Alex Swarbrick
@alexswarbrick.bsky.social
Professor of Breast & Prostate cancer, Melanoma research. Tumour Ecosystems, Single Cell and Spatial Genomics. Sydney/Gadigal Australia. Views are my own & not my employers
Felling inspired after my visit to The Broad Institute. Brilliant science in a collaborative energised environment. Thanks @azizalkhafaji.bsky.social and Gammy Al-Eryani for hosting
August 10, 2025 at 2:03 PM
Felling inspired after my visit to The Broad Institute. Brilliant science in a collaborative energised environment. Thanks @azizalkhafaji.bsky.social and Gammy Al-Eryani for hosting
I’m looking for a PhD student to work on an exciting new collaboration with @azizalkhafaji.bsky.social at the @broadinstitute.org. Together we are using single cell long-read sequencing to understand tumour evolution and microenvironments. Hybrid computational and molecular role. 🧬
August 1, 2025 at 5:26 PM
I’m looking for a PhD student to work on an exciting new collaboration with @azizalkhafaji.bsky.social at the @broadinstitute.org. Together we are using single cell long-read sequencing to understand tumour evolution and microenvironments. Hybrid computational and molecular role. 🧬
Thankyou for hosting us! We are so impressed by the quality of the science, collaboration and facilities at @pmresearch-uhn.bsky.social. Looking forward to developing exciting new projects together
🇨🇦🇦🇺 Thank you to @garvaninstitute.bsky.social for joining us at the Allan Slaight Breakthrough Forum! Scientists were brought together to tackle tumour complexity for translational impact. Together, we’re accelerating the path toward more precise and effective cancer care.💙
August 1, 2025 at 5:23 PM
Thankyou for hosting us! We are so impressed by the quality of the science, collaboration and facilities at @pmresearch-uhn.bsky.social. Looking forward to developing exciting new projects together
Reposted by Alex Swarbrick
In this #Perspective @alexswarbrick.bsky.social @jeremymedonc.bsky.social &co argue that better preclinical models and understanding of stromal cells in the tumor microenvironment are needed to improve #cancer therapies 7/9
plos.io/4of0fXe
plos.io/4of0fXe
TiME for a change: The tumor microenvironment as the missing piece in cancer therapeutics
Current anti-cancer treatments often neglect the role of the tumor microenvironment (TME) in resistance and progression. In this Perspective, the authors argue that better preclinical models, understa...
plos.io
August 1, 2025 at 8:05 AM
In this #Perspective @alexswarbrick.bsky.social @jeremymedonc.bsky.social &co argue that better preclinical models and understanding of stromal cells in the tumor microenvironment are needed to improve #cancer therapies 7/9
plos.io/4of0fXe
plos.io/4of0fXe
An exciting new paper on the application of federated deep learning to pan-cancer proteomic data. Congrats to the Procan team for this achievement! Very happy to have contributed our breast cancer dataset to this important work.
doi.org/10.1158/2159...
www.cmrijeansforgenes.org.au/research/res...
doi.org/10.1158/2159...
www.cmrijeansforgenes.org.au/research/res...
June 13, 2025 at 2:54 AM
An exciting new paper on the application of federated deep learning to pan-cancer proteomic data. Congrats to the Procan team for this achievement! Very happy to have contributed our breast cancer dataset to this important work.
doi.org/10.1158/2159...
www.cmrijeansforgenes.org.au/research/res...
doi.org/10.1158/2159...
www.cmrijeansforgenes.org.au/research/res...
Today is the last day in the lab for for Marion Motard, who joined the lab for her Masters then stayed on as a research assistant. She did brilliant work on GNNs to predict gene module enrichment in histology images. She is returning to Europe, quickly offer her a job in ML/computational !
June 13, 2025 at 2:48 AM
Today is the last day in the lab for for Marion Motard, who joined the lab for her Masters then stayed on as a research assistant. She did brilliant work on GNNs to predict gene module enrichment in histology images. She is returning to Europe, quickly offer her a job in ML/computational !
I had a great time at the #wehispatial25 meeting. So much excellent spatial ‘omics going on in Oz.
But weware the @wehi rubber chicken
But weware the @wehi rubber chicken
June 9, 2025 at 5:03 AM
I had a great time at the #wehispatial25 meeting. So much excellent spatial ‘omics going on in Oz.
But weware the @wehi rubber chicken
But weware the @wehi rubber chicken
I'm chairing session ED52 "Innovative Approaches in TME Biology: From Profiling to Function" at #AACR2025. I'll present data using cellular and functional genomics to identify small molecule mediators of stromal plasticity. Also the amazing Illaria Malanchi and Nick Navin. LMK if u will be there!
March 27, 2025 at 6:36 AM
I'm chairing session ED52 "Innovative Approaches in TME Biology: From Profiling to Function" at #AACR2025. I'll present data using cellular and functional genomics to identify small molecule mediators of stromal plasticity. Also the amazing Illaria Malanchi and Nick Navin. LMK if u will be there!
Reposted by Alex Swarbrick
SCVI — Integrating or not? - www.nxn.se/p/scvi-integ...
SCVI — Integrating or not?
In modern single cell analysis workflows you fit a model to your data that allow you to ask questions about the data.
www.nxn.se
March 18, 2025 at 2:29 AM
SCVI — Integrating or not? - www.nxn.se/p/scvi-integ...
Reposted by Alex Swarbrick
The four basic kinds of scientific papers:
1. Noise (no claim and no evidence)
2. Resource (no claim but lots of data)
3. Conjecture (makes a claim, but no evidence)
4. Scientific advance (both makes a claim and presents evidence)
1. Noise (no claim and no evidence)
2. Resource (no claim but lots of data)
3. Conjecture (makes a claim, but no evidence)
4. Scientific advance (both makes a claim and presents evidence)
January 2, 2025 at 1:39 PM
The four basic kinds of scientific papers:
1. Noise (no claim and no evidence)
2. Resource (no claim but lots of data)
3. Conjecture (makes a claim, but no evidence)
4. Scientific advance (both makes a claim and presents evidence)
1. Noise (no claim and no evidence)
2. Resource (no claim but lots of data)
3. Conjecture (makes a claim, but no evidence)
4. Scientific advance (both makes a claim and presents evidence)
Reposted by Alex Swarbrick
If you are interested in joining our growing Lab of CAFs enthusiasts @mdanderson.bsky.social and to understand how CAF metabolism can be harnessed to modulate the immune-TME, we are looking for talented postdocs! 👇🏻
jobs.mdanderson.org/search/jobde...
jobs.mdanderson.org/search/jobde...
Postdoctoral Fellow - Experimental Therapeutics (Zanivan Lab) at MD Anderson
MD Anderson is Hiring! Search available jobs or submit your resume now by visiting this link. Please share with anyone you feel would be a great fit.
jobs.mdanderson.org
December 18, 2024 at 12:42 AM
If you are interested in joining our growing Lab of CAFs enthusiasts @mdanderson.bsky.social and to understand how CAF metabolism can be harnessed to modulate the immune-TME, we are looking for talented postdocs! 👇🏻
jobs.mdanderson.org/search/jobde...
jobs.mdanderson.org/search/jobde...
Wanted- *Bioinformatics Research Assistant*. Projects include generation of an international, large-scale, multi-omic breast cancer atlas and understanding response to immunotherapy in breast cancer, prostate cancer and melanoma. Great training opportunities 🧬💻
More info ⤵️
tinyurl.com/33wxkswz
More info ⤵️
tinyurl.com/33wxkswz
Research Assistant - Bioinformatics
The Garvan Institute of Medical Research brings together world leading researchers and clinicians, collaborating locally and globally, to improve human health. Our mission is to harness all the inform...
tinyurl.com
December 16, 2024 at 4:22 AM
Wanted- *Bioinformatics Research Assistant*. Projects include generation of an international, large-scale, multi-omic breast cancer atlas and understanding response to immunotherapy in breast cancer, prostate cancer and melanoma. Great training opportunities 🧬💻
More info ⤵️
tinyurl.com/33wxkswz
More info ⤵️
tinyurl.com/33wxkswz
Jobortunities: Shortly advertising for 2 positions, both working on the Breast Cancer Atlas, in Sydney.
- Wet lab research assistant: mol bio +/- pathology desirable
- Comp. Research Assistant: scRNA-Seq, spatial transcriptomics and ML
Details to follow, DM or email if you are a great fit.
- Wet lab research assistant: mol bio +/- pathology desirable
- Comp. Research Assistant: scRNA-Seq, spatial transcriptomics and ML
Details to follow, DM or email if you are a great fit.
December 12, 2024 at 3:13 AM
Jobortunities: Shortly advertising for 2 positions, both working on the Breast Cancer Atlas, in Sydney.
- Wet lab research assistant: mol bio +/- pathology desirable
- Comp. Research Assistant: scRNA-Seq, spatial transcriptomics and ML
Details to follow, DM or email if you are a great fit.
- Wet lab research assistant: mol bio +/- pathology desirable
- Comp. Research Assistant: scRNA-Seq, spatial transcriptomics and ML
Details to follow, DM or email if you are a great fit.
Im thrilled for this recogntion of Christina Curtis and Steffi Oesterreich by the @theaacr.bsky.social at @sabcs.bsky.social. I'm in awe of their achievements and impacts on breast cancer research. They are also two of the nicest people you'll ever meet !
sabcs.cmail19.com/t/d-l-smtjdd...
sabcs.cmail19.com/t/d-l-smtjdd...
AACR to honor trailblazing breast cancer researchers during the 2024 SABCS® - SABCS Meeting News
Christina Curtis, PhD, MSc, left, and Steffi Oesterreich, PhD, will be recognized by the American Association for Cancer Research (AACR) for significant contributions to breast cancer research.
www.sabcsmeetingnews.org
December 12, 2024 at 2:14 AM
Im thrilled for this recogntion of Christina Curtis and Steffi Oesterreich by the @theaacr.bsky.social at @sabcs.bsky.social. I'm in awe of their achievements and impacts on breast cancer research. They are also two of the nicest people you'll ever meet !
sabcs.cmail19.com/t/d-l-smtjdd...
sabcs.cmail19.com/t/d-l-smtjdd...
Reposted by Alex Swarbrick
One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 4, 2024 at 9:20 PM
One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Thanks to @aruthak.bsky.social and colleagues for the invitation to this fantastic, unique meeting #multi-omics2024.
Thnx for the shoutout to the awesome @martinalexsmith.bsky.social
Thnx for the shoutout to the awesome @martinalexsmith.bsky.social
One of the Multi-Omics O.G.s, @alexswarbrick.bsky.social from @garvaninstitute.bsky.social, speaking on charting an atlas of #cancer #ecosystems with single-cell and spatial omics #multiomics2024
Finished talk with an appeal to join @bsky.app
Finished talk with an appeal to join @bsky.app
December 5, 2024 at 1:31 AM
Thanks to @aruthak.bsky.social and colleagues for the invitation to this fantastic, unique meeting #multi-omics2024.
Thnx for the shoutout to the awesome @martinalexsmith.bsky.social
Thnx for the shoutout to the awesome @martinalexsmith.bsky.social
Reposted by Alex Swarbrick
When you get to be your own caricature!! Grateful to be in #oz sharing science with #friends. For those missing out #multiomics2024 is where #singlecell #spatial #omics #immunology #oncology and #precisionmedicine is where it’s at🥳
December 1, 2024 at 6:29 AM
When you get to be your own caricature!! Grateful to be in #oz sharing science with #friends. For those missing out #multiomics2024 is where #singlecell #spatial #omics #immunology #oncology and #precisionmedicine is where it’s at🥳
Reposted by Alex Swarbrick
Yesterday, I presented our latest results mining single molecule m6A data at #multiomics2024:
We see changes in m6A levels following CRISPR-cas13 knock-down of oncogenic lncRNAs that are independent of mRNA expression levels, revealing new dimensions of highly pertinent biological information
We see changes in m6A levels following CRISPR-cas13 knock-down of oncogenic lncRNAs that are independent of mRNA expression levels, revealing new dimensions of highly pertinent biological information
December 2, 2024 at 1:10 AM
Yesterday, I presented our latest results mining single molecule m6A data at #multiomics2024:
We see changes in m6A levels following CRISPR-cas13 knock-down of oncogenic lncRNAs that are independent of mRNA expression levels, revealing new dimensions of highly pertinent biological information
We see changes in m6A levels following CRISPR-cas13 knock-down of oncogenic lncRNAs that are independent of mRNA expression levels, revealing new dimensions of highly pertinent biological information
Reposted by Alex Swarbrick
A nice explanation of the space our Cancer Ecosystems Program researchers work in - its tricky! but they are applying spatial and single cell multiomics to clinical samples and taking big steps forward towards better outcomes for patients - check out our team at www.garvan.org.au/research/str...
November 29, 2024 at 11:58 PM
A nice explanation of the space our Cancer Ecosystems Program researchers work in - its tricky! but they are applying spatial and single cell multiomics to clinical samples and taking big steps forward towards better outcomes for patients - check out our team at www.garvan.org.au/research/str...
Reposted by Alex Swarbrick
Public Service Announcement: Check colorblind-compatibility in Illustrator! Under 'View', 'Proof Setup' you can selected a colorblindness type to view your image in that spectra. Click 'Proof Colors' after to remove filter. We chose pink/green, yellow/blue here for accessibility (PMID 38112643).
November 25, 2024 at 9:05 PM
Public Service Announcement: Check colorblind-compatibility in Illustrator! Under 'View', 'Proof Setup' you can selected a colorblindness type to view your image in that spectra. Click 'Proof Colors' after to remove filter. We chose pink/green, yellow/blue here for accessibility (PMID 38112643).
Reposted by Alex Swarbrick
Both #Cancer #Research starter packs are now completely full!
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
November 23, 2024 at 1:27 PM
Both #Cancer #Research starter packs are now completely full!
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
Reposted by Alex Swarbrick
Truly brilliant work. Calling it a foundation model is a stretch (a mistake many people in the field make). But, the only single-cell AI model in its class that I think is worth the GPU energy expended and one that I excited to utilize. My stamp of approval. www.nature.com/articles/s41...
A cell atlas foundation model for scalable search of similar human cells - Nature
Nature - A cell atlas foundation model for scalable search of similar human cells
www.nature.com
November 22, 2024 at 10:34 PM
Truly brilliant work. Calling it a foundation model is a stretch (a mistake many people in the field make). But, the only single-cell AI model in its class that I think is worth the GPU energy expended and one that I excited to utilize. My stamp of approval. www.nature.com/articles/s41...
Reposted by Alex Swarbrick
People deserve a world in which they can live in peace as themselves. What steps are people taking to ensure that in their communities, particularly as the world is going dark?
Today is International Trans Day of Remembrance. This is the toughest time in history to be trans and visible in the world, thanks to certain politicians, billionaires, trash media and Evangelicals. And it’s particularly tough for children and teens. Now, more than ever, we need our allies. Ty ❤️🏳️⚧️🏳️🌈
November 20, 2024 at 12:07 PM
People deserve a world in which they can live in peace as themselves. What steps are people taking to ensure that in their communities, particularly as the world is going dark?
Reposted by Alex Swarbrick
We are ramping up our attempts to get DC1 immunotherapy into the clinic for colorectal and lung cancer. Here me talk about why DC1s are the right choice, and how
WEHI and PeterMacCC will get it to clinical trial within 2 yrs. Start ~13 min in. podcasts.apple.com/au/podcast/v...
WEHI and PeterMacCC will get it to clinical trial within 2 yrs. Start ~13 min in. podcasts.apple.com/au/podcast/v...
VAXXED: Game on, with BASE and WEHI
Podcast Episode · Phase III · 19/11/2024 · 26m
podcasts.apple.com
November 19, 2024 at 11:21 PM
We are ramping up our attempts to get DC1 immunotherapy into the clinic for colorectal and lung cancer. Here me talk about why DC1s are the right choice, and how
WEHI and PeterMacCC will get it to clinical trial within 2 yrs. Start ~13 min in. podcasts.apple.com/au/podcast/v...
WEHI and PeterMacCC will get it to clinical trial within 2 yrs. Start ~13 min in. podcasts.apple.com/au/podcast/v...