Alexandru Stieber
@alexstieber.bsky.social
Internal Medicine resident | Passionate about rare diseases, rheumatology and neurology | Aspiring diagnostician
Recent publication of the #SplenoMegaly study (SMS), with very interesting insights into the various etiologies and their possible predictive factors.
A short thread with the results 🧵
#medsky #rheumsky #hemesky
A short thread with the results 🧵
#medsky #rheumsky #hemesky
August 15, 2025 at 3:54 PM
Recent publication of the #SplenoMegaly study (SMS), with very interesting insights into the various etiologies and their possible predictive factors.
A short thread with the results 🧵
#medsky #rheumsky #hemesky
A short thread with the results 🧵
#medsky #rheumsky #hemesky
Important to acknowledge that #Mycoplasma infections go beyond atypical #pneumonia and should be included on the EM/SJS/TEN differential!! #dermsky #medsky #pneumosky
🔗 journal.chestnet.org/article/S001...
🔗 journal.chestnet.org/article/S001...
August 12, 2025 at 5:39 PM
Important to acknowledge that #Mycoplasma infections go beyond atypical #pneumonia and should be included on the EM/SJS/TEN differential!! #dermsky #medsky #pneumosky
🔗 journal.chestnet.org/article/S001...
🔗 journal.chestnet.org/article/S001...
A great overview of inborn errors of #immunity with #atopic phenotypes (IElwA) highlighting the main entities included in this category, such as Hyper-IgE syndromes, #IPEX and Wiskott-Aldrich syndrome, and the major red flags that should lead clinicians to consider these primary atopic disorders.
August 8, 2025 at 5:20 PM
Further discussions on the role #upadacitinib will likely play in the therapeutic landscape of #giantcellarteritis treatment.
#medsky #rheumsky
🔗https://www.sciencedirect.com/science/article/abs/pii/S0248866325006265?via%3Dihub
#medsky #rheumsky
🔗https://www.sciencedirect.com/science/article/abs/pii/S0248866325006265?via%3Dihub
July 8, 2025 at 9:48 AM
Further discussions on the role #upadacitinib will likely play in the therapeutic landscape of #giantcellarteritis treatment.
#medsky #rheumsky
🔗https://www.sciencedirect.com/science/article/abs/pii/S0248866325006265?via%3Dihub
#medsky #rheumsky
🔗https://www.sciencedirect.com/science/article/abs/pii/S0248866325006265?via%3Dihub
Rare occurence of cutaneous hemosiderin deposits in the context of secondary #hemochromatosis due to metabolic dysfunction.
#medsky #hyperferritinemia
🔗https://www.ejinme.com/article/S0953-6205(25)00121-9/fulltext
#medsky #hyperferritinemia
🔗https://www.ejinme.com/article/S0953-6205(25)00121-9/fulltext
June 11, 2025 at 4:05 PM
Rare occurence of cutaneous hemosiderin deposits in the context of secondary #hemochromatosis due to metabolic dysfunction.
#medsky #hyperferritinemia
🔗https://www.ejinme.com/article/S0953-6205(25)00121-9/fulltext
#medsky #hyperferritinemia
🔗https://www.ejinme.com/article/S0953-6205(25)00121-9/fulltext
Key points from #ISSAID2025
This #autoinflammatory disease congress wouldn't have been complete without some updates on #VEXAS syndrome:
- new "VEXAS man" schema, with updated manifestations
- better defined risk factors for a worse prognosis
- VEXAS-like syndromes DO exist!!
#rheumsky #medsky
This #autoinflammatory disease congress wouldn't have been complete without some updates on #VEXAS syndrome:
- new "VEXAS man" schema, with updated manifestations
- better defined risk factors for a worse prognosis
- VEXAS-like syndromes DO exist!!
#rheumsky #medsky
April 19, 2025 at 11:02 AM
Key points from #ISSAID2025
This #autoinflammatory disease congress wouldn't have been complete without some updates on #VEXAS syndrome:
- new "VEXAS man" schema, with updated manifestations
- better defined risk factors for a worse prognosis
- VEXAS-like syndromes DO exist!!
#rheumsky #medsky
This #autoinflammatory disease congress wouldn't have been complete without some updates on #VEXAS syndrome:
- new "VEXAS man" schema, with updated manifestations
- better defined risk factors for a worse prognosis
- VEXAS-like syndromes DO exist!!
#rheumsky #medsky
Reposted by Alexandru Stieber
🆕 Exciting time to dive into this, especially with the FDA’s recent approval of the first and only treatment, Inebilizumab😀❣️
#IgG4RD #Rheumsky
#IgG4RD #Rheumsky
April 9, 2025 at 9:24 AM
Romanian team at #ISSAID2025 with our posters on:
➡️ RO_FMF study: patients with MEFV mutations (mostly heterozygous mutations and mild phenotypes)
➡️ case series of Romanian patients with NOD2 mutations and their clinical phenotypes
#autoinflammatory #rheumsky
➡️ RO_FMF study: patients with MEFV mutations (mostly heterozygous mutations and mild phenotypes)
➡️ case series of Romanian patients with NOD2 mutations and their clinical phenotypes
#autoinflammatory #rheumsky
April 10, 2025 at 9:30 AM
Romanian team at #ISSAID2025 with our posters on:
➡️ RO_FMF study: patients with MEFV mutations (mostly heterozygous mutations and mild phenotypes)
➡️ case series of Romanian patients with NOD2 mutations and their clinical phenotypes
#autoinflammatory #rheumsky
➡️ RO_FMF study: patients with MEFV mutations (mostly heterozygous mutations and mild phenotypes)
➡️ case series of Romanian patients with NOD2 mutations and their clinical phenotypes
#autoinflammatory #rheumsky
Amazing overview of actinopathies by @philippe-mertz.bsky.social, Hentgen Veronique, Guilaine Boursier, Jérôme Delon and @sophiegeorgin.bsky.social, highlighting their increasingly relevant #autoinflammatory phenotypes.
#medsky #rheumsky #pedsky
⬇️⬇️
www.sciencedirect.com/science/arti...
#medsky #rheumsky #pedsky
⬇️⬇️
www.sciencedirect.com/science/arti...
Current landscape of monogenic autoinflammatory actinopathies: A literature review
Autoinflammatory diseases (AID) are conditions leading to a hyperactivation of innate immunity without any underlying infection, and may be poly- (e.g…
www.sciencedirect.com
March 24, 2025 at 5:48 PM
Amazing overview of actinopathies by @philippe-mertz.bsky.social, Hentgen Veronique, Guilaine Boursier, Jérôme Delon and @sophiegeorgin.bsky.social, highlighting their increasingly relevant #autoinflammatory phenotypes.
#medsky #rheumsky #pedsky
⬇️⬇️
www.sciencedirect.com/science/arti...
#medsky #rheumsky #pedsky
⬇️⬇️
www.sciencedirect.com/science/arti...
Small case series that highlights lupus tumidus as a new ddx for skin lesions of #VEXASsyndrome!!
*p.Met41Leu mutations are frequently associated with significant dermatological manifestations and mild systemic involvement
#autoinflammatory #medsky #dermsky
www.jaadcasereports.org/article/S235...
*p.Met41Leu mutations are frequently associated with significant dermatological manifestations and mild systemic involvement
#autoinflammatory #medsky #dermsky
www.jaadcasereports.org/article/S235...
VEXAS syndrome with p.Met41Leu UBA1 gene mutation misdiagnosed as tumid lupus: A series of 3 cases
Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a newly
characterized late-onset systemic inflammatory syndrome with cutaneous findings and
multiorgan system involvement.1...
www.jaadcasereports.org
March 20, 2025 at 6:39 PM
Small case series that highlights lupus tumidus as a new ddx for skin lesions of #VEXASsyndrome!!
*p.Met41Leu mutations are frequently associated with significant dermatological manifestations and mild systemic involvement
#autoinflammatory #medsky #dermsky
www.jaadcasereports.org/article/S235...
*p.Met41Leu mutations are frequently associated with significant dermatological manifestations and mild systemic involvement
#autoinflammatory #medsky #dermsky
www.jaadcasereports.org/article/S235...
Reposted by Alexandru Stieber
A case of "gravity is winning" masterfully dissected by Mike🚶
Episode 8 of www.dxatypia.com out now...
Episode 8 of www.dxatypia.com out now...
March 17, 2025 at 8:05 PM
A case of "gravity is winning" masterfully dissected by Mike🚶
Episode 8 of www.dxatypia.com out now...
Episode 8 of www.dxatypia.com out now...
What to do about pts with lymphadenopathies and histology suggestive for #Castleman? More info in this article, delineating a possibly early stage of iMCD: ⚠️asymptomatic MCD⚠️ #medsky #hemesky
ashpublications.org/bloodadvance...
ashpublications.org/bloodadvance...
March 17, 2025 at 9:27 AM
What to do about pts with lymphadenopathies and histology suggestive for #Castleman? More info in this article, delineating a possibly early stage of iMCD: ⚠️asymptomatic MCD⚠️ #medsky #hemesky
ashpublications.org/bloodadvance...
ashpublications.org/bloodadvance...
Congratulations to Chloe Grolleau, @sophiegeorgin.bsky.social, @terrierben.bsky.social and the entire team behind this beautiful work analysing the inflammatory signatures seen in #VEXAS, MDS-cutis and refractory Sweet syndrome lesions.
#medsky #rheumsky #dermsky
jamanetwork.com/journals/jam...
#medsky #rheumsky #dermsky
jamanetwork.com/journals/jam...
Inflammatory Signatures in VEXAS Syndrome, Myelodysplasia Cutis, and Sweet Syndrome
This translational study examines the inflammatory pathways activated in skin lesions of idiopathic Sweet syndrome, myelodysplasia-cutis, and VEXAS syndrome.
jamanetwork.com
March 16, 2025 at 6:33 PM
Congratulations to Chloe Grolleau, @sophiegeorgin.bsky.social, @terrierben.bsky.social and the entire team behind this beautiful work analysing the inflammatory signatures seen in #VEXAS, MDS-cutis and refractory Sweet syndrome lesions.
#medsky #rheumsky #dermsky
jamanetwork.com/journals/jam...
#medsky #rheumsky #dermsky
jamanetwork.com/journals/jam...
Reposted by Alexandru Stieber
So proud and grateful for the international collaboration on #IEI and #PID in the ESID registry resulting in the preprint manuscript on current real world observational data of >30k patients‘ courses, treatments, survival estimations… #RareDiseaseDay #ResearchMatters www.medrxiv.org/content/10.1...
Inborn errors of immunity: manifestation, treatment, and outcome – an ESID registry 1994-2024 report on 30,628 patients
The European Society for Immunodeficiencies patient registry (ESID-R), established in 1994, is one of the world’s largest databases on inborn errors of immunity (IEI). IEI are genetic disorders predis...
www.medrxiv.org
February 26, 2025 at 2:18 PM
So proud and grateful for the international collaboration on #IEI and #PID in the ESID registry resulting in the preprint manuscript on current real world observational data of >30k patients‘ courses, treatments, survival estimations… #RareDiseaseDay #ResearchMatters www.medrxiv.org/content/10.1...
Major development regarding this long researched link with inflammation
March 12, 2025 at 10:24 PM
Major development regarding this long researched link with inflammation
Latest diagnosis and treatment recommendations for chronic non-bacterial osteitis #rheumsky #CNO #SAPHO #axSpA
ard.bmj.com/content/earl...
ard.bmj.com/content/earl...
March 12, 2025 at 8:57 PM
Latest diagnosis and treatment recommendations for chronic non-bacterial osteitis #rheumsky #CNO #SAPHO #axSpA
ard.bmj.com/content/earl...
ard.bmj.com/content/earl...
Work-up in suspected PMR patients
via @acr-journals.bsky.social and @medscape.com
#medsky #rheumsky #polymyalgiarheumatica
via @acr-journals.bsky.social and @medscape.com
#medsky #rheumsky #polymyalgiarheumatica
March 12, 2025 at 6:39 AM
Work-up in suspected PMR patients
via @acr-journals.bsky.social and @medscape.com
#medsky #rheumsky #polymyalgiarheumatica
via @acr-journals.bsky.social and @medscape.com
#medsky #rheumsky #polymyalgiarheumatica
Reposted by Alexandru Stieber
Experts are raising concerns about possible misinterpretations of #RFK Jr.'s messaging on #measles.
"Vitamin A is absolutely not a substitute nor an equivalent for #MMR vaccination," said Ericka Hayes, MD.
www.medpagetoday.com/special-repo...
"Vitamin A is absolutely not a substitute nor an equivalent for #MMR vaccination," said Ericka Hayes, MD.
www.medpagetoday.com/special-repo...
Vitamin A, While Helpful for Measles, Is Not a Replacement for Vaccination
Experts raise concerns about possible misinterpretations of HHS messaging on measles
www.medpagetoday.com
March 10, 2025 at 8:58 PM
Experts are raising concerns about possible misinterpretations of #RFK Jr.'s messaging on #measles.
"Vitamin A is absolutely not a substitute nor an equivalent for #MMR vaccination," said Ericka Hayes, MD.
www.medpagetoday.com/special-repo...
"Vitamin A is absolutely not a substitute nor an equivalent for #MMR vaccination," said Ericka Hayes, MD.
www.medpagetoday.com/special-repo...
March 10, 2025 at 5:10 PM
Reposted by Alexandru Stieber
In two trials involving patients with chronic spontaneous urticaria, remibrutinib led to significantly greater reductions than placebo in itching and hives at week 12. Full results of the REMIX-1 and REMIX-2 trials: nej.md/41uQD07
#MedSky #DermSky
#MedSky #DermSky
March 9, 2025 at 1:36 PM
In two trials involving patients with chronic spontaneous urticaria, remibrutinib led to significantly greater reductions than placebo in itching and hives at week 12. Full results of the REMIX-1 and REMIX-2 trials: nej.md/41uQD07
#MedSky #DermSky
#MedSky #DermSky
Brief presentation of the international cohort of SOCS1 insufficiency patients, autoimmune lymphoproliferative disease distinguished by frequent rheumatological and atopic manifestations.
#medsky #rheumsky #allergysky
www.thelancet.com/journals/lan...
#medsky #rheumsky #allergysky
www.thelancet.com/journals/lan...
March 7, 2025 at 6:02 PM
Brief presentation of the international cohort of SOCS1 insufficiency patients, autoimmune lymphoproliferative disease distinguished by frequent rheumatological and atopic manifestations.
#medsky #rheumsky #allergysky
www.thelancet.com/journals/lan...
#medsky #rheumsky #allergysky
www.thelancet.com/journals/lan...
Reposted by Alexandru Stieber
Cod liver oil does not treat measles (it’s a virus).
Antibiotics like clarithromycin does not treat measles (it’s a virus).
Both do, however, cause diarrhea.
Antibiotics like clarithromycin does not treat measles (it’s a virus).
Both do, however, cause diarrhea.
March 5, 2025 at 12:34 AM
Cod liver oil does not treat measles (it’s a virus).
Antibiotics like clarithromycin does not treat measles (it’s a virus).
Both do, however, cause diarrhea.
Antibiotics like clarithromycin does not treat measles (it’s a virus).
Both do, however, cause diarrhea.