Claire Rougeulle
@crougeulle.bsky.social
Director of Institut Curie research center
Group leader, X chromosome lover, Epigenetics, Development, ncRNA
Group leader, X chromosome lover, Epigenetics, Development, ncRNA
Reposted by Claire Rougeulle
Last chance! Early bird rates and oral presentation abstract submissions for Lorne Genome 𝐞𝐧𝐝 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫 𝟕𝐭𝐡, 𝟐𝟎𝟐𝟓 - only one week away: https://www.lornegenome.org/registrations
We have a fantastic lineup of national and international speakers: https://www.lornegenome.org/speakers. Join us!
We have a fantastic lineup of national and international speakers: https://www.lornegenome.org/speakers. Join us!
Speakers — Lorne Genome
No description found
www.lornegenome.org
October 30, 2025 at 9:30 PM
Last chance! Early bird rates and oral presentation abstract submissions for Lorne Genome 𝐞𝐧𝐝 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫 𝟕𝐭𝐡, 𝟐𝟎𝟐𝟓 - only one week away: https://www.lornegenome.org/registrations
We have a fantastic lineup of national and international speakers: https://www.lornegenome.org/speakers. Join us!
We have a fantastic lineup of national and international speakers: https://www.lornegenome.org/speakers. Join us!
À ne manquer sous aucun prétexte!
🎙️ Le podcast de l'Institut Curie est de retour pour une deuxième saison ! RDV le 28 octobre pour 6 nouveaux épisodes qui vous feront plonger dans les laboratoires de l’Institut Curie et découvrir la science autrement. 👀
October 21, 2025 at 2:57 PM
À ne manquer sous aucun prétexte!
Reposted by Claire Rougeulle
#ESMO25 | New insights from the SOHO-01 study presented by Prof. NIcolas Girard @institutcurie.bsky.social:
Molecular factors and ctDNA dynamics may help predict outcomes in patients with HER2-mutant #NSCLC treated with sevabertinib, paving the way for more personalized care.
#medonc #lungcancer
Molecular factors and ctDNA dynamics may help predict outcomes in patients with HER2-mutant #NSCLC treated with sevabertinib, paving the way for more personalized care.
#medonc #lungcancer
October 19, 2025 at 1:13 PM
#ESMO25 | New insights from the SOHO-01 study presented by Prof. NIcolas Girard @institutcurie.bsky.social:
Molecular factors and ctDNA dynamics may help predict outcomes in patients with HER2-mutant #NSCLC treated with sevabertinib, paving the way for more personalized care.
#medonc #lungcancer
Molecular factors and ctDNA dynamics may help predict outcomes in patients with HER2-mutant #NSCLC treated with sevabertinib, paving the way for more personalized care.
#medonc #lungcancer
Reposted by Claire Rougeulle
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
www.biorxiv.org
October 17, 2025 at 5:22 PM
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Reposted by Claire Rougeulle
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 1:02 PM
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reposted by Claire Rougeulle
Job alert!
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA
Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...
forum.image.sc
October 7, 2025 at 12:39 PM
Job alert!
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
Reposted by Claire Rougeulle
"Transposable elements are vectors of recurrent transgenerational epigenetic inheritance"
Congrats Vincent Colot and team!
www.science.org/doi/10.1126/...
Congrats Vincent Colot and team!
www.science.org/doi/10.1126/...
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
www.science.org
September 18, 2025 at 8:27 PM
"Transposable elements are vectors of recurrent transgenerational epigenetic inheritance"
Congrats Vincent Colot and team!
www.science.org/doi/10.1126/...
Congrats Vincent Colot and team!
www.science.org/doi/10.1126/...
Reposted by Claire Rougeulle
Professor Fuller is brilliant and you need to read what she has to say.
If you’re wondering how much of what RFK Jr said yesterday about vaccines was true—almost none of it was.
@FullerLab_UW is one of the most accomplished vaccinologists out there and her article is required reading to separate truth from falsehoods.
theconversation.com/how-rfk-jr-s...
@FullerLab_UW is one of the most accomplished vaccinologists out there and her article is required reading to separate truth from falsehoods.
theconversation.com/how-rfk-jr-s...
How RFK Jr.’s misguided science on mRNA vaccines is shaping policy − a vaccine expert examines the false claims
Chaos at the CDC and the sharp move away from mRNA vaccines has public health experts alarmed.
theconversation.com
September 5, 2025 at 9:36 PM
Professor Fuller is brilliant and you need to read what she has to say.
Reposted by Claire Rougeulle
▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 12:37 PM
▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...
Congrats Charlène!
I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 8:24 PM
Congrats Charlène!
Reposted by Claire Rougeulle
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 1:10 PM
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Reposted by Claire Rougeulle
We had #four interdisciplinary teams, integrating dev-bio, evolution, tissue mechanics, and biophysical modeling, all going full throttle to understand the #CF. Still, it took more than 7 years to publish two papers back-to-back (10/12)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Patterned invagination prevents mechanical instability during gastrulation - Nature
In Drosophila, the cephalic furrow counteracts mechanical stress as the developing head and the trunk tissues meet, providing evidence for how mechanical forces influence the evolution of morphog...
www.nature.com
September 4, 2025 at 8:22 AM
We had #four interdisciplinary teams, integrating dev-bio, evolution, tissue mechanics, and biophysical modeling, all going full throttle to understand the #CF. Still, it took more than 7 years to publish two papers back-to-back (10/12)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The @crick.ac.uk is in good hands! Not that it wasn’t before
Exciting day for @crick.ac.uk today: Edith Heard takes over as Director
We're looking forward to this new chapter in the story
www.crick.ac.uk/about-us/lea...
We're looking forward to this new chapter in the story
www.crick.ac.uk/about-us/lea...
Edith Heard
www.crick.ac.uk
September 1, 2025 at 7:59 PM
The @crick.ac.uk is in good hands! Not that it wasn’t before
Reposted by Claire Rougeulle
if you are willing to look clear-eyed at the cumulative evidence, the inescapable conclusion is that our deeply held beliefs about American democracy no longer match our present reality.
donmoynihan.substack.com/p/the-author...
donmoynihan.substack.com/p/the-author...
The authoritarian checklist
It is time to admit that America is no longer a functioning democracy
donmoynihan.substack.com
August 29, 2025 at 10:54 AM
if you are willing to look clear-eyed at the cumulative evidence, the inescapable conclusion is that our deeply held beliefs about American democracy no longer match our present reality.
donmoynihan.substack.com/p/the-author...
donmoynihan.substack.com/p/the-author...
Reposted by Claire Rougeulle
CHAOS ERUPTS AT CDC
CDC Director Susan Monarez has been ousted after RFK Jr. demanded she change her policy on the COVID vaccine. Top officials from the Vaccine Unit, Zoonotic Division, and the Chief Medical Officer are resigning, per reports.
Horrifying news for public health.
CDC Director Susan Monarez has been ousted after RFK Jr. demanded she change her policy on the COVID vaccine. Top officials from the Vaccine Unit, Zoonotic Division, and the Chief Medical Officer are resigning, per reports.
Horrifying news for public health.
August 27, 2025 at 10:31 PM
CHAOS ERUPTS AT CDC
CDC Director Susan Monarez has been ousted after RFK Jr. demanded she change her policy on the COVID vaccine. Top officials from the Vaccine Unit, Zoonotic Division, and the Chief Medical Officer are resigning, per reports.
Horrifying news for public health.
CDC Director Susan Monarez has been ousted after RFK Jr. demanded she change her policy on the COVID vaccine. Top officials from the Vaccine Unit, Zoonotic Division, and the Chief Medical Officer are resigning, per reports.
Horrifying news for public health.
Reposted by Claire Rougeulle
Sen Patty Murray (D-WA):
“If there are any adults left in the White House, it’s well past time they face reality… We cannot let RFK Jr. burn what’s left of the CDC and our other critical health agencies to the ground—he must be fired.”
“If there are any adults left in the White House, it’s well past time they face reality… We cannot let RFK Jr. burn what’s left of the CDC and our other critical health agencies to the ground—he must be fired.”
August 28, 2025 at 2:02 AM
Sen Patty Murray (D-WA):
“If there are any adults left in the White House, it’s well past time they face reality… We cannot let RFK Jr. burn what’s left of the CDC and our other critical health agencies to the ground—he must be fired.”
“If there are any adults left in the White House, it’s well past time they face reality… We cannot let RFK Jr. burn what’s left of the CDC and our other critical health agencies to the ground—he must be fired.”
Reposted by Claire Rougeulle
Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: marie-helene.verlhac@college-de-france.fr
For more information, please contact: marie-helene.verlhac@college-de-france.fr
August 28, 2025 at 8:23 AM
Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: marie-helene.verlhac@college-de-france.fr
For more information, please contact: marie-helene.verlhac@college-de-france.fr
Reposted by Claire Rougeulle
In Brief: A new center in San Francisco will offer tailor-made CRISPR therapies to cure children with rare diseases www.nature.com/articles/s41...
Children with rare genetic diseases get CRISPR Cures center - Nature Biotechnology
Nature Biotechnology - Children with rare genetic diseases get CRISPR Cures center
www.nature.com
August 26, 2025 at 4:04 PM
In Brief: A new center in San Francisco will offer tailor-made CRISPR therapies to cure children with rare diseases www.nature.com/articles/s41...
Reposted by Claire Rougeulle
Just a few more days left to apply!
We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
August 26, 2025 at 12:54 PM
Just a few more days left to apply!
Reposted by Claire Rougeulle
📅 Apply by Sept 14 to our International Course “Multiscale integration in Biological Systems” in partnership with @normalesup.bsky.social
👉 Open to MSc/PhD students, postdocs & researchers: training.institut-curie.org/courses/mult...
👉 Open to MSc/PhD students, postdocs & researchers: training.institut-curie.org/courses/mult...
August 26, 2025 at 2:37 PM
📅 Apply by Sept 14 to our International Course “Multiscale integration in Biological Systems” in partnership with @normalesup.bsky.social
👉 Open to MSc/PhD students, postdocs & researchers: training.institut-curie.org/courses/mult...
👉 Open to MSc/PhD students, postdocs & researchers: training.institut-curie.org/courses/mult...
Reposted by Claire Rougeulle
Wow, maybe genomic imprinting as we know it is just the tip of then iceberg. Hopefully this helps usher in a wave of mechanistic studies www.nature.com/articles/s41...
Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature
A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.
www.nature.com
August 23, 2025 at 11:06 AM
Wow, maybe genomic imprinting as we know it is just the tip of then iceberg. Hopefully this helps usher in a wave of mechanistic studies www.nature.com/articles/s41...
Reposted by Claire Rougeulle
Want to see the impact of #NIH, #NSF and #EPA grant cuts in your community? Check out @noamross.net, @scott-delaney.bsky.social and colleagues' project here. Tell your friends and neighbors about what is happening. grant-witness.us
Grant Witness
grant-witness.us
August 23, 2025 at 1:17 PM
Want to see the impact of #NIH, #NSF and #EPA grant cuts in your community? Check out @noamross.net, @scott-delaney.bsky.social and colleagues' project here. Tell your friends and neighbors about what is happening. grant-witness.us
Well done Katja!
Eliminating both #separase inhibition mechanisms –via securin and via cyclin B1-Cdk1– reveals absence of robust cohesin protection in metaphase II #oocytes
Katja Wassmann @meiosis-mom.bsky.social and colleagues
www.embopress.org/doi/full/10....
Katja Wassmann @meiosis-mom.bsky.social and colleagues
www.embopress.org/doi/full/10....
August 22, 2025 at 9:27 PM
Well done Katja!
Reposted by Claire Rougeulle
Excited that our paper was published in Science Advances 🧪
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!
Wyss researchers have induced human stem cells to initiate meiosis – a key step in creating eggs and sperm – in the lab for the first time. This work was published in @science.org Advances.
Recapitulating egg and sperm development in the dish
By Benjamin Boettner (BOSTON) — More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-q...
wyss.harvard.edu
August 16, 2025 at 8:35 PM
Excited that our paper was published in Science Advances 🧪
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!
Reposted by Claire Rougeulle
Our institution has given a generous donation as well as our fly labs. Convince yours to do so as well!
A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
August 14, 2025 at 7:32 AM
Our institution has given a generous donation as well as our fly labs. Convince yours to do so as well!