Marin Barisic
@barisiclab.bsky.social
studying cell division and cytoskeleton at the Danish Cancer Institute, Copenhagen
Pinned
Marin Barisic
@barisiclab.bsky.social
· May 27
How does natural compound #parthenolide exert its #antimitotic activity?
Marin Barisic and coworkers @barisiclab.bsky.social find it not to target microtubules, but to instead modify #kinetochore protein BUGZ to prevent spindle attachment and chromosome congression
www.embopress.org/doi/full/10....
Marin Barisic and coworkers @barisiclab.bsky.social find it not to target microtubules, but to instead modify #kinetochore protein BUGZ to prevent spindle attachment and chromosome congression
www.embopress.org/doi/full/10....
Check out our latest research now out @embojournal.org. Huge shout-out to our postdocs Susana Eibes and Bhagya Lakshmi and the rest of the team for their amazing work! 1/11
Reposted by Marin Barisic
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
November 11, 2025 at 9:26 AM
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
Reposted by Marin Barisic
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.
The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR
candidate.hr-manager.net
October 23, 2025 at 4:18 PM
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
Reposted by Marin Barisic
Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy
Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…
www.sciencedirect.com
October 23, 2025 at 7:14 AM
Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Marin Barisic
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
More info: www.crg.eu/en/content/t...
October 23, 2025 at 7:56 AM
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
More info: www.crg.eu/en/content/t...
Reposted by Marin Barisic
⚡Ready to grow and be inspired as a scientist?
We’re looking for a *PhD student* to join our lab at @crg.eu
in Barcelona and explore how cells self-organize, uncovering life’s inner design💡
We offer strong mentoring, cutting-edge science, and a vibrant international team🌍
Check the link below!
We’re looking for a *PhD student* to join our lab at @crg.eu
in Barcelona and explore how cells self-organize, uncovering life’s inner design💡
We offer strong mentoring, cutting-edge science, and a vibrant international team🌍
Check the link below!
October 23, 2025 at 9:56 AM
⚡Ready to grow and be inspired as a scientist?
We’re looking for a *PhD student* to join our lab at @crg.eu
in Barcelona and explore how cells self-organize, uncovering life’s inner design💡
We offer strong mentoring, cutting-edge science, and a vibrant international team🌍
Check the link below!
We’re looking for a *PhD student* to join our lab at @crg.eu
in Barcelona and explore how cells self-organize, uncovering life’s inner design💡
We offer strong mentoring, cutting-edge science, and a vibrant international team🌍
Check the link below!
Reposted by Marin Barisic
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
October 15, 2025 at 4:02 PM
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
Reposted by Marin Barisic
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
October 14, 2025 at 1:50 PM
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
Reposted by Marin Barisic
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 6:21 PM
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
Reposted by Marin Barisic
New Aurora A kinase role in maintaining proper nuclear shape organization at mitotic exit:
NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes
Sachin Kotak @spindlebehavior.bsky.social et al
www.embopress.org/doi/full/10....
NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes
Sachin Kotak @spindlebehavior.bsky.social et al
www.embopress.org/doi/full/10....
September 19, 2025 at 7:49 AM
New Aurora A kinase role in maintaining proper nuclear shape organization at mitotic exit:
NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes
Sachin Kotak @spindlebehavior.bsky.social et al
www.embopress.org/doi/full/10....
NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes
Sachin Kotak @spindlebehavior.bsky.social et al
www.embopress.org/doi/full/10....
Reposted by Marin Barisic
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Computational image analyst (m/f/d)
The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a
jobs.mpi-muenster.mpg.de
September 12, 2025 at 6:17 AM
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Reposted by Marin Barisic
Microtubules: from atoms to complex systems www.embl.org/about/info/c...
Microtubules: from atoms to complex systems
www.embl.org
September 15, 2025 at 5:17 AM
Microtubules: from atoms to complex systems www.embl.org/about/info/c...
Reposted by Marin Barisic
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.
www.science.org
September 15, 2025 at 4:50 AM
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
Reposted by Marin Barisic
The kinetochore corona orchestrates chromosome congression through transient microtubule interactions https://www.biorxiv.org/content/10.1101/2025.09.10.675486v1
September 13, 2025 at 8:30 AM
The kinetochore corona orchestrates chromosome congression through transient microtubule interactions https://www.biorxiv.org/content/10.1101/2025.09.10.675486v1
Reposted by Marin Barisic
September 13, 2025 at 7:00 AM
Reposted by Marin Barisic
Happy to share our work in @embojournal 👉 shorturl.at/zXNyn
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
September 13, 2025 at 5:14 AM
Happy to share our work in @embojournal 👉 shorturl.at/zXNyn
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
Reposted by Marin Barisic
New preprint from the lab! Please check it out. 🚨
Have you ever wondered how cells decide when it’s time to divide? So did we!
www.biorxiv.org/content/10.1...
Have you ever wondered how cells decide when it’s time to divide? So did we!
www.biorxiv.org/content/10.1...
Chromosome condensation mechanically primes the nucleus for mitosis
Timely and accurate transition into mitosis is essential to preserve genome integrity and avoid chromosome segregation errors. This transition depends on spatial and temporal activity patterns of the ...
www.biorxiv.org
September 3, 2025 at 10:07 AM
New preprint from the lab! Please check it out. 🚨
Have you ever wondered how cells decide when it’s time to divide? So did we!
www.biorxiv.org/content/10.1...
Have you ever wondered how cells decide when it’s time to divide? So did we!
www.biorxiv.org/content/10.1...
Reposted by Marin Barisic
Check out our new manuscript on biorxiv on the role of MOS in mammalian oocyte meiosis: www.biorxiv.org/cgi/content/...
With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social
With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social
A persistent intracellular bridge and cell cycle misregulation enable polar body cell divisions and tumor formation in Mos-deficient eggs
Mammalian female meiosis is uniquely regulated to produce a developmentally competent egg capable of supporting embryogenesis. During meiosis I, homologous chromosomes segregate, with half extruded in...
www.biorxiv.org
August 29, 2025 at 5:34 PM
Check out our new manuscript on biorxiv on the role of MOS in mammalian oocyte meiosis: www.biorxiv.org/cgi/content/...
With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social
With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social
Reposted by Marin Barisic
Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells - Nature Communications
The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers…
www.nature.com
August 28, 2025 at 11:07 AM
Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Marin Barisic
Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!
August 25, 2025 at 8:03 PM
Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!
Reposted by Marin Barisic
Narozna et al @gorbskylab.bsky.social uncover a high-frequency, chromosome 12-specific mis-segregation error in iPSCs. Eroded 12p arms lead to bridging & micronucleation, enabling widespread trisomy 12. A slight growth advantage allows trisomic cells to persist & dominate rupress.org/jcb/article/...
August 13, 2025 at 5:15 PM
Narozna et al @gorbskylab.bsky.social uncover a high-frequency, chromosome 12-specific mis-segregation error in iPSCs. Eroded 12p arms lead to bridging & micronucleation, enabling widespread trisomy 12. A slight growth advantage allows trisomic cells to persist & dominate rupress.org/jcb/article/...
Reposted by Marin Barisic
The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out.
link.springer.com/article/10.1...
Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out.
link.springer.com/article/10.1...
July 29, 2025 at 11:05 AM
The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out.
link.springer.com/article/10.1...
Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out.
link.springer.com/article/10.1...
Reposted by Marin Barisic
Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...
August 11, 2025 at 5:15 PM
Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...
Check out our latest research now out @embojournal.org. Huge shout-out to our postdocs Susana Eibes and Bhagya Lakshmi and the rest of the team for their amazing work! 1/11
How does natural compound #parthenolide exert its #antimitotic activity?
Marin Barisic and coworkers @barisiclab.bsky.social find it not to target microtubules, but to instead modify #kinetochore protein BUGZ to prevent spindle attachment and chromosome congression
www.embopress.org/doi/full/10....
Marin Barisic and coworkers @barisiclab.bsky.social find it not to target microtubules, but to instead modify #kinetochore protein BUGZ to prevent spindle attachment and chromosome congression
www.embopress.org/doi/full/10....
May 27, 2025 at 6:17 PM
Check out our latest research now out @embojournal.org. Huge shout-out to our postdocs Susana Eibes and Bhagya Lakshmi and the rest of the team for their amazing work! 1/11
Reposted by Marin Barisic
If you would like to attend a #microscopy or #bioimageanalysis training course in the next 6 months but don’t have funding, check out our Microscopy Training Grant from @jcellsci.bsky.social and @focalplane.bsky.social.
Next deadline: 6 June 2025
www.biologists.com/grants/jcs-f...
#Training
Next deadline: 6 June 2025
www.biologists.com/grants/jcs-f...
#Training
May 13, 2025 at 8:46 AM
If you would like to attend a #microscopy or #bioimageanalysis training course in the next 6 months but don’t have funding, check out our Microscopy Training Grant from @jcellsci.bsky.social and @focalplane.bsky.social.
Next deadline: 6 June 2025
www.biologists.com/grants/jcs-f...
#Training
Next deadline: 6 June 2025
www.biologists.com/grants/jcs-f...
#Training
Reposted by Marin Barisic
