Charlie Arber
@celarber.bsky.social
Stem cell researcher | fighting dementia | UCL London
Reposted by Charlie Arber
If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 7:21 AM
If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...
Reposted by Charlie Arber
and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz
October 31, 2025 at 1:53 PM
and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz
Reposted by Charlie Arber
Catching changes in morphology of your human pluripotent stem cell (hPSC) maintenance cultures early helps ensure reproducible, reliable experiments.
But what should you look for?
But what should you look for?
October 16, 2025 at 4:09 PM
Catching changes in morphology of your human pluripotent stem cell (hPSC) maintenance cultures early helps ensure reproducible, reliable experiments.
But what should you look for?
But what should you look for?
Reposted by Charlie Arber
✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼 www.stemcelltuebingen.com #neuroscience #stemcells
October 2, 2025 at 3:43 PM
✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼 www.stemcelltuebingen.com #neuroscience #stemcells
Thank you @alzsocresearch.bsky.social and @dementiaresearcher.bsky.social for chatting with me about our recent paper.
So grateful for all the coauthors and mentors who made this work possible.
Certainly a team effort!
So grateful for all the coauthors and mentors who made this work possible.
Certainly a team effort!
"It’s been fantastic to come up with an idea... and have an output like this."
On @dementiaresearcher.bsky.social, we spoke to Dr Charlie Arber @celarber.bsky.social about his first senior author paper from his Alzheimer's Society funded fellowship: www.dementiaresearcher.nihr.ac.uk/blog-first-a...
On @dementiaresearcher.bsky.social, we spoke to Dr Charlie Arber @celarber.bsky.social about his first senior author paper from his Alzheimer's Society funded fellowship: www.dementiaresearcher.nihr.ac.uk/blog-first-a...
Dr Charlie Arber - Blog – First and last of publication authorship
Dr Charlie Arber shares his journey to senior authorship, developing iPSC astrocyte and microglia models to explore inflammation in Alzheimer’s disease.
www.dementiaresearcher.nihr.ac.uk
September 22, 2025 at 4:49 PM
Thank you @alzsocresearch.bsky.social and @dementiaresearcher.bsky.social for chatting with me about our recent paper.
So grateful for all the coauthors and mentors who made this work possible.
Certainly a team effort!
So grateful for all the coauthors and mentors who made this work possible.
Certainly a team effort!
Eeek. I've signed up to run my first ever half marathon, raising money for Race Against Dementia, funders for research into dementia.
Any contributions very much appreciated and any tips even more so! 🏃♂️🍝
www.givengain.com/project/char...
Any contributions very much appreciated and any tips even more so! 🏃♂️🍝
www.givengain.com/project/char...
Join Me in the Race Against Dementia
I’m excited to run my first half marathon around the track at Silverstone. I am doing this to support Race Against Dementia, a charity that holds special significance for me and which began with Sir J...
www.givengain.com
September 17, 2025 at 2:57 PM
Eeek. I've signed up to run my first ever half marathon, raising money for Race Against Dementia, funders for research into dementia.
Any contributions very much appreciated and any tips even more so! 🏃♂️🍝
www.givengain.com/project/char...
Any contributions very much appreciated and any tips even more so! 🏃♂️🍝
www.givengain.com/project/char...
Reposted by Charlie Arber
Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, a study by @uclqsion.bsky.social researchers found.
buff.ly/dBRRQvY #WorldAlzheimersMonth
buff.ly/dBRRQvY #WorldAlzheimersMonth
Key differences between visual- and memory-led Alzheimer’s discovered
Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, finds a new…
www.ucl.ac.uk
September 13, 2025 at 10:08 AM
Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, a study by @uclqsion.bsky.social researchers found.
buff.ly/dBRRQvY #WorldAlzheimersMonth
buff.ly/dBRRQvY #WorldAlzheimersMonth
Reposted by Charlie Arber
🧠 This #WorldAlzheimersMonth, discover how UCL’s AI tool SuStaIn is transforming Alzheimer’s diagnosis and care—by identifying subtypes and predicting progression from just a snapshot of data.
buff.ly/DmzYSlb @uclengineering.bsky.social
buff.ly/DmzYSlb @uclengineering.bsky.social
September 16, 2025 at 10:08 AM
🧠 This #WorldAlzheimersMonth, discover how UCL’s AI tool SuStaIn is transforming Alzheimer’s diagnosis and care—by identifying subtypes and predicting progression from just a snapshot of data.
buff.ly/DmzYSlb @uclengineering.bsky.social
buff.ly/DmzYSlb @uclengineering.bsky.social
Reposted by Charlie Arber
Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease.
www.biorxiv.org/content/10.1...
Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
www.biorxiv.org/content/10.1...
Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Parkinson's disease (PD) is characterised by insoluble α-synuclein (αSyn) aggregates in Lewy bodies (LBs) within the substantia nigra, with cortical pathology appearing as the disease progresses. Late...
www.biorxiv.org
September 1, 2025 at 9:14 AM
Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease.
www.biorxiv.org/content/10.1...
Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
www.biorxiv.org/content/10.1...
Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
Reposted by Charlie Arber
Excited contribute to this year’s lunch hour lecture program! It’s a free event and accessible to a non-specialist audience so please come and join me :)
🧠 What if we could watch dementia unfold in a dish—and stop it before it starts?
Join Prof @selinawray.bsky.social (@uclqsion.bsky.social) on 18 Sept for a free @UCL Lunch Hour Lecture exploring the future of dementia research.
📅 1–2pm | 💻 Online
🔗 www.ucl.ac.uk/events/event...
Join Prof @selinawray.bsky.social (@uclqsion.bsky.social) on 18 Sept for a free @UCL Lunch Hour Lecture exploring the future of dementia research.
📅 1–2pm | 💻 Online
🔗 www.ucl.ac.uk/events/event...
August 22, 2025 at 4:08 PM
Excited contribute to this year’s lunch hour lecture program! It’s a free event and accessible to a non-specialist audience so please come and join me :)
Reposted by Charlie Arber
Post a non-religious photo you think of as holy
August 20, 2025 at 9:18 PM
Post a non-religious photo you think of as holy
Reposted by Charlie Arber
These are the most challenging times for early-career scientists and engineers.
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
August 11, 2025 at 11:54 AM
These are the most challenging times for early-career scientists and engineers.
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
Reposted by Charlie Arber
I’m a huge fan of the work done by @typlab.bsky.social - so it was great to have the opportunity to write a preview of their work describing an in vitro triculture model of Alzheimer’s (with @celarber.bsky.social & Tatiana). Check it out & go read their paper!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reconstructing Alzheimer’s disease one cell type at a time using in vitro tricultures
In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes,…
www.sciencedirect.com
July 29, 2025 at 3:00 PM
I’m a huge fan of the work done by @typlab.bsky.social - so it was great to have the opportunity to write a preview of their work describing an in vitro triculture model of Alzheimer’s (with @celarber.bsky.social & Tatiana). Check it out & go read their paper!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
What a treat to share a walkies and a BBQ with my colleagues.
The rain in the background caught us on the way home. But that’s normal for a British bbq, right?
The rain in the background caught us on the way home. But that’s normal for a British bbq, right?
July 21, 2025 at 7:24 PM
What a treat to share a walkies and a BBQ with my colleagues.
The rain in the background caught us on the way home. But that’s normal for a British bbq, right?
The rain in the background caught us on the way home. But that’s normal for a British bbq, right?
Reposted by Charlie Arber
💊 First ever treatment for Friedreich’s ataxia – for which @uclqsion.bsky.social and UCLH led the UK trial – has been approved for use in the UK by the medicines’ regulator.
buff.ly/3dSwwzJ #ResearchersAppreciationDay
buff.ly/3dSwwzJ #ResearchersAppreciationDay
First treatment for rare disease approved by UK medicines regulator
The first ever treatment for the rare neurodegenerative disease Friedreich’s ataxia – for which UCL and UCLH led the UK trial – has been approved for use in the UK by the medicines’ regulator.
www.ucl.ac.uk
July 5, 2025 at 10:08 AM
💊 First ever treatment for Friedreich’s ataxia – for which @uclqsion.bsky.social and UCLH led the UK trial – has been approved for use in the UK by the medicines’ regulator.
buff.ly/3dSwwzJ #ResearchersAppreciationDay
buff.ly/3dSwwzJ #ResearchersAppreciationDay
Reposted by Charlie Arber
'Stem Cells in Neuroscience' is returning to Tübingen, Germany.
SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com
Please share
#stemcelltuebingen2026
@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social
SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com
Please share
#stemcelltuebingen2026
@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social
July 1, 2025 at 7:07 AM
'Stem Cells in Neuroscience' is returning to Tübingen, Germany.
SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com
Please share
#stemcelltuebingen2026
@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social
SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com
Please share
#stemcelltuebingen2026
@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social
Reposted by Charlie Arber
Currently listening to Mina Ryten (@ukdri.ac.uk) describing advances towards improved transcriptomic maps, providing new insights into variant to function for Alzheimer’s disease 🧠 #MilnerSymp25
June 30, 2025 at 1:37 PM
Currently listening to Mina Ryten (@ukdri.ac.uk) describing advances towards improved transcriptomic maps, providing new insights into variant to function for Alzheimer’s disease 🧠 #MilnerSymp25
Reposted by Charlie Arber
I've been really hoping to see more manuscript threads here on 🦋, so here comes one!!! This is brand new work from the lab that took us in very unexpected directions and to exciting findings led by the amazing @emily-hill.bsky.social. Preprint here www.biorxiv.org/content/10.1...
and 🧵below:
and 🧵below:
June 30, 2025 at 6:26 PM
I've been really hoping to see more manuscript threads here on 🦋, so here comes one!!! This is brand new work from the lab that took us in very unexpected directions and to exciting findings led by the amazing @emily-hill.bsky.social. Preprint here www.biorxiv.org/content/10.1...
and 🧵below:
and 🧵below:
It's out!
More than just making amyloid?
What if mutations in PSEN1 also predispose inflammation.
We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes. molecularneurodegeneration.biomedcentral.com/articles/10.....
More than just making amyloid?
What if mutations in PSEN1 also predispose inflammation.
We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes. molecularneurodegeneration.biomedcentral.com/articles/10.....
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration
Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...
molecularneurodegeneration.biomedcentral.com
June 26, 2025 at 1:06 PM
It's out!
More than just making amyloid?
What if mutations in PSEN1 also predispose inflammation.
We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes. molecularneurodegeneration.biomedcentral.com/articles/10.....
More than just making amyloid?
What if mutations in PSEN1 also predispose inflammation.
We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes. molecularneurodegeneration.biomedcentral.com/articles/10.....
Reposted by Charlie Arber
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 24, 2025 at 12:58 PM
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
Reposted by Charlie Arber
'Mutations in #PSEN1 predispose #inflammation in an #astrocyte model of familial #AlzheimersDisease through disrupted regulated intramembrane proteolysis'
Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration
Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...
molecularneurodegeneration.biomedcentral.com
June 20, 2025 at 10:33 PM
'Mutations in #PSEN1 predispose #inflammation in an #astrocyte model of familial #AlzheimersDisease through disrupted regulated intramembrane proteolysis'
Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
Reposted by Charlie Arber
New paper from the lab, under the leadership of @celarber.bsky.social !
'Mutations in #PSEN1 predispose #inflammation in an #astrocyte model of familial #AlzheimersDisease through disrupted regulated intramembrane proteolysis'
Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration
Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...
molecularneurodegeneration.biomedcentral.com
June 21, 2025 at 9:22 AM
New paper from the lab, under the leadership of @celarber.bsky.social !
Reposted by Charlie Arber
🚨🚨Job Alert🚨🚨!! Neuroscience, Physiology and Pharmacology are recruiting a new lecturer/associate professor! an amazing opportunity to join our fantastic dept! @ucl.ac.uk @ucllifesciences.bsky.social @uclnpp.bsky.social post here:
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Lecturer / Associate Professor - London, England job with University College London (UCL) | 12840324
About usThe Division of Biosciences at UCL is one of the world's foremost centres for research and teaching in the biological sciences. We have an out
www.nature.com
June 19, 2025 at 12:59 PM
🚨🚨Job Alert🚨🚨!! Neuroscience, Physiology and Pharmacology are recruiting a new lecturer/associate professor! an amazing opportunity to join our fantastic dept! @ucl.ac.uk @ucllifesciences.bsky.social @uclnpp.bsky.social post here:
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Wow. What does this mean for Alzheimer’s disease? 🧐
Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor
🎯Unexpected discovery: H. pylori CagA strongly blocks amyloid formation with a broad substrate spectrum.
Open Access
www.science.org/doi/10.1126/...
🎯Unexpected discovery: H. pylori CagA strongly blocks amyloid formation with a broad substrate spectrum.
Open Access
www.science.org/doi/10.1126/...
June 17, 2025 at 7:45 PM
Wow. What does this mean for Alzheimer’s disease? 🧐
Reposted by Charlie Arber
We are excited to be recruiting 3 post-doctoral researchers to study glial cell dysfunction in #agingresearch and #neurodegeneration, including one position using #Drosophila models! If you are interested, please read more below to get in touch or apply (links in thread).
June 1, 2025 at 3:26 PM
We are excited to be recruiting 3 post-doctoral researchers to study glial cell dysfunction in #agingresearch and #neurodegeneration, including one position using #Drosophila models! If you are interested, please read more below to get in touch or apply (links in thread).