Rolando Claure
@runningkidneys.bsky.social
#KidneyDoctor #Researcher
Member Executive Committee @kdigo.org Member #SLANH #AKI committee
Views do not represent those of my employer
#KidneyRunner 🏃🏻♂️ #StopAKI
Member Executive Committee @kdigo.org Member #SLANH #AKI committee
Views do not represent those of my employer
#KidneyRunner 🏃🏻♂️ #StopAKI
Reposted by Rolando Claure
Hi, I’m Cello Tonelli, President of the ISN.
Join us for the #ISNWCN in March. Register today ➡️ lite.spr.ly/6007Ol8D
Join us for the #ISNWCN in March. Register today ➡️ lite.spr.ly/6007Ol8D
January 7, 2026 at 9:39 PM
Hi, I’m Cello Tonelli, President of the ISN.
Join us for the #ISNWCN in March. Register today ➡️ lite.spr.ly/6007Ol8D
Join us for the #ISNWCN in March. Register today ➡️ lite.spr.ly/6007Ol8D
PPIs have been linked to AKI/CKD risk. A 📑 in 🇰🇷 found P-CAB users had fewer kidney events than PPI users: creatinine doubling and eGFR ≥50% decline were lower; adjusted risk reductions 48% and 37%. Observational—needs confirmation.
🔗 doi.org/10.1093/ckj/...
🔗 doi.org/10.1093/ckj/...
January 8, 2026 at 3:26 PM
PPIs have been linked to AKI/CKD risk. A 📑 in 🇰🇷 found P-CAB users had fewer kidney events than PPI users: creatinine doubling and eGFR ≥50% decline were lower; adjusted risk reductions 48% and 37%. Observational—needs confirmation.
🔗 doi.org/10.1093/ckj/...
🔗 doi.org/10.1093/ckj/...
AKI is rising 🗺️ hit hardest in LMICs. The 5R framework (Risk, Recognition, Response, Renal Support, Rehab) guides action: advocacy + access, better detection, patient-centered care, closing gaps, equity & climate action, & tools like POC tests, EMRs, digital health & AI. #AKI
January 8, 2026 at 12:50 PM
AKI is rising 🗺️ hit hardest in LMICs. The 5R framework (Risk, Recognition, Response, Renal Support, Rehab) guides action: advocacy + access, better detection, patient-centered care, closing gaps, equity & climate action, & tools like POC tests, EMRs, digital health & AI. #AKI
Reposted by Rolando Claure
Grow professionally with the ISN. Access high-impact scientific and clinical research through our journals. Join/renew your ISN Membership ➡️ http://lite.spr.ly/6...
#ThisIsISN - Advancing kidney health worldwide. Together.
#ThisIsISN - Advancing kidney health worldwide. Together.
ISN Membership: Advance Global Kidney Care | Join or Renew Today
Access cutting-edge research content, connect with a global community, grow professionally, and make a difference in kidney health with the International Society of Nephrology.
lite.spr.ly
January 2, 2026 at 2:01 PM
Grow professionally with the ISN. Access high-impact scientific and clinical research through our journals. Join/renew your ISN Membership ➡️ http://lite.spr.ly/6...
#ThisIsISN - Advancing kidney health worldwide. Together.
#ThisIsISN - Advancing kidney health worldwide. Together.
Non-tunneled vs tunneled HD catheters: a 301-patient study found no significant difference in CRBSI rates with pre-curved non-tunneled catheters vs tunneled. Suggests longer use may be reasonable while awaiting AVF/PD cath/transplant. doi.org/10.1093/ckj/...
Comparable rates of catheter-related bloodstream infections between non-tunneled and tunneled hemodialysis catheters: a retrospective single-center study
AbstractBackground. A hemodialysis catheter may serve as a short- or medium-term vascular access solution. Current guidelines suggest restricting non-tunne
doi.org
January 2, 2026 at 2:30 PM
Non-tunneled vs tunneled HD catheters: a 301-patient study found no significant difference in CRBSI rates with pre-curved non-tunneled catheters vs tunneled. Suggests longer use may be reasonable while awaiting AVF/PD cath/transplant. doi.org/10.1093/ckj/...
Reposted by Rolando Claure
As the year draws to a close, we invite you to look back at 25 KDIGO resources from 2025, organized alphabetically by topic. KDIGO wishes you a happy and healthy 2026!
KDIGO 25 from 2025: kdigo.co/25-from-2025
KDIGO 25 from 2025: kdigo.co/25-from-2025
December 31, 2025 at 6:14 PM
As the year draws to a close, we invite you to look back at 25 KDIGO resources from 2025, organized alphabetically by topic. KDIGO wishes you a happy and healthy 2026!
KDIGO 25 from 2025: kdigo.co/25-from-2025
KDIGO 25 from 2025: kdigo.co/25-from-2025
🌍🏃♂️ We’re ending the year running around the world: 3 continents (Americas, Europe, Asia), 7 countries (🇧🇴🇪🇨🇺🇸🇮🇳🇩🇪🇵🇦🇲🇽) & 10 cities—1,450 km total. Proud to complete the #850Challenge again, raising kidney disease awareness worldwide. 💚🩺🌎 #Run4Kidneys 🫘
December 31, 2025 at 9:43 PM
🌍🏃♂️ We’re ending the year running around the world: 3 continents (Americas, Europe, Asia), 7 countries (🇧🇴🇪🇨🇺🇸🇮🇳🇩🇪🇵🇦🇲🇽) & 10 cities—1,450 km total. Proud to complete the #850Challenge again, raising kidney disease awareness worldwide. 💚🩺🌎 #Run4Kidneys 🫘
December 25, 2025 at 1:51 PM
Key updates on IgAN & complement-mediated kidney disease from KI/KIR: felzartamab, vWF–platelet targeting, and advances in C3G & IC-MPGN. Plus endotyping, biomarkers, and trial updates refining risk stratification & therapy.
ISN eDigest team 👏🏻
🔗 www.theisn.org/edigest-isn-...
ISN eDigest team 👏🏻
🔗 www.theisn.org/edigest-isn-...
December 17, 2025 at 4:43 PM
Key updates on IgAN & complement-mediated kidney disease from KI/KIR: felzartamab, vWF–platelet targeting, and advances in C3G & IC-MPGN. Plus endotyping, biomarkers, and trial updates refining risk stratification & therapy.
ISN eDigest team 👏🏻
🔗 www.theisn.org/edigest-isn-...
ISN eDigest team 👏🏻
🔗 www.theisn.org/edigest-isn-...
VTL-308 post-hoc 📑 (n=151) in severe alcohol-associated hepatitis, AKI → higher 90-day mortality. Higher bilirubin ↑ AKI risk; corticosteroids were linked to ↓ AKI incidence. After AKI, steroids didn’t improve recovery; high bilirubin ↓ reversal.
🔗 doi.org/10.1038/s415...
🔗 doi.org/10.1038/s415...
Steroid therapy is linked to lower incidence of acute kidney injury in patients with severe alcohol-associated hepatitis - Scientific Reports
Scientific Reports - Steroid therapy is linked to lower incidence of acute kidney injury in patients with severe alcohol-associated hepatitis
doi.org
December 17, 2025 at 3:22 PM
VTL-308 post-hoc 📑 (n=151) in severe alcohol-associated hepatitis, AKI → higher 90-day mortality. Higher bilirubin ↑ AKI risk; corticosteroids were linked to ↓ AKI incidence. After AKI, steroids didn’t improve recovery; high bilirubin ↓ reversal.
🔗 doi.org/10.1038/s415...
🔗 doi.org/10.1038/s415...
POCUS is changing nephrology at the 🛌 answering focused questions fast and sharpening decisions. But untrained use can cause diagnostic errors and harm. As adoption grows, we need standardized training + certification to keep #POCUS safe and effective. doi.org/10.62716/kn....
doi.org
December 16, 2025 at 3:34 PM
POCUS is changing nephrology at the 🛌 answering focused questions fast and sharpening decisions. But untrained use can cause diagnostic errors and harm. As adoption grows, we need standardized training + certification to keep #POCUS safe and effective. doi.org/10.62716/kn....
Inactive lupus nephritis & SGLT2i data: NDT cross-over trial (n=30). Dapagliflozin + standard care vs usual therapy for 6 mo; 9 excluded (flare/LTFU). Proteinuria ↓ –36.1% vs –3.5%. More hypotension symptoms; no sig BP/weight changes. #LupusNephritis
🔗 doi.org/10.1093/ndt/...
🔗 doi.org/10.1093/ndt/...
December 10, 2025 at 4:06 PM
Inactive lupus nephritis & SGLT2i data: NDT cross-over trial (n=30). Dapagliflozin + standard care vs usual therapy for 6 mo; 9 excluded (flare/LTFU). Proteinuria ↓ –36.1% vs –3.5%. More hypotension symptoms; no sig BP/weight changes. #LupusNephritis
🔗 doi.org/10.1093/ndt/...
🔗 doi.org/10.1093/ndt/...
In 102 PICU children 🇮🇷 Ultrasound ❤️ Output Monitoring showed CI as the only useful USCOM predictor for early AKI. AUC: CI 0.66 vs RAI 0.70. +RAI ↑ AKI risk 6.23x; abnormal CI 3.92x. PPV 60% (RAI) vs 57.1% (CI). USCOM may complement RAI. #AKI
🔗 doi.org/10.1007/s004...
🔗 doi.org/10.1007/s004...
Ultrasound cardiac output monitoring compared to the renal angina index for early prediction of pediatric acute kidney injury - Pediatric Nephrology
Background Acute kidney injury (AKI) is a significant concern within pediatric intensive care units (PICUs), leading to increased morbidity, longer hospitalization, and increased healthcare costs.…
doi.org
December 10, 2025 at 3:59 PM
In 102 PICU children 🇮🇷 Ultrasound ❤️ Output Monitoring showed CI as the only useful USCOM predictor for early AKI. AUC: CI 0.66 vs RAI 0.70. +RAI ↑ AKI risk 6.23x; abnormal CI 3.92x. PPV 60% (RAI) vs 57.1% (CI). USCOM may complement RAI. #AKI
🔗 doi.org/10.1007/s004...
🔗 doi.org/10.1007/s004...
Our 🆕 review out in Nature Reviews Nephrology! We discuss the global epidemiology of #AKI why major gaps and inequities persist 🗺️ , & practical opportunities to improve outcomes through the 5R framework, stronger surveillance, & digital/innovation-enabled care.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 6, 2025 at 4:26 PM
Our 🆕 review out in Nature Reviews Nephrology! We discuss the global epidemiology of #AKI why major gaps and inequities persist 🗺️ , & practical opportunities to improve outcomes through the 5R framework, stronger surveillance, & digital/innovation-enabled care.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
After 🏥#AKI, albuminuria at 3 months is recommended—but often missed. In 554 CRIC pts, uPCR measured within 1 year still strongly predicted risk. Each doubling of proteinuria → ~3x higher kidney disease progression risk. #AKI to #CKD
🔗 journals.lww.com/kidney360/ab...
🔗 journals.lww.com/kidney360/ab...
journals.lww.com
December 5, 2025 at 4:22 PM
After 🏥#AKI, albuminuria at 3 months is recommended—but often missed. In 554 CRIC pts, uPCR measured within 1 year still strongly predicted risk. Each doubling of proteinuria → ~3x higher kidney disease progression risk. #AKI to #CKD
🔗 journals.lww.com/kidney360/ab...
🔗 journals.lww.com/kidney360/ab...
🚨 Abstracts close Dec 12 for the International AKI & CRRT Conference.
Showcase your research, boost visibility, and connect with the AKI & CRRT and critical care community.
Submit today!
#AKI #CRRT #MedicalResearch #AKICRRT
🔗 crrtonline.com/crrtconferen...
Showcase your research, boost visibility, and connect with the AKI & CRRT and critical care community.
Submit today!
#AKI #CRRT #MedicalResearch #AKICRRT
🔗 crrtonline.com/crrtconferen...
December 5, 2025 at 12:11 PM
🚨 Abstracts close Dec 12 for the International AKI & CRRT Conference.
Showcase your research, boost visibility, and connect with the AKI & CRRT and critical care community.
Submit today!
#AKI #CRRT #MedicalResearch #AKICRRT
🔗 crrtonline.com/crrtconferen...
Showcase your research, boost visibility, and connect with the AKI & CRRT and critical care community.
Submit today!
#AKI #CRRT #MedicalResearch #AKICRRT
🔗 crrtonline.com/crrtconferen...
High early fluid + sodium intake may fuel AKI in very-low-birthweight infants
In a cohort of 421 infants <32 wks, AKI incidence was 8.6%, & those in the highest D1 fluid quartile had a 5.6-fold ↑ AKI risk. Volume expanders were major Na⁺/fluid sources.
link.springer.com/article/10.1...
In a cohort of 421 infants <32 wks, AKI incidence was 8.6%, & those in the highest D1 fluid quartile had a 5.6-fold ↑ AKI risk. Volume expanders were major Na⁺/fluid sources.
link.springer.com/article/10.1...
High early fluid and sodium intake as risk factors for acute kidney injury in very-low-birthweight infants - Pediatric Nephrology
Background Acute kidney injury (AKI) is common in very-low-birthweight (VLBW) infants. Both fluid overload and dehydration can lead to AKI. Our aim was to examine the associations between early fluid…
link.springer.com
December 3, 2025 at 2:18 PM
High early fluid + sodium intake may fuel AKI in very-low-birthweight infants
In a cohort of 421 infants <32 wks, AKI incidence was 8.6%, & those in the highest D1 fluid quartile had a 5.6-fold ↑ AKI risk. Volume expanders were major Na⁺/fluid sources.
link.springer.com/article/10.1...
In a cohort of 421 infants <32 wks, AKI incidence was 8.6%, & those in the highest D1 fluid quartile had a 5.6-fold ↑ AKI risk. Volume expanders were major Na⁺/fluid sources.
link.springer.com/article/10.1...
Troubleshooting ionized hypocalcemia in CKRT with RCA? 🧪🩸
A new case-based review in Kidney360 explains how to distinguish systemic citrate accumulation from net calcium loss and how to adjust Ca/citrate to keep patients safe. #CKRT
journals.lww.com/kidney360/ab...
A new case-based review in Kidney360 explains how to distinguish systemic citrate accumulation from net calcium loss and how to adjust Ca/citrate to keep patients safe. #CKRT
journals.lww.com/kidney360/ab...
journals.lww.com
December 3, 2025 at 2:14 PM
Troubleshooting ionized hypocalcemia in CKRT with RCA? 🧪🩸
A new case-based review in Kidney360 explains how to distinguish systemic citrate accumulation from net calcium loss and how to adjust Ca/citrate to keep patients safe. #CKRT
journals.lww.com/kidney360/ab...
A new case-based review in Kidney360 explains how to distinguish systemic citrate accumulation from net calcium loss and how to adjust Ca/citrate to keep patients safe. #CKRT
journals.lww.com/kidney360/ab...
New NEJM RCT in 1,228 maintenance HD pts: 4 g/day n-3 PUFA (fish oil) vs corn oil placebo reduced serious CV events (HR 0.57) and non-cardiac death (HR 0.77). Time to revisit fish oil in HD? #NephJC
December 1, 2025 at 9:55 PM
New NEJM RCT in 1,228 maintenance HD pts: 4 g/day n-3 PUFA (fish oil) vs corn oil placebo reduced serious CV events (HR 0.57) and non-cardiac death (HR 0.77). Time to revisit fish oil in HD? #NephJC
New 📑 👉🏻 In anticoagulation-free CKRT for high-bleeding-risk patients, higher blood flow (250 vs 200 mL/min) prolonged circuit life and lowered in-hospital mortality. Effect seems mediated by lower TMP. Important for circuit prescription. #CRRT #AKI
🔗 doi.org/10.1093/ckj/...
🔗 doi.org/10.1093/ckj/...
Higher blood flow rates in anticoagulation free CRRT improve circuit survival and clinical outcomes
AbstractObjective. Anticoagulation-free continuous renal replacement therapy (CRRT) is an essential modality for managing patients with a high bleeding ris
doi.org
November 30, 2025 at 12:03 AM
New 📑 👉🏻 In anticoagulation-free CKRT for high-bleeding-risk patients, higher blood flow (250 vs 200 mL/min) prolonged circuit life and lowered in-hospital mortality. Effect seems mediated by lower TMP. Important for circuit prescription. #CRRT #AKI
🔗 doi.org/10.1093/ckj/...
🔗 doi.org/10.1093/ckj/...
AI 🤖 (ML, DL, RL & generative AI) could transform critical care nephrology from AKI prediction & nephrotoxin surveillance to intradialytic hypotension forecasting & AI-guided CKRT, but validation, alert fatigue & cost remain key hurdles. #AKI #AI
🔗 journals.lww.com/kidney360/ab...
🔗 journals.lww.com/kidney360/ab...
journals.lww.com
November 29, 2025 at 10:29 PM
AI 🤖 (ML, DL, RL & generative AI) could transform critical care nephrology from AKI prediction & nephrotoxin surveillance to intradialytic hypotension forecasting & AI-guided CKRT, but validation, alert fatigue & cost remain key hurdles. #AKI #AI
🔗 journals.lww.com/kidney360/ab...
🔗 journals.lww.com/kidney360/ab...
New in Journal of Biomedical Informatics: EHR data used to map 15 post-AKI clinical states in 20,699 patients; 17% progressed to CKD. Classical (AKI severity, diabetes, HTN, HF, liver disease) & novel risk factors had state-specific impact. #AKI #CKD 👉🏻 www.sciencedirect.com:5037/science/arti...
www.sciencedirect.com
November 26, 2025 at 1:16 PM
New in Journal of Biomedical Informatics: EHR data used to map 15 post-AKI clinical states in 20,699 patients; 17% progressed to CKD. Classical (AKI severity, diabetes, HTN, HF, liver disease) & novel risk factors had state-specific impact. #AKI #CKD 👉🏻 www.sciencedirect.com:5037/science/arti...
New #Kidney360 study in 134 ICU pts: 15% developed severe AKI within 72h. Renal Angina Indices alone had modest performance, but adding urinary biomarkers—especially [TIMP-2]×[IGFBP7]—improved prediction & specificity for severe #AKI #ICU
🔗 journals.lww.com/kidney360/ab...
🔗 journals.lww.com/kidney360/ab...
journals.lww.com
November 25, 2025 at 5:14 PM
New #Kidney360 study in 134 ICU pts: 15% developed severe AKI within 72h. Renal Angina Indices alone had modest performance, but adding urinary biomarkers—especially [TIMP-2]×[IGFBP7]—improved prediction & specificity for severe #AKI #ICU
🔗 journals.lww.com/kidney360/ab...
🔗 journals.lww.com/kidney360/ab...
Just received my complimentary copy of Tropical Nephrology (2nd Ed.) 📘🌿
Recently discussed my chapter on kidney disease from herbal medicine with our fellows—2 days later we saw an AKI case linked to these products.
We must ask about herbal meds/supplements routinely. #AKI #CKD
Recently discussed my chapter on kidney disease from herbal medicine with our fellows—2 days later we saw an AKI case linked to these products.
We must ask about herbal meds/supplements routinely. #AKI #CKD
November 25, 2025 at 4:57 PM
New PLOS ONE paper from the ISARIC ICU cohort: during the Omicron wave, AKI risk in severe COVID-19 🦠 was lower than in earlier waves, but AKI still carried a high risk of death. #AKI #COVID19
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Omicron surge impact on acute kidney injury in ICU patients: A study using the ISARIC COVID-19 database
Background Acute Kidney Injury (AKI) is common among COVID-19 patients and is associated with a higher risk of death. Compared to earlier COVID-19 variants, Omicron has reduced mortality. To study…
journals.plos.org
November 24, 2025 at 3:31 PM
New PLOS ONE paper from the ISARIC ICU cohort: during the Omicron wave, AKI risk in severe COVID-19 🦠 was lower than in earlier waves, but AKI still carried a high risk of death. #AKI #COVID19
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...