New in this release

- Heart rate zones display
- More monthly metrics, eg walking and stair speed, stability
- Interface improvements
- iOS 26 compatibility

One of the identified genes is SUDS3 which is proposed to be linked to microglial activation.

https://www.pure.ed.ac.uk/ws/portalfiles/portal/533352484/Candidate_Genes.pdf

"We propose that skeletal muscle tissue in ME/CFS and Long COVID-19 progresses through a hypermetabolic state, leading to severe muscular and mitochondrial deterioration. This is the first study to suggest such transient metabolic adaptation."

"Structural analyses confirmed myotube hypertrophy and elevated mitochondrial oxygen consumption in ME/CFS. While muscles initially adapted by increasing glycolysis, prolonged exposure (96–144 hours) caused muscle fragility and weakness, with mitochondria fragmenting into a toroidal conformation."

"Short exposures (48 hours) to patient sera led to a significant reduction in muscle contractile strength. Transcriptomic analysis revealed the upregulation of protein translation, glycolytic enzymes, disturbances in calcium homeostasis, hypertrophy, and mitochondrial hyperfusion."