Christophe Chapard
@christophechapard.bsky.social
Reposted by Christophe Chapard
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:43 PM
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
Reposted by Christophe Chapard
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
October 9, 2025 at 2:43 PM
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
Reposted by Christophe Chapard
#ÉchappéesInattendues 👀 Échappez-vous le temps d'un week-end ! Mars, l'océan, les néandertaliens, l'intelligence... autant de sujets à explorer avec nos scientifiques pour répondre aux questions des petits et des grands.
📍 @citedessciences.bsky.social
👉 echappeesinattendues.cnrs.fr/main-event/o...
📍 @citedessciences.bsky.social
👉 echappeesinattendues.cnrs.fr/main-event/o...
October 4, 2025 at 8:30 AM
#ÉchappéesInattendues 👀 Échappez-vous le temps d'un week-end ! Mars, l'océan, les néandertaliens, l'intelligence... autant de sujets à explorer avec nos scientifiques pour répondre aux questions des petits et des grands.
📍 @citedessciences.bsky.social
👉 echappeesinattendues.cnrs.fr/main-event/o...
📍 @citedessciences.bsky.social
👉 echappeesinattendues.cnrs.fr/main-event/o...
Reposted by Christophe Chapard
New work from my lab with the Brown lab on how genome folding changes during motor neuron maturation, and how this process goes awry in ALS motor neurons. Led by Dr. Ozgun Uyan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dynamic changes in chromosome and nuclear architecture during maturation of normal and ALS C9orf72 motor neurons
We have investigated changes in chromosome conformation, nuclear organization, and transcription during differentiation and maturation of control and mutant motor neurons harboring hexanucleotide expa...
www.biorxiv.org
September 23, 2025 at 9:13 PM
New work from my lab with the Brown lab on how genome folding changes during motor neuron maturation, and how this process goes awry in ALS motor neurons. Led by Dr. Ozgun Uyan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Christophe Chapard
Our reporter hopping scaled up to thousands of integrations in a single locus, to produce high-resolution functional maps, with plenty of interesting insights: www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 24, 2025 at 8:56 AM
Our reporter hopping scaled up to thousands of integrations in a single locus, to produce high-resolution functional maps, with plenty of interesting insights: www.science.org/doi/10.1126/...
Reposted by Christophe Chapard
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts
Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...
www.biorxiv.org
August 11, 2025 at 2:56 PM
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Pleased to see this study out, combining experimental work from our lab at the @cbitoulouse.bsky.social, in particular by @nathaliebastie.bsky.social and @beckof.bsky.social, and from Laura Chaptal and @alengronne.bsky.social at IGH Montpellier
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
RNA Pol II-based regulations of chromosome folding
How transcription and cohesin complexes interact to regulate 3D genome organization
remains unclear. Chapard et al. dissect their respective contributions and their interplay
in shaping the genome arc...
www.cell.com
August 9, 2025 at 10:47 AM
Pleased to see this study out, combining experimental work from our lab at the @cbitoulouse.bsky.social, in particular by @nathaliebastie.bsky.social and @beckof.bsky.social, and from Laura Chaptal and @alengronne.bsky.social at IGH Montpellier
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
@cnrs.fr @cnrsbiologie.bsky.social
Congrats to all!
Reposted by Christophe Chapard
Two major events today on our campus!
🚴♀️First, the Tour de France is passing right next to us — @cnrsoccitanieest.bsky.social!
🧬Second, our latest paper on the role of G-quadruplexes (G4s) at promoters is now online at @natgenet.nature.com!
🚴♀️First, the Tour de France is passing right next to us — @cnrsoccitanieest.bsky.social!
🧬Second, our latest paper on the role of G-quadruplexes (G4s) at promoters is now online at @natgenet.nature.com!
July 22, 2025 at 12:25 PM
Two major events today on our campus!
🚴♀️First, the Tour de France is passing right next to us — @cnrsoccitanieest.bsky.social!
🧬Second, our latest paper on the role of G-quadruplexes (G4s) at promoters is now online at @natgenet.nature.com!
🚴♀️First, the Tour de France is passing right next to us — @cnrsoccitanieest.bsky.social!
🧬Second, our latest paper on the role of G-quadruplexes (G4s) at promoters is now online at @natgenet.nature.com!
Reposted by Christophe Chapard
Quand l’ARN s’invite dans la réparation de l’ADN ... 🧬
🤝 @lablegube.bsky.social @cbitoulouse.bsky.social
👉 Lire l'article dans @natcellbio.nature.com
buff.ly/CxP2P6N
buff.ly/PY2loYA
🤝 @lablegube.bsky.social @cbitoulouse.bsky.social
👉 Lire l'article dans @natcellbio.nature.com
buff.ly/CxP2P6N
buff.ly/PY2loYA
Quand l’ARN s’invite dans la réparation de l’ADN
Quand notre ADN se casse, nos cellules le réparent avec une haute précision.
www.insb.cnrs.fr
July 17, 2025 at 5:01 AM
Quand l’ARN s’invite dans la réparation de l’ADN ... 🧬
🤝 @lablegube.bsky.social @cbitoulouse.bsky.social
👉 Lire l'article dans @natcellbio.nature.com
buff.ly/CxP2P6N
buff.ly/PY2loYA
🤝 @lablegube.bsky.social @cbitoulouse.bsky.social
👉 Lire l'article dans @natcellbio.nature.com
buff.ly/CxP2P6N
buff.ly/PY2loYA
Some interesting scientific talks going on!
June 26, 2025 at 6:56 PM
Some interesting scientific talks going on!
Reposted by Christophe Chapard
Reposted by Christophe Chapard
🔥That was #pint25 day 2: WHAT A NIGHT!🔥
Are you ready for the final night? 👓🧠 It's already starting in some countries!
Have a great time and share your photos with us to be featured in the final collage! #pint25
All the info pintofscience.com
Are you ready for the final night? 👓🧠 It's already starting in some countries!
Have a great time and share your photos with us to be featured in the final collage! #pint25
All the info pintofscience.com
May 21, 2025 at 8:47 AM
🔥That was #pint25 day 2: WHAT A NIGHT!🔥
Are you ready for the final night? 👓🧠 It's already starting in some countries!
Have a great time and share your photos with us to be featured in the final collage! #pint25
All the info pintofscience.com
Are you ready for the final night? 👓🧠 It's already starting in some countries!
Have a great time and share your photos with us to be featured in the final collage! #pint25
All the info pintofscience.com
Reposted by Christophe Chapard
💥That was #pint25 day 1 and it was ABSOLUTELY INCREDIBLE! ✨
Ready for day 2?
👓🧠 Teams across 27 countries are already prepping for tonight's science adventures!
📷Share your experience with us to feature in tomorrow's highlight collage!
All festival details at pintofscience.com
Ready for day 2?
👓🧠 Teams across 27 countries are already prepping for tonight's science adventures!
📷Share your experience with us to feature in tomorrow's highlight collage!
All festival details at pintofscience.com
May 20, 2025 at 7:00 AM
💥That was #pint25 day 1 and it was ABSOLUTELY INCREDIBLE! ✨
Ready for day 2?
👓🧠 Teams across 27 countries are already prepping for tonight's science adventures!
📷Share your experience with us to feature in tomorrow's highlight collage!
All festival details at pintofscience.com
Ready for day 2?
👓🧠 Teams across 27 countries are already prepping for tonight's science adventures!
📷Share your experience with us to feature in tomorrow's highlight collage!
All festival details at pintofscience.com
On y est ! La science sous toutes ses formes, accessible pour toutes et tous! Hâte d'échanger de manière directe et conviviale avec les spécialistes...
Événements à Toulouse
Pint of Science provoque LA rencontre entre scientifiques et grand public et lève le voile sur les découvertes et les avancées scientifiques et technologiques. Parce que non, dans un labo ça ne se pas...
pintofscience.fr
May 17, 2025 at 7:53 AM
On y est ! La science sous toutes ses formes, accessible pour toutes et tous! Hâte d'échanger de manière directe et conviviale avec les spécialistes...
Reposted by Christophe Chapard
Together with the De Ridder lab www.deridderlab.nl we just published a review on deep learning as a tool for gene expression analysis/ prediction: rdcu.be/elQCc.
Predicting gene expression from DNA sequence using deep learning models
Nature Reviews Genetics - Barbadilla-Martínez et al. review recent progress in deep-learning-based sequence-to-expression models, which predict gene expression levels solely from DNA sequence....
rdcu.be
May 17, 2025 at 7:30 AM
Together with the De Ridder lab www.deridderlab.nl we just published a review on deep learning as a tool for gene expression analysis/ prediction: rdcu.be/elQCc.
Reposted by Christophe Chapard
To the top of the "to-read" list. Looks like a heroic amount of work from the Hahn lab (large-scale ChEC-seq compendium!) www.nature.com/articles/s41...
Low overlap of transcription factor DNA binding and regulatory targets - Nature
A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between t...
www.nature.com
April 16, 2025 at 4:04 PM
To the top of the "to-read" list. Looks like a heroic amount of work from the Hahn lab (large-scale ChEC-seq compendium!) www.nature.com/articles/s41...
Reposted by Christophe Chapard
🎉WOUHOU !
Les tickets pour les soirées #pint25 sont disponibles sur le site, le plus dur sera de faire un choix !
🎟 pintofscience.fr 🎟
🗓 19-21 mai /📍60 villes
Les places dans les bars étant limitées, ne tardez pas à réserver vos places pour vos évènements préférés !
Les tickets pour les soirées #pint25 sont disponibles sur le site, le plus dur sera de faire un choix !
🎟 pintofscience.fr 🎟
🗓 19-21 mai /📍60 villes
Les places dans les bars étant limitées, ne tardez pas à réserver vos places pour vos évènements préférés !
April 14, 2025 at 6:11 AM
🎉WOUHOU !
Les tickets pour les soirées #pint25 sont disponibles sur le site, le plus dur sera de faire un choix !
🎟 pintofscience.fr 🎟
🗓 19-21 mai /📍60 villes
Les places dans les bars étant limitées, ne tardez pas à réserver vos places pour vos évènements préférés !
Les tickets pour les soirées #pint25 sont disponibles sur le site, le plus dur sera de faire un choix !
🎟 pintofscience.fr 🎟
🗓 19-21 mai /📍60 villes
Les places dans les bars étant limitées, ne tardez pas à réserver vos places pour vos évènements préférés !
Reposted by Christophe Chapard
How do SMC complexes capture DNA? 🧪
Led by Frank Bürmann, Jan Löwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway.
Read more: tinyurl.com/4s8nrrkk
#LMBResearch
Led by Frank Bürmann, Jan Löwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway.
Read more: tinyurl.com/4s8nrrkk
#LMBResearch
March 31, 2025 at 2:40 PM
How do SMC complexes capture DNA? 🧪
Led by Frank Bürmann, Jan Löwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway.
Read more: tinyurl.com/4s8nrrkk
#LMBResearch
Led by Frank Bürmann, Jan Löwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway.
Read more: tinyurl.com/4s8nrrkk
#LMBResearch
Reposted by Christophe Chapard
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Rules of Engagement
YouTube video by Johan Gibcus
www.youtube.com
April 11, 2025 at 7:45 AM
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Venez découvrir les intervenants du @cbitoulouse.bsky.social
🎉ÇA Y EST !!
Le programme #pint25 de presque toutes les villes est en ligne !!
À consulter ici 👉 pintofscience.fr 👈
🎫Vous avez deux semaines pour le découvrir tranquillement, les tickets seront en ligne lundi 14 avril !
👓🧠❤🔥Alors, quelle est votre soirée préférée
Le programme #pint25 de presque toutes les villes est en ligne !!
À consulter ici 👉 pintofscience.fr 👈
🎫Vous avez deux semaines pour le découvrir tranquillement, les tickets seront en ligne lundi 14 avril !
👓🧠❤🔥Alors, quelle est votre soirée préférée
March 31, 2025 at 12:46 PM
Venez découvrir les intervenants du @cbitoulouse.bsky.social
Reposted by Christophe Chapard
Synthetic biologists have the know-how and ambition to retool whole genomes, but hidden complexity continues to surprise them
https://go.nature.com/4gL1QPB
https://go.nature.com/4gL1QPB
Why is it so hard to rewrite a genome?
Synthetic biologists have the know-how and ambition to retool whole genomes. But the hidden complexity of biological systems continues to surprise them.
go.nature.com
February 18, 2025 at 1:26 PM
Synthetic biologists have the know-how and ambition to retool whole genomes, but hidden complexity continues to surprise them
https://go.nature.com/4gL1QPB
https://go.nature.com/4gL1QPB
Reposted by Christophe Chapard
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 12, 2025 at 6:28 AM
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Christophe Chapard
Great start of the New Year for Krys from our neighbour lab @oxfordbiochemistry.bsky.social. Have a look at his paper - www.nature.com/articles/s41...
DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts - Nature Communications
The critical events in transcription termination of RNA polymerase II (Pol II) remain not fully understood. Here, the authors find that the transcription factor Spt5 enhances the activity of RNA exonu...
www.nature.com
January 7, 2025 at 8:29 AM
Great start of the New Year for Krys from our neighbour lab @oxfordbiochemistry.bsky.social. Have a look at his paper - www.nature.com/articles/s41...
Reposted by Christophe Chapard
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
The PNUTS phosphatase complex controls transcription pause release
Kelley et al. discover that the PNUTS phosphatase complex plays an essential role
in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves
this through its TND, which recog...
www.cell.com
November 26, 2024 at 4:18 PM
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)