Bending Lab UK
@bendinglab.bsky.social
T cell immunology group. Interested in T cell regulation and checkpoint receptor control of adaptive immunity. #CD4Tcells #TCRsignalling #immunotherapy
Pinned
Bending Lab UK
@bendinglab.bsky.social
· May 12
PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
Reposted by Bending Lab UK
It's today! Our #BSIMidlands25 kicks off with an overview of the history of clinical immunology in the Midlands by Dr Aarnoud Huissoon
June 20, 2025 at 9:06 AM
It's today! Our #BSIMidlands25 kicks off with an overview of the history of clinical immunology in the Midlands by Dr Aarnoud Huissoon
Reposted by Bending Lab UK
We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...
June 19, 2025 at 11:08 AM
We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...
Reposted by Bending Lab UK
Honoured to receive this prize alongside an inspiring group of scientists. This will support our work to improve mRNA therapies for precision medicine. #mRNA #immunoSky #Science
We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...
June 19, 2025 at 11:23 AM
Honoured to receive this prize alongside an inspiring group of scientists. This will support our work to improve mRNA therapies for precision medicine. #mRNA #immunoSky #Science
Lovely work!
Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.
#ImmunoSky
www.biorxiv.org/content/10.1...
#ImmunoSky
www.biorxiv.org/content/10.1...
Inhibitory TIGIT signalling is dependent on T cell receptor activation
TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...
www.biorxiv.org
May 15, 2025 at 5:49 PM
Lovely work!
Reposted by Bending Lab UK
PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
May 12, 2025 at 8:03 AM
PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
Reposted by Bending Lab UK
Congrats to the team! Very nice study. I find it especially interesting that blocking NFAT can compensate for the effects of anti-PD1/LAG3.
May 12, 2025 at 1:29 PM
Congrats to the team! Very nice study. I find it especially interesting that blocking NFAT can compensate for the effects of anti-PD1/LAG3.
Thank you! Yes, we have only largely looked at a few markers in the functional assays. I think as our model is very TCR signal driven (tolerogenic) it suggests it may more preferentially signal down that pathway. In terms of under co-stimulation or CD8 biology, we have not yet looked!
May 12, 2025 at 1:35 PM
Thank you! Yes, we have only largely looked at a few markers in the functional assays. I think as our model is very TCR signal driven (tolerogenic) it suggests it may more preferentially signal down that pathway. In terms of under co-stimulation or CD8 biology, we have not yet looked!
We are now seeking to understand relevance of these pathways are relevant in the immune related adverse events (irAEs) space and tumour environment!
May 12, 2025 at 8:03 AM
We are now seeking to understand relevance of these pathways are relevant in the immune related adverse events (irAEs) space and tumour environment!
PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
May 12, 2025 at 8:03 AM
PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
Reposted by Bending Lab UK
🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
April 13, 2025 at 3:58 PM
🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
Reposted by Bending Lab UK
Our new blog post spotlights the Lister Institute's ties with @unibirmingham.bsky.social, home to Lister Fellows past and present @bendinglab.bsky.social @agagambus.bsky.social @sarahdimeloe.bsky.social sky.social @therad-lab.bsky.social @tunglejic.bsky.social lister-institute.org.uk/shining-a-li...
Shining a light on the Lister Institute’s connection to the University of Birmingham – Lister Institute
lister-institute.org.uk
April 14, 2025 at 2:33 PM
Our new blog post spotlights the Lister Institute's ties with @unibirmingham.bsky.social, home to Lister Fellows past and present @bendinglab.bsky.social @agagambus.bsky.social @sarahdimeloe.bsky.social sky.social @therad-lab.bsky.social @tunglejic.bsky.social lister-institute.org.uk/shining-a-li...
Reposted by Bending Lab UK
#Immunology out now @science.org
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
April 11, 2025 at 4:17 PM
#Immunology out now @science.org
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
Reposted by Bending Lab UK
Check out latest work from @bendinglab.bsky.social - new insights into IFNg regulation of TCR signalling! 🧪 #immunosky
Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
April 11, 2025 at 8:54 AM
Check out latest work from @bendinglab.bsky.social - new insights into IFNg regulation of TCR signalling! 🧪 #immunosky
Highlights:
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNγ
- Anti-IFNγ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNγ additively reduces Tr1 cell frequency
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNγ
- Anti-IFNγ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNγ additively reduces Tr1 cell frequency
April 11, 2025 at 7:21 AM
Highlights:
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNγ
- Anti-IFNγ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNγ additively reduces Tr1 cell frequency
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNγ
- Anti-IFNγ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNγ additively reduces Tr1 cell frequency
Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
April 11, 2025 at 7:21 AM
Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
Reposted by Bending Lab UK
Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans
@jem.org
rupress.org/jem/article-...
@jem.org
rupress.org/jem/article-...
April 8, 2025 at 12:11 AM
Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans
@jem.org
rupress.org/jem/article-...
@jem.org
rupress.org/jem/article-...
Reposted by Bending Lab UK
A new paper from #ListerFellow @linterman.bsky.social and colleagues explores the role of tertiary lymphoid structures (TLS) in #bcell immune response. @pnas.org doi.org/10.1073/pnas...
Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS
The lungs are constantly exposed to the external environment and a myriad of antigenic
challenges within the air. Chronic exposure to allergens and...
doi.org
April 8, 2025 at 12:39 PM
A new paper from #ListerFellow @linterman.bsky.social and colleagues explores the role of tertiary lymphoid structures (TLS) in #bcell immune response. @pnas.org doi.org/10.1073/pnas...
Reposted by Bending Lab UK
What better way to get into that Friday feeling than reading our new paper? First author @hlpeks.bsky.social and I will be doing a tutorial on @arrdept-ucldom.bsky.social next Tuesday lunchtime for those who are interested in reading the highlights 📖
Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...
March 28, 2025 at 1:19 PM
What better way to get into that Friday feeling than reading our new paper? First author @hlpeks.bsky.social and I will be doing a tutorial on @arrdept-ucldom.bsky.social next Tuesday lunchtime for those who are interested in reading the highlights 📖
Reposted by Bending Lab UK
Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...
March 28, 2025 at 1:12 PM
Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...
Reposted by Bending Lab UK
📣 New Review Alert!
Do you think glial cells are simply neuronal support cells in the CNS?
Did you know glial cells are integral to barrier organs?
Check out our latest review exploring the fascinating crosstalk between glia and immune cells in the gut, lung and skin!
#GlialCells #ImmuneSystem
Do you think glial cells are simply neuronal support cells in the CNS?
Did you know glial cells are integral to barrier organs?
Check out our latest review exploring the fascinating crosstalk between glia and immune cells in the gut, lung and skin!
#GlialCells #ImmuneSystem
Glial-immune interactions in barrier organs are reviewed by @franzeprogatzky.bsky.social and colleagues:
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
January 23, 2025 at 10:11 AM
📣 New Review Alert!
Do you think glial cells are simply neuronal support cells in the CNS?
Did you know glial cells are integral to barrier organs?
Check out our latest review exploring the fascinating crosstalk between glia and immune cells in the gut, lung and skin!
#GlialCells #ImmuneSystem
Do you think glial cells are simply neuronal support cells in the CNS?
Did you know glial cells are integral to barrier organs?
Check out our latest review exploring the fascinating crosstalk between glia and immune cells in the gut, lung and skin!
#GlialCells #ImmuneSystem
Reposted by Bending Lab UK
Excited for our lab's FIRST paper #ScienceImmunology! 🎉
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
www.science.org
January 31, 2025 at 7:51 PM
Excited for our lab's FIRST paper #ScienceImmunology! 🎉
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Reposted by Bending Lab UK
The BSI has grants available for our members who want to help get more people excited about #immunology
Our Communication and Engagement Grant is open to all BSI members who want to take part in #PublicEngagement 🌟
Share your passion, build skills, and make a difference to the world of #immunology 💪
Application deadline: 1 Feb 2025 🗓️
Apply now 👉 bit.ly/3Y9j8gm
Share your passion, build skills, and make a difference to the world of #immunology 💪
Application deadline: 1 Feb 2025 🗓️
Apply now 👉 bit.ly/3Y9j8gm
January 16, 2025 at 4:40 PM
The BSI has grants available for our members who want to help get more people excited about #immunology
Reposted by Bending Lab UK
⏰ Last few days before the deadline of midday (GMT) Friday 10 January if you are thinking of applying for one of our Medical Research Council fully funded 4 year PhD studentships at our partner institutions @uniofnottingham.bsky.social @unibirmingham.bsky.social or University of Leicester 🧵
PhD Opportunities – MRC AIM
more.bham.ac.uk
January 7, 2025 at 11:49 AM
⏰ Last few days before the deadline of midday (GMT) Friday 10 January if you are thinking of applying for one of our Medical Research Council fully funded 4 year PhD studentships at our partner institutions @uniofnottingham.bsky.social @unibirmingham.bsky.social or University of Leicester 🧵