Ani Deshpande Lab
@anideshpande.bsky.social
Assoc. Prof. at SBP, La Jolla. Epigenetics, Pediatric Cancers, Leukemia, Stem Cells. LinkedIn: http://tinyurl.com/4yn4tj98
A 60 second video clip of Episode 5 in which we chronicle the fascinating story behind Continuous Glucose Monitors (CGMs) and of Adam Heller the man who built technologies that advanced these devices.
September 20, 2025 at 12:53 AM
A 60 second video clip of Episode 5 in which we chronicle the fascinating story behind Continuous Glucose Monitors (CGMs) and of Adam Heller the man who built technologies that advanced these devices.
Reposted by Ani Deshpande Lab
🔬 New research from the @anideshpande.bsky.social Deshpande lab at Sanford Burnham Prebys.
The study demonstrates how public genomic screening data can be used to uncover a new genetic vulnerability in synovial sarcoma.
👏 Shout out to Rema Iyer, PhD lead author of the manuscript.
The study demonstrates how public genomic screening data can be used to uncover a new genetic vulnerability in synovial sarcoma.
👏 Shout out to Rema Iyer, PhD lead author of the manuscript.
September 10, 2025 at 6:01 AM
🔬 New research from the @anideshpande.bsky.social Deshpande lab at Sanford Burnham Prebys.
The study demonstrates how public genomic screening data can be used to uncover a new genetic vulnerability in synovial sarcoma.
👏 Shout out to Rema Iyer, PhD lead author of the manuscript.
The study demonstrates how public genomic screening data can be used to uncover a new genetic vulnerability in synovial sarcoma.
👏 Shout out to Rema Iyer, PhD lead author of the manuscript.
Really excited that our manuscript on Synovial Sarcoma is now online. Link to Open Access PDF: tinyurl.com/55bnssws
A summary🧵 :
A summary🧵 :
August 18, 2025 at 9:18 AM
Really excited that our manuscript on Synovial Sarcoma is now online. Link to Open Access PDF: tinyurl.com/55bnssws
A summary🧵 :
A summary🧵 :
Sugar is the fuel of life, but we are drowning in it in the modern world. Where does all that excess sugar go, and what quiet damage might it be causing inside us?
E4 Diabetes - A Secret in Your Blood
YouTube video by Discovery Dialogues
www.youtube.com
August 11, 2025 at 6:00 PM
Sugar is the fuel of life, but we are drowning in it in the modern world. Where does all that excess sugar go, and what quiet damage might it be causing inside us?
I’m excited to share that as of July 1, I’ve been promoted to Full Professor. I am immensely grateful for the support of my trainees, mentors, letter writers and colleagues who supported me in reaching this milestone and for those who made this journey meaningful and worthwhile.
July 2, 2025 at 9:26 PM
I’m excited to share that as of July 1, I’ve been promoted to Full Professor. I am immensely grateful for the support of my trainees, mentors, letter writers and colleagues who supported me in reaching this milestone and for those who made this journey meaningful and worthwhile.
Reposted by Ani Deshpande Lab
Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
June 14, 2025 at 6:35 PM
Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
Always a bittersweet moment when a PhD student from the lab graduates.Terrific work and what a thesis defense talk Rema Iyer ! Congratulations on your degree!
June 7, 2025 at 2:36 AM
Always a bittersweet moment when a PhD student from the lab graduates.Terrific work and what a thesis defense talk Rema Iyer ! Congratulations on your degree!
Reposted by Ani Deshpande Lab
Science is under attack. The NIH, the NSF, and our research universities.
So today, I have a message for America's scientists:
youtu.be/MeoZDPy5cIY?...
So today, I have a message for America's scientists:
youtu.be/MeoZDPy5cIY?...
A Message to Scientists
YouTube video by Sen. Adam Schiff
youtu.be
May 28, 2025 at 9:54 PM
Science is under attack. The NIH, the NSF, and our research universities.
So today, I have a message for America's scientists:
youtu.be/MeoZDPy5cIY?...
So today, I have a message for America's scientists:
youtu.be/MeoZDPy5cIY?...
Reposted by Ani Deshpande Lab
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
May 24, 2025 at 1:13 AM
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Venoms can kill, but can they also heal? Here's Episode 3 of The Discovery Dialogues Podcast
𝗬𝗼𝘂𝗧𝘂𝗯𝗲: tinyurl.com/u7p3r8n9
𝗦𝗽𝗼𝘁𝗶𝗳𝘆: tinyurl.com/mryvvjsr
𝗔𝗽𝗽𝗹𝗲: tinyurl.com/bswzh583
𝗬𝗼𝘂𝗧𝘂𝗯𝗲: tinyurl.com/u7p3r8n9
𝗦𝗽𝗼𝘁𝗶𝗳𝘆: tinyurl.com/mryvvjsr
𝗔𝗽𝗽𝗹𝗲: tinyurl.com/bswzh583
E3 Diabetes - Venoms Lethal or Lifesaving?
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
tinyurl.com
May 23, 2025 at 11:40 PM
Venoms can kill, but can they also heal? Here's Episode 3 of The Discovery Dialogues Podcast
𝗬𝗼𝘂𝗧𝘂𝗯𝗲: tinyurl.com/u7p3r8n9
𝗦𝗽𝗼𝘁𝗶𝗳𝘆: tinyurl.com/mryvvjsr
𝗔𝗽𝗽𝗹𝗲: tinyurl.com/bswzh583
𝗬𝗼𝘂𝗧𝘂𝗯𝗲: tinyurl.com/u7p3r8n9
𝗦𝗽𝗼𝘁𝗶𝗳𝘆: tinyurl.com/mryvvjsr
𝗔𝗽𝗽𝗹𝗲: tinyurl.com/bswzh583
Reposted by Ani Deshpande Lab
In this episode, we talked with @anideshpande.bsky.social from @sbpdiscovery.bsky.social about his work on epigenetic regulation and developing small molecules through high throughput screens for AML. #epigenetics #podcast #chromatin #cancer #leukemia
Listen here: activemotif.com/podcasts-ani...
Listen here: activemotif.com/podcasts-ani...
May 23, 2025 at 7:34 AM
In this episode, we talked with @anideshpande.bsky.social from @sbpdiscovery.bsky.social about his work on epigenetic regulation and developing small molecules through high throughput screens for AML. #epigenetics #podcast #chromatin #cancer #leukemia
Listen here: activemotif.com/podcasts-ani...
Listen here: activemotif.com/podcasts-ani...
Reposted by Ani Deshpande Lab
We live in such a golden age of science with so much potential for discovery and alleviating some of the most severe human diseases.
And we are going to piss it all away because … I’m not exactly sure why. No one has made a convincing case why this helps anyone, red or blue or purple.
And we are going to piss it all away because … I’m not exactly sure why. No one has made a convincing case why this helps anyone, red or blue or purple.
We've launched the Armamentarium, a new toolkit for targeted gene delivery to the brain and spinal cord.
This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators.
🧠📈 www.nih.gov/news-events/...
This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators.
🧠📈 www.nih.gov/news-events/...
Scientists design gene delivery systems for cells in the brain and spinal cord
NIH-funded breakthrough could enable targeted therapies for many neurological disorders.
www.nih.gov
May 22, 2025 at 7:16 PM
We live in such a golden age of science with so much potential for discovery and alleviating some of the most severe human diseases.
And we are going to piss it all away because … I’m not exactly sure why. No one has made a convincing case why this helps anyone, red or blue or purple.
And we are going to piss it all away because … I’m not exactly sure why. No one has made a convincing case why this helps anyone, red or blue or purple.
Reposted by Ani Deshpande Lab
As someone who covered both:
-NIH cuts came first; there is some news exhaustion;
- “Curing cancer” is an easier story to tell than the varied domains funded by NSF, and easier for citizens to find applicable;
- You’re not going to like this, but people don’t know what “science” is.
-NIH cuts came first; there is some news exhaustion;
- “Curing cancer” is an easier story to tell than the varied domains funded by NSF, and easier for citizens to find applicable;
- You’re not going to like this, but people don’t know what “science” is.
I know NIH is ~5x bigger than NSF but I think the gutting of NSF is getting a lot less than 1/5 the attention— in the news media and in higher ed— compared with what's happened to NIH.
May 12, 2025 at 1:25 AM
As someone who covered both:
-NIH cuts came first; there is some news exhaustion;
- “Curing cancer” is an easier story to tell than the varied domains funded by NSF, and easier for citizens to find applicable;
- You’re not going to like this, but people don’t know what “science” is.
-NIH cuts came first; there is some news exhaustion;
- “Curing cancer” is an easier story to tell than the varied domains funded by NSF, and easier for citizens to find applicable;
- You’re not going to like this, but people don’t know what “science” is.
Reposted by Ani Deshpande Lab
I’m fascinated by scientific breakthroughs that were universally hailed in the moment, like pasteurization, that are now vilified by some people. Is this a uniquely American thing? Anybody written a book about why/how this happens? Like the psychology behind it. I’d love to learn more.
May 11, 2025 at 3:06 AM
I’m fascinated by scientific breakthroughs that were universally hailed in the moment, like pasteurization, that are now vilified by some people. Is this a uniquely American thing? Anybody written a book about why/how this happens? Like the psychology behind it. I’d love to learn more.
Reposted by Ani Deshpande Lab
Ben Franklin on inoculation, after his son died from smallpox.
“In 1736, I lost one of my sons, a fine boy of four years old, by the small-pox, taken in the common way. I long regretted bitterly, and still regret that I had not given it to him by inoculation”.
“In 1736, I lost one of my sons, a fine boy of four years old, by the small-pox, taken in the common way. I long regretted bitterly, and still regret that I had not given it to him by inoculation”.
May 3, 2025 at 9:44 PM
Ben Franklin on inoculation, after his son died from smallpox.
“In 1736, I lost one of my sons, a fine boy of four years old, by the small-pox, taken in the common way. I long regretted bitterly, and still regret that I had not given it to him by inoculation”.
“In 1736, I lost one of my sons, a fine boy of four years old, by the small-pox, taken in the common way. I long regretted bitterly, and still regret that I had not given it to him by inoculation”.
Reposted by Ani Deshpande Lab
Every now again it’s useful to repeat advice about accessing papers that are behind a paywall that excludes you. Email the author. My estimate is that 90% of academics are so thrilled that a living, breathing, possibly even reading, person shows interest that they will swiftly send you a copy.
May 3, 2025 at 1:44 PM
Every now again it’s useful to repeat advice about accessing papers that are behind a paywall that excludes you. Email the author. My estimate is that 90% of academics are so thrilled that a living, breathing, possibly even reading, person shows interest that they will swiftly send you a copy.
In Episode 2 of the Discovery Dialogues Podcast, we recount the fascinating story of the race to clone the first human gene. Featuring Herb Boyer and Keiichi Itakura. 🎥YouTube: tinyurl.com/4x7fkzzu
🎧 Spotify: tinyurl.com/3af8zrt8
🎧 Apple Podcasts: tinyurl.com/2st95bb9
🎧 Spotify: tinyurl.com/3af8zrt8
🎧 Apple Podcasts: tinyurl.com/2st95bb9
E2 Diabetes The Race for Human Insulin
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
tinyurl.com
April 17, 2025 at 9:34 PM
In Episode 2 of the Discovery Dialogues Podcast, we recount the fascinating story of the race to clone the first human gene. Featuring Herb Boyer and Keiichi Itakura. 🎥YouTube: tinyurl.com/4x7fkzzu
🎧 Spotify: tinyurl.com/3af8zrt8
🎧 Apple Podcasts: tinyurl.com/2st95bb9
🎧 Spotify: tinyurl.com/3af8zrt8
🎧 Apple Podcasts: tinyurl.com/2st95bb9
Reposted by Ani Deshpande Lab
I feel like the conference talk format has gotten so stale, even for those who are good at it. How can we switch it up? One idea we've been toying with is an "interview" style, where after a 5 minute presentation, an interviewer who has read the paper engages in a structured conversation. Thoughts?
April 15, 2025 at 2:48 PM
I feel like the conference talk format has gotten so stale, even for those who are good at it. How can we switch it up? One idea we've been toying with is an "interview" style, where after a 5 minute presentation, an interviewer who has read the paper engages in a structured conversation. Thoughts?
I have always felt there is a monumental disconnect between how transformative science has been in improving the human condition, and how it is generally perceived. With this in mind, we are launching The Discovery Dialogues Podcast. Please listen/share.
E1 Diabetes Roots
YouTube video by Discovery Dialogues
www.youtube.com
March 21, 2025 at 6:48 PM
I have always felt there is a monumental disconnect between how transformative science has been in improving the human condition, and how it is generally perceived. With this in mind, we are launching The Discovery Dialogues Podcast. Please listen/share.
Listening to the Airborne audiobook by @carlzimmer.com while driving to work and it makes you want to stay in the car even when you have arrived at your destination and keep listening. What a terrific piece of science writing!
March 19, 2025 at 5:18 PM
Listening to the Airborne audiobook by @carlzimmer.com while driving to work and it makes you want to stay in the car even when you have arrived at your destination and keep listening. What a terrific piece of science writing!
Reposted by Ani Deshpande Lab
Genome editing success for the first time in nine patients with alpha-1 antitrypsin deficiency, a heritable disease which can cause cirrhosis and emphysema, affecting ~100,000 Americans, which is similar to the prevalence of sickle cell disease
www.nytimes.com/2025/03/10/h...
www.nytimes.com/2025/03/10/h...
Mutated DNA Restored to Normal in Gene Therapy Advance
The small study in patients with a rare disorder that causes liver and lung damage showed the potential for precisely targeted infusions.
www.nytimes.com
March 11, 2025 at 1:59 AM
Genome editing success for the first time in nine patients with alpha-1 antitrypsin deficiency, a heritable disease which can cause cirrhosis and emphysema, affecting ~100,000 Americans, which is similar to the prevalence of sickle cell disease
www.nytimes.com/2025/03/10/h...
www.nytimes.com/2025/03/10/h...
Reposted by Ani Deshpande Lab
This would have never, ever-ever been done by a for-profit entity. At the time this was way too experimental - only an "academic" team could have taken on this risk.
pubmed.ncbi.nlm.nih.gov/23527958/
pubmed.ncbi.nlm.nih.gov/23527958/
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia - PubMed
Chimeric antigen receptor-modified T cells with specificity for CD19 have shown promise in the treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether chimeric antigen re...
pubmed.ncbi.nlm.nih.gov
March 9, 2025 at 12:34 PM
This would have never, ever-ever been done by a for-profit entity. At the time this was way too experimental - only an "academic" team could have taken on this risk.
pubmed.ncbi.nlm.nih.gov/23527958/
pubmed.ncbi.nlm.nih.gov/23527958/
Reposted by Ani Deshpande Lab
Emily Whitehead's life was saved by an "academic" team at Penn Medicine - this yielded an approved therapy, Kymriah, since used by Novartius to treat ~20,000 patients with cancer.
= science at research universities saves lives.
Pls read second subunit below.
www.cnn.com/2025/03/07/h...
= science at research universities saves lives.
Pls read second subunit below.
www.cnn.com/2025/03/07/h...
Cancer survivor warns against threats to health funding | CNN
Emily Whitehead and Tom Whitehead join The Lead
www.cnn.com
March 9, 2025 at 12:34 PM
Emily Whitehead's life was saved by an "academic" team at Penn Medicine - this yielded an approved therapy, Kymriah, since used by Novartius to treat ~20,000 patients with cancer.
= science at research universities saves lives.
Pls read second subunit below.
www.cnn.com/2025/03/07/h...
= science at research universities saves lives.
Pls read second subunit below.
www.cnn.com/2025/03/07/h...
Reposted by Ani Deshpande Lab
I heard some folks try Bluesky, don’t get enough engagement, and go back to Twitter! Be generous with posts you like—it doesn’t cost a dime!
a red heart with the number 994 on it
ALT: a red heart with the number 994 on it
media.tenor.com
March 7, 2025 at 4:57 PM
I heard some folks try Bluesky, don’t get enough engagement, and go back to Twitter! Be generous with posts you like—it doesn’t cost a dime!
There are thousands of studies published on the cancer-causing protein MYC – but some big pieces of the puzzle have been missing. I am excited to share a preprint of one of the coolest studies I have seen go from inception to completion from my colleague Anindya Bagchi's Lab. tinyurl.com/447f2jur
Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements
MYC-driven (MYC+) cancers are aggressive and often fatal. MYC dysregulation is a key event in these cancers, but overexpression of MYC alone is not always enough to cause cancer. Plasmocytoma Variant ...
tinyurl.com
February 24, 2025 at 5:38 PM
There are thousands of studies published on the cancer-causing protein MYC – but some big pieces of the puzzle have been missing. I am excited to share a preprint of one of the coolest studies I have seen go from inception to completion from my colleague Anindya Bagchi's Lab. tinyurl.com/447f2jur