Tristan Croll
@crolltristan.bsky.social
Structural biologist and lover of all things biochemistry. Principal Scientist at Altos Labs. Developer of ISOLDE for macromolecular modelling in cryo-EM and Xtal maps: https://tristanic.github.io/isolde/
Reposted by Tristan Croll
This is amazing work lead by Tom (@tlitfin.bsky.social) in my team. Always trying to get more for less and making computing efficient. So satisfying making science resources go further. Boltz2 is great for protein structure prediction and hopefully LMI4Boltz extends its use. Code on GitHub… 🧶🧬
LMI4Boltz: Optimizing VRAM utilization to predict large macromolecular complexes with consumer grade hardware
AlphaFold2 has revolutionized structural biology by enabling the prediction of protein structures approaching experimental quality. AlphaFold3 extends this framework to support modelling broad biomole...
www.biorxiv.org
October 31, 2025 at 9:40 PM
This is amazing work lead by Tom (@tlitfin.bsky.social) in my team. Always trying to get more for less and making computing efficient. So satisfying making science resources go further. Boltz2 is great for protein structure prediction and hopefully LMI4Boltz extends its use. Code on GitHub… 🧶🧬
Possibly the most evergreen Onion article in history: theonion.com/recession-pl...
May 5, 2025 at 10:09 AM
Possibly the most evergreen Onion article in history: theonion.com/recession-pl...
Reposted by Tristan Croll
Had a very long social media break after the last #SynchrotronMugMadness and the bird site's decent into horror.
So hello bluesky, I'm a staff structural biologist helping @imperiallifesci.bsky.social solve protein structures with #crystallography and #CryoEM.
Please enjoy these protein crystals 💎
So hello bluesky, I'm a staff structural biologist helping @imperiallifesci.bsky.social solve protein structures with #crystallography and #CryoEM.
Please enjoy these protein crystals 💎
January 8, 2025 at 4:34 PM
Had a very long social media break after the last #SynchrotronMugMadness and the bird site's decent into horror.
So hello bluesky, I'm a staff structural biologist helping @imperiallifesci.bsky.social solve protein structures with #crystallography and #CryoEM.
Please enjoy these protein crystals 💎
So hello bluesky, I'm a staff structural biologist helping @imperiallifesci.bsky.social solve protein structures with #crystallography and #CryoEM.
Please enjoy these protein crystals 💎
Kids were complaining that their gaming laptop was getting a bit sluggish… 😳🤢
December 31, 2024 at 2:41 PM
Kids were complaining that their gaming laptop was getting a bit sluggish… 😳🤢
Interviewer: Can you explain this gap on your CV?
Evolutionary biology: Well, yeah… but then I’ll have two *new* gaps you’ll want me to explain.
Evolutionary biology: Well, yeah… but then I’ll have two *new* gaps you’ll want me to explain.
Interviewer: Can you explain this gap on your CV?
Chemist: Yeah, that's what's between the HOMO and the LUMO #chemsky
Chemist: Yeah, that's what's between the HOMO and the LUMO #chemsky
Interviewer: Can you explain this gap in your resume?
Gravitational-wave astronomer: It depends on the maximum neutron star mass and details of the supernova mechanism ... or it could just be a selection effect
🧪⚛🔭
Gravitational-wave astronomer: It depends on the maximum neutron star mass and details of the supernova mechanism ... or it could just be a selection effect
🧪⚛🔭
December 22, 2024 at 3:57 PM
Interviewer: Can you explain this gap on your CV?
Evolutionary biology: Well, yeah… but then I’ll have two *new* gaps you’ll want me to explain.
Evolutionary biology: Well, yeah… but then I’ll have two *new* gaps you’ll want me to explain.
Reposted by Tristan Croll
🎄 xmas preprint 🎄 we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...
December 21, 2024 at 10:46 AM
🎄 xmas preprint 🎄 we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...
You know what they say about never releasing on a Friday… what does it say about me that I’m releasing on the last Friday before Christmas? 😬
Anyway, ISOLDE builds for ChimeraX 1.9 are now up. Enjoy!
Anyway, ISOLDE builds for ChimeraX 1.9 are now up. Enjoy!
December 20, 2024 at 4:19 PM
You know what they say about never releasing on a Friday… what does it say about me that I’m releasing on the last Friday before Christmas? 😬
Anyway, ISOLDE builds for ChimeraX 1.9 are now up. Enjoy!
Anyway, ISOLDE builds for ChimeraX 1.9 are now up. Enjoy!
Reposted by Tristan Croll
An interesting finding that some types of HPV infection might be preventing cancer (as opposed to the ones that can cause it).
Also features G.K. Chesterton and a brief cameo by RFK Jr.
Also features G.K. Chesterton and a brief cameo by RFK Jr.
HPV Infections: Friend and Foe
www.science.org
December 18, 2024 at 9:17 PM
An interesting finding that some types of HPV infection might be preventing cancer (as opposed to the ones that can cause it).
Also features G.K. Chesterton and a brief cameo by RFK Jr.
Also features G.K. Chesterton and a brief cameo by RFK Jr.
Man… the fact that there’s a *second* ring galaxy visible in the gap? The sci-fi story (where these are the still-growing explosions from the past firing of some unimaginably powerful galaxy-killing beam weapon) practically writes itself.
Hoag’s Object is a rare ring galaxy located over 600 million light-years from Earth.
A nearly perfect circle full of young blue stars surrounds a spheroid of mostly older red giant stars. In between is a gap that appears almost completely empty.
Delightfully distinctive.
📸 Credit: NASA/STScl/AURA
A nearly perfect circle full of young blue stars surrounds a spheroid of mostly older red giant stars. In between is a gap that appears almost completely empty.
Delightfully distinctive.
📸 Credit: NASA/STScl/AURA
December 16, 2024 at 3:26 PM
Man… the fact that there’s a *second* ring galaxy visible in the gap? The sci-fi story (where these are the still-growing explosions from the past firing of some unimaginably powerful galaxy-killing beam weapon) practically writes itself.
Reposted by Tristan Croll
Rare sighting of wild G-protein in Virginia
December 12, 2024 at 11:10 AM
Rare sighting of wild G-protein in Virginia
Structural biology people: @ucsfchimerax.bsky.social has entered the building.
December 4, 2024 at 9:55 PM
Structural biology people: @ucsfchimerax.bsky.social has entered the building.
Reposted by Tristan Croll
Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 3, 2024 at 7:05 AM
Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tristan Croll
Discussing Bluesky migration in terms of liberal flight misses the simple fact that most people use social media for fun not influence and this platform, unlike X and cruddified Facebook, doesn’t feel like you’re wading through shit to reach your friends. It’s not that deep.
November 16, 2024 at 11:19 AM
Discussing Bluesky migration in terms of liberal flight misses the simple fact that most people use social media for fun not influence and this platform, unlike X and cruddified Facebook, doesn’t feel like you’re wading through shit to reach your friends. It’s not that deep.
… has anyone coined the term “Xit” yet?
November 15, 2024 at 8:09 PM
… has anyone coined the term “Xit” yet?
For ISOLDE users who like to live on the edge: I uploaded dev builds for ChimeraX 1.8.dev… yesterday. While most things seem fine, if you want to use the “isolde add aa” command then *don’t* use this version. Something badly broken, killing the ChimeraX session.
March 27, 2024 at 1:38 PM
For ISOLDE users who like to live on the edge: I uploaded dev builds for ChimeraX 1.8.dev… yesterday. While most things seem fine, if you want to use the “isolde add aa” command then *don’t* use this version. Something badly broken, killing the ChimeraX session.
Bugfix released! Unrelated, but I’d strongly recommend updating to ChimeraX 1.7.1 (particularly for Mac users - the 1.7 release inadvertently left out the Metal2 OpenMM implementation; 1.7.1 should get you back up to full speed).
Ahh, the pitfalls of software design… turns out ISOLDE breaks when you try to load an MTZ file containing only map coefficients (because I basically never use it that way myself, so didn’t notice when I broke it). Will try to push a fixed version out tomorrow.
January 26, 2024 at 3:00 PM
Bugfix released! Unrelated, but I’d strongly recommend updating to ChimeraX 1.7.1 (particularly for Mac users - the 1.7 release inadvertently left out the Metal2 OpenMM implementation; 1.7.1 should get you back up to full speed).
Ahh, the pitfalls of software design… turns out ISOLDE breaks when you try to load an MTZ file containing only map coefficients (because I basically never use it that way myself, so didn’t notice when I broke it). Will try to push a fixed version out tomorrow.
January 25, 2024 at 12:59 PM
Ahh, the pitfalls of software design… turns out ISOLDE breaks when you try to load an MTZ file containing only map coefficients (because I basically never use it that way myself, so didn’t notice when I broke it). Will try to push a fixed version out tomorrow.
Reposted by Tristan Croll
Excited to share our first preprint of 2024! 🎉
researchsquare.com/article/rs-3...
This study focuses on PDCoV, an emerging enteric pathogen.
We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies.
#virology #cryoEM
researchsquare.com/article/rs-3...
This study focuses on PDCoV, an emerging enteric pathogen.
We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies.
#virology #cryoEM
January 12, 2024 at 2:41 PM
Excited to share our first preprint of 2024! 🎉
researchsquare.com/article/rs-3...
This study focuses on PDCoV, an emerging enteric pathogen.
We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies.
#virology #cryoEM
researchsquare.com/article/rs-3...
This study focuses on PDCoV, an emerging enteric pathogen.
We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies.
#virology #cryoEM
<ahem> This thing on?
January 12, 2024 at 8:13 PM
<ahem> This thing on?