Alisa 愛理沙
@alisaiakupova.bsky.social
PhD student studying structural variants in allergy @mdc-berlin.bsky.social 🥜 @preprintclub.bsky.social & long reads enthusiast. Moscow State & Univ of Groningen alumna
Reposted by Alisa 愛理沙
Tomorrow, Rob Crozier from the University of Toronto will present a #preprint from the Morais da Fonseca lab about how Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses
Background The incidence of lung allergies is reduced in countries with higher prevalence of infection and environmental exposure to microbes. However, enteric bacterial infections do not always corre...
www.biorxiv.org
December 2, 2025 at 5:51 PM
Tomorrow, Rob Crozier from the University of Toronto will present a #preprint from the Morais da Fonseca lab about how Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
happy advent! @mdc-berlin.bsky.social such a great idea 🙈
December 1, 2025 at 4:09 PM
happy advent! @mdc-berlin.bsky.social such a great idea 🙈
Reposted by Alisa 愛理沙
Interesting investigation into a dodgy Elsevier journal -- with the additional nugget that the CEO of Elsevier's parent company made more than €15 million in total compensation last year.
english.elpais.com/science-tech...
english.elpais.com/science-tech...
The fall of a prolific science journal exposes the billion-dollar profits of scientific publishing
One of the 15 publications that put out the most studies globally has been expelled from the indexing system for irregularities. Its publisher, Elsevier, has a 38% profit margin that reached $1.5 bill...
english.elpais.com
November 28, 2025 at 8:51 PM
Interesting investigation into a dodgy Elsevier journal -- with the additional nugget that the CEO of Elsevier's parent company made more than €15 million in total compensation last year.
english.elpais.com/science-tech...
english.elpais.com/science-tech...
Join us for an MDC Afternoon for Immunology at the @mdc-bimsb.bsky.social on December 8th with student/postdoc talks and two keynotes, Jeffrey A. Hubbell and Stefano Casola 🙂
🔗 Register: www.mdc-berlin.de/news/events/...
🔗 Register: www.mdc-berlin.de/news/events/...
November 27, 2025 at 9:24 AM
Join us for an MDC Afternoon for Immunology at the @mdc-bimsb.bsky.social on December 8th with student/postdoc talks and two keynotes, Jeffrey A. Hubbell and Stefano Casola 🙂
🔗 Register: www.mdc-berlin.de/news/events/...
🔗 Register: www.mdc-berlin.de/news/events/...
Reposted by Alisa 愛理沙
Effects of butyrylated high amylose maize starch (HAMSB) as an adjuvant for oral immunotherapy https://www.medrxiv.org/content/10.1101/2025.09.11.25335560v1
September 15, 2025 at 2:55 AM
Effects of butyrylated high amylose maize starch (HAMSB) as an adjuvant for oral immunotherapy https://www.medrxiv.org/content/10.1101/2025.09.11.25335560v1
I want to know if Th2-MPP cells could be found in the gastrointestinal biopsies… (www.nature.com/articles/s41... ), besides that, a nice study in line with what our group published recently! :)
November 22, 2025 at 4:34 PM
I want to know if Th2-MPP cells could be found in the gastrointestinal biopsies… (www.nature.com/articles/s41... ), besides that, a nice study in line with what our group published recently! :)
Reposted by Alisa 愛理沙
Also today at #PreprintHub1, Frederika Rentzeperis from Mt.Sinai will present a #preprint by Xueping Zhu from Professor Sokol's lab on how "Sensory neuronal mTORC1 signaling establishes neuroimmune memory that initiates allergic immunity"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 19, 2025 at 6:59 AM
Also today at #PreprintHub1, Frederika Rentzeperis from Mt.Sinai will present a #preprint by Xueping Zhu from Professor Sokol's lab on how "Sensory neuronal mTORC1 signaling establishes neuroimmune memory that initiates allergic immunity"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
featuring Thetis cells! (I should go to sleep)
Review @natimmunol.nature.com
Antigen-presenting cells as arbiters of mucosal tolerance and immunity
www.nature.com/articles/s41...
Antigen-presenting cells as arbiters of mucosal tolerance and immunity
www.nature.com/articles/s41...
November 18, 2025 at 9:05 PM
featuring Thetis cells! (I should go to sleep)
A cool study + it was so nice to write this highlight with @theonlylabever.bsky.social 🥕
by Alisa Iakupova & @theonlylabever.bsky.social
The OCR369 cis-regulatory element controls gut peacekeeping cells - Nature Reviews Immunology
A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory re...
www.nature.com
November 11, 2025 at 9:02 PM
A cool study + it was so nice to write this highlight with @theonlylabever.bsky.social 🥕
Reposted by Alisa 愛理沙
🚨#job alert 🚨
I am recruiting a technician and #postdoc in #bioinformatics to investigate T cell transcription networks in skin and gut #inflammation. We are a growing and diverse team at @ubcmedicine.bsky.social. Links below:
tinyurl.com/42w4vh7s
tinyurl.com/4n5wva6c
Please repost #immunosky
I am recruiting a technician and #postdoc in #bioinformatics to investigate T cell transcription networks in skin and gut #inflammation. We are a growing and diverse team at @ubcmedicine.bsky.social. Links below:
tinyurl.com/42w4vh7s
tinyurl.com/4n5wva6c
Please repost #immunosky
October 31, 2025 at 3:33 PM
🚨#job alert 🚨
I am recruiting a technician and #postdoc in #bioinformatics to investigate T cell transcription networks in skin and gut #inflammation. We are a growing and diverse team at @ubcmedicine.bsky.social. Links below:
tinyurl.com/42w4vh7s
tinyurl.com/4n5wva6c
Please repost #immunosky
I am recruiting a technician and #postdoc in #bioinformatics to investigate T cell transcription networks in skin and gut #inflammation. We are a growing and diverse team at @ubcmedicine.bsky.social. Links below:
tinyurl.com/42w4vh7s
tinyurl.com/4n5wva6c
Please repost #immunosky
)))
Erroneous articles can undermine scientific progress & mislead future research. Rene Aquarius &co show that 40% of articles on early #BrainInjury in animal studies have #ImageDuplication & #ImageManipulation problems, but correction by #journals remains limited @plosbiology.org 🧪 plos.io/4p59QzN
October 31, 2025 at 10:14 AM
)))
please submit preprints, this small study showing what adaptive sampling (AS) by #ONT can do helped me to compare my own results and *perhaps* improve them very soon. actually, AS is probably the best way to do targeted sequencing with long reads. www.researchsquare.com/article/rs-7...
Flexible and rapid validation of structural variation using adaptive sampling
Identification of genomic rearrangement by microarrays or short-read sequencing frequently lacks information about the exact architecture and breakpoints of variants due to technical limitations. Inde...
www.researchsquare.com
October 17, 2025 at 2:22 PM
please submit preprints, this small study showing what adaptive sampling (AS) by #ONT can do helped me to compare my own results and *perhaps* improve them very soon. actually, AS is probably the best way to do targeted sequencing with long reads. www.researchsquare.com/article/rs-7...
A nice review about mucosal mechanisms in celiac disease and food allergy, loved all #IgA mentions 🥸👇
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Gut mucosal immune responses – Implications for celiac disease and food allergy
The intestinal mucosa employs a diverse set of defense mechanisms—from mucosal barrier regulation to immunoregulatory pathways—to maintain homeostasis…
www.sciencedirect.com
September 29, 2025 at 3:12 PM
A nice review about mucosal mechanisms in celiac disease and food allergy, loved all #IgA mentions 🥸👇
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Got excited too quickly it is actually about some IgE mechanisms, in fact it is about IgE from the clinical perspective! Worth reading if you are interested in current anti-IgE therapies against atopic diseases onlinelibrary.wiley.com/doi/abs/10.1...
IgE in Allergic Diseases
Immunoglobulin E (IgE) is key in the pathogenesis of allergic diseases, exerting both systemic and local effects through high-affinity binding to FcεRI on mast cells and basophils. Cross-linking of a....
onlinelibrary.wiley.com
September 28, 2025 at 5:14 PM
Got excited too quickly it is actually about some IgE mechanisms, in fact it is about IgE from the clinical perspective! Worth reading if you are interested in current anti-IgE therapies against atopic diseases onlinelibrary.wiley.com/doi/abs/10.1...
Reposted by Alisa 愛理沙
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 23, 2025 at 3:32 PM
Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alisa 愛理沙
Tomorrow in #PreprintHub2,
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
RORγt+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens
Oral tolerance represents a hallmark of intestinal mucosal immunity to prevent inflammatory responses to harmless natural antigens, such as dietary components or commensal organisms. However, the unde...
www.researchsquare.com
September 22, 2025 at 8:29 PM
Tomorrow in #PreprintHub2,
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
@alisaiakupova.bsky.social from
@mdc-berlin.bsky.social will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...
JCI Insight - Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions insight.jci.org/articles/vie...
JCI Insight -
Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions
insight.jci.org
September 17, 2025 at 7:13 AM
JCI Insight - Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions insight.jci.org/articles/vie...
Reposted by Alisa 愛理沙
@biorxivpreprint.bsky.social There are some cool aspects to this new genetic study, so forgive my poking for fun:
1. HLA is associated control of virus infections (uh, duh?)
2. Is it even significant? (p = 9.1×10-851 )
www.biorxiv.org/content/10.1... @harvardmed.bsky.social
1. HLA is associated control of virus infections (uh, duh?)
2. Is it even significant? (p = 9.1×10-851 )
www.biorxiv.org/content/10.1... @harvardmed.bsky.social
September 12, 2025 at 2:58 PM
@biorxivpreprint.bsky.social There are some cool aspects to this new genetic study, so forgive my poking for fun:
1. HLA is associated control of virus infections (uh, duh?)
2. Is it even significant? (p = 9.1×10-851 )
www.biorxiv.org/content/10.1... @harvardmed.bsky.social
1. HLA is associated control of virus infections (uh, duh?)
2. Is it even significant? (p = 9.1×10-851 )
www.biorxiv.org/content/10.1... @harvardmed.bsky.social
I wish I have met David Baltimore.. it is very very sad.
www.latimes.com/obituaries/s... RIP David Baltimore. A true giant of biomedical research. Made so many fundamental discoveries: Reverse transcriptase; NF-kB; Rag genes (among others) Also shut down his lab for a week in 1970 to protest the US invasion of Cambodia.
David Baltimore, Nobel Prize-winning scientist and former Caltech president, dies at 87
Baltimore played a role in virtually every important national debate over the use and potential misuse of the science of genetic engineering.
www.latimes.com
September 8, 2025 at 12:55 PM
I wish I have met David Baltimore.. it is very very sad.
Today we learnt a lot about tuft cells from @jmoltke.bsky.social at the @mdc-berlin.bsky.social afternoon for immunology. Thank you! 😊
September 4, 2025 at 5:38 PM
Today we learnt a lot about tuft cells from @jmoltke.bsky.social at the @mdc-berlin.bsky.social afternoon for immunology. Thank you! 😊
Reposted by Alisa 愛理沙
📢 Interested in #immunology research? Join our “Afternoon for Immunology”! Scientists at all career stages will present their research.
📍 September 4, 15:00-18:00
Robert-Rössle-Str 10
Dendrit 2/3
13125 Berlin
🔗 www.mdc-berlin.de/Afternoonfor...
📍 September 4, 15:00-18:00
Robert-Rössle-Str 10
Dendrit 2/3
13125 Berlin
🔗 www.mdc-berlin.de/Afternoonfor...
August 28, 2025 at 3:56 PM
📢 Interested in #immunology research? Join our “Afternoon for Immunology”! Scientists at all career stages will present their research.
📍 September 4, 15:00-18:00
Robert-Rössle-Str 10
Dendrit 2/3
13125 Berlin
🔗 www.mdc-berlin.de/Afternoonfor...
📍 September 4, 15:00-18:00
Robert-Rössle-Str 10
Dendrit 2/3
13125 Berlin
🔗 www.mdc-berlin.de/Afternoonfor...
Our new paper is out in Allergy! 🚨
Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells
I personally like the ILC3 link with OIT :^)
onlinelibrary.wiley.com/doi/10.1111/...
Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells
I personally like the ILC3 link with OIT :^)
onlinelibrary.wiley.com/doi/10.1111/...
Understanding the Variability of Peanut‐Oral Immunotherapy Responses by Multi‐Omics Profiling of Immune Cells
This study analyzes molecular drivers of OIT responsiveness. Multi-omics profiling of peanut-stimulated PBMCs in a controlled peanut-OIT trial identifies immune, transcriptomic, and epigenetic change...
onlinelibrary.wiley.com
July 22, 2025 at 1:28 PM
Our new paper is out in Allergy! 🚨
Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells
I personally like the ILC3 link with OIT :^)
onlinelibrary.wiley.com/doi/10.1111/...
Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells
I personally like the ILC3 link with OIT :^)
onlinelibrary.wiley.com/doi/10.1111/...
will be there!
🏳️🌈 Resilience in Times of Change: Join #mdcBerlin’s LGBTQI+ community for the 4th Pride Symposium on July 18 at #mdcBIMSB.
Talks, panel discussion, bake sale, and a Pride After Hour – amplifying queer voices in science.
Info and registration:
👉 www.mdc-berlin.de/news/news/me... 👈
Talks, panel discussion, bake sale, and a Pride After Hour – amplifying queer voices in science.
Info and registration:
👉 www.mdc-berlin.de/news/news/me... 👈
July 17, 2025 at 9:05 AM
will be there!
Reposted by Alisa 愛理沙
Online Now! A new @genomicspc.bsky.social Spotlight:
"Psychiatric disorders: teasing apart genetic similarities and differences"
by Jiayi Xu (徐佳依) (@xujiayi.bsky.social) & Laura M. Huckins (@laurahuckins.bsky.social)
Read for FREE till Aug. 23rd at this link:
authors.elsevier.com/a/1lNROcQbJF...
"Psychiatric disorders: teasing apart genetic similarities and differences"
by Jiayi Xu (徐佳依) (@xujiayi.bsky.social) & Laura M. Huckins (@laurahuckins.bsky.social)
Read for FREE till Aug. 23rd at this link:
authors.elsevier.com/a/1lNROcQbJF...
July 7, 2025 at 1:20 PM
Online Now! A new @genomicspc.bsky.social Spotlight:
"Psychiatric disorders: teasing apart genetic similarities and differences"
by Jiayi Xu (徐佳依) (@xujiayi.bsky.social) & Laura M. Huckins (@laurahuckins.bsky.social)
Read for FREE till Aug. 23rd at this link:
authors.elsevier.com/a/1lNROcQbJF...
"Psychiatric disorders: teasing apart genetic similarities and differences"
by Jiayi Xu (徐佳依) (@xujiayi.bsky.social) & Laura M. Huckins (@laurahuckins.bsky.social)
Read for FREE till Aug. 23rd at this link:
authors.elsevier.com/a/1lNROcQbJF...