Andrew Caldwell
@andrewbcaldwell.bsky.social
Research scientist in Bioengineering at @ucsandiego.bsky.social working on systems biology of Alzheimer's disease. andrewbcaldwell.com
Pinned
Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease - Alzheimer's Research & Therapy
Background PSEN1, PSEN2, and APP mutations cause Alzheimer’s disease (AD) with an early age at onset (AAO) and progressive cognitive decline. PSEN1 mutations are more common and generally have an earl...
alzres.biomedcentral.com
Excited to share our new work out in Alzheimer's Research & Therapy! We profiled FAD-causal mutations in PSEN1, PSEN2, and APP using patient-derived iPSC neurons and multiomics (RNA-seq and ATAC-seq) to ascertain regulatory mechanisms associated with disease. alzres.biomedcentral.com/articles/10....
Reposted by Andrew Caldwell
The NIH continues to be fully halted. 11/11 study sections canceled today, which includes the study section my grant was meant to be reviewed at. This is never ending and so damaging.
www.csr.nih.gov/RevPanelsAnd...
www.csr.nih.gov/RevPanelsAnd...
Review Dates
www.csr.nih.gov
February 24, 2025 at 4:13 PM
The NIH continues to be fully halted. 11/11 study sections canceled today, which includes the study section my grant was meant to be reviewed at. This is never ending and so damaging.
www.csr.nih.gov/RevPanelsAnd...
www.csr.nih.gov/RevPanelsAnd...
Reposted by Andrew Caldwell
Reposted by Andrew Caldwell
Incredible new work from the Macauley lab! Just the beginning of what will be an incredible series of papers that mechanistically interrogates gene x environment in AD.
@macauleylab.bsky.social
@macauleylab.bsky.social
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS
Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate
fluctuations are a biomarker of sleep/wake transitions, where in...
www.pnas.org
February 18, 2025 at 6:03 PM
Incredible new work from the Macauley lab! Just the beginning of what will be an incredible series of papers that mechanistically interrogates gene x environment in AD.
@macauleylab.bsky.social
@macauleylab.bsky.social
Reposted by Andrew Caldwell
Post-doc opening to join our lab @ebi.embl.org to develop&apply #bioinformatics and #machine-learning methods to study intra-/extra cellular networks to extract disease mechanisms from #single-cell and #spatial multiomic data - please share 🙏 : embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
Postdoctoral fellow - Saez-Rodriguez Group
Your group Saez-Rodriguez Research Group Your supervisor Julio Saez-Rodriguez Your role As a postdoctoral fellow in the Saez Rodriguez group, you will develop and apply computational methods and tools...
embl.wd103.myworkdayjobs.com
February 11, 2025 at 10:17 AM
Post-doc opening to join our lab @ebi.embl.org to develop&apply #bioinformatics and #machine-learning methods to study intra-/extra cellular networks to extract disease mechanisms from #single-cell and #spatial multiomic data - please share 🙏 : embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
Reposted by Andrew Caldwell
Tabak was incredibly encouraging to young scientists including myself and a great example of someone who was able to help different sides see their common interests to help bring resolution. I feel his leaving is a sign that reason may have left the building 🤦🏾♀️
www.nytimes.com/2025/02/12/u...
www.nytimes.com/2025/02/12/u...
Top N.I.H. Official Abruptly Resigns as Trump Orders Deep Cuts
Dr. Lawrence Tabak, the No. 2 official at the National Institutes of Health, did not give a reason for his departure.
www.nytimes.com
February 12, 2025 at 9:02 PM
Tabak was incredibly encouraging to young scientists including myself and a great example of someone who was able to help different sides see their common interests to help bring resolution. I feel his leaving is a sign that reason may have left the building 🤦🏾♀️
www.nytimes.com/2025/02/12/u...
www.nytimes.com/2025/02/12/u...
Reposted by Andrew Caldwell
It sounds weird coming from the CEO of a company that makes 500-mile EVs. But hear him out.
Why Lucid's CEO Thinks 180-Mile EVs Are 'The Future'
It sounds weird coming from the CEO of a company that makes 500-mile EVs. But hear him out.
insideevs.com
February 11, 2025 at 9:01 PM
It sounds weird coming from the CEO of a company that makes 500-mile EVs. But hear him out.
Reposted by Andrew Caldwell
New, from me:
So much is happening, so quickly. The purpose of shock and awe is to bewilder and overwhelm. It is important not to look away, or get discouraged. Try to discern the what is a big and real threat. Here is my best effort to do so. 🧵
donmoynihan.substack.com/p/meditation...
So much is happening, so quickly. The purpose of shock and awe is to bewilder and overwhelm. It is important not to look away, or get discouraged. Try to discern the what is a big and real threat. Here is my best effort to do so. 🧵
donmoynihan.substack.com/p/meditation...
Meditations in an Emergency
It's good to be shocked, but don't be awed
donmoynihan.substack.com
February 5, 2025 at 3:33 PM
New, from me:
So much is happening, so quickly. The purpose of shock and awe is to bewilder and overwhelm. It is important not to look away, or get discouraged. Try to discern the what is a big and real threat. Here is my best effort to do so. 🧵
donmoynihan.substack.com/p/meditation...
So much is happening, so quickly. The purpose of shock and awe is to bewilder and overwhelm. It is important not to look away, or get discouraged. Try to discern the what is a big and real threat. Here is my best effort to do so. 🧵
donmoynihan.substack.com/p/meditation...
Reposted by Andrew Caldwell
Reposted by Andrew Caldwell
It’s a golden age of disassociation.
Good reminder of art as refuge on the cover of this week’s New Yorker
February 4, 2025 at 4:50 AM
It’s a golden age of disassociation.
Reposted by Andrew Caldwell
You keep doing this.
As many times as it takes.
As many times as it takes.
🚨 BREAKING: OMB has just issued a memo *rescinding* the previous memo freezing all federal financial assistance programs.
Full text, per government source:
Full text, per government source:
January 29, 2025 at 6:39 PM
You keep doing this.
As many times as it takes.
As many times as it takes.
Reposted by Andrew Caldwell
Without govt funding you simply don't have the community of scientists scattered across the US that helped the US to take the lead in scientific development in the 20th century!
Members of Congress should be all over how this affects their districts!
bsky.app/profile/mons...
Members of Congress should be all over how this affects their districts!
bsky.app/profile/mons...
NIH appears to have canceled/postponed all of its study sections—the independent review panels that approve federal grants for health research.
Such grants fund the work/salaries of 300k people at more than 2,500 institutions
Such grants fund the work/salaries of 300k people at more than 2,500 institutions
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 23, 2025 at 1:28 AM
Without govt funding you simply don't have the community of scientists scattered across the US that helped the US to take the lead in scientific development in the 20th century!
Members of Congress should be all over how this affects their districts!
bsky.app/profile/mons...
Members of Congress should be all over how this affects their districts!
bsky.app/profile/mons...
Reposted by Andrew Caldwell
The assault on NIH is a test for how the national media covers the Trump admin: Trump is shutting down medical research!
That is easy to communicate. Will they treat it as a 5 alarm fire in a way that forces the government to respond, or will they downplay & caveat it?
That is easy to communicate. Will they treat it as a 5 alarm fire in a way that forces the government to respond, or will they downplay & caveat it?
January 23, 2025 at 1:16 AM
The assault on NIH is a test for how the national media covers the Trump admin: Trump is shutting down medical research!
That is easy to communicate. Will they treat it as a 5 alarm fire in a way that forces the government to respond, or will they downplay & caveat it?
That is easy to communicate. Will they treat it as a 5 alarm fire in a way that forces the government to respond, or will they downplay & caveat it?
Reposted by Andrew Caldwell
We just had this whole election cycle about how inflation is the unforgivable political sin, which no other widely felt benefit can counterbalance, and it’s discarded two days into the new administration.
JPMorgan Chase CEO Jamie Dimon said Wednesday that the looming tariffs that President Donald Trump is expected to slap on U.S. trading partners could be viewed positively.
Read more here: cnb.cx/40uxoTI
Read more here: cnb.cx/40uxoTI
January 22, 2025 at 4:37 PM
We just had this whole election cycle about how inflation is the unforgivable political sin, which no other widely felt benefit can counterbalance, and it’s discarded two days into the new administration.
Reposted by Andrew Caldwell
wow, they're already getting rid of unqualified and incompetent employees
WASHINGTON (AP) - Vivek Ramaswamy will not serve in Trump's new Department of Government Efficiency, the White House says
January 20, 2025 at 10:02 PM
wow, they're already getting rid of unqualified and incompetent employees
Reposted by Andrew Caldwell
For years, execs in auto + tech spun a fantastical future vision in which fleets of robotaxis would imminently replace normal cars.
Cruise’s demise suggests the wild promises of AI-chatbot operators—and companies w/sky-high valuations using them—should be met w/caution if not outright skepticism.
Cruise’s demise suggests the wild promises of AI-chatbot operators—and companies w/sky-high valuations using them—should be met w/caution if not outright skepticism.
Why AI Investors Should Worry About the Self-Driving Car Crash
Robotaxis were supposed to be the easy part of automation. The failure of GM’s effort shows how far the industry is from living up to its wild promises.
www.bloomberg.com
January 16, 2025 at 12:36 AM
For years, execs in auto + tech spun a fantastical future vision in which fleets of robotaxis would imminently replace normal cars.
Cruise’s demise suggests the wild promises of AI-chatbot operators—and companies w/sky-high valuations using them—should be met w/caution if not outright skepticism.
Cruise’s demise suggests the wild promises of AI-chatbot operators—and companies w/sky-high valuations using them—should be met w/caution if not outright skepticism.
We had a now-published paper reviewed at a different journal. 4/5 reviewers asked for revisions and additional analysis, and the last reviewer asked for all experiments redone. Editor insisted they would consider w/o the last reviewer’s (expensive, >year of time) requests. 1/2
I wonder how much the system would improve if authors were allowed to simply ignore one review in its entirety when they revise their manuscript.
January 15, 2025 at 11:12 PM
We had a now-published paper reviewed at a different journal. 4/5 reviewers asked for revisions and additional analysis, and the last reviewer asked for all experiments redone. Editor insisted they would consider w/o the last reviewer’s (expensive, >year of time) requests. 1/2
Reposted by Andrew Caldwell
Link to British dementia work with @selinawray.bsky.social : link.springer.com/article/10.1...
Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...
Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia - Acta Neuropathologica
Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-ter...
link.springer.com
January 9, 2025 at 1:39 PM
Link to British dementia work with @selinawray.bsky.social : link.springer.com/article/10.1...
Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...
Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...
Reposted by Andrew Caldwell
We got aid in Florida from Joe Biden despite this state not only doing zero mitigation for storms but also banning cities from doing their own global warming mitigation
Ron Johnson on federal disaster relief for California: "I certainly wouldn't vote for anything unless we see a dramatic change in how they're gonna be handling these things in the future."
January 13, 2025 at 4:38 PM
We got aid in Florida from Joe Biden despite this state not only doing zero mitigation for storms but also banning cities from doing their own global warming mitigation
Reposted by Andrew Caldwell
The (free-to-read) newsletter this week is about the fires and visualizations that explain or inform about what’s unfolding.
s2.washingtonpost.com/camp-rw/?tra...
s2.washingtonpost.com/camp-rw/?tra...
How To Read This Chart: Falsehoods around the L.A. fires are proliferating on the right
s2.washingtonpost.com
January 11, 2025 at 3:14 PM
The (free-to-read) newsletter this week is about the fires and visualizations that explain or inform about what’s unfolding.
s2.washingtonpost.com/camp-rw/?tra...
s2.washingtonpost.com/camp-rw/?tra...
Reposted by Andrew Caldwell
Congratulations Dr. Chandrashekar 💐
Using human neurons homozygously-engineered with familial AD mutations, Harshini found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs
doi.org/10.1101/2024...
Using human neurons homozygously-engineered with familial AD mutations, Harshini found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs
doi.org/10.1101/2024...
November 25, 2024 at 11:05 AM
Congratulations Dr. Chandrashekar 💐
Using human neurons homozygously-engineered with familial AD mutations, Harshini found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs
doi.org/10.1101/2024...
Using human neurons homozygously-engineered with familial AD mutations, Harshini found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs
doi.org/10.1101/2024...
Reposted by Andrew Caldwell
Excited to share our new work out in Alzheimer's Research & Therapy! We profiled FAD-causal mutations in PSEN1, PSEN2, and APP using patient-derived iPSC neurons and multiomics (RNA-seq and ATAC-seq) to ascertain regulatory mechanisms associated with disease. alzres.biomedcentral.com/articles/10....
Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease - Alzheimer's Research & Therapy
Background PSEN1, PSEN2, and APP mutations cause Alzheimer’s disease (AD) with an early age at onset (AAO) and progressive cognitive decline. PSEN1 mutations are more common and generally have an earl...
alzres.biomedcentral.com
January 9, 2025 at 5:57 PM
Excited to share our new work out in Alzheimer's Research & Therapy! We profiled FAD-causal mutations in PSEN1, PSEN2, and APP using patient-derived iPSC neurons and multiomics (RNA-seq and ATAC-seq) to ascertain regulatory mechanisms associated with disease. alzres.biomedcentral.com/articles/10....
Reposted by Andrew Caldwell
Here's the reality about the #LAFires this week: this isn't the first time ANY of these places have burned. Not even close. In 2018, we mapped CA fire history to look at fire frequency across SoCal. Santa Monica Mtns area burns more than anywhere else -- up to once per decade in a given spot. 🧵
January 9, 2025 at 5:33 PM
Here's the reality about the #LAFires this week: this isn't the first time ANY of these places have burned. Not even close. In 2018, we mapped CA fire history to look at fire frequency across SoCal. Santa Monica Mtns area burns more than anywhere else -- up to once per decade in a given spot. 🧵
Reposted by Andrew Caldwell
Public stuck between an incoming govt that won't help them prepare for climate change (instead preferring to blame DEI), and an insurance industry that is paying attention to climate change but won't insure them
easy to read "insurers stopped covering homes in California right before these fires" as something sinister, but from covering this industry, I gotta say I think it's the opposite: no one is more aware of increased risk due to climate change than insurers
www.businessinsider.com/california-f...
www.businessinsider.com/california-f...
Insurers dropped fire coverage for California homes months ago. Now, wildfires are claiming more houses in Los Angeles.
Some insurers have scaled back their coverage in California because of wildfires over the past few years, creating a challenge for rebuilding.
www.businessinsider.com
January 9, 2025 at 8:47 PM
Public stuck between an incoming govt that won't help them prepare for climate change (instead preferring to blame DEI), and an insurance industry that is paying attention to climate change but won't insure them
Reposted by Andrew Caldwell
Our new paper is online: Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks. academic.oup.com/brain/advanc... @uclbrainscience.bsky.social @uclqsion.bsky.social
Validate User
academic.oup.com
January 9, 2025 at 7:23 PM
Our new paper is online: Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks. academic.oup.com/brain/advanc... @uclbrainscience.bsky.social @uclqsion.bsky.social
Reposted by Andrew Caldwell
I think it also should be mentioned that the person who really got this going was Rick Caruso, the West Coast Trump/developer who Bass kicked the ass of in the election, and who falsely spread conspiracy theories about fire hydrants in the same radio interview.
Not going to stick up for Bass because this is the job, but we’re all in our feelings right now and going after a mayor in a weak-mayor city over a countywide disaster is cope. www.nytimes.com/2025/01/09/u...
L.A. Mayor Karen Bass Should Have Canceled Africa Trip Amid Fires, Residents Say
Some residents said Mayor Karen Bass should have canceled her trip to Ghana when weather warnings in Los Angeles grew increasingly dire.
www.nytimes.com
January 9, 2025 at 4:39 PM
I think it also should be mentioned that the person who really got this going was Rick Caruso, the West Coast Trump/developer who Bass kicked the ass of in the election, and who falsely spread conspiracy theories about fire hydrants in the same radio interview.