Anne Kühnel
@akuehnel.bsky.social
Neuroscientist working on computational psychiatry @neuromadlab in Bonn
Reposted by Anne Kühnel
First up, this paper led by Bronagh McCoy: journals.plos.org/ploscompbiol...
When noise and volatility are independently manipulated people behave differently depending on their anxious traits.
When noise and volatility are independently manipulated people behave differently depending on their anxious traits.
The relationship between anxious traits and learning about changes in stochasticity and volatility
Author summary Adapting to changes in our environment is a daily endeavour. To do so, humans and animals alike make use of feedback to guide future actions. Uncertainty in the environment can arise fr...
journals.plos.org
November 13, 2025 at 11:51 AM
First up, this paper led by Bronagh McCoy: journals.plos.org/ploscompbiol...
When noise and volatility are independently manipulated people behave differently depending on their anxious traits.
When noise and volatility are independently manipulated people behave differently depending on their anxious traits.
Reposted by Anne Kühnel
Happy to say that our overview of how to modify your taVNS setup for safe use in the MR scanner is now published!
dx.doi.org/10.1111/jon....
There are more details in the thread below but next to lower temperatures 🌡️, we also saw better signal-to-noise ratio with the modification 📶 #neuroskyence
dx.doi.org/10.1111/jon....
There are more details in the thread below but next to lower temperatures 🌡️, we also saw better signal-to-noise ratio with the modification 📶 #neuroskyence
November 7, 2025 at 3:22 PM
Happy to say that our overview of how to modify your taVNS setup for safe use in the MR scanner is now published!
dx.doi.org/10.1111/jon....
There are more details in the thread below but next to lower temperatures 🌡️, we also saw better signal-to-noise ratio with the modification 📶 #neuroskyence
dx.doi.org/10.1111/jon....
There are more details in the thread below but next to lower temperatures 🌡️, we also saw better signal-to-noise ratio with the modification 📶 #neuroskyence
Reposted by Anne Kühnel
I am pleased to announce that our new book on "Decision Making: Fundamentals and Applications" is now published by @springernature.com ! A collection of 17 chapters over 325 pages on #DecisionMaking #Psychology #Philosophy #Psychiatry @carstenmurawski.bsky.social link.springer.com/book/10.1007...
Decision Making
This book offers reports on new findings relating to mechanisms of decisions, modeling of decision making and impaired decision making upon diseases.
link.springer.com
November 5, 2025 at 7:36 AM
I am pleased to announce that our new book on "Decision Making: Fundamentals and Applications" is now published by @springernature.com ! A collection of 17 chapters over 325 pages on #DecisionMaking #Psychology #Philosophy #Psychiatry @carstenmurawski.bsky.social link.springer.com/book/10.1007...
Reposted by Anne Kühnel
🔈 Our edited volume "Decision Making: Fundamentals and Applications", co-edited with @ulrichettinger.bsky.social and Bert Heinrichs, is out.
url.au.m.mimecastprotect.com/s/9P5mCROAEn...
#DecisionScience #DecisionMaking #Psychology #Psychiatry #Neuroscience #Philosophy
url.au.m.mimecastprotect.com/s/9P5mCROAEn...
#DecisionScience #DecisionMaking #Psychology #Psychiatry #Neuroscience #Philosophy
November 4, 2025 at 9:54 PM
🔈 Our edited volume "Decision Making: Fundamentals and Applications", co-edited with @ulrichettinger.bsky.social and Bert Heinrichs, is out.
url.au.m.mimecastprotect.com/s/9P5mCROAEn...
#DecisionScience #DecisionMaking #Psychology #Psychiatry #Neuroscience #Philosophy
url.au.m.mimecastprotect.com/s/9P5mCROAEn...
#DecisionScience #DecisionMaking #Psychology #Psychiatry #Neuroscience #Philosophy
Reposted by Anne Kühnel
📆Save the date: new lecture series
[1/4] This Wednesday, October 29 at 1 p.m., we are launching a new, hybrid series of guest talks organized the Center of Artificial Intelligence and Neuroscience (CAIAN) in Bonn.
[1/4] This Wednesday, October 29 at 1 p.m., we are launching a new, hybrid series of guest talks organized the Center of Artificial Intelligence and Neuroscience (CAIAN) in Bonn.
October 27, 2025 at 2:37 PM
📆Save the date: new lecture series
[1/4] This Wednesday, October 29 at 1 p.m., we are launching a new, hybrid series of guest talks organized the Center of Artificial Intelligence and Neuroscience (CAIAN) in Bonn.
[1/4] This Wednesday, October 29 at 1 p.m., we are launching a new, hybrid series of guest talks organized the Center of Artificial Intelligence and Neuroscience (CAIAN) in Bonn.
Reposted by Anne Kühnel
My first post into the bsky void, the first preprint of my PhD! A novel task to bridge learning and effort decision-making.
Of course, we find that effort choice is sensitive to prior learning, but this integration of beliefs into action is affected by anhedonia.
doi.org/10.1101/2025...
Of course, we find that effort choice is sensitive to prior learning, but this integration of beliefs into action is affected by anhedonia.
doi.org/10.1101/2025...
Effort choices are sensitive to prior learning
Motivated behaviour relies on both learning and effort-based decision-making, yet these processes are often studied in isolation. We developed a novel paradigm combining probabilistic associative lear...
doi.org
August 1, 2025 at 10:00 AM
My first post into the bsky void, the first preprint of my PhD! A novel task to bridge learning and effort decision-making.
Of course, we find that effort choice is sensitive to prior learning, but this integration of beliefs into action is affected by anhedonia.
doi.org/10.1101/2025...
Of course, we find that effort choice is sensitive to prior learning, but this integration of beliefs into action is affected by anhedonia.
doi.org/10.1101/2025...
Reposted by Anne Kühnel
📣 Excited to share that my first paper is now published!
📄"Metabolic state shapes cortisol reactivity to acute stress: A systematic review and meta-analysis of metabolic and hormonal modulators"
You can find the full paper here:
doi.org/10.1016/j.yn...
📄"Metabolic state shapes cortisol reactivity to acute stress: A systematic review and meta-analysis of metabolic and hormonal modulators"
You can find the full paper here:
doi.org/10.1016/j.yn...
Redirecting
doi.org
October 15, 2025 at 11:27 AM
📣 Excited to share that my first paper is now published!
📄"Metabolic state shapes cortisol reactivity to acute stress: A systematic review and meta-analysis of metabolic and hormonal modulators"
You can find the full paper here:
doi.org/10.1016/j.yn...
📄"Metabolic state shapes cortisol reactivity to acute stress: A systematic review and meta-analysis of metabolic and hormonal modulators"
You can find the full paper here:
doi.org/10.1016/j.yn...
Reposted by Anne Kühnel
So glad to have been part of the #ECNP2025 conference!
It was a great opportunity to present my poster on how different oral contraceptive states affect physiological and neural stress reactivity, and discuss new perspectives on mental health and well-being 🧠
It was a great opportunity to present my poster on how different oral contraceptive states affect physiological and neural stress reactivity, and discuss new perspectives on mental health and well-being 🧠
October 14, 2025 at 9:10 AM
So glad to have been part of the #ECNP2025 conference!
It was a great opportunity to present my poster on how different oral contraceptive states affect physiological and neural stress reactivity, and discuss new perspectives on mental health and well-being 🧠
It was a great opportunity to present my poster on how different oral contraceptive states affect physiological and neural stress reactivity, and discuss new perspectives on mental health and well-being 🧠
Reposted by Anne Kühnel
1st Sharp Lab preprint! 🚨 We tested how anxiety affects task generalization—not how people generalize threat stimuli, but how they reuse action-outcome structures when planning in new contexts.
Worry makes people avoid reusing actions that co-occurred w/ threat!
📄: osf.io/preprints/ps...
🧵 1/12
Worry makes people avoid reusing actions that co-occurred w/ threat!
📄: osf.io/preprints/ps...
🧵 1/12
October 13, 2025 at 6:30 AM
1st Sharp Lab preprint! 🚨 We tested how anxiety affects task generalization—not how people generalize threat stimuli, but how they reuse action-outcome structures when planning in new contexts.
Worry makes people avoid reusing actions that co-occurred w/ threat!
📄: osf.io/preprints/ps...
🧵 1/12
Worry makes people avoid reusing actions that co-occurred w/ threat!
📄: osf.io/preprints/ps...
🧵 1/12
Reposted by Anne Kühnel
Published now (after long last & 10 citations). Although tVNS does not alter food reward ratings in healthy people, it acutely improved liking ratings in patients with MDD (also correlated with anhedonia). #neuroskyence 🩺
Work w/ @akuehnel.bsky.social
www.sciencedirect.com/science/arti...
Work w/ @akuehnel.bsky.social
www.sciencedirect.com/science/arti...
October 11, 2025 at 11:40 AM
Published now (after long last & 10 citations). Although tVNS does not alter food reward ratings in healthy people, it acutely improved liking ratings in patients with MDD (also correlated with anhedonia). #neuroskyence 🩺
Work w/ @akuehnel.bsky.social
www.sciencedirect.com/science/arti...
Work w/ @akuehnel.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Anne Kühnel
** We have up to TWO funded PhD positions available in our lab!! Apply below to find new ways to enhance memory👇 Pls retweet **
Deadline: 2nd December
1. Cross-species closed-loopTMR: tinyurl.com/bddu4tp6
2. TUS and TMR in humans:
tinyurl.com/jjws5ctj
Happy to chat to interested applicants.
Deadline: 2nd December
1. Cross-species closed-loopTMR: tinyurl.com/bddu4tp6
2. TUS and TMR in humans:
tinyurl.com/jjws5ctj
Happy to chat to interested applicants.
Enhancing memory using cross-species closed-loop Targeted Memory Reactivation | mrcbndu
tinyurl.com
October 6, 2025 at 11:51 AM
** We have up to TWO funded PhD positions available in our lab!! Apply below to find new ways to enhance memory👇 Pls retweet **
Deadline: 2nd December
1. Cross-species closed-loopTMR: tinyurl.com/bddu4tp6
2. TUS and TMR in humans:
tinyurl.com/jjws5ctj
Happy to chat to interested applicants.
Deadline: 2nd December
1. Cross-species closed-loopTMR: tinyurl.com/bddu4tp6
2. TUS and TMR in humans:
tinyurl.com/jjws5ctj
Happy to chat to interested applicants.
Reposted by Anne Kühnel
Second day of the conference of Experimental endocrinology in Freising! 🥨
Really enjoyed the talk by Henrik Oster on circadian appetite regulation which gave a lot of food for thought: should I really give this dessert in the evening a go? 💭
Really enjoyed the talk by Henrik Oster on circadian appetite regulation which gave a lot of food for thought: should I really give this dessert in the evening a go? 💭
September 30, 2025 at 8:04 AM
Second day of the conference of Experimental endocrinology in Freising! 🥨
Really enjoyed the talk by Henrik Oster on circadian appetite regulation which gave a lot of food for thought: should I really give this dessert in the evening a go? 💭
Really enjoyed the talk by Henrik Oster on circadian appetite regulation which gave a lot of food for thought: should I really give this dessert in the evening a go? 💭
Reposted by Anne Kühnel
I came across a terrific interview with Peter Dayan, always a delight to listen to.
Peter's speed of mind and talk is possibly unsurpassable.
www.youtube.com/watch?v=Cttx...
Peter's speed of mind and talk is possibly unsurpassable.
www.youtube.com/watch?v=Cttx...
Peter Dayan: How to study the brain from a computational view | Q-Learning, Memory, Decision Making
YouTube video by Neuroscience and Beyond
www.youtube.com
September 27, 2025 at 8:58 AM
I came across a terrific interview with Peter Dayan, always a delight to listen to.
Peter's speed of mind and talk is possibly unsurpassable.
www.youtube.com/watch?v=Cttx...
Peter's speed of mind and talk is possibly unsurpassable.
www.youtube.com/watch?v=Cttx...
Reposted by Anne Kühnel
What drives the bidirectional relationship between metabolic and mental ill-health?
Read our new metabolic psychiatry paper, “An interoceptive model of energy allostasis linking metabolic and mental health” www.science.org/doi/10.1126/... led by @saramehrhof.bsky.social @hugofleming.bsky.social
Read our new metabolic psychiatry paper, “An interoceptive model of energy allostasis linking metabolic and mental health” www.science.org/doi/10.1126/... led by @saramehrhof.bsky.social @hugofleming.bsky.social
An interoceptive model of energy allostasis linking metabolic and mental health
Interactions between metabolic interoception and regulation may drive comorbidity between mental and metabolic ill-health.
www.science.org
September 25, 2025 at 9:48 AM
What drives the bidirectional relationship between metabolic and mental ill-health?
Read our new metabolic psychiatry paper, “An interoceptive model of energy allostasis linking metabolic and mental health” www.science.org/doi/10.1126/... led by @saramehrhof.bsky.social @hugofleming.bsky.social
Read our new metabolic psychiatry paper, “An interoceptive model of energy allostasis linking metabolic and mental health” www.science.org/doi/10.1126/... led by @saramehrhof.bsky.social @hugofleming.bsky.social
Reposted by Anne Kühnel
Please RT
2 new positions in the lab as postdoc & PhD!
Interested in stress, pain, or reward? This project has it all!
We are a friendly but ambitious group. Oslo is a capital city on the fjord & bordered by forest, great urban & outdoors opportunities: 💃 ⛷️ 🚣 🎭 🎶
www.jobbnorge.no/en/available...
2 new positions in the lab as postdoc & PhD!
Interested in stress, pain, or reward? This project has it all!
We are a friendly but ambitious group. Oslo is a capital city on the fjord & bordered by forest, great urban & outdoors opportunities: 💃 ⛷️ 🚣 🎭 🎶
www.jobbnorge.no/en/available...
Postdoctoral Research Fellowship (286516) | University of Oslo
Job title: Postdoctoral Research Fellowship (286516), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025
www.jobbnorge.no
September 24, 2025 at 12:22 PM
Please RT
2 new positions in the lab as postdoc & PhD!
Interested in stress, pain, or reward? This project has it all!
We are a friendly but ambitious group. Oslo is a capital city on the fjord & bordered by forest, great urban & outdoors opportunities: 💃 ⛷️ 🚣 🎭 🎶
www.jobbnorge.no/en/available...
2 new positions in the lab as postdoc & PhD!
Interested in stress, pain, or reward? This project has it all!
We are a friendly but ambitious group. Oslo is a capital city on the fjord & bordered by forest, great urban & outdoors opportunities: 💃 ⛷️ 🚣 🎭 🎶
www.jobbnorge.no/en/available...
Reposted by Anne Kühnel
Mental and metabolic health are closely linked - but what drives this connection? In our new theory paper, we (w/ @camillanord.bsky.social & @hugofleming.bsky.social g.bsky.social) propose dysregulation of interoceptive energy allostasis as a key mechanism.
www.science.org/doi/10.1126/... 🧵 1/n
www.science.org/doi/10.1126/... 🧵 1/n
An interoceptive model of energy allostasis linking metabolic and mental health
Interactions between metabolic interoception and regulation may drive comorbidity between mental and metabolic ill-health.
www.science.org
September 25, 2025 at 10:39 AM
Mental and metabolic health are closely linked - but what drives this connection? In our new theory paper, we (w/ @camillanord.bsky.social & @hugofleming.bsky.social g.bsky.social) propose dysregulation of interoceptive energy allostasis as a key mechanism.
www.science.org/doi/10.1126/... 🧵 1/n
www.science.org/doi/10.1126/... 🧵 1/n
Reposted by Anne Kühnel
Big congrats to Marishka on this. I know how much time and effort went into it. Really happy to see it out! For those interested, she replicated prior longitudinal results using an approach-avoidance conflict task and showed how model parameters afforded out-of-sample clinical prediction.
New paper in CPsy - 'Computational Mechanisms of Approach-Avoidance Conflict Predictively Differentiate Between Affective and Substance Use Disorders' from Marishka Mehta and the group of @rssmith.bsky.social
doi.org/10.5334/cpsy...
doi.org/10.5334/cpsy...
Computational Mechanisms of Approach-Avoidance Conflict Predictively Differentiate Between Affective and Substance Use Disorders | Computational Psychiatry
doi.org
September 16, 2025 at 4:16 AM
Big congrats to Marishka on this. I know how much time and effort went into it. Really happy to see it out! For those interested, she replicated prior longitudinal results using an approach-avoidance conflict task and showed how model parameters afforded out-of-sample clinical prediction.
Reposted by Anne Kühnel
New qualitative paper! A foray into gastric interception. @lucysta02475610.bsky.social ran a LOT of focus groups, across groups with eating disorders, gastric disorders and neither, to understand how people experience the sensations from their GI system. www.sciencedirect.com/science/arti...
"I feel full with shame": A qualitative perspective on gastric interoceptive sensibility
“Am I hungry? Did I overeat at lunch?” Gastric interoception - the sensing, interpretation, and regulation of signals from the gastrointestinal system…
www.sciencedirect.com
September 13, 2025 at 7:03 AM
New qualitative paper! A foray into gastric interception. @lucysta02475610.bsky.social ran a LOT of focus groups, across groups with eating disorders, gastric disorders and neither, to understand how people experience the sensations from their GI system. www.sciencedirect.com/science/arti...
Reposted by Anne Kühnel
In our new paper 📖🔥, we conducted a pooled analysis (n=443; 5 studies) to test if state affect (momentary mood) or trait dispositions (approach/avoidance) predict cortisol reactivity beyond biological & contextual factors. (1/4)
#neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
#neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
Unpacking cortisol stress reactivity: Associations with psychological state and trait data in a pooled data sample
Prior research suggests that cortisol responses to acute stress induction paradigms (i.e., “cortisol stress reactivity”) likely arise from complex int…
www.sciencedirect.com
September 10, 2025 at 10:57 AM
In our new paper 📖🔥, we conducted a pooled analysis (n=443; 5 studies) to test if state affect (momentary mood) or trait dispositions (approach/avoidance) predict cortisol reactivity beyond biological & contextual factors. (1/4)
#neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
#neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
We recently reported higher variability of reinforcement learning in obesity and BED, but what about neural representations? In our new preprint, we show higher variability in NAcc responses to reward cues in obesity and disinhibited eating www.medrxiv.org/content/10.1... w/ @nbkroemer.bsky.social
September 8, 2025 at 3:44 PM
We recently reported higher variability of reinforcement learning in obesity and BED, but what about neural representations? In our new preprint, we show higher variability in NAcc responses to reward cues in obesity and disinhibited eating www.medrxiv.org/content/10.1... w/ @nbkroemer.bsky.social
Reposted by Anne Kühnel
When we encounter the same reward repeatedly, we show variable responses; is this just noise?
In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺
W/ @akuehnel.bsky.social
www.medrxiv.org/content/10.1...
In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺
W/ @akuehnel.bsky.social
www.medrxiv.org/content/10.1...
September 8, 2025 at 6:44 AM
When we encounter the same reward repeatedly, we show variable responses; is this just noise?
In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺
W/ @akuehnel.bsky.social
www.medrxiv.org/content/10.1...
In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺
W/ @akuehnel.bsky.social
www.medrxiv.org/content/10.1...
Reposted by Anne Kühnel
The German government is investing €120 million in expanding the German Center for Mental Health (DZPG). Glad to join Thomas Nickl-Jockschat @jockschat.bsky.social and Daniela Dieterich with our project on cognitive flexibility and uncertainty in mental health.
www.dzpg.org/aktuelles/pr...
www.dzpg.org/aktuelles/pr...
Start der Ausbauphase am DZPG: Mehr Forschung, mehr Vernetzung, mehr Wirkung
Heute beginnt an allen sechs Standorten des Deutschen Zentrums für Psychische Gesundheit (DZPG) offiziell die fünfjährige Ausbauphase. Das Bundesministerium für Forschung, Technologie und Raumfahrt (B...
www.dzpg.org
September 5, 2025 at 11:21 AM
The German government is investing €120 million in expanding the German Center for Mental Health (DZPG). Glad to join Thomas Nickl-Jockschat @jockschat.bsky.social and Daniela Dieterich with our project on cognitive flexibility and uncertainty in mental health.
www.dzpg.org/aktuelles/pr...
www.dzpg.org/aktuelles/pr...
Reposted by Anne Kühnel
Continuing the general thread, Peter Dyan does a very nice summary of Berridge's liking/wanting distinction, the evidence for it, and how it links to RL and interoception here (21:30):
www.youtube.com/watch?v=vLA7...
www.youtube.com/watch?v=vLA7...
Peter Dayan: The Marriage of Natural and Engineered Reinforcement Learning
YouTube video by Reinforcement Learning Conference
www.youtube.com
September 3, 2025 at 8:36 PM
Continuing the general thread, Peter Dyan does a very nice summary of Berridge's liking/wanting distinction, the evidence for it, and how it links to RL and interoception here (21:30):
www.youtube.com/watch?v=vLA7...
www.youtube.com/watch?v=vLA7...
Reposted by Anne Kühnel
One of the last projects of my PhD looking into insular functional segregation in depression is finally out as a preprint 🙏👇 Have a look and let us know what you think! #neuroskyence
New preprint...and this one is truly EPIC 🚨.
Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
August 31, 2025 at 7:33 PM
One of the last projects of my PhD looking into insular functional segregation in depression is finally out as a preprint 🙏👇 Have a look and let us know what you think! #neuroskyence
Reposted by Anne Kühnel
If you are interested in using functional neuroimaging and neuromodulation to improve key symptoms of depression, we are still looking for PhD students:
Official ad (in German, B2 level or better is required): karriereamukb.de/jobs/doktora...
Official ad (in German, B2 level or better is required): karriereamukb.de/jobs/doktora...
September 1, 2025 at 11:15 AM
If you are interested in using functional neuroimaging and neuromodulation to improve key symptoms of depression, we are still looking for PhD students:
Official ad (in German, B2 level or better is required): karriereamukb.de/jobs/doktora...
Official ad (in German, B2 level or better is required): karriereamukb.de/jobs/doktora...