Akul Mehta
akulmehta.bsky.social
Akul Mehta
@akulmehta.bsky.social
Glycoscientist @theNCFG BIDMC-Harvard Medical School
👨‍💻👨‍🔬⚽📷
(Views are my own)
Reposted by Akul Mehta
Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field.

1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis

2. Proteins are a source of glycans found in preparations of glycoRNA
#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
November 17, 2025 at 8:35 AM
Reposted by Akul Mehta
Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!
employment.ku.dk/faculty/?sho...

Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine
employment.ku.dk
November 11, 2025 at 8:38 AM
Reposted by Akul Mehta
The @nuxt.com team is highly underrated 💯

I'm working with Nuxt Content, and this product blows my mind 🤯

It's easy, flexible, and fast. Open sourcing Nuxt UI was a solid move too.

You know you're crushing it when a SERVER GUY compliments JavaScript 🤓
October 22, 2025 at 4:33 PM
Reposted by Akul Mehta
Sharing our recent pre-print where we drill down further into the transcriptional regulation of Siglec ligands. Here we show that tissue specific regulatory networks dictate changes in sialoglycan patterns. Work led by Rebecca Garnham and postdoc Adam Duxfield.

www.biorxiv.org/content/10.1...
The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer
Glyco-immune checkpoints have recently been shown to be critical mediators of immunotherapy resistance across multiple cancer types. In clinical trials, immunotherapeutic treatments for prostate cance...
www.biorxiv.org
October 20, 2025 at 11:50 AM
Reposted by Akul Mehta
Breaking down fucoidan takes some innovative thinking, but evolution already got it! #glycotime 🧪🔺

"Remarkably, two-thirds of the interacting residues are dedicated to the recognition of sulfate groups along the glycoside chains." 🤯😍

www.nature.com/articles/s41...
Structure-function relationship of the GH168 fucanase reveals an unusual enzyme recognition mechanism for sulfated polysaccharide - Nature Communications
Authors identify and characterize 16 endo−1,3-fucanases within the GH168 family sequence space, unveiling a recognition mechanism for sulfate polysaccharides. These findings can promote the applicatio...
www.nature.com
October 19, 2025 at 8:01 AM
Reposted by Akul Mehta
You're kidding me!? 👀

TIL about "post_start" in Docker Compose 🐳

You can run commands as a privileged user on startup, but still run your services as an unprivileged user.

This dramatically simplifies bootstrapping an app! 🤩
October 15, 2025 at 8:24 PM
Reposted by Akul Mehta
serversideup/php v4.0-beta1 is now available!!!

It's a next level Docker image:

🐘 FrankenPHP now available
❤️ Improved native health checks
🤖 Advanced Laravel automations
🤩 12 new contributors

Our biggest open source release yet. LET'S GO PHP!! 🚀
October 12, 2025 at 6:08 PM
Reposted by Akul Mehta
🧑‍💻 New GitHub integration is here!
Connect your GitHub account, choose an existing markdown repo (or create a new one), and hosted.md will build your site automatically.
Push to GitHub, rebuild instantly ⚡

Full update 👉 https://link.hosted.md/kDSFq
The Best Markdown Site Generator for Blogs, Docs, and More - Hosted.MD
With hosted.md, you can publish Markdown online without setting up servers, configuring a CMS, or dealing with complicated tools.
link.hosted.md
October 11, 2025 at 7:57 PM
Reposted by Akul Mehta
If there was a certain vendor developing a brand new ion mobility instrument and is in the process of choosing a file format, this is timed incredibly well for them to catch the wave.
I'm a huge fan of this proposal!

If we can get vendor buy-in to an open, common format, it could bring more computational folks into the field. How can these folks be excited about #proteomics when its hard to even read the already complicated data?

pubs.acs.org/doi/10.1021/...
mzPeak: Designing a Scalable, Interoperable, and Future-Ready Mass Spectrometry Data Format
Advances in mass spectrometry (MS) instrumentation, including higher resolution, faster scan speeds, and improved sensitivity, have dramatically increased the data volume and complexity. The adoption of imaging and ion mobility further amplifies these challenges in proteomics, metabolomics, and lipidomics. Current open formats such as mzML and imzML struggle to keep pace due to large file sizes, slow data access, and limited metadata support. Vendor-specific formats offer faster access but lack interoperability and long-term archival guarantees. We here lay the groundwork for mzPeak, a next-generation community data format designed to address these challenges and support high-throughput, multidimensional MS workflows. By adopting a hybrid model that combines efficient binary storage for numerical data and both human- and machine-readable metadata storage, mzPeak will reduce file sizes, accelerate data access, and offer a scalable, adaptable solution for evolving MS technologies. For researchers, mzPeak will support complex workflows and regulatory compliance through faster access, improved metadata, and interoperability. For vendors, it offers a streamlined, open alternative to proprietary formats. mzPeak aims to become a cornerstone of MS data management, enabling sustainable, high-performance solutions for future data types and fostering collaboration across the mass spectrometry community.
pubs.acs.org
October 10, 2025 at 7:09 PM
Reposted by Akul Mehta
We're hiring! 🚀

**PhD positions:**
Computational focus:
web103.reachmee.com/ext/I005/103...
Experimental focus:
web103.reachmee.com/ext/I005/103...

**Postdoc positions:**
Computational focus:
web103.reachmee.com/ext/I005/103...
Experimental focus:
web103.reachmee.com/ext/I005/103...
Doctoral student in Natural Science Specialising in Biology
Doctoral position in Natural Science Specialising in Biology focusing on Bioinformatics The Department of Chemistry and Molecular
web103.reachmee.com
October 10, 2025 at 11:38 AM
Reposted by Akul Mehta
employment.ku.dk/faculty/?sho...

Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine
employment.ku.dk
October 9, 2025 at 6:24 PM
Most people think that #glycosylation is only extracellular. But there is increasing evidence for the existence of intracellular proteins also being glycosylated. Check out this blog post to learn more about this topic!
🤯 Did you know proteins inside cells can be glycosylated?! 🔬 Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in biology!
👉 research.bidmc.org/ncfg/blog/21...

#glycans #glycosylation #posttranslationalmodification #glycotime
21] Facts About: Intracellular Protein Glycosylation
research.bidmc.org
October 8, 2025 at 3:06 PM
Reposted by Akul Mehta
Here's something non-science-y for a change:
Check out the free demo of my upcoming game on Steam! 🥳
store.steampowered.com/app/3858960/...
(Arcaneering is a cozy factory automation game, with a bit of RPG elements, made in Godot)
#gamedev #indie #pcgaming #automation #basebuilding
Arcaneering: Beyond Automation on Steam
Automate the arcane! Build spell-powered factories, reclaim ancient territories filled with magical secrets, and discover game-changing technology hidden across procedurally generated worlds. Master b...
store.steampowered.com
September 30, 2025 at 12:45 PM
Reposted by Akul Mehta
Our work @benschulz.bsky.social on the specificity and the mechanism of activation of the eukaryotic oligosaccharyltransferase is now on Glycopedia ⬇️🎉🥳, the largest repository of #glycotime news and educational material online!

Thank you Serge Perez 🤓❤️

glycopedia.eu/2025/09/09/r...
Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase - Glycopedia
Oligosaccharyltransferase (OST) catalyses the key step of N-glycosylation, transferring immature N-glycans to select Asn residues in nascent proteins in the endoplasmic reticulum (ER). Asn are more li...
glycopedia.eu
September 16, 2025 at 7:16 PM
A colleague received an 18 page review for a manuscript they recently submitted. They took several days to respond to all the comments meticulously (even though some of them didn't make any sense to them). When I saw the review, I was able to immediately recognize that this was AI generated. 🧵
September 16, 2025 at 7:19 PM
Reposted by Akul Mehta
Thrilled to share some news!! We'll be recruiting soon to start with some exciting new work in glycobiology, so watch this space... #ERCStG
📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 10:28 AM
Reposted by Akul Mehta
New paper! The characterisation of PNGaseL published in The Royal Society Open Science New Talent Collection. This paper describes a successful bioprospecting-to-commercialisation project royalsocietypublishing.org/doi/10.1098/... #glycotime @cassiebakshani.bsky.social
PNGaseL from Flavobacterium akiainvivens targets a diverse range of N-glycan structures | Royal Society Open Science
Peptide:N-glycosidases (PNGases) are used by a wide range of organisms to remove N-glycan structures from proteins for use as either nutrients or in glycoprotein processing. PNGaseF is the most well-characterized enzyme of this family and is widely used ...
royalsocietypublishing.org
August 27, 2025 at 8:58 AM
Reposted by Akul Mehta
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
August 27, 2025 at 3:27 AM
Reposted by Akul Mehta
It’s certainly Not Good.
Federal funding for US science research has been disrupted dramatically in 2025. Other countries are enticing US students and scientists to move abroad, leaving the overall impact on chemistry and science uncertain. cen.acs.org/careers/US-s... #chemsky 🧪
US science research was gutted in 2025. How will it rebuild?
New strategies as diverse as venture capitalism and investments from abroad are emerging to sustain the field
cen.acs.org
August 13, 2025 at 12:55 PM
Reposted by Akul Mehta
Preset searching in GlycoPOST will allow you to perform AND searches by keyword or by update date and time, making it much easier to find the desired preset among the large number of glycomics data registered.
This feature will be available in the next release!
#glycotime #glycosmos
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
August 6, 2025 at 11:19 PM
Reposted by Akul Mehta
Exciting virtual seminar by Dr. Maxence Noel (From Dr. Richard Cummings' Lab) - "Brain N and O glycosylation: Discoveries, Tools and Dysregulation in Disease", held by the BGDG.
Thursday July 17, 2025 at 12pm EDT.
Register: docs.google.com/forms/d/e/1F...
#glycotime #neuroglycobiology #neuroscience
July 15, 2025 at 3:56 PM
Reposted by Akul Mehta
📢New article alert! 'Blood group O expression in normal tissues and tumors', just published in FEBS Journal, highlights findings using our lamprey-derived monoclonal antibodies towards specific H antigen epitopes.
Read at: febs.onlinelibrary.wiley.com/doi/10.1111/...
#glycotime #glycans #bloodgroups
FEBS Press
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4-31L and OmcFL3-...
febs.onlinelibrary.wiley.com
July 7, 2025 at 11:59 PM
Reposted by Akul Mehta
Antifreeze glycoproteins: not just for fish! 🤔 They could revolutionize food preservation and organ cryopreservation. Read more about this exciting potential in our latest interesting fact: research.bidmc.org/ncfg/blog/19...

#glycotime #glycofacts #cryopreservation
19] Facts About: Antifreeze Glycoproteins (AFGPs)
research.bidmc.org
June 13, 2025 at 6:19 PM
Reposted by Akul Mehta
New fabulous #glycotime fresh off the bioRxiv press!⬇️ 🎉 In this brilliant team effort led by Klaudia Sobczak, Jesús Jimenez-Barbero, and June Ereño Orbea 🤩 with many contributions 🌍, we characterised the 3D structure + binding mechanism of sialosides by Siglec-10 🧵 1/3

doi.org/10.1101/2025...
doi.org
June 12, 2025 at 8:20 AM
Reposted by Akul Mehta
By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.
June 10, 2025 at 1:11 PM