Akul Mehta
akulmehta.bsky.social
Akul Mehta
@akulmehta.bsky.social
Glycoscientist @theNCFG BIDMC-Harvard Medical School
👨‍💻👨‍🔬⚽📷
(Views are my own)
Reposted by Akul Mehta
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
January 28, 2026 at 5:45 PM
#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.
Have you ever wondered how many N-Glycans or #glycoproteins there are on cells?

The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!

Read the full blog post: research.bidmc.org/ncfg/blog/24...

#glycobiology #glycotime #cells #biology
January 15, 2026 at 3:52 PM
Reposted by Akul Mehta
The rate of global mean sea level rise has increased from ~2.1 mm/year in 1993 to ~4.5 mm/year in 2023. www.nature.com/articles/s43...
The rate of global sea level rise doubled during the past three decades - Communications Earth & Environment
Global mean sea level rise amounted to 4.5 mm per year as a result of warming oceans and melting land ice, more than twice the rate of 2.1 mm/year observed at the start of satellite data in 1993, base...
www.nature.com
January 3, 2026 at 9:18 PM
Reposted by Akul Mehta
Happy new year 2026 #glycotime! 🥳 We just introduced some useful options to Re-Glyco Ensemble.

In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,
January 3, 2026 at 7:53 PM
Reposted by Akul Mehta
OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy

www.federalregister.gov/documents/20...
Notice of Request for Information; Accelerating the American Scientific Enterprise
The Office of Science and Technology Policy (OSTP) requests input from all interested parties on Federal policy updates that aim to accelerate the American scientific enterprise, enable groundbreaking...
www.federalregister.gov
December 23, 2025 at 10:56 PM
Reposted by Akul Mehta
Happy birthday to us! 🥂🎂🥳 We are only 2 yo, but so much #glycotime happened since Dec 2023! ⬇️🧵

We truly appreciate your support, you fabulous glycoengineers around the world and we have so many exciting new tools for you coming up in 2026 to make your 3D glycoforms even better and faster! 🤩
December 15, 2025 at 10:37 AM
Reposted by Akul Mehta
Have you heard of sugar alcohols / artificial sweeteners, such as erythritol, sorbitol, mannitol and xylitol? Learn more about these interesting small sugars and where they are found in our latest blog post, research.bidmc.org/ncfg/blog/23...
#glycotime #glycosylation #science #artificialsweeteners
23] Facts About: Sugar Alcohols
research.bidmc.org
December 5, 2025 at 4:52 PM
Reposted by Akul Mehta
For some unique #glycotime: C-man is a rare (but evolutionarily very old[1]) post translational modification of proteins, where the C2 of Trp in W-x-x-W/C sequons are linked to a single man through a C-C bond 🤯 This and its position within the structure stabilises the (unusual for man) 1C4 chair[2]
December 4, 2025 at 6:52 PM
Reposted by Akul Mehta
Cannot hide my joy, relief, excitement being able to share the outcome of persevering (to say the least) collaborative work. So... the MS glyco(proteomics) guidelines are published!! www.mcponline.org/article/S153...
Many thanks to @beilstein-institut.bsky.social @glycosmos.bsky.social @sib.swiss
Update and new implementation of the MIRAGE reporting guidelines for mass spectrometry experiments in glycoscience
The MIRAGE (Minimum Information Required for A Glycomics Experiment) guidelines for mass spectrometry (MS) data were initially developed to standardize the reporting of instrumentation, data acquisiti...
www.mcponline.org
November 25, 2025 at 9:34 AM
Reposted by Akul Mehta
We are excited to share our #glycotime meeting report on the 1st GlyCosmos Symposium & Jamboree in *Glycobiology*!
DOI: doi.org/10.1093/glyc...

Participants advanced glycan-binding molecule resources through hands-on work on lectin curation and FAIR glycoinformatics within #GlyCosmos.
Meeting Report on the 1st GlyCosmos Symposium & Jamboree —Community-Driven Expansion of Glycan-Binding Molecules Resources
Chiaki Nagai-Okatani, Masae Hosoda, Winnie Hsiung, Takashi Sato, Hiroaki Sakaue, Sayaka Fuseya, Eriko Fukuda, Issaku Yamada, Kiyoko F Aoki-Kinoshita, Atsus
doi.org
November 25, 2025 at 2:34 AM
Reposted by Akul Mehta
It's finally here! serversideup/php v4 is now stable 🎉

😅 Over a year of work
🐘 FrankenPHP & Laravel Octane support
🤖 LLM integration on our docs
🤝 13 new contributors
❤️ All open source

Run PHP and Laravel anywhere you want.

Now go build awesome stuff, Internet. 🚀
November 19, 2025 at 5:49 PM
Reposted by Akul Mehta
Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field.

1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis

2. Proteins are a source of glycans found in preparations of glycoRNA
#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
November 17, 2025 at 8:35 AM
Reposted by Akul Mehta
Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!
employment.ku.dk/faculty/?sho...

Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine
employment.ku.dk
November 11, 2025 at 8:38 AM
Reposted by Akul Mehta
The @nuxt.com team is highly underrated 💯

I'm working with Nuxt Content, and this product blows my mind 🤯

It's easy, flexible, and fast. Open sourcing Nuxt UI was a solid move too.

You know you're crushing it when a SERVER GUY compliments JavaScript 🤓
October 22, 2025 at 4:33 PM
Reposted by Akul Mehta
Sharing our recent pre-print where we drill down further into the transcriptional regulation of Siglec ligands. Here we show that tissue specific regulatory networks dictate changes in sialoglycan patterns. Work led by Rebecca Garnham and postdoc Adam Duxfield.

www.biorxiv.org/content/10.1...
The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer
Glyco-immune checkpoints have recently been shown to be critical mediators of immunotherapy resistance across multiple cancer types. In clinical trials, immunotherapeutic treatments for prostate cance...
www.biorxiv.org
October 20, 2025 at 11:50 AM
Reposted by Akul Mehta
Breaking down fucoidan takes some innovative thinking, but evolution already got it! #glycotime 🧪🔺

"Remarkably, two-thirds of the interacting residues are dedicated to the recognition of sulfate groups along the glycoside chains." 🤯😍

www.nature.com/articles/s41...
Structure-function relationship of the GH168 fucanase reveals an unusual enzyme recognition mechanism for sulfated polysaccharide - Nature Communications
Authors identify and characterize 16 endo−1,3-fucanases within the GH168 family sequence space, unveiling a recognition mechanism for sulfate polysaccharides. These findings can promote the applicatio...
www.nature.com
October 19, 2025 at 8:01 AM
Reposted by Akul Mehta
You're kidding me!? 👀

TIL about "post_start" in Docker Compose 🐳

You can run commands as a privileged user on startup, but still run your services as an unprivileged user.

This dramatically simplifies bootstrapping an app! 🤩
October 15, 2025 at 8:24 PM
Reposted by Akul Mehta
serversideup/php v4.0-beta1 is now available!!!

It's a next level Docker image:

🐘 FrankenPHP now available
❤️ Improved native health checks
🤖 Advanced Laravel automations
🤩 12 new contributors

Our biggest open source release yet. LET'S GO PHP!! 🚀
October 12, 2025 at 6:08 PM
Reposted by Akul Mehta
🧑‍💻 New GitHub integration is here!
Connect your GitHub account, choose an existing markdown repo (or create a new one), and hosted.md will build your site automatically.
Push to GitHub, rebuild instantly ⚡

Full update 👉 https://link.hosted.md/kDSFq
The Best Markdown Site Generator for Blogs, Docs, and More - Hosted.MD
With hosted.md, you can publish Markdown online without setting up servers, configuring a CMS, or dealing with complicated tools.
link.hosted.md
October 11, 2025 at 7:57 PM
Reposted by Akul Mehta
If there was a certain vendor developing a brand new ion mobility instrument and is in the process of choosing a file format, this is timed incredibly well for them to catch the wave.
I'm a huge fan of this proposal!

If we can get vendor buy-in to an open, common format, it could bring more computational folks into the field. How can these folks be excited about #proteomics when its hard to even read the already complicated data?

pubs.acs.org/doi/10.1021/...
mzPeak: Designing a Scalable, Interoperable, and Future-Ready Mass Spectrometry Data Format
Advances in mass spectrometry (MS) instrumentation, including higher resolution, faster scan speeds, and improved sensitivity, have dramatically increased the data volume and complexity. The adoption of imaging and ion mobility further amplifies these challenges in proteomics, metabolomics, and lipidomics. Current open formats such as mzML and imzML struggle to keep pace due to large file sizes, slow data access, and limited metadata support. Vendor-specific formats offer faster access but lack interoperability and long-term archival guarantees. We here lay the groundwork for mzPeak, a next-generation community data format designed to address these challenges and support high-throughput, multidimensional MS workflows. By adopting a hybrid model that combines efficient binary storage for numerical data and both human- and machine-readable metadata storage, mzPeak will reduce file sizes, accelerate data access, and offer a scalable, adaptable solution for evolving MS technologies. For researchers, mzPeak will support complex workflows and regulatory compliance through faster access, improved metadata, and interoperability. For vendors, it offers a streamlined, open alternative to proprietary formats. mzPeak aims to become a cornerstone of MS data management, enabling sustainable, high-performance solutions for future data types and fostering collaboration across the mass spectrometry community.
pubs.acs.org
October 10, 2025 at 7:09 PM
Reposted by Akul Mehta
We're hiring! 🚀

**PhD positions:**
Computational focus:
web103.reachmee.com/ext/I005/103...
Experimental focus:
web103.reachmee.com/ext/I005/103...

**Postdoc positions:**
Computational focus:
web103.reachmee.com/ext/I005/103...
Experimental focus:
web103.reachmee.com/ext/I005/103...
Doctoral student in Natural Science Specialising in Biology
Doctoral position in Natural Science Specialising in Biology focusing on Bioinformatics The Department of Chemistry and Molecular
web103.reachmee.com
October 10, 2025 at 11:38 AM
Reposted by Akul Mehta
employment.ku.dk/faculty/?sho...

Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine
employment.ku.dk
October 9, 2025 at 6:24 PM