6, 2025 at 7:03 PM
Thank you Professor Chris Ponting @cgatist.bsky.social and the team at @decodemestudy.bsky.social
#MECFS #genomics
#MECFS #genomics
#MECFS and #LongCovid pilot study 👀
(Small numbers: 4 ME, 5 LC and 4 healthy sedentary controls)
Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to Chronic Fatigue Syndrome and Long COVID-19 sera
iopscience.iop.org/article/10.1...
(Small numbers: 4 ME, 5 LC and 4 healthy sedentary controls)
Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to Chronic Fatigue Syndrome and Long COVID-19 sera
iopscience.iop.org/article/10.1...
August 1, 2025 at 5:40 AM
#MECFS and #LongCovid pilot study 👀
(Small numbers: 4 ME, 5 LC and 4 healthy sedentary controls)
Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to Chronic Fatigue Syndrome and Long COVID-19 sera
iopscience.iop.org/article/10.1...
(Small numbers: 4 ME, 5 LC and 4 healthy sedentary controls)
Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to Chronic Fatigue Syndrome and Long COVID-19 sera
iopscience.iop.org/article/10.1...
On the outdated, flawed and harmful 'current' review on exercise in #MECFS. From one of Cochrane's founder members:
"Given the Cochrane Collaboration’s reliance on their exceptional status and members, that is untenable. Not retiring influential out-of-date reviews is a ticking time bomb."
"Given the Cochrane Collaboration’s reliance on their exceptional status and members, that is untenable. Not retiring influential out-of-date reviews is a ticking time bomb."
Six months later: What their response on ME/CFS tells us about the Cochrane Collaboration.
New post at Absolutely Maybe .... 1/2
absolutelymaybe.plos.org/2025/07/31/s...
#MECFS
New post at Absolutely Maybe .... 1/2
absolutelymaybe.plos.org/2025/07/31/s...
#MECFS
Six Months Later: What Their Response on ME/CFS Tells Us About the Cochrane Collaboration - Absolutely Maybe
Six months ago, I wrote a post called “When journal, scientific society, and community values clash.” I recounted the tale of the…
absolutelymaybe.plos.org
August 1, 2025 at 2:56 AM
On the outdated, flawed and harmful 'current' review on exercise in #MECFS. From one of Cochrane's founder members:
"Given the Cochrane Collaboration’s reliance on their exceptional status and members, that is untenable. Not retiring influential out-of-date reviews is a ticking time bomb."
"Given the Cochrane Collaboration’s reliance on their exceptional status and members, that is untenable. Not retiring influential out-of-date reviews is a ticking time bomb."
WatchME for iPhone and Apple Watch
v2.7 now available
To help #pwME with daily pacing for #MECFS
iOS 17 | watchOS 10
Free. No data collected.
apps.apple.com/app/watchme/...
Phone
- Adds more widget options
- Adds heart and HRV gauges to status tab
- Adds O2 sat gauge to status tab if available
v2.7 now available
To help #pwME with daily pacing for #MECFS
iOS 17 | watchOS 10
Free. No data collected.
apps.apple.com/app/watchme/...
Phone
- Adds more widget options
- Adds heart and HRV gauges to status tab
- Adds O2 sat gauge to status tab if available
WatchME
For people with ME/CFS. This app helps you to pace and stay within your capacity envelope. Use your watch and phone to monitor your daily heart rate, steps and distance.
Integrated with HealthKit....
apps.apple.com
July 31, 2025 at 10:45 PM
WatchME for iPhone and Apple Watch
v2.7 now available
To help #pwME with daily pacing for #MECFS
iOS 17 | watchOS 10
Free. No data collected.
apps.apple.com/app/watchme/...
Phone
- Adds more widget options
- Adds heart and HRV gauges to status tab
- Adds O2 sat gauge to status tab if available
v2.7 now available
To help #pwME with daily pacing for #MECFS
iOS 17 | watchOS 10
Free. No data collected.
apps.apple.com/app/watchme/...
Phone
- Adds more widget options
- Adds heart and HRV gauges to status tab
- Adds O2 sat gauge to status tab if available
"UK Biobank analyses show that cancer survivors had increased cancer mortality after SARS-CoV-2 infection. This risk peaked in the months after infection, paralleling mouse models showing greater than 100-fold DCC expansion into metastatic lesions within two weeks"
#BreastCancer #Cancer #Covid
#BreastCancer #Cancer #Covid
Hidden in the lungs of some breast cancer survivors are tumour cells that can remain dormant for decades — until they one day trigger a relapse
go.nature.com/41iIdJR
go.nature.com/41iIdJR
‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu
Inflammation from the respiratory infections seems to be the culprit, study in mice finds.
go.nature.com
July 31, 2025 at 5:02 AM
"UK Biobank analyses show that cancer survivors had increased cancer mortality after SARS-CoV-2 infection. This risk peaked in the months after infection, paralleling mouse models showing greater than 100-fold DCC expansion into metastatic lesions within two weeks"
#BreastCancer #Cancer #Covid
#BreastCancer #Cancer #Covid
Reposted by David Davies-Payne
My rapid response at BMJ is online now. I joined the chorus of protest about an opinion piece claiming people with severe ME/CFS can recover by "reframing their beliefs" &c. People with ME/CFS deserve so much better than that:
www.bmj.com/content/389/...
#MECFS
www.bmj.com/content/389/...
#MECFS
Patients with severe ME/CFS deserve better than unproven theories
www.bmj.com
July 25, 2025 at 1:03 PM
My rapid response at BMJ is online now. I joined the chorus of protest about an opinion piece claiming people with severe ME/CFS can recover by "reframing their beliefs" &c. People with ME/CFS deserve so much better than that:
www.bmj.com/content/389/...
#MECFS
www.bmj.com/content/389/...
#MECFS
"work presented here and by these two independent research teams provides strong support for investing in research focused on dissecting innate immunity in ME/CFS"
"mechanistic dissection of its pathobiology is revealing subtype-specific biomarkers"
#MECFS #LongCovid
"mechanistic dissection of its pathobiology is revealing subtype-specific biomarkers"
#MECFS #LongCovid
Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS https://www.medrxiv.org/content/10.1101/2025.07.23.25332049v1
July 25, 2025 at 3:11 AM
"work presented here and by these two independent research teams provides strong support for investing in research focused on dissecting innate immunity in ME/CFS"
"mechanistic dissection of its pathobiology is revealing subtype-specific biomarkers"
#MECFS #LongCovid
"mechanistic dissection of its pathobiology is revealing subtype-specific biomarkers"
#MECFS #LongCovid
Reposted by David Davies-Payne
Incredibly powerful watch about the government plan on ME from @binitakane.bsky.social and Sarah, whose daughter Maeve died from ME.
NHS urgently needs to commission specialist services for the 100,000s people living with this debilitating condition.
watch here
youtu.be/GZbSrdtiA9k?...
NHS urgently needs to commission specialist services for the 100,000s people living with this debilitating condition.
watch here
youtu.be/GZbSrdtiA9k?...
July 22, 2025 at 11:08 AM
Incredibly powerful watch about the government plan on ME from @binitakane.bsky.social and Sarah, whose daughter Maeve died from ME.
NHS urgently needs to commission specialist services for the 100,000s people living with this debilitating condition.
watch here
youtu.be/GZbSrdtiA9k?...
NHS urgently needs to commission specialist services for the 100,000s people living with this debilitating condition.
watch here
youtu.be/GZbSrdtiA9k?...