Alisa 愛理沙
@alisaiakupova.bsky.social
PhD student studying structural variants in allergy @mdc-berlin.bsky.social 🥜 @preprintclub.bsky.social & long reads enthusiast. Moscow State & Univ of Groningen alumna
Pinned
featuring Thetis cells! (I should go to sleep)
Review @natimmunol.nature.com
Antigen-presenting cells as arbiters of mucosal tolerance and immunity
www.nature.com/articles/s41...
Antigen-presenting cells as arbiters of mucosal tolerance and immunity
www.nature.com/articles/s41...
November 18, 2025 at 9:05 PM
featuring Thetis cells! (I should go to sleep)
A cool study + it was so nice to write this highlight with @theonlylabever.bsky.social 🥕
by Alisa Iakupova & @theonlylabever.bsky.social
The OCR369 cis-regulatory element controls gut peacekeeping cells - Nature Reviews Immunology
A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory re...
www.nature.com
November 11, 2025 at 9:02 PM
A cool study + it was so nice to write this highlight with @theonlylabever.bsky.social 🥕
Reposted by Alisa 愛理沙
🚨#job alert 🚨
I am recruiting a technician and #postdoc in #bioinformatics to investigate T cell transcription networks in skin and gut #inflammation. We are a growing and diverse team at @ubcmedicine.bsky.social. Links below:
tinyurl.com/42w4vh7s
tinyurl.com/4n5wva6c
Please repost #immunosky
I am recruiting a technician and #postdoc in #bioinformatics to investigate T cell transcription networks in skin and gut #inflammation. We are a growing and diverse team at @ubcmedicine.bsky.social. Links below:
tinyurl.com/42w4vh7s
tinyurl.com/4n5wva6c
Please repost #immunosky
October 31, 2025 at 3:33 PM
🚨#job alert 🚨
I am recruiting a technician and #postdoc in #bioinformatics to investigate T cell transcription networks in skin and gut #inflammation. We are a growing and diverse team at @ubcmedicine.bsky.social. Links below:
tinyurl.com/42w4vh7s
tinyurl.com/4n5wva6c
Please repost #immunosky
I am recruiting a technician and #postdoc in #bioinformatics to investigate T cell transcription networks in skin and gut #inflammation. We are a growing and diverse team at @ubcmedicine.bsky.social. Links below:
tinyurl.com/42w4vh7s
tinyurl.com/4n5wva6c
Please repost #immunosky
)))
Erroneous articles can undermine scientific progress & mislead future research. Rene Aquarius &co show that 40% of articles on early #BrainInjury in animal studies have #ImageDuplication & #ImageManipulation problems, but correction by #journals remains limited @plosbiology.org 🧪 plos.io/4p59QzN
October 31, 2025 at 10:14 AM
)))
please submit preprints, this small study showing what adaptive sampling (AS) by #ONT can do helped me to compare my own results and *perhaps* improve them very soon. actually, AS is probably the best way to do targeted sequencing with long reads. www.researchsquare.com/article/rs-7...
Flexible and rapid validation of structural variation using adaptive sampling
Identification of genomic rearrangement by microarrays or short-read sequencing frequently lacks information about the exact architecture and breakpoints of variants due to technical limitations. Inde...
www.researchsquare.com
October 17, 2025 at 2:22 PM
please submit preprints, this small study showing what adaptive sampling (AS) by #ONT can do helped me to compare my own results and *perhaps* improve them very soon. actually, AS is probably the best way to do targeted sequencing with long reads. www.researchsquare.com/article/rs-7...
A nice review about mucosal mechanisms in celiac disease and food allergy, loved all #IgA mentions 🥸👇
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Gut mucosal immune responses – Implications for celiac disease and food allergy
The intestinal mucosa employs a diverse set of defense mechanisms—from mucosal barrier regulation to immunoregulatory pathways—to maintain homeostasis…
www.sciencedirect.com
September 29, 2025 at 3:12 PM
A nice review about mucosal mechanisms in celiac disease and food allergy, loved all #IgA mentions 🥸👇
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Got excited too quickly it is actually about some IgE mechanisms, in fact it is about IgE from the clinical perspective! Worth reading if you are interested in current anti-IgE therapies against atopic diseases onlinelibrary.wiley.com/doi/abs/10.1...
IgE in Allergic Diseases
Immunoglobulin E (IgE) is key in the pathogenesis of allergic diseases, exerting both systemic and local effects through high-affinity binding to FcεRI on mast cells and basophils. Cross-linking of a....
onlinelibrary.wiley.com
September 28, 2025 at 5:14 PM
Got excited too quickly it is actually about some IgE mechanisms, in fact it is about IgE from the clinical perspective! Worth reading if you are interested in current anti-IgE therapies against atopic diseases onlinelibrary.wiley.com/doi/abs/10.1...
Reposted by Alisa 愛理沙
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 23, 2025 at 3:32 PM
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alisa 愛理沙
Tomorrow in #PreprintHub2,
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
RORγt+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens
Oral tolerance represents a hallmark of intestinal mucosal immunity to prevent inflammatory responses to harmless natural antigens, such as dietary components or commensal organisms. However, the unde...
www.researchsquare.com
September 22, 2025 at 8:29 PM
Tomorrow in #PreprintHub2,
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
JCI Insight - Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions insight.jci.org/articles/vie...
JCI Insight -
Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions
insight.jci.org
September 17, 2025 at 7:13 AM
JCI Insight - Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions insight.jci.org/articles/vie...
Reposted by Alisa 愛理沙
@biorxivpreprint.bsky.social There are some cool aspects to this new genetic study, so forgive my poking for fun:
1. HLA is associated control of virus infections (uh, duh?)
2. Is it even significant? (p = 9.1×10-851 )
www.biorxiv.org/content/10.1... @harvardmed.bsky.social
1. HLA is associated control of virus infections (uh, duh?)
2. Is it even significant? (p = 9.1×10-851 )
www.biorxiv.org/content/10.1... @harvardmed.bsky.social
September 12, 2025 at 2:58 PM
@biorxivpreprint.bsky.social There are some cool aspects to this new genetic study, so forgive my poking for fun:
1. HLA is associated control of virus infections (uh, duh?)
2. Is it even significant? (p = 9.1×10-851 )
www.biorxiv.org/content/10.1... @harvardmed.bsky.social
1. HLA is associated control of virus infections (uh, duh?)
2. Is it even significant? (p = 9.1×10-851 )
www.biorxiv.org/content/10.1... @harvardmed.bsky.social
I wish I have met David Baltimore.. it is very very sad.
www.latimes.com/obituaries/s... RIP David Baltimore. A true giant of biomedical research. Made so many fundamental discoveries: Reverse transcriptase; NF-kB; Rag genes (among others) Also shut down his lab for a week in 1970 to protest the US invasion of Cambodia.
David Baltimore, Nobel Prize-winning scientist and former Caltech president, dies at 87
Baltimore played a role in virtually every important national debate over the use and potential misuse of the science of genetic engineering.
www.latimes.com
September 8, 2025 at 12:55 PM
I wish I have met David Baltimore.. it is very very sad.
Today we learnt a lot about tuft cells from @jmoltke.bsky.social at the @mdc-berlin.bsky.social afternoon for immunology. Thank you! 😊
September 4, 2025 at 5:38 PM
Today we learnt a lot about tuft cells from @jmoltke.bsky.social at the @mdc-berlin.bsky.social afternoon for immunology. Thank you! 😊
Reposted by Alisa 愛理沙
📢 Interested in #immunology research? Join our “Afternoon for Immunology”! Scientists at all career stages will present their research.
📍 September 4, 15:00-18:00
Robert-Rössle-Str 10
Dendrit 2/3
13125 Berlin
🔗 www.mdc-berlin.de/Afternoonfor...
📍 September 4, 15:00-18:00
Robert-Rössle-Str 10
Dendrit 2/3
13125 Berlin
🔗 www.mdc-berlin.de/Afternoonfor...
August 28, 2025 at 3:56 PM
📢 Interested in #immunology research? Join our “Afternoon for Immunology”! Scientists at all career stages will present their research.
📍 September 4, 15:00-18:00
Robert-Rössle-Str 10
Dendrit 2/3
13125 Berlin
🔗 www.mdc-berlin.de/Afternoonfor...
📍 September 4, 15:00-18:00
Robert-Rössle-Str 10
Dendrit 2/3
13125 Berlin
🔗 www.mdc-berlin.de/Afternoonfor...
Our new paper is out in Allergy! 🚨
Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells
I personally like the ILC3 link with OIT :^)
onlinelibrary.wiley.com/doi/10.1111/...
Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells
I personally like the ILC3 link with OIT :^)
onlinelibrary.wiley.com/doi/10.1111/...
Understanding the Variability of Peanut‐Oral Immunotherapy Responses by Multi‐Omics Profiling of Immune Cells
This study analyzes molecular drivers of OIT responsiveness. Multi-omics profiling of peanut-stimulated PBMCs in a controlled peanut-OIT trial identifies immune, transcriptomic, and epigenetic change...
onlinelibrary.wiley.com
July 22, 2025 at 1:28 PM
Our new paper is out in Allergy! 🚨
Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells
I personally like the ILC3 link with OIT :^)
onlinelibrary.wiley.com/doi/10.1111/...
Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells
I personally like the ILC3 link with OIT :^)
onlinelibrary.wiley.com/doi/10.1111/...
will be there!
🏳️🌈 Resilience in Times of Change: Join #mdcBerlin’s LGBTQI+ community for the 4th Pride Symposium on July 18 at #mdcBIMSB.
Talks, panel discussion, bake sale, and a Pride After Hour – amplifying queer voices in science.
Info and registration:
👉 www.mdc-berlin.de/news/news/me... 👈
Talks, panel discussion, bake sale, and a Pride After Hour – amplifying queer voices in science.
Info and registration:
👉 www.mdc-berlin.de/news/news/me... 👈
July 17, 2025 at 9:05 AM
will be there!
Reposted by Alisa 愛理沙
Online Now! A new @genomicspc.bsky.social Spotlight:
"Psychiatric disorders: teasing apart genetic similarities and differences"
by Jiayi Xu (徐佳依) (@xujiayi.bsky.social) & Laura M. Huckins (@laurahuckins.bsky.social)
Read for FREE till Aug. 23rd at this link:
authors.elsevier.com/a/1lNROcQbJF...
"Psychiatric disorders: teasing apart genetic similarities and differences"
by Jiayi Xu (徐佳依) (@xujiayi.bsky.social) & Laura M. Huckins (@laurahuckins.bsky.social)
Read for FREE till Aug. 23rd at this link:
authors.elsevier.com/a/1lNROcQbJF...
July 7, 2025 at 1:20 PM
Online Now! A new @genomicspc.bsky.social Spotlight:
"Psychiatric disorders: teasing apart genetic similarities and differences"
by Jiayi Xu (徐佳依) (@xujiayi.bsky.social) & Laura M. Huckins (@laurahuckins.bsky.social)
Read for FREE till Aug. 23rd at this link:
authors.elsevier.com/a/1lNROcQbJF...
"Psychiatric disorders: teasing apart genetic similarities and differences"
by Jiayi Xu (徐佳依) (@xujiayi.bsky.social) & Laura M. Huckins (@laurahuckins.bsky.social)
Read for FREE till Aug. 23rd at this link:
authors.elsevier.com/a/1lNROcQbJF...
Reposted by Alisa 愛理沙
🥜 Food Allergies may start in the Skin, not just the Gut🥜
Damaged skin (as with eczema) can let food proteins in, priming IgE responses that later trigger gut Mast Cells, which drives allergic reactions & anaphylaxis. buff.ly/Nfo06vB
#medsky #pedsky #foodallergy #immunosky 🛟🧪
Damaged skin (as with eczema) can let food proteins in, priming IgE responses that later trigger gut Mast Cells, which drives allergic reactions & anaphylaxis. buff.ly/Nfo06vB
#medsky #pedsky #foodallergy #immunosky 🛟🧪
July 8, 2025 at 4:45 AM
🥜 Food Allergies may start in the Skin, not just the Gut🥜
Damaged skin (as with eczema) can let food proteins in, priming IgE responses that later trigger gut Mast Cells, which drives allergic reactions & anaphylaxis. buff.ly/Nfo06vB
#medsky #pedsky #foodallergy #immunosky 🛟🧪
Damaged skin (as with eczema) can let food proteins in, priming IgE responses that later trigger gut Mast Cells, which drives allergic reactions & anaphylaxis. buff.ly/Nfo06vB
#medsky #pedsky #foodallergy #immunosky 🛟🧪
Reposted by Alisa 愛理沙
Our first preprint Spotlight is now online!
"Toward Equitable Biomarkers of Aging: Rethinking Methylation Clocks"
by Chen & colleagues (@genomicspc.bsky.social)
It highlights a bioRxiv preprint (@biorxivpreprint.bsky.social) by Cruz-González et al.
Read here:
authors.elsevier.com/a/1lHcdcQbJF...
"Toward Equitable Biomarkers of Aging: Rethinking Methylation Clocks"
by Chen & colleagues (@genomicspc.bsky.social)
It highlights a bioRxiv preprint (@biorxivpreprint.bsky.social) by Cruz-González et al.
Read here:
authors.elsevier.com/a/1lHcdcQbJF...
June 19, 2025 at 1:59 PM
Our first preprint Spotlight is now online!
"Toward Equitable Biomarkers of Aging: Rethinking Methylation Clocks"
by Chen & colleagues (@genomicspc.bsky.social)
It highlights a bioRxiv preprint (@biorxivpreprint.bsky.social) by Cruz-González et al.
Read here:
authors.elsevier.com/a/1lHcdcQbJF...
"Toward Equitable Biomarkers of Aging: Rethinking Methylation Clocks"
by Chen & colleagues (@genomicspc.bsky.social)
It highlights a bioRxiv preprint (@biorxivpreprint.bsky.social) by Cruz-González et al.
Read here:
authors.elsevier.com/a/1lHcdcQbJF...
My dreams come true 🥺 a preprint club in genomics!!
📣 Hello Bluesky! We’re hosting our June Genomics Preprint Club meeting this Friday, June 27 from 3–4pm EST!
📩 Contact us to join!
🗣️ Presenters:
- Krzysiek Gogolewski: www.medrxiv.org/content/10.1...
- Arnav Wadhawan: www.medrxiv.org/content/10.1...
📩 Contact us to join!
🗣️ Presenters:
- Krzysiek Gogolewski: www.medrxiv.org/content/10.1...
- Arnav Wadhawan: www.medrxiv.org/content/10.1...
June 27, 2025 at 6:46 AM
My dreams come true 🥺 a preprint club in genomics!!
@bsky.app you have to improve, name tags are awfully long. plus, it would be useful to allow drafts for posts. X is still better, if ignoring all the sex bots attacking my dm and hate speech. 😬
June 10, 2025 at 12:29 PM
@bsky.app you have to improve, name tags are awfully long. plus, it would be useful to allow drafts for posts. X is still better, if ignoring all the sex bots attacking my dm and hate speech. 😬
I look like these T cells:
Today, in #preprinthub2 @cleeterichter.bsky.social will lead a discussion of a #preprint from @santoshvardhana.bsky.social @mskcancercenter.bsky.social on MEK-dependent bioenergetic demand driving terminal CD8+ T cell exhaustion. 🍰💥 #immunosky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 10, 2025 at 12:27 PM
I look like these T cells:
Reposted by Alisa 愛理沙
Iwasaki and colleagues show that mucosal vaccine boosters can induce protective immune responses without any adjuvant by retooling lymph node resident memory B cells with memory T cells acting as a natural adjuvant. Read it here: rdcu.be/elTur
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
Nature Immunology - Iwasaki and colleagues show that an intranasal booster with an unadjuvanted recombinant SARS-CoV-2 spike protein, after intramuscular immunization with an mRNA vaccine encoding...
rdcu.be
May 13, 2025 at 5:27 PM
Iwasaki and colleagues show that mucosal vaccine boosters can induce protective immune responses without any adjuvant by retooling lymph node resident memory B cells with memory T cells acting as a natural adjuvant. Read it here: rdcu.be/elTur
www.nature.com/articles/s41...
www.nature.com/articles/s41...
congrats to my friend @encent.bsky.social and the team 😊
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature
The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...
www.nature.com
May 7, 2025 at 5:03 PM
congrats to my friend @encent.bsky.social and the team 😊