Aniol Santo-Angles
@aniolet.bsky.social
Neuroscience. University of Helsinki.
Reposted by Aniol Santo-Angles
𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻?
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...
January 22, 2026 at 5:35 PM
𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻?
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...
Reposted by Aniol Santo-Angles
With some trepidation, I'm putting this out into the world:
gershmanlab.com/textbook.html
It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class.
My hope is that this will be a living document, continuously improved as I get feedback.
gershmanlab.com/textbook.html
It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class.
My hope is that this will be a living document, continuously improved as I get feedback.
January 9, 2026 at 1:27 AM
With some trepidation, I'm putting this out into the world:
gershmanlab.com/textbook.html
It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class.
My hope is that this will be a living document, continuously improved as I get feedback.
gershmanlab.com/textbook.html
It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class.
My hope is that this will be a living document, continuously improved as I get feedback.
Reposted by Aniol Santo-Angles
My simulation is here if anyone wants to play with it: github.com/alexhuth/not...
notebook-sharing/bold-cmro2-cbf-r2.ipynb at master · alexhuth/notebook-sharing
Contribute to alexhuth/notebook-sharing development by creating an account on GitHub.
github.com
January 5, 2026 at 5:22 PM
My simulation is here if anyone wants to play with it: github.com/alexhuth/not...
Reposted by Aniol Santo-Angles
Would love to hear expert views on this paper. It appears to show that the operationalization of brain activity the field has relied on for 3 decades—the BOLD response—is not actually a sensible measure of brain activity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
BOLD signal changes can oppose oxygen metabolism across the human cortex - Nature Neuroscience
Using quantitative brain imaging, the authors show opposite fMRI BOLD signal to metabolic activity due to variable oxygen extraction across the human cortex. This questions the canonical interpretatio...
www.nature.com
January 5, 2026 at 11:55 AM
Would love to hear expert views on this paper. It appears to show that the operationalization of brain activity the field has relied on for 3 decades—the BOLD response—is not actually a sensible measure of brain activity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aniol Santo-Angles
A must-read review. It argues that brain areas are only one of several organizing principles and are not especially central, given their weak correspondence to function. Cytoarchitecture and connectivity are a starting point, not the endpoint.
www.nature.com/articles/s41...
#neuroscience
www.nature.com/articles/s41...
#neuroscience
Rethinking the centrality of brain areas in understanding functional organization - Nature Neuroscience
Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas in neuroscience from the ...
www.nature.com
December 23, 2025 at 5:21 PM
A must-read review. It argues that brain areas are only one of several organizing principles and are not especially central, given their weak correspondence to function. Cytoarchitecture and connectivity are a starting point, not the endpoint.
www.nature.com/articles/s41...
#neuroscience
www.nature.com/articles/s41...
#neuroscience
Reposted by Aniol Santo-Angles
Happy to share our new paper in @nathumbehav.nature.com: t.co/Ciq7AKvle5. Using 500k+ behavioral trials, we show that #serialdependence deviates from #Bayesian predictions, pointing to a new narrative about how recent experience shapes perception. @aozkirli.bsky.social @achetverikov.bsky.social
December 22, 2025 at 11:09 AM
Happy to share our new paper in @nathumbehav.nature.com: t.co/Ciq7AKvle5. Using 500k+ behavioral trials, we show that #serialdependence deviates from #Bayesian predictions, pointing to a new narrative about how recent experience shapes perception. @aozkirli.bsky.social @achetverikov.bsky.social
Reposted by Aniol Santo-Angles
Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it.
PhD students: choose someone you like to talk to!
PhD students: choose someone you like to talk to!
December 19, 2025 at 4:35 PM
Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it.
PhD students: choose someone you like to talk to!
PhD students: choose someone you like to talk to!
Reposted by Aniol Santo-Angles
fMRI signals “up,” but neural metabolism might be going “down.”
In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
December 16, 2025 at 3:43 PM
fMRI signals “up,” but neural metabolism might be going “down.”
In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
Reposted by Aniol Santo-Angles
🚨 new preprint alert! biorxiv.org/content/10.1...
what is the architecture of an individual working memory?
1/n
what is the architecture of an individual working memory?
1/n
biorxiv.org
December 11, 2025 at 8:56 AM
🚨 new preprint alert! biorxiv.org/content/10.1...
what is the architecture of an individual working memory?
1/n
what is the architecture of an individual working memory?
1/n
New preprint! 🎉 We investigate how the brain maintains multiple items in working memory, testing two competing hypotheses for sequential memory: neural subspaces vs. neural sequences.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Neural Subspaces Encode Sequential Working Memory, but Neural Sequences Do Not
The neural mechanisms of multiple-item working memory are not well understood. In the current study, we address two competing hypotheses about the neural basis of sequential working memory: neural sub...
www.biorxiv.org
December 10, 2025 at 8:06 AM
New preprint! 🎉 We investigate how the brain maintains multiple items in working memory, testing two competing hypotheses for sequential memory: neural subspaces vs. neural sequences.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Aniol Santo-Angles
It is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason
Same for neuroscience. The lack of ability to measure many neurons’ activity, perturb them, and measure intracellular processes and connections is what limits understanding the brain.
The key barriers are not algorithms or AI.
🧪#neuroscience 🧠🤖 #MLSky
The key barriers are not algorithms or AI.
🧪#neuroscience 🧠🤖 #MLSky
November 17, 2025 at 1:23 AM
It is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason
Reposted by Aniol Santo-Angles
To those who access published (nonhuman) neurophysiology data & analysis code: what’s your favorite place to find it?
October 26, 2025 at 12:01 PM
To those who access published (nonhuman) neurophysiology data & analysis code: what’s your favorite place to find it?
Reposted by Aniol Santo-Angles
Colombo et al., Plos Biology, "Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans"
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans
Hemispherotomy is a neurosurgical procedure for treating refractory epilepsy by disconnecting a significant portion of the cortex. This study shows that the isolated cortex exhibits EEG patterns resem...
journals.plos.org
October 16, 2025 at 6:13 PM
Colombo et al., Plos Biology, "Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans"
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Aniol Santo-Angles
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
October 10, 2025 at 4:47 PM
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
Reposted by Aniol Santo-Angles
It's never occurred to me that it IS an assumption. This is the most astonishing start to a paper I've read in years:
"Living organisms are assumed to produce same-species offspring. Here, we report a shift from this norm in Messor ibericus, an ant that lays individuals from two distinct species."
"Living organisms are assumed to produce same-species offspring. Here, we report a shift from this norm in Messor ibericus, an ant that lays individuals from two distinct species."
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same mother having distinct genomes and morphologies.
www.nature.com
September 24, 2025 at 5:26 PM
It's never occurred to me that it IS an assumption. This is the most astonishing start to a paper I've read in years:
"Living organisms are assumed to produce same-species offspring. Here, we report a shift from this norm in Messor ibericus, an ant that lays individuals from two distinct species."
"Living organisms are assumed to produce same-species offspring. Here, we report a shift from this norm in Messor ibericus, an ant that lays individuals from two distinct species."
Reposted by Aniol Santo-Angles
Talk: Cognition is Emergent - Earl K. Miller
Neuroscience and Philosophy Salon, 9-12-25
youtu.be/Sk4ehOcsDmM?...
Neuroscience and Philosophy Salon, 9-12-25
youtu.be/Sk4ehOcsDmM?...
"Cognition is emergent" by Earl Miller
YouTube video by Neuroscience & Philosophy Salon
youtu.be
September 13, 2025 at 12:38 PM
Talk: Cognition is Emergent - Earl K. Miller
Neuroscience and Philosophy Salon, 9-12-25
youtu.be/Sk4ehOcsDmM?...
Neuroscience and Philosophy Salon, 9-12-25
youtu.be/Sk4ehOcsDmM?...
Reposted by Aniol Santo-Angles
Will try!
But I'll say in advance that I view the mouse brain as very different. Their anatomical connectivity is very high, with almost the entire cortex interconnected. Something like 97% if the Kennedy figures are right. Experiments in primates and humans are needed but obvly cannot be done now.
But I'll say in advance that I view the mouse brain as very different. Their anatomical connectivity is very high, with almost the entire cortex interconnected. Something like 97% if the Kennedy figures are right. Experiments in primates and humans are needed but obvly cannot be done now.
September 10, 2025 at 6:27 PM
Will try!
But I'll say in advance that I view the mouse brain as very different. Their anatomical connectivity is very high, with almost the entire cortex interconnected. Something like 97% if the Kennedy figures are right. Experiments in primates and humans are needed but obvly cannot be done now.
But I'll say in advance that I view the mouse brain as very different. Their anatomical connectivity is very high, with almost the entire cortex interconnected. Something like 97% if the Kennedy figures are right. Experiments in primates and humans are needed but obvly cannot be done now.
Reposted by Aniol Santo-Angles
(1/26) Excited to share a new preprint led by grad student Albert Wakhloo, with me and Larry Abbott: "Associative synaptic plasticity creates dynamic persistent activity."
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Associative synaptic plasticity creates dynamic persistent activity
In biological neural circuits, the dynamics of neurons and synapses are tightly coupled. We study the consequences of this coupling and show that it enables a novel form of working memory. In recurren...
www.biorxiv.org
August 25, 2025 at 5:17 PM
(1/26) Excited to share a new preprint led by grad student Albert Wakhloo, with me and Larry Abbott: "Associative synaptic plasticity creates dynamic persistent activity."
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Aniol Santo-Angles
🚨New paper🚨
Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.
Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW
Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.
Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW
August 1, 2025 at 9:57 AM
🚨New paper🚨
Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.
Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW
Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.
Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW
Reposted by Aniol Santo-Angles
1/3) This may be a very important paper, it suggests that there are no prediction error encoding neurons in sensory areas of cortex:
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
Sensory responses of visual cortical neurons are not prediction errors
Predictive coding is theorized to be a ubiquitous cortical process to explain sensory responses. It asserts that the brain continuously predicts sensory information and imposes those predictions on lo...
www.biorxiv.org
July 11, 2025 at 3:45 PM
1/3) This may be a very important paper, it suggests that there are no prediction error encoding neurons in sensory areas of cortex:
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
Reposted by Aniol Santo-Angles
a friend of mine shared this ai-generated "emotion wheel" and unfortunately i have been laughing my ass off at it for like 15 minutes now. today i am feeling Fnliinneon
June 5, 2025 at 2:46 PM
a friend of mine shared this ai-generated "emotion wheel" and unfortunately i have been laughing my ass off at it for like 15 minutes now. today i am feeling Fnliinneon
Reposted by Aniol Santo-Angles
Because we must build good things while we scream about the bad, I have started a "Data for Good" team @data-for-good-team.bsky.social that partners with organizations needing short-term data science help. We have three projects ongoing & will add more as our capacity grows.
data-for-good-team.org
data-for-good-team.org
May 10, 2025 at 3:33 PM
Because we must build good things while we scream about the bad, I have started a "Data for Good" team @data-for-good-team.bsky.social that partners with organizations needing short-term data science help. We have three projects ongoing & will add more as our capacity grows.
data-for-good-team.org
data-for-good-team.org
Reposted by Aniol Santo-Angles
Depressed individuals often experience a profound slowing/standstill of time. Northoff argues this is due to a desynchronization between “self-time” (inner) and “world-time” (external); inner sense of time becomes abnormally slow, making external events feel overwhelmingly fast or unmanageable. This
May 3, 2025 at 7:51 PM
Depressed individuals often experience a profound slowing/standstill of time. Northoff argues this is due to a desynchronization between “self-time” (inner) and “world-time” (external); inner sense of time becomes abnormally slow, making external events feel overwhelmingly fast or unmanageable. This
Reposted by Aniol Santo-Angles
It's kinda obvious. #AGIComics has already figured out which brain region is the most important. 😇
April 27, 2025 at 8:56 PM
It's kinda obvious. #AGIComics has already figured out which brain region is the most important. 😇
Reposted by Aniol Santo-Angles
High-Dimensional Dynamics in Low-Dimensional Networks.
New preprint with a former undergrad, Yue Wan.
I'm not totally sure how to talk about these results. They're counterintuitive on the surface, seem somewhat obvious in hindsight, but then there's more to them when you dig deeper.
New preprint with a former undergrad, Yue Wan.
I'm not totally sure how to talk about these results. They're counterintuitive on the surface, seem somewhat obvious in hindsight, but then there's more to them when you dig deeper.
April 21, 2025 at 5:00 PM
High-Dimensional Dynamics in Low-Dimensional Networks.
New preprint with a former undergrad, Yue Wan.
I'm not totally sure how to talk about these results. They're counterintuitive on the surface, seem somewhat obvious in hindsight, but then there's more to them when you dig deeper.
New preprint with a former undergrad, Yue Wan.
I'm not totally sure how to talk about these results. They're counterintuitive on the surface, seem somewhat obvious in hindsight, but then there's more to them when you dig deeper.