Carlos Moreno-Yruela
LightNews LightNews
banner
carlosmyruela.bsky.social
Carlos Moreno-Yruela
@carlosmyruela.bsky.social
420 followers 610 following 28 posts
Postdoc at LCBM (EPFL), funded by SNSF🇨🇭 and formerly IRFD🇩🇰 | Chemical biology of epigenetic enzymes
Posts Replies Media Videos
Pinned
carlosmyruela.bsky.social
Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
Reposted by Carlos Moreno-Yruela
rseq-quimica.bsky.social
🎉 ¡Orgullo RSEQ! Nuestros socios @casadevallcarla.bsky.social,
@nikinikki87.bsky.social y @carlosmyruela.bsky.social han sido galardonados con una prestigiosa #ERCStartingGrant 2025🔬 Enhorabuena!!!!!

📖 rseq.org/tres-miembro...

@urv.cat
@lcbm-epfl.bsky.social
@iciq.org @icfo.eu
Tres miembros de la RSEQ han conseguido una ERC... – RSEQ
Los miembros de la RSEQ: Carla Casadevall, Nicoletta Liguori y Carlos Moreno Yruela consiguen una ERC Starting Grant en la convocatoria 2025.
rseq.org
September 10, 2025 at 1:44 PM
carlosmyruela.bsky.social
I am really excited that #CHEMTUBIO will be funded through an @erc.europa.eu Starting Grant!
This funding will kickstart my lab next year and help us unveil the mechanisms and therapeutic implications of erasers of microtubule modifications.
Stay tuned!
erc.europa.eu European Research Council (ERC) @erc.europa.eu · Sep 4
📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 5, 2025 at 11:24 AM
Reposted by Carlos Moreno-Yruela
bist.eu
Six #BISTcommunity early-career researchers have secured prestigious ERC grants 👏

These awards highlight the ability of BIST Community centres to attract and nurture outstanding young international talent.

@crg.eu @icfo.eu @iciq.org @ibecbarcelona.eu

👉http://bit.ly/486ENOq
September 4, 2025 at 3:08 PM
carlosmyruela.bsky.social
Pint of Science was again a great success in Lausanne, with >500 people attending our events!
Kudos to co-coordinators @miriamlisci.bsky.social and @juliensluneau.bsky.social, and to the fantastic team of 19 volunteers at the bars 🥳!

#PINT25 #scicomm
May 24, 2025 at 9:07 AM
Reposted by Carlos Moreno-Yruela
alexateslenko.bsky.social
If you always wanted to know the kinetics of how the Polycomb enzymes modify chromatin, we are thrilled to share our work!!! 🎉📄🧬🔬

Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support!
doi.org/10.1126/scia...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
doi.org
May 22, 2025 at 11:00 AM
Reposted by Carlos Moreno-Yruela
lcbm-epfl.bsky.social
Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. 👇👇👇
www.science.org/doi/10.1126/...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
www.science.org
May 22, 2025 at 10:47 AM
carlosmyruela.bsky.social
The program for Pint of Science Lausanne 🧪 is ready!
pintofscience.ch/events/lausa...

This year we have again three venues covering topics from aging to robotic surgery or sustainable agriculture

Come join us on the 19th, 20th and 21st of May 🥳

#PintCH #scicomm @pintofscience.ch
Lausanne
Explore Pint of Science Switzerland events in Lausanne
pintofscience.ch
April 24, 2025 at 8:57 AM
carlosmyruela.bsky.social
Very happy to see this story out in #JACS_Au!

Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
pubs.acs.org/doi/10.1021/...

#ChemBio #chemsky #HDAC
Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...
pubs.acs.org
February 19, 2025 at 11:54 AM
Reposted by Carlos Moreno-Yruela
marcusbuschbeck.bsky.social
!THREE OPPORTUNITIES TO JOIN US!

We are looking for 3 (!!!) PhD students interested in:
How Metabolism affects Genome Regulation.

Join us at @carrerasijc.bsky.social as Marie Sklodowska Curie network fellow.

More info:
2 x experimental: www.nuclear-dn.eu
1 x computational: www.hubmol.eu
February 12, 2025 at 3:34 PM
Reposted by Carlos Moreno-Yruela
hmariclab.bsky.social
🚨 Excited to share our work @elife.bsky.social doi.org/10.7554/eLife.98827.2 on targeting Hepatitis B virus #HBV 🦠 capsid aggregation by designed molecules! #DrugDiscovery #ChemBio

Thanks V Khayenko C Makbul @clemensschulte.bsky.social & @boettchercryoem.bsky.social for stunning #CryoEM visuals!
January 28, 2025 at 7:07 PM
carlosmyruela.bsky.social
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
February 4, 2025 at 1:13 PM
Reposted by Carlos Moreno-Yruela
elife.bsky.social
Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules. #CryoEm
https://elifesciences.org/articles/105335?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights
High-resolution structural imaging using customised magnetic beads.
January 25, 2025 at 9:21 AM
Reposted by Carlos Moreno-Yruela
erictopol.bsky.social
Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉)
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...
January 24, 2025 at 3:22 PM
Reposted by Carlos Moreno-Yruela
nature.com
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X

https://go.nature.com/42tH8Ai
Bluesky’s science takeover: 70% of Nature poll respondents use platform
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.
go.nature.com
January 24, 2025 at 11:52 AM
Reposted by Carlos Moreno-Yruela
hirofunabiki.bsky.social

A nice commentary article by @carlosmyruela.bsky.social y.social and @beatfierz.bsky.social has been already published! Thank you, Carlos and Beat!
elifesciences.org/articles/105...
Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules
Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.
elifesciences.org
January 22, 2025 at 6:31 PM
Reposted by Carlos Moreno-Yruela
hirofunabiki.bsky.social
Here is our most recent reviewed preprint on MagIC-cryo-EM invented by @yarimura.bsky.social
elifesciences.org/reviewed-pre...

Please note that this is not the final version, or VOR. A revised version (www.biorxiv.org/content/10.1...) is currently being reviewed at eLife.
MagIC-Cryo-EM: Structural determination on magnetic beads for scarce macromolecules in heterogeneous samples
elifesciences.org
January 22, 2025 at 6:31 PM
Reposted by Carlos Moreno-Yruela
danieladankova.bsky.social
Happy to share the latest preprint from my PhD studies on the discovery of de novo macrocyclic inhibitors of HDAC11. This was a great collaboration between @christianaolsen.bsky.social lab (@carlosmyruela.bsky.social, @tnhansen.bsky.social) and Christian Heinis lab (@alexanderln.bsky.social).
christianaolsen.bsky.social Christian A. Olsen @christianaolsen.bsky.social · Dec 10
New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL

Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social

🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶

chemrxiv.org/engage/chemr...
December 13, 2024 at 7:06 AM
Reposted by Carlos Moreno-Yruela
christianaolsen.bsky.social
New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL

Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social

🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶

chemrxiv.org/engage/chemr...
December 10, 2024 at 2:28 PM
Reposted by Carlos Moreno-Yruela
alexanderln.bsky.social
Happy to share a fun collaboration between EPFL and UCPH initiated by @carlosmyruela.bsky.social, Christian Heinis, @christianaolsen.bsky.social and I!

Big shout-out to @danieladankova.bsky.social who spearheaded the project.

Now out on @chemrxiv.bsky.social

chemrxiv.org/engage/chemr...
Discovery of de novo Macrocycle Inhibitors of Histone Deacetylase 11
Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...
chemrxiv.org
December 9, 2024 at 12:44 PM
Reposted by Carlos Moreno-Yruela
altmetric.com
We’re no experts but this sounds like it might be suboptimal for disseminating research.
juddlegum.bsky.social Judd Legum @juddlegum.bsky.social · Nov 25
Elon admits that any post on X with a link is throttled

He advises you to upload content directly to X instead, where he can monetize it

Musk is the richest person in the world and his view is everyone should work for him for free
November 25, 2024 at 5:55 AM
Reposted by Carlos Moreno-Yruela
chembiotalks.bsky.social
We are working on the program for the 5th Virtual ChemBioTalks on September 30th, 2025. While we already have commitments by our keynotes @oconnorlab.bsky.social and @craigmcrews.bsky.social, the remaining program is still in planning. Whom would you most like to hear at our next event?
November 21, 2024 at 5:05 AM
Reposted by Carlos Moreno-Yruela
thornsesholdlab.bsky.social
📯📯 Chemical Biology starter pack 📯📯
140 PIs & groups posting primary research in chemical biology.

Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj

Let's make ChemBioSky even greater again!

#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
November 17, 2024 at 10:58 PM
Reposted by Carlos Moreno-Yruela
lucas.farnunglab.com
Btw check out our collaborative effort with the Walter Lab to map nucleosome acidic patch interactors for all nuclear proteins: predictomes.org/view/acidicp...
Predictomes | H. sapiens H2A/H2B vs. nuclear proteome
A free interactive resource for viewing predicted AlphaFold multimer structures for protein pairs in biological pathways.
predictomes.org
November 15, 2024 at 3:43 PM
Reposted by Carlos Moreno-Yruela
bsky.app
If you're seeing "Invalid Handle" on your profile, this should resolve on its own — thanks for your patience!! 🦋
November 14, 2024 at 6:55 PM
Reposted by Carlos Moreno-Yruela
ninahartrampf.bsky.social
Are you looking for a PhD position in peptide synthesis, automation, and computational analysis? 🧪 💊💻

We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: jobs.uzh.ch/job-vacancie...

⏰ Application deadline = November 15
UZH: PhD Position in Solid-Phase Peptide Synthesis (Industry Collaboration)
A PhD position is available in the group of Prof. Dr. Nina Hartrampf at the Department of Chemistry, University of Zurich (Switzerland), in collaboration with the company Novo Nordisk in Måløv, Denmar...
jobs.uzh.ch
November 13, 2024 at 6:11 AM