Bending Lab UK
@bendinglab.bsky.social
T cell immunology group. Interested in T cell regulation and checkpoint receptor control of adaptive immunity. #CD4Tcells #TCRsignalling #immunotherapy
PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
May 12, 2025 at 8:03 AM
PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social
Highlights:
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNγ
- Anti-IFNγ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNγ additively reduces Tr1 cell frequency
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNγ
- Anti-IFNγ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNγ additively reduces Tr1 cell frequency
April 11, 2025 at 7:21 AM
Highlights:
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNγ
- Anti-IFNγ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNγ additively reduces Tr1 cell frequency
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNγ
- Anti-IFNγ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNγ additively reduces Tr1 cell frequency
Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
April 11, 2025 at 7:21 AM
Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...