Alan Grossfield
@agrossfield.bsky.social
Expert in biomolecular simulation and biophysics.
http://membrane.urmc.rochester.edu/
http://grossfieldlab.github.io/loos/
https://orcid.org/0000-0002-5877-2789
http://membrane.urmc.rochester.edu/
http://grossfieldlab.github.io/loos/
https://orcid.org/0000-0002-5877-2789
Reposted by Alan Grossfield
is it good that everyone i know being made to find a use for AI at work is just having to manage the politics of the fact that they're expected to use it whilst fixing all of its mistakes? it seems to have the same impact on the workplace as a bad intern who's only there cause hes the CEOs son
February 20, 2026 at 11:38 AM
is it good that everyone i know being made to find a use for AI at work is just having to manage the politics of the fact that they're expected to use it whilst fixing all of its mistakes? it seems to have the same impact on the workplace as a bad intern who's only there cause hes the CEOs son
Reposted by Alan Grossfield
I just did the dumbest thing of my entire career to prove a much more serious point.
I tricked ChatGPT and Google, and made them tell other users I’m a competitive hot-dog-eating world champion
People are using this trick on a massive scale to make AI tell you lies. I’ll explain how I did it
I tricked ChatGPT and Google, and made them tell other users I’m a competitive hot-dog-eating world champion
People are using this trick on a massive scale to make AI tell you lies. I’ll explain how I did it
February 18, 2026 at 4:37 PM
I just did the dumbest thing of my entire career to prove a much more serious point.
I tricked ChatGPT and Google, and made them tell other users I’m a competitive hot-dog-eating world champion
People are using this trick on a massive scale to make AI tell you lies. I’ll explain how I did it
I tricked ChatGPT and Google, and made them tell other users I’m a competitive hot-dog-eating world champion
People are using this trick on a massive scale to make AI tell you lies. I’ll explain how I did it
Reposted by Alan Grossfield
Writing is thinking.
It's not some marginal boring task you can skip. It's the heart of it.
It's not some marginal boring task you can skip. It's the heart of it.
It’s easy to think writing is mainly the transcription of ideas you already have—that is, until you try to write something worthwhile, and you find what you thought were saying transform into something far more interesting in the process. This skips that last step, and that is *not* an improvement.
“We plan to hire an AI rewrite specialist to ingest the reporting by Hannah and others and use AI to convert it into stories.”
The editor of the Cleveland Plain Dealer said it will use AI to ‘write’ its articles.
www.cleveland.com/news/2025/10...
The editor of the Cleveland Plain Dealer said it will use AI to ‘write’ its articles.
www.cleveland.com/news/2025/10...
February 16, 2026 at 2:55 PM
Writing is thinking.
It's not some marginal boring task you can skip. It's the heart of it.
It's not some marginal boring task you can skip. It's the heart of it.
Reposted by Alan Grossfield
Hey #chemchat #chemsky question - an app I used to track journal feeds will be dead soon.
Any good tools to keep track of new literature articles? Ideally I'd like something I can 👍👎 and filter out topics or authors (e.g., "exclude this paper mill")
Suggestions welcome - I'll post a summary
Any good tools to keep track of new literature articles? Ideally I'd like something I can 👍👎 and filter out topics or authors (e.g., "exclude this paper mill")
Suggestions welcome - I'll post a summary
February 17, 2026 at 2:06 AM
Reposted by Alan Grossfield
Hello bluesky, I'm a theoretical chemist at University of Bayreuth. My group works on atomistic modeling of energy materials with electronic structure methods and ML. I'm hoping to connect to other #compchem and #materials folks!
February 16, 2026 at 9:44 PM
Hello bluesky, I'm a theoretical chemist at University of Bayreuth. My group works on atomistic modeling of energy materials with electronic structure methods and ML. I'm hoping to connect to other #compchem and #materials folks!
Katya was feeling very insecure tonight
February 15, 2026 at 2:09 AM
Katya was feeling very insecure tonight
Reposted by Alan Grossfield
Fuentes, yesterday: “Our #1 political enemy is women because women constrain everything, every conversation, every man, everything. They have to be imprisoned. They are the ones that are hurting the fertility rate. They're the ones making us sympathetic to poor people, which are also brown people.”
Nick Fuentes: “The number one political enemy in America is women. … They have to be imprisoned.”
www.mediamatters.org
February 12, 2026 at 12:13 PM
Fuentes, yesterday: “Our #1 political enemy is women because women constrain everything, every conversation, every man, everything. They have to be imprisoned. They are the ones that are hurting the fertility rate. They're the ones making us sympathetic to poor people, which are also brown people.”
Is GitHub flaky for anyone else this morning? I keep getting “No server is currently available to service your request”
February 9, 2026 at 4:21 PM
Is GitHub flaky for anyone else this morning? I keep getting “No server is currently available to service your request”
Reposted by Alan Grossfield
At Findlay Market in Cincy. It’s called Yee Mama; i think it’s relatively new; first time for me and the fam today. The food is EXCELLENT but that is not the reason i want to keep going back again and again, spot the reason
February 8, 2026 at 6:43 PM
At Findlay Market in Cincy. It’s called Yee Mama; i think it’s relatively new; first time for me and the fam today. The food is EXCELLENT but that is not the reason i want to keep going back again and again, spot the reason
Small pleasure: reviewing decisions on papers by editorial board members this morning, and every reviewer appeared to be thoughtful and respectful. It makes me feel proud to be associated with Biophysical Journal @biophysj.bsky.social
February 9, 2026 at 1:23 PM
Small pleasure: reviewing decisions on papers by editorial board members this morning, and every reviewer appeared to be thoughtful and respectful. It makes me feel proud to be associated with Biophysical Journal @biophysj.bsky.social
Reposted by Alan Grossfield
Lately I'm regretting that we didn't talk about space data centers in A City on Mars, but tbh the idea just seemed so transparently silly. Now Musk and apparently the CNA (www.reuters.com/science/chin...) are talking about it.
China plans space‑based AI data centres, challenging Musk's SpaceX ambitions
China's main space contractor vowed to construct "digital-intelligence infrastructure" that will enable data from Earth to be processed in space.
www.reuters.com
February 5, 2026 at 1:24 PM
Lately I'm regretting that we didn't talk about space data centers in A City on Mars, but tbh the idea just seemed so transparently silly. Now Musk and apparently the CNA (www.reuters.com/science/chin...) are talking about it.
Reposted by Alan Grossfield
Floored by this story. A man wrote a pollite email to a federal prosecutor objecting to the deportation of an Afghan seeking asylum. DHS responded with an administrative warrant to get the man's info from Google, then visited his home to intimidate him.
DHS Hunts Down 67-Year-Old U.S. Citizen Who Criticized Them in Email
The Department of Homeland Security is using a little-known tool to go after its critics.
newrepublic.com
February 3, 2026 at 11:14 PM
Floored by this story. A man wrote a pollite email to a federal prosecutor objecting to the deportation of an Afghan seeking asylum. DHS responded with an administrative warrant to get the man's info from Google, then visited his home to intimidate him.
Reposted by Alan Grossfield
This is a truly timeless piece... harpers.org/archive/1941...
February 1, 2026 at 12:28 PM
This is a truly timeless piece... harpers.org/archive/1941...
Reposted by Alan Grossfield
I am hearing that RFK Jr.’s minions are going to go after HPV vaccines. I’ve got problems with these people and now you’re going to hear about them, first from a personal perspective and then from a professional one.
It all boils down to this: WE HAVE A SAFE VACCINE THAT PREVENTS CANCER.
It all boils down to this: WE HAVE A SAFE VACCINE THAT PREVENTS CANCER.
January 28, 2026 at 7:52 PM
I am hearing that RFK Jr.’s minions are going to go after HPV vaccines. I’ve got problems with these people and now you’re going to hear about them, first from a personal perspective and then from a professional one.
It all boils down to this: WE HAVE A SAFE VACCINE THAT PREVENTS CANCER.
It all boils down to this: WE HAVE A SAFE VACCINE THAT PREVENTS CANCER.
Reposted by Alan Grossfield
Oh goody...Andrew Huberman is going to be a commentator on CBS News.
I first learned of him when he did a 4+ hour podcast with Director Bhattacharya (also the first time I heard Bhattacharya on a podcast).
1/7
I first learned of him when he did a 4+ hour podcast with Director Bhattacharya (also the first time I heard Bhattacharya on a podcast).
1/7
January 28, 2026 at 12:59 PM
Oh goody...Andrew Huberman is going to be a commentator on CBS News.
I first learned of him when he did a 4+ hour podcast with Director Bhattacharya (also the first time I heard Bhattacharya on a podcast).
1/7
I first learned of him when he did a 4+ hour podcast with Director Bhattacharya (also the first time I heard Bhattacharya on a podcast).
1/7
Reposted by Alan Grossfield
Jane Richardson was born #OTD in 1941
+ Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures)
+ MacArthur Fellow, 1985
+ Elected, Nat'l Academy of Sciences, 1991
+ President, Biophysical Society, 2012
#WomenInSTEM
+ Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures)
+ MacArthur Fellow, 1985
+ Elected, Nat'l Academy of Sciences, 1991
+ President, Biophysical Society, 2012
#WomenInSTEM
January 26, 2026 at 12:06 AM
Jane Richardson was born #OTD in 1941
+ Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures)
+ MacArthur Fellow, 1985
+ Elected, Nat'l Academy of Sciences, 1991
+ President, Biophysical Society, 2012
#WomenInSTEM
+ Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures)
+ MacArthur Fellow, 1985
+ Elected, Nat'l Academy of Sciences, 1991
+ President, Biophysical Society, 2012
#WomenInSTEM
Reposted by Alan Grossfield
Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
August 7, 2025 at 8:45 AM
Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
Reposted by Alan Grossfield
I just thought everyone should see this
January 22, 2026 at 11:02 PM
I just thought everyone should see this
Reposted by Alan Grossfield
I started reading up on the whole "loneliness pandemic" narrative because this seems like a literature where the age-period-cohort problem may be relevant (or maybe it isn't?).
Here's data from Australia (HILDA), average agreement with the statement "I often feel very lonely" (SD of ca. 1.8).>
Here's data from Australia (HILDA), average agreement with the statement "I often feel very lonely" (SD of ca. 1.8).>
January 15, 2026 at 1:24 PM
I started reading up on the whole "loneliness pandemic" narrative because this seems like a literature where the age-period-cohort problem may be relevant (or maybe it isn't?).
Here's data from Australia (HILDA), average agreement with the statement "I often feel very lonely" (SD of ca. 1.8).>
Here's data from Australia (HILDA), average agreement with the statement "I often feel very lonely" (SD of ca. 1.8).>
Reposted by Alan Grossfield
hey European hivemind, I need some help...PhD students here, especially foreign ones, are feeling a lot of concern related to evolving immigration restrictions here. Those students are increasingly looking to postdocs in EU. To help advise them better, what are expectations for postdocs?
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1/2
January 12, 2026 at 6:37 PM
hey European hivemind, I need some help...PhD students here, especially foreign ones, are feeling a lot of concern related to evolving immigration restrictions here. Those students are increasingly looking to postdocs in EU. To help advise them better, what are expectations for postdocs?
1/2
1/2
Reposted by Alan Grossfield
Following coverage over the weekend of Sir Paul Nurse's comments that suggested that the only reason that a Fellow should be expelled from @royalsociety.org is scientific misconduct, I have written to him to explain the risks such an attitude poses of increasing sexual harassment in STEM.
January 12, 2026 at 8:59 AM
Following coverage over the weekend of Sir Paul Nurse's comments that suggested that the only reason that a Fellow should be expelled from @royalsociety.org is scientific misconduct, I have written to him to explain the risks such an attitude poses of increasing sexual harassment in STEM.
The world is on fire, but at least I made something yummy for dinner: beef borguignon pot pie
January 10, 2026 at 10:35 PM
The world is on fire, but at least I made something yummy for dinner: beef borguignon pot pie
Reposted by Alan Grossfield
My TL has been unremittingly dark, lately. Guessing I'm not alone. Got to visit Lisbon's zoo, yesterday. An exemplar of good animal stewardship (lots of enrichment props/activities in large spaces for the animals) while allowing awesome viewing. So, a TL cleanse of animal pics follows, if you need.
January 9, 2026 at 12:57 PM
My TL has been unremittingly dark, lately. Guessing I'm not alone. Got to visit Lisbon's zoo, yesterday. An exemplar of good animal stewardship (lots of enrichment props/activities in large spaces for the animals) while allowing awesome viewing. So, a TL cleanse of animal pics follows, if you need.