Amali Samarasinghe
@amali92.bsky.social
🫘 Nephrology/General Medicine
Australian🇦🇺| MBBS, MHPEd 🎓
📍Vancouver, UBC Nephrology Fellow 🇨🇦
Australian🇦🇺| MBBS, MHPEd 🎓
📍Vancouver, UBC Nephrology Fellow 🇨🇦
Reposted by Amali Samarasinghe
a conservative dialysis strategy in possibly recovering AKI helps people recover faster!
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury
This trial examines whether a conservative dialysis strategy can improve recovery of kidney function for patients with acute kidney injury who require dialysis.
jamanetwork.com
November 7, 2025 at 6:50 PM
a conservative dialysis strategy in possibly recovering AKI helps people recover faster!
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
Reposted by Amali Samarasinghe
We are 2 for 2 with positive trials so far. LIBERATE-D shows benefit with a conservative vs conventional dialysis strategy in AKI-D. The difference in mortality is concerning though? Simultaneous pub 👇🏾 #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
November 7, 2025 at 5:10 PM
We are 2 for 2 with positive trials so far. LIBERATE-D shows benefit with a conservative vs conventional dialysis strategy in AKI-D. The difference in mortality is concerning though? Simultaneous pub 👇🏾 #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Amali Samarasinghe
Nature Reviews Nephrology comment on the harms of NIH grant terminations related to kidney disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 6, 2025 at 12:52 PM
Nature Reviews Nephrology comment on the harms of NIH grant terminations related to kidney disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
⚠️Trial exclusions of pregnant & child-bearing age women🤰an ongoing challenge
🙏 Dr Vesna Garovic highlighting this #KidneyWk @asnkidney.bsky.social
🙏 Dr Vesna Garovic highlighting this #KidneyWk @asnkidney.bsky.social
November 6, 2025 at 9:44 PM
⚠️Trial exclusions of pregnant & child-bearing age women🤰an ongoing challenge
🙏 Dr Vesna Garovic highlighting this #KidneyWk @asnkidney.bsky.social
🙏 Dr Vesna Garovic highlighting this #KidneyWk @asnkidney.bsky.social
Reposted by Amali Samarasinghe
The KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease recommends using equations that include both creatinine and cystatin C for more accurate GFR estimation and risk assessment in CKD.
ja.ma/43QS5vy
ja.ma/43QS5vy
November 5, 2025 at 4:30 PM
The KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease recommends using equations that include both creatinine and cystatin C for more accurate GFR estimation and risk assessment in CKD.
ja.ma/43QS5vy
ja.ma/43QS5vy
Reposted by Amali Samarasinghe
I like to lump patients with type IV collagen variants into 4 main categories that can help predict risk of progression and recommended treatment. #KidneyWk
November 6, 2025 at 6:39 PM
I like to lump patients with type IV collagen variants into 4 main categories that can help predict risk of progression and recommended treatment. #KidneyWk
Fantastic Day 1 ✅ #KidneyWk @asnkidney.bsky.social
November 5, 2025 at 11:37 PM
Fantastic Day 1 ✅ #KidneyWk @asnkidney.bsky.social
Reposted by Amali Samarasinghe
Forgot to post the two at plenary on Thursday
FINEONE: finerenone in T1DM
ORIGIN: Atacicept (pronounced attack-e-sept) in IgAN (pronounced eye-gee-A-N)
Possible NEJM or Lancet simulpubs?
#KidneyWk
FINEONE: finerenone in T1DM
ORIGIN: Atacicept (pronounced attack-e-sept) in IgAN (pronounced eye-gee-A-N)
Possible NEJM or Lancet simulpubs?
#KidneyWk
November 5, 2025 at 7:17 PM
Reposted by Amali Samarasinghe
Ben Wooden kicks off the #KidneyWk Glomerular Disease conference showing the explosion of discovery of glomerular disease genes since 1990. pubmed.ncbi.nlm.nih.gov/32205319/
November 5, 2025 at 2:13 PM
Ben Wooden kicks off the #KidneyWk Glomerular Disease conference showing the explosion of discovery of glomerular disease genes since 1990. pubmed.ncbi.nlm.nih.gov/32205319/
Time for my first ASN 👩🏫 @asnkidney.bsky.social
November 4, 2025 at 8:21 PM
Time for my first ASN 👩🏫 @asnkidney.bsky.social
Reposted by Amali Samarasinghe
A review revealed which #CKD drugs are safe to use while #breastfeeding but evidence for many therapies is still lacking. #kidneydisease #nephrology #nephsky docwirenews.com/post/review-...
Review of CKD Drug Safety With Breastfeeding | Docwire News
A review revealed which drugs commonly used in chronic kidney disease (CKD) have been found safe to use while breastfeeding. However, evidence for many therapies is still lacking.
docwirenews.com
September 19, 2025 at 7:03 PM
A review revealed which #CKD drugs are safe to use while #breastfeeding but evidence for many therapies is still lacking. #kidneydisease #nephrology #nephsky docwirenews.com/post/review-...
Reposted by Amali Samarasinghe
Going to add this to my lecture slides.
August 26, 2025 at 6:05 PM
Going to add this to my lecture slides.
Reposted by Amali Samarasinghe
Reposted by Amali Samarasinghe
T1b
BP Measurement: In 2017 ‘proper’ technique was recommended and that has transitioned to standardized technique in 2025. Let’s all use a checklist…and let’s use it every time! How close is your regular practice to this standard?
#NephJC
BP Measurement: In 2017 ‘proper’ technique was recommended and that has transitioned to standardized technique in 2025. Let’s all use a checklist…and let’s use it every time! How close is your regular practice to this standard?
#NephJC
September 17, 2025 at 1:15 AM
T1b
BP Measurement: In 2017 ‘proper’ technique was recommended and that has transitioned to standardized technique in 2025. Let’s all use a checklist…and let’s use it every time! How close is your regular practice to this standard?
#NephJC
BP Measurement: In 2017 ‘proper’ technique was recommended and that has transitioned to standardized technique in 2025. Let’s all use a checklist…and let’s use it every time! How close is your regular practice to this standard?
#NephJC
Reposted by Amali Samarasinghe
Use of genetics for kidney disease research reveals an array of variants in COL4A genes and a resulting range of disease presentations. From hematuria to Alport syndrome, genetic data has provided a new basic research basis for genotype-phenotype correlations. kidney.pub/KN1707-08 #ASNKidneyNews
July 18, 2025 at 3:00 PM
Use of genetics for kidney disease research reveals an array of variants in COL4A genes and a resulting range of disease presentations. From hematuria to Alport syndrome, genetic data has provided a new basic research basis for genotype-phenotype correlations. kidney.pub/KN1707-08 #ASNKidneyNews
Reposted by Amali Samarasinghe
Poignant cartoon on therapeutics (here vaccines) in pregnancy
absolutelymaybe.plos.org/2025/06/27/d...
Renalism is a similar issue!
From @hildabast.bsky.social
absolutelymaybe.plos.org/2025/06/27/d...
Renalism is a similar issue!
From @hildabast.bsky.social
June 28, 2025 at 12:46 AM
Poignant cartoon on therapeutics (here vaccines) in pregnancy
absolutelymaybe.plos.org/2025/06/27/d...
Renalism is a similar issue!
From @hildabast.bsky.social
absolutelymaybe.plos.org/2025/06/27/d...
Renalism is a similar issue!
From @hildabast.bsky.social
Reposted by Amali Samarasinghe
Cystatin C vs. Creatinine in AKI recovery
eGFRcr may overestimate kidney function post-AKI due to muscle loss. A KI Reports study found eGFRcys was lower, flagged more CKD, and a higher creatinine–cystatin C index (CMI) predicted lower 5-year mortality. www.kireports.org/article/S246...
eGFRcr may overestimate kidney function post-AKI due to muscle loss. A KI Reports study found eGFRcys was lower, flagged more CKD, and a higher creatinine–cystatin C index (CMI) predicted lower 5-year mortality. www.kireports.org/article/S246...
May 21, 2025 at 12:29 PM
Cystatin C vs. Creatinine in AKI recovery
eGFRcr may overestimate kidney function post-AKI due to muscle loss. A KI Reports study found eGFRcys was lower, flagged more CKD, and a higher creatinine–cystatin C index (CMI) predicted lower 5-year mortality. www.kireports.org/article/S246...
eGFRcr may overestimate kidney function post-AKI due to muscle loss. A KI Reports study found eGFRcys was lower, flagged more CKD, and a higher creatinine–cystatin C index (CMI) predicted lower 5-year mortality. www.kireports.org/article/S246...
Reposted by Amali Samarasinghe
Promising!
flozination in ADPKD (mostly older adults with DM or CVD) - presumably those with another valid indication - associated with slower GFR slope
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social #CJASN
With no obvious harm signal
flozination in ADPKD (mostly older adults with DM or CVD) - presumably those with another valid indication - associated with slower GFR slope
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social #CJASN
With no obvious harm signal
Sodium-Glucose Cotransporter-2 Inhibitor Therapy and... : Clinical Journal of the American Society of Nephrology
study within the Veterans Health Administration included adults with an ADPKD diagnosis code who initiated SGLT2i between January 2017 and May 2023. Repeated measures models were used to evaluate eGFR...
journals.lww.com
May 20, 2025 at 9:49 PM
Promising!
flozination in ADPKD (mostly older adults with DM or CVD) - presumably those with another valid indication - associated with slower GFR slope
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social #CJASN
With no obvious harm signal
flozination in ADPKD (mostly older adults with DM or CVD) - presumably those with another valid indication - associated with slower GFR slope
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social #CJASN
With no obvious harm signal
Reposted by Amali Samarasinghe
We’re making measles great again
😡😡😡
😡😡😡
May 15, 2025 at 5:19 PM
We’re making measles great again
😡😡😡
😡😡😡
Reposted by Amali Samarasinghe
Hey #NephSky and #MedSky
Check out the VA for our discussion 4/15/25 at 9pm EST
Metformin-Should I Stay or Should I Go (in patients with advanced CKD)
VA by @nephroseeker.medsky.social
www.nephjc.com/news/metformin-ckd-va
Check out the VA for our discussion 4/15/25 at 9pm EST
Metformin-Should I Stay or Should I Go (in patients with advanced CKD)
VA by @nephroseeker.medsky.social
www.nephjc.com/news/metformin-ckd-va
Metformin in Advanced CKD — NephJC
Should we continue metformin in eGFR under 30 ml/min? The visual abstract by Cristina Popa summarizes the conclusions from the Scottish cohort using target trial methodology.
www.nephjc.com
April 15, 2025 at 2:30 AM
Hey #NephSky and #MedSky
Check out the VA for our discussion 4/15/25 at 9pm EST
Metformin-Should I Stay or Should I Go (in patients with advanced CKD)
VA by @nephroseeker.medsky.social
www.nephjc.com/news/metformin-ckd-va
Check out the VA for our discussion 4/15/25 at 9pm EST
Metformin-Should I Stay or Should I Go (in patients with advanced CKD)
VA by @nephroseeker.medsky.social
www.nephjc.com/news/metformin-ckd-va
Reposted by Amali Samarasinghe
Interesting study of sleep duration by using Fitbit trackers in hemodialysis
From the Renal Research Institute in @asnpublications.bsky.social K360
journals.lww.com/kidney360/pa...
1/
#NephSky
From the Renal Research Institute in @asnpublications.bsky.social K360
journals.lww.com/kidney360/pa...
1/
#NephSky
Dialysis-Imposed Patterns of Nocturnal Sleep Duration: A... : Kidney360
nal study, patients on in-center hemodialysis were equipped with activity trackers (Fitbit® Charge 2™). Nocturnal sleep duration was assessed according to dialysis start time (early starters: before 8...
journals.lww.com
April 10, 2025 at 2:13 AM
Interesting study of sleep duration by using Fitbit trackers in hemodialysis
From the Renal Research Institute in @asnpublications.bsky.social K360
journals.lww.com/kidney360/pa...
1/
#NephSky
From the Renal Research Institute in @asnpublications.bsky.social K360
journals.lww.com/kidney360/pa...
1/
#NephSky
Spring has sprung - Vancouver
April 6, 2025 at 5:47 PM
Spring has sprung - Vancouver
Reposted by Amali Samarasinghe
Venous Thromboembolism Prevention in Nephrotic Syndrome: The Role of Aspirin, Vitamin K Antagonists, and Direct Oral Anticoagulants ca. 2025 from @kireports.bsky.social @saynanorouzi.bsky.social @kdjhaveri.bsky.social
#Nephpearls #NephSky
👉 www.kireports.org/article/S246...
#Nephpearls #NephSky
👉 www.kireports.org/article/S246...
April 3, 2025 at 12:38 PM
Venous Thromboembolism Prevention in Nephrotic Syndrome: The Role of Aspirin, Vitamin K Antagonists, and Direct Oral Anticoagulants ca. 2025 from @kireports.bsky.social @saynanorouzi.bsky.social @kdjhaveri.bsky.social
#Nephpearls #NephSky
👉 www.kireports.org/article/S246...
#Nephpearls #NephSky
👉 www.kireports.org/article/S246...
Reposted by Amali Samarasinghe
Daily monitoring of sCys in patients at risk of AKI would facilitate timely detection and potentially improve clinical outcomes. Future research should focus on validating sCys diagnostic criteria and integrating it with other biomarkers to enhance AKI management. bit.ly/CJASN0654
#ASNCJASN
#ASNCJASN
April 2, 2025 at 8:00 PM
Daily monitoring of sCys in patients at risk of AKI would facilitate timely detection and potentially improve clinical outcomes. Future research should focus on validating sCys diagnostic criteria and integrating it with other biomarkers to enhance AKI management. bit.ly/CJASN0654
#ASNCJASN
#ASNCJASN
Reposted by Amali Samarasinghe
Even if CONVINCE had lower enrollment than planned and a healthier cohort than average ESKD patient, name another 1000+ person RCT that shows a mortality benefit for people on HD.
#nephmadness
#nephmadness
Don'T Worry, I'Ll Wait - Worry GIF
ALT: Don'T Worry, I'Ll Wait - Worry GIF
media.tenor.com
April 2, 2025 at 5:02 PM
Even if CONVINCE had lower enrollment than planned and a healthier cohort than average ESKD patient, name another 1000+ person RCT that shows a mortality benefit for people on HD.
#nephmadness
#nephmadness